Research Topics
Genomes and GenesSpecies | Alexander L RakhmilevichSummaryAffiliation: University of Wisconsin Country: USA Publications
| Collaborators
|
Detail Information
Publications
Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effectsAlexander L Rakhmilevich
Department of Human Oncology, University of Wisconsin, 4136 WIMR, 1111 Highland Avenue, Madison, WI 53705, USA
Cancer Immunol Immunother 61:1683-97. 2012..Inhibition of NO did not abrogate the antitumor effects of stimulated myeloid cells. Taken together, the results indicate that in tumor-bearing hosts, tumor-associated myeloid cells can be activated to mediate antitumor effects...
T-cell-independent antitumor effects of CD40 ligationAlexander L Rakhmilevich
Department of Human Oncology and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, WI 53705, USA
Int Rev Immunol 31:267-78. 2012..In this review the authors focus on the ability of CD40 ligation to activate antitumor effector mechanisms of the cells of innate immunity such as macrophages and NK cells...
CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumorsAlexander L Rakhmilevich
The Department of Human Oncology, University of Wisconsin, K4 413 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
Cancer Immunol Immunother 57:1151-60. 2008..Taken together, our results indicate that antitumor effects induced by alphaCD40, even against immunogenic tumors, can be observed in the absence of T cells and may involve macrophages...- Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibodyAlexander L Rakhmilevich
K4 413 Clinical Science Center, Department of Human Oncology, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792, USA
Mol Cancer Ther 3:969-76. 2004..Our results show a therapeutic benefit of combining IL-12 gene therapy and anti-VEGFR-2 mAb for cancer treatment... - In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophagesHillary D Lum
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
J Leukoc Biol 79:1181-92. 2006..Taken together, our results show that anti-CD40 mAb immunotherapy of mice can inhibit tumor growth in the absence of T cells, NK cells, and PMN through the involvement of activated Mphi... - Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotidesIlia N Buhtoiarov
Department of Human Oncology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 4672, USA
Immunology 120:412-23. 2007..Taken together, our results indicate that the growth control of weakly immunogenic tumours during CpG-immunotherapy is mediated predominantly by Mphi, rather than T cells or NK cells... - Tumoristatic effects of anti-CD40 mAb-activated macrophages involve nitric oxide and tumour necrosis factor-alphaHillary D Lum
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
Immunology 118:261-70. 2006..Taken together, these results suggest that NO and TNF-alpha are involved in, but not solely responsible for, the antitumour effects of macrophages after activation by CD40 ligation... - Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retentionRichard K Yang
Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
J Immunol 189:2656-64. 2012..v.-IC. Overall, IT-IC resulted in increased numbers of activated T and NK cells within tumors, better IC retention in the tumor, enhanced inhibition of tumor growth, and improved survival compared with i.v.-IC... - Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapyBrenda L Soto
Department of Human Oncology, University of Wisconsin, Madison, WI 53706, USA
Int Immunopharmacol 11:1877-86. 2011..Results showed that this RV regimen inhibited the growth of NXS2 tumors in vivo but did not appear to interfere with blood cell count, splenocyte or macrophage function. Thus, RV may be a candidate for combining with immunotherapy... - Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapyZane C Neal
Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA
Clin Cancer Res 10:4839-47. 2004..Animals showing prolonged tumor eradication of established tumors after the combined hu14.18-IL2 plus IL-2 regimen exhibited a protective T-cell-dependent antitumor memory response against NXS2 rechallenge... - Intratumoral immunocytokine treatment results in enhanced antitumor effectsErik E Johnson
Department of Surgery, University of Wisconsin, Madison, WI, 53792, USA
Cancer Immunol Immunother 57:1891-902. 2008..Further testing is required to determine how to potentially incorporate IT administration of IC into an antitumor regimen that optimizes local and systemic anticancer therapy... - CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitroIlia N Buhtoiarov
Department of Human Oncology and UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
J Immunol 174:6013-22. 2005..IFN-gamma production by macrophages was dependent on IL-12. Taken together, the results show that murine macrophages are activated directly by anti-CD40 mAb to secrete IFN-gamma and mediate tumor cell destruction... - Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effectsIlia N Buhtoiarov
Department of Human Oncology and Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
J Immunol 176:309-18. 2006.... - Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in miceErik E Johnson
Paul P Carbone Comprehensive Cancer Center, Department of Surgery, University of Wisconsin, Madison, WI, USA
J Immunother 34:76-84. 2011..These results suggest that therapeutic strategies to activate macrophages may have potential for clinical application in cancer patients receiving chemotherapy... - Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 moleculesIlia N Buhtoiarov
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
J Immunol 182:1940-53. 2009..These results suggest that contact with certain tumor cells via CD40, NKG2D, and CD18 molecules on the Mphi may facilitate Mphi-mediated antitumor immune surveillance... - Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemiaQing Li Wu
Department of Pathology and Laboratory Medicine, Pediatrics University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
J Immunol 182:6771-8. 2009..Our results suggest a novel immunotherapeutic strategy for CLL that may be effective even in the face of tumor or chemotherapy-induced T cell immunodeficiency... - The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma modelBrenda L Soto
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
Cancer Immunol Immunother 60:731-8. 2011..These results demonstrate that the combination therapy of peritumoral resveratrol plus intravenous immunocytokine provides better anti-tumor effects in this model than either therapy alone... - Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophagesIlia N Buhtoiarov
Department of Human Oncology, University of Wisconsin, Madison, WI 53705 2275, USA
Immunology 132:226-39. 2011..Together, the results show that CT and anti-CD40 + CpG-ODN IT synergize in the induction of anti-tumour effects which are associated with the phenotypic repolarization of tumour-associated Mφ... - Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinomaErik E Johnson
Departments of Surgery, Human Oncology, and Pediatrics and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
Clin Cancer Res 15:4875-84. 2009..Radiofrequency ablation (RFA) is a common treatment modality for surgically unresectable tumors. However, there is a high rate of both local and systemic recurrence... - Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targetingIlia N Buhtoiarov
UW Carbone Cancer Center, 4159 MACC Fund UW Childhood Cancer Research Wing, WIMR, 1111 Highland Ave, Madison, WI 53705 2275, USA
J Leukoc Biol 89:625-38. 2011..These studies demonstrate that once IC binds to the tumor, it is present on the tumor surface for a prolonged time, inducing the recruitment of NK cells to the tumor site, followed by tumor cell killing... - NXS2 murine neuroblastomas express increased levels of MHC class I antigens upon recurrence following NK-dependent immunotherapyZane C Neal
University of Wisconsin Comprehensive Cancer Center, University of Wisconsin-Madison, 600 Highland Ave, K4/448, Madison, WI 53792, USA
Cancer Immunol Immunother 53:41-52. 2004.... - Intratumoral Delivery of Low Doses of Anti-CD40 mAb Combined With Monophosphoryl Lipid A Induces Local and Systemic Antitumor Effects in Immunocompetent and T Cell-Deficient MiceTyler J Van De Voort
Departments of Human Oncology Obstetrics and Gynecology Pediatrics Paul P Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, WI
J Immunother 36:29-40. 2013..These preclinical data suggest that an anti-CD40+MPL combined regimen is appropriate for clinical testing in human patients, including cancer patients who may be immunosuppressed from prior chemotherapy... - Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine modelFushun Shi
Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA
Mol Cancer Ther 1:949-57. 2002..These results indicate that direct intratumoral gene transfer with naked nonviral IL-12 DNA provides an effective and simple method for the treatment of murine tumors, suggesting an approach for clinical application... - Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansionAndrew J Russ
Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
Cell Immunol 271:104-9. 2011....