J C Ralphe

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue
    Willem J de Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Gen Physiol 141:73-84. 2013
  2. pmc E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction
    Willem J de Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Gen Physiol 142:241-55. 2013
  3. ncbi request reprint 3D engineered cardiac tissue models of human heart disease: learning more from our mice
    J Carter Ralphe
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Trends Cardiovasc Med 23:27-32. 2013
  4. pmc Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease
    W J De Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Circ Res 109:8-19. 2011

Collaborators

  • Adrian C Grimes
  • Willem J de Lange
  • Laura F Hegge
  • W J De Lange
  • Taylor M Brost
  • Alexander M Spring
  • R L Moss
  • C W Tong
  • L F Hegge
  • T M Brost

Detail Information

Publications4

  1. pmc Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue
    Willem J de Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Gen Physiol 141:73-84. 2013
    ....
  2. pmc E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction
    Willem J de Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Gen Physiol 142:241-55. 2013
    ....
  3. ncbi request reprint 3D engineered cardiac tissue models of human heart disease: learning more from our mice
    J Carter Ralphe
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Trends Cardiovasc Med 23:27-32. 2013
    ..Human ECTs generated from iPSCMs represent the next logical step for this technology and offer significant promise of an integrated, fully human, cardiac tissue model...
  4. pmc Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease
    W J De Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Circ Res 109:8-19. 2011
    ..Development of a murine ECT would provide access to many existing models of cardiac disease and open the possibility of performing targeted genetic manipulation with the ability to directly assess contractile and molecular variables...