Chander Raman

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5
    C Raman
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 273:19183-9. 1998
  2. ncbi request reprint Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: implication on TCR/CD3-mediated activation
    C Raman
    Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 161:5817-20. 1998
  3. ncbi request reprint CD5, an important regulator of lymphocyte selection and immune tolerance
    Chander Raman
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Immunol Res 26:255-63. 2002
  4. pmc CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system
    Robert C Axtell
    Department of Medicine, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA
    J Immunol 177:8542-9. 2006
  5. pmc Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling
    Amber L Rowse
    Department of Microbiology, University of Alabama at Birmingham, Alabama, USA
    PLoS ONE 7:e52658. 2012
  6. pmc The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis
    Rodrigo Naves
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 191:2967-77. 2013
  7. ncbi request reprint Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice
    Robert C Axtell
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    J Immunol 173:2928-32. 2004
  8. ncbi request reprint CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as a binding and phosphoacceptor site for casein kinase 2
    S F Greer
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 166:7208-18. 2001
  9. pmc CD5-dependent CK2 activation pathway regulates threshold for T cell anergy
    Christine M Sestero
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 189:2918-30. 2012
  10. ncbi request reprint Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis
    Alexander J Szalai
    Department of Medicine at The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Immunol 35:3487-92. 2005

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5
    C Raman
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 273:19183-9. 1998
    ..This direct regulation of CK2 by a cell surface receptor provides a novel pathway for control of cell activation that could play a significant role in regulation of CD5-dependent antigen receptor activation in T and B cells...
  2. ncbi request reprint Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: implication on TCR/CD3-mediated activation
    C Raman
    Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 161:5817-20. 1998
    ..We propose that CD5 modulates Ag receptor activity through developmentally regulated activation of CD5-associated CK2...
  3. ncbi request reprint CD5, an important regulator of lymphocyte selection and immune tolerance
    Chander Raman
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Immunol Res 26:255-63. 2002
    ..I and others, reviewed here, now provide clear evidence that CD5 is a key regulator of immune tolerance and that alterations of its activity can promote development of autoreactivity...
  4. pmc CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system
    Robert C Axtell
    Department of Medicine, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA
    J Immunol 177:8542-9. 2006
    ..This study predicts that targeting of IFN-gamma(+)/IL-17(+) infiltrating Th cells will be useful for the treatment of multiple sclerosis and other systemic autoimmune diseases...
  5. pmc Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling
    Amber L Rowse
    Department of Microbiology, University of Alabama at Birmingham, Alabama, USA
    PLoS ONE 7:e52658. 2012
    ..Overall our findings set the framework for the use of GSK3 inhibitors as therapeutic agents in autoimmune neuroinflammation...
  6. pmc The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis
    Rodrigo Naves
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 191:2967-77. 2013
    ..Collectively, our data show that type I and II IFNs function in an integrated manner to regulate pathogenesis in EAE. ..
  7. ncbi request reprint Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice
    Robert C Axtell
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    J Immunol 173:2928-32. 2004
    ..Our studies indicate that CD5 regulates survival of activated T cells and provides a target for treatment of T cell-dependent autoimmune diseases such as multiple sclerosis...
  8. ncbi request reprint CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as a binding and phosphoacceptor site for casein kinase 2
    S F Greer
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 166:7208-18. 2001
    ..These findings support the hypothesis that a physical interaction between the CD45 cytoplasmic domain and CK2 is important for post-translational modification of CD45, which, in turn, regulates its catalytic function...
  9. pmc CD5-dependent CK2 activation pathway regulates threshold for T cell anergy
    Christine M Sestero
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 189:2918-30. 2012
    ..This property was recapitulated in in vitro restimulation assays. These results demonstrate that CD5-CK2 signaling sets the threshold for T cell responsiveness and is necessary for efficient generation of Th2 and Th17 cells...
  10. ncbi request reprint Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis
    Alexander J Szalai
    Department of Medicine at The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Immunol 35:3487-92. 2005
    ..Expression of the common gamma-chain by gammadelta T cells, probably in conjunction with the T cell receptor/CD3 complex, is likely the key requirement for full development of EAE...
  11. ncbi request reprint Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis
    Daniel C Bullard
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    J Immunol 175:6327-33. 2005
    ..Our results indicate that Mac-1 expression is critical on both phagocytic cells and T cells for the development of demyelinating disease...
  12. pmc Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G
    Andrew W Gibson
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Leukoc Biol 91:97-103. 2012
    ..These data are consistent with a phosphoserine-dependent tethering role for protein 4.1G in maintaining FcγRI in lipid rafts and provide insight into the unique phosphoserine-based regulation of receptor signaling by FcγRI CY...
  13. pmc Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity
    John H Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:442-51. 2010
    ....
  14. pmc Lithium prevents and ameliorates experimental autoimmune encephalomyelitis
    Patrizia De Sarno
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 181:338-45. 2008
    ....
  15. ncbi request reprint AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells
    Xianghuai Lu
    Division of Clinical Immunology and Rheumatology, Departments of Medicine, Cell Biology, and Microbiology, University of Alabama, Birmingham, AL 35294
    J Immunol 168:5612-20. 2002
    ..The ability to differentially alter posttranslational CD5 expression in T and B cells is likely to be key in regulation of Ag receptor signaling and generation of tolerance in T and B lymphocytes...
  16. doi request reprint Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis
    Yudong Liu
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294
    J Immunol 192:59-72. 2014
    ..Inhibition of the JAK/STAT pathway has clinical efficacy in multiple preclinical models of MS, suggesting the feasibility of the JAK/STAT pathway as a target for neuroinflammatory diseases. ..
  17. doi request reprint MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration
    Ashley S Harms
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 33:9592-600. 2013
    ....
  18. pmc Janus-like effects of type I interferon in autoimmune diseases
    Robert C Axtell
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305 5316, USA
    Immunol Rev 248:23-35. 2012
    ....

Research Grants11

  1. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2010
    ..The role of CD5 in the development of B-cells has been extensively interrogated, but remains unresolved;the goal of this proposal is to fill this gap in our understanding. ..
  2. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2009
    ..The role of CD5 in the development of B-cells has been extensively interrogated, but remains unresolved; the goal of this proposal is to fill this gap in our understanding. ..
  3. CD5 REGULATION OF CK2 IN T CELLS OF DIFFERENT AGES
    Chander Raman; Fiscal Year: 2004
    ..Novel therapeutic strategies can then be devised to target these pathways. ..
  4. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2010
    ..The role of CD5 in the development of B-cells has been extensively interrogated, but remains unresolved;the goal of this proposal is to fill this gap in our understanding. ..