Miguel Ramalho-Santos

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi CompMoby: comparative MobyDick for detection of cis-regulatory motifs
    Christina Chaivorapol
    Department of Biochemistry and Biophysics, California Institute for Quantitative Biomedical Research, Graduate Program in Biological and Medical Informatics, University of California, San Francisco, CA 94143 2540, USA
    BMC Bioinformatics 9:455. 2008
  2. ncbi iPS cells: insights into basic biology
    Miguel Ramalho-Santos
    Department of Ob Gyn, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Cell 138:616-8. 2009
  3. ncbi On the origin of the term "stem cell"
    Miguel Ramalho-Santos
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 1:35-8. 2007
  4. ncbi Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming
    Han Qin
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Diabetes Center, South San Francisco, CA, USA
    Hum Mol Genet 21:2054-67. 2012
  5. ncbi Parallel gateways to pluripotency: open chromatin in stem cells and development
    Fong Ming Koh
    Departments of Ob Gyn and Pathology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Curr Opin Genet Dev 20:492-9. 2010
  6. ncbi Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal
    Julie Hunkapiller
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 8:e1002576. 2012
  7. ncbi Open chromatin in pluripotency and reprogramming
    Alexandre Gaspar-Maia
    Departments of Ob Gyn and Pathology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California, San Francisco, 513 Parnassus Ave, San Francisco, California 94143 0525, USA
    Nat Rev Mol Cell Biol 12:36-47. 2011
  8. ncbi Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
    Yuki Ohi
    Department of Ob Gyn and Center for Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Cell Biol 13:541-9. 2011
  9. ncbi Stem cells as probabilistic self-producing entities
    Miguel Ramalho-Santos
    Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco CA 94143 0540, USA
    Bioessays 26:1013-6. 2004
  10. ncbi Chd1 regulates open chromatin and pluripotency of embryonic stem cells
    Alexandre Gaspar-Maia
    Department of Ob Gyn and Pathology, Center for Reproductive Sciences and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0525, USA
    Nature 460:863-8. 2009

Collaborators

Detail Information

Publications12

  1. ncbi CompMoby: comparative MobyDick for detection of cis-regulatory motifs
    Christina Chaivorapol
    Department of Biochemistry and Biophysics, California Institute for Quantitative Biomedical Research, Graduate Program in Biological and Medical Informatics, University of California, San Francisco, CA 94143 2540, USA
    BMC Bioinformatics 9:455. 2008
    ..Therefore, a computational algorithm should account for both conserved and nonconserved cis-regulatory elements in metazoans...
  2. ncbi iPS cells: insights into basic biology
    Miguel Ramalho-Santos
    Department of Ob Gyn, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Cell 138:616-8. 2009
    ..The discovery that adult somatic cells can be induced to become pluripotent by overexpression of a few key transcription factors provides an exciting new window into the basic biology of pluripotency and differentiation...
  3. ncbi On the origin of the term "stem cell"
    Miguel Ramalho-Santos
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 1:35-8. 2007
    ..The original meanings of the term stem cell, rather than being historical relics, continue to capture important aspects of the biology of stem cells as we see them today...
  4. ncbi Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming
    Han Qin
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Diabetes Center, South San Francisco, CA, USA
    Hum Mol Genet 21:2054-67. 2012
    ..These results reveal transcriptional parallels between germ cell transformation and the generation of iPS cells and indicate that the Hippo pathway constitutes a barrier to cellular reprogramming...
  5. ncbi Parallel gateways to pluripotency: open chromatin in stem cells and development
    Fong Ming Koh
    Departments of Ob Gyn and Pathology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Curr Opin Genet Dev 20:492-9. 2010
    ..The combination of in vitro and in vivo approaches is expected to provide a comprehensive understanding of the epigenetic regulation of pluripotency and reprograming...
  6. ncbi Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal
    Julie Hunkapiller
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 8:e1002576. 2012
    ..Thus, Pcl3 is a component of PRC2 critical for ESC self-renewal, histone methylation, and recruitment of PRC2 to a subset of its genomic sites...
  7. ncbi Open chromatin in pluripotency and reprogramming
    Alexandre Gaspar-Maia
    Departments of Ob Gyn and Pathology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California, San Francisco, 513 Parnassus Ave, San Francisco, California 94143 0525, USA
    Nat Rev Mol Cell Biol 12:36-47. 2011
    ..These same principles may apply during reacquisition of an open chromatin state upon reprogramming to pluripotency, and during de-differentiation in cancer...
  8. ncbi Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
    Yuki Ohi
    Department of Ob Gyn and Center for Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Cell Biol 13:541-9. 2011
    ..Knockdown of the incompletely reprogrammed gene C9orf64 (chromosome 9 open reading frame 64) reduces the efficiency of human iPS cell generation, indicating that somatic memory genes may be functionally relevant during reprogramming...
  9. ncbi Stem cells as probabilistic self-producing entities
    Miguel Ramalho-Santos
    Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco CA 94143 0540, USA
    Bioessays 26:1013-6. 2004
    ..I discuss how this framework generates testable hypotheses regarding stem-cell functions...
  10. ncbi Chd1 regulates open chromatin and pluripotency of embryonic stem cells
    Alexandre Gaspar-Maia
    Department of Ob Gyn and Pathology, Center for Reproductive Sciences and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0525, USA
    Nature 460:863-8. 2009
    ..Our results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state...
  11. ncbi High-efficiency stem cell fusion-mediated assay reveals Sall4 as an enhancer of reprogramming
    Connie C Wong
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e1955. 2008
    ..These results indicate that improvements in reprogramming assays, including fusion assays, may allow the systematic identification and molecular characterization of enhancers of somatic cell reprogramming...
  12. ncbi "Stemness": transcriptional profiling of embryonic and adult stem cells
    Miguel Ramalho-Santos
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute (HHMI, Harvard University, Cambridge, MA 02138, USA
    Science 298:597-600. 2002
    ..Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology...