Research Topics
Species | G RajkowskaSummaryAffiliation: University of Mississippi Medical Center Country: USA Publications
Research Grants
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Publications
Gliogenesis and glial pathology in depressionG Rajkowska
Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
CNS Neurol Disord Drug Targets 6:219-33. 2007..Finally, we will consider the temporal relationship between glial and neuronal cell pathology in depression...
Depression: what we can learn from postmortem studiesGrazyna Rajkowska
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
Neuroscientist 9:273-84. 2003..Future studies will determine whether these genes may be novel targets of therapeutic medications...- Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patientsGrazyna Rajkowska
Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Biol Psychiatry 58:297-306. 2005..Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined... - Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophreniaGrazyna Rajkowska
Laboratory of Quantitative Neuroanatomy, Department of Psychiatry and Human Behavior, Box 127, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
Schizophr Res 57:127-38. 2002..Astroglial pathology in dlPFC may reflect disturbances of the neuron-glia interactions in layer V and may be related to the dysfunctional prefronto-striatal circuits, dopaminergic alterations and cognitive pathology in SCHZ... - GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depressionGrazyna Rajkowska
Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Neuropsychopharmacology 32:471-82. 2007..These cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of GABA in depression... - Cell pathology in bipolar disorderGrazyna Rajkowska
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
Bipolar Disord 4:105-16. 2002.... - Neuronal and glial somal size in the prefrontal cortex: a postmortem morphometric study of schizophrenia and Huntington diseaseG Rajkowska
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
Arch Gen Psychiatry 55:215-24. 1998.... - Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptomsJose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
Biol Psychiatry 52:1121-33. 2002..In alcohol dependence, often comorbid with depression, it is unclear whether there are changes in the density and size of glial cells in the dlPFC... - Neurokinin-1 receptors are decreased in major depressive disorderCraig A Stockmeier
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson 39216, USA
Neuroreport 13:1223-7. 2002..024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex... - Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship with suicide and duration of alcohol dependenceJose J Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Alcohol Clin Exp Res 30:1845-55. 2006.... - Distribution of ICAM-1 immunoreactivity during aging in the human orbitofrontal cortexJose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
Brain Behav Immun 21:100-11. 2007..This increase may contribute to an enhanced risk for brain inflammatory processes during aging, although a role of extravascular ICAM-1 as a barrier to further inflammation cannot be ruled out... - Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorderCraig A Stockmeier
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216, USA
J Psychiatr Res 43:887-94. 2009..Decreased antagonist binding to serotonin-1A receptors in outer layers of orbitofrontal cortex suggests diminished receptor signaling and may be linked to corresponding neuronal changes detected previously in these depressed subjects... - Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindanXiao Ming Ou
Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior G 109, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
Neurotox Res 16:148-59. 2009.... - Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depressionJose Javier Miguel-Hidalgo
Department of Psychiatry, University of Mississippi Medical Center, 2500 North State Street, P O Box 127, Jackson, MS 39216, USA
Schizophr Res 76:159-71. 2005..In addition, the enlarged somal size in schizophrenia as compared to controls suggests that NF200 neurons may contribute differentially to unique cognitive disturbances present in schizophrenia and not in MDD subjects... - Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studiesDorota Maciag
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Biol Psychiatry 67:465-70. 2010..The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease... - Cellular changes in the postmortem hippocampus in major depressionCraig A Stockmeier
Department of Psychiatry and Human Behavior Box 127, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Biol Psychiatry 56:640-50. 2004..Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not been identified... - Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depressionBeata Karolewicz
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
Int J Neuropsychopharmacol 13:411-20. 2010..Moreover, our data support previous neuroimaging observations that antidepressant medication normalizes GABA deficits in depression... - Comparison of prefrontal cell pathology between depression and alcohol dependenceJose J Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
J Psychiatr Res 37:411-20. 2003..In either case abnormal function related to glial reduction would be associated with depression due to insufficient glial support to the surrounding neurons... - Cell pathology in mood disordersGrazyna Rajkowska
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
Semin Clin Neuropsychiatry 7:281-92. 2002..This article reviews the current findings from postmortem studies on glial and neuronal cell counts in primary mood disorders and discusses a possible link between cellular changes and the action of psychotherapeutic drugs... - Morphological brain changes in depression: can antidepressants reverse them?Jose Javier Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
CNS Drugs 16:361-72. 2002.... - Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorderG Rajkowska
Laboratory of Quantitative Neuroanatomy, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
Biol Psychiatry 49:741-52. 2001..Thus, the neuropathologic distinctions between BPD and SCHZ are indicative of separate mental illnesses, each with a unique morphologic disturbance of specific neural circuits... - Reductions in neuronal density in elderly depressed are region specificEric Van Otterloo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Int J Geriatr Psychiatry 24:856-64. 2009..Prominent reductions in pyramidal neuron density have been recently reported in the ORB of older depressed subjects. However, the cellular pathology of the dlPFC has not yet been examined in these subjects... - Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depressionXiaohong Si
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
Neuropsychopharmacology 29:2088-96. 2004..These findings indicate that a decrease in levels of GFAP may contribute to the pathophysiology of MDD, particularly in subjects of relatively young age... - Immunohistochemistry of neural markers for the study of the laminar architecture in celloidin sections from the human cerebral cortexJ J Miguel-Hidalgo
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216 4505, USA
J Neurosci Methods 93:69-79. 1999..The present paper provides an antigen recovery technique for celloidin sections that can be applied to optimize studies on the cytoarchitecture and distribution of specific neural elements in the human cerebral cortex... - Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorderBernadeta Szewczyk
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Int J Neuropsychopharmacol 12:155-68. 2009..In addition, the gender-specific alterations in cortical NUDR and 5-HT1A receptor proteins could represent an underlying biological mechanism associated with the higher incidence of depression in women... - Differential expression of alpha2-adrenoceptor vs. imidazoline binding sites in postmortem orbitofrontal cortex and amygdala of depressed subjectsJohn E Piletz
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216 4505, USA
J Psychiatr Res 37:399-409. 2003..The results support previous western blot data indicating a cortex-selective shift away from alpha(2)AR towards I-site preponderance in depressed patients... - Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patientsG Rajkowska
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216 4505, USA
Ann N Y Acad Sci 836:253-68. 1997.... - Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activityC A Stockmeier
Program in Basic and Clinical Neuroscience, Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 18:7394-401. 1998.... - Two-dimensional versus three-dimensional cell countingLynn D Selemon
Biol Psychiatry 51:838-40; author reply, 842-6. 2002 - Cerebral cortex astroglia and the brain of a genius: a propos of A. Einstein'sJorge A Colombo
Unidad de NeurobiologĂa Aplicada, UNA, CEMIC CONICET, Av Galván 4102, C1431FWO Ciudad de Buenos Aires, Argentina
Brain Res Rev 52:257-63. 2006.... - Gene expression profiling in postmortem prefrontal cortex of major depressive disorderHyo Jung Kang
Department Psychiatry, Yale University, New Haven, Connecticut 06508, USA
J Neurosci 27:13329-40. 2007..These findings identify abnormal gene expression in a discrete region of MDD subjects and contribute to further elucidation of the molecular alterations of this complex mood disorder... - Evidence for progression in frontal cortical pathology in late-stage Huntington's diseaseLynn D Selemon
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Comp Neurol 468:190-204. 2004..Prominent involvement of corticothalamic neurons is discussed in the context of striatal loop circuitry and a possible pathologic cascade of cortical degeneration...
Research Grants
- Prefrontal Cell Pathology Distinguishes Mental DisordersGrazyna Rajkowska; Fiscal Year: 2003..The proposed study will illuminate disrupted cortical circuits involved in psychotic and depressed symptomatology and possibly cortical Sites of action for antidepressant and antipsychotic medications. ..