Shyam Ramachandran

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint Microarray mRNA expression profiling to study cystic fibrosis
    Shyam Ramachandran
    Interdisciplinary Program in Genetics, Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Methods Mol Biol 742:193-212. 2011
  2. doi request reprint Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro
    Shyam Ramachandran
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 305:L23-32. 2013
  3. pmc Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways
    Maisam Abu-El-Haija
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Pathol 181:499-507. 2012
  4. pmc A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator
    Shyam Ramachandran
    Department of Pediatrics, Interdisciplinary Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 109:13362-7. 2012
  5. pmc Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
    Alejandro A Pezzulo
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Nature 487:109-13. 2012
  6. pmc Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    David A Stoltz
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 2:29ra31. 2010
  7. pmc Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia
    Sateesh Krishnamurthy
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Mol Ther Nucleic Acids 1:e41. 2012
  8. pmc microRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating groups of microRNAs
    Eric J Devor
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, 3234 MERF, Iowa City, IA 52242, USA
    Oncol Rep 26:995-1002. 2011
  9. pmc Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children
    David K Meyerholz
    Department of Pathology, University of Iowa, Iowa City, 52242, USA
    Am J Respir Crit Care Med 182:1251-61. 2010
  10. doi request reprint PLUNC is a secreted product of neutrophil granules
    Jennifer A Bartlett
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Leukoc Biol 83:1201-6. 2008

Collaborators

Detail Information

Publications10

  1. doi request reprint Microarray mRNA expression profiling to study cystic fibrosis
    Shyam Ramachandran
    Interdisciplinary Program in Genetics, Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Methods Mol Biol 742:193-212. 2011
    ..We also outline novel strategies for experimental design and data analysis, and describe some powerful gene and pathway discovery tools...
  2. doi request reprint Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro
    Shyam Ramachandran
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 305:L23-32. 2013
    ....
  3. pmc Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways
    Maisam Abu-El-Haija
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Pathol 181:499-507. 2012
    ..Proinflammatory, complement cascade, proapoptotic, and profibrotic pathways are activated in CF pig pancreas, and likely contribute to the destructive process...
  4. pmc A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator
    Shyam Ramachandran
    Department of Pediatrics, Interdisciplinary Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 109:13362-7. 2012
    ..This discovery also provides therapeutic avenues for restoring CFTR function to cells affected by the most common cystic fibrosis mutation...
  5. pmc Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
    Alejandro A Pezzulo
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Nature 487:109-13. 2012
    ..These findings suggest that increasing ASL pH might prevent the initial infection in patients with CF, and that assaying bacterial killing could report on the benefit of therapeutic interventions...
  6. pmc Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    David A Stoltz
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 2:29ra31. 2010
    ....
  7. pmc Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia
    Sateesh Krishnamurthy
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Mol Ther Nucleic Acids 1:e41. 2012
    ..Molecular Therapy - Nucleic Acids (2012) 1, e41; doi:10.1038/mtna.2012.36; published online 28 August 2012...
  8. pmc microRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating groups of microRNAs
    Eric J Devor
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, 3234 MERF, Iowa City, IA 52242, USA
    Oncol Rep 26:995-1002. 2011
    ..Understanding these differences may permit the development of both prognostic and diagnostic biomarkers...
  9. pmc Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children
    David K Meyerholz
    Department of Pathology, University of Iowa, Iowa City, 52242, USA
    Am J Respir Crit Care Med 182:1251-61. 2010
    ..Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize the disease...
  10. doi request reprint PLUNC is a secreted product of neutrophil granules
    Jennifer A Bartlett
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Leukoc Biol 83:1201-6. 2008
    ..These studies suggest that PLUNC expression is less restricted than previously believed, and highlight new avenues of research for the study of PLUNC function...