J Rajfer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US
    J Rajfer
    Division of Urology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 19:95-103. 2007
  2. doi request reprint Discovery of NO in the penis
    J Rajfer
    Division of Urology, Department of Surgery, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 20:431-6. 2008
  3. ncbi request reprint Opportunities and challenges in oral therapy
    J Rajfer
    Harbor UCLA Medical Center, Division of Urology, Torrance, California 90502, USA
    Int J Impot Res 12:S59-61. 2000
  4. ncbi request reprint Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis
    M Ferrini
    Department of Urology, UCLA School of Medicine, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, California 90509, USA
    Biol Reprod 64:974-82. 2001
  5. ncbi request reprint Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats
    I Kovanecz
    LA Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Torrance, CA 90502 2064, USA
    Int J Impot Res 20:202-12. 2008
  6. ncbi request reprint Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat
    M G Ferrini
    Division of Urology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Biol Reprod 76:915-23. 2007
  7. ncbi request reprint Transforming growth factor-beta1 (TGF-beta1) in penile and prostate growth in the rat during sexual maturation
    J Gelman
    Department of Surgery, Harbor UCLA Medical Center, University of California School of Medicine, Torrance 90509, USA
    J Androl 19:50-7. 1998
  8. ncbi request reprint Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Biol Reprod 63:704-14. 2000
  9. ncbi request reprint Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis
    N Gonzalez-Cadavid
    Department of Surgery, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509
    Mol Cell Endocrinol 90:219-29. 1993
  10. ncbi request reprint Androgens are not major down-regulators of androgen receptor levels during growth of the immature rat penis
    R Shen
    Division of Urology, Department of Surgery, Harbor UCLA Medical Center, University of California School of Medicine, Torrance 90509, USA
    J Steroid Biochem Mol Biol 57:301-13. 1996

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US
    J Rajfer
    Division of Urology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 19:95-103. 2007
    ..Tadalafil 2.5 mg and 5 mg, dosed once a day for 24 weeks, was well tolerated and significantly improved erectile function...
  2. doi request reprint Discovery of NO in the penis
    J Rajfer
    Division of Urology, Department of Surgery, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 20:431-6. 2008
    ..For one of us, a Nobel Prize lay in the future. This review, which comes one decade following the introduction of Viagra into the marketplace, chronicles the actual events involved in the discovery...
  3. ncbi request reprint Opportunities and challenges in oral therapy
    J Rajfer
    Harbor UCLA Medical Center, Division of Urology, Torrance, California 90502, USA
    Int J Impot Res 12:S59-61. 2000
    ..At the present time, there are no methods to improve smooth muscle compliance but advances in tissue engineering may allow us to accomplish this in the future. International Journal of Impotence Research (2000) 12, Suppl 4, S59-S61...
  4. ncbi request reprint Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis
    M Ferrini
    Department of Urology, UCLA School of Medicine, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, California 90509, USA
    Biol Reprod 64:974-82. 2001
    ....
  5. ncbi request reprint Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats
    I Kovanecz
    LA Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Torrance, CA 90502 2064, USA
    Int J Impot Res 20:202-12. 2008
    ....
  6. ncbi request reprint Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat
    M G Ferrini
    Division of Urology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Biol Reprod 76:915-23. 2007
    ..It may be speculated that similar effects may be achieved with this paradigm in men...
  7. ncbi request reprint Transforming growth factor-beta1 (TGF-beta1) in penile and prostate growth in the rat during sexual maturation
    J Gelman
    Department of Surgery, Harbor UCLA Medical Center, University of California School of Medicine, Torrance 90509, USA
    J Androl 19:50-7. 1998
    ....
  8. ncbi request reprint Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Biol Reprod 63:704-14. 2000
    ....
  9. ncbi request reprint Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis
    N Gonzalez-Cadavid
    Department of Surgery, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509
    Mol Cell Endocrinol 90:219-29. 1993
    ....
  10. ncbi request reprint Androgens are not major down-regulators of androgen receptor levels during growth of the immature rat penis
    R Shen
    Division of Urology, Department of Surgery, Harbor UCLA Medical Center, University of California School of Medicine, Torrance 90509, USA
    J Steroid Biochem Mol Biol 57:301-13. 1996
    ..Our results suggest that increases in serum T or DHT are not major factors in the physiological down-regulation of ARs and androgen-dependent growth in the rat corpora cavernosa...
  11. ncbi request reprint Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review
    A Rambhatla
    Division of Urology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 20:30-4. 2008
    ..In this review article we will examine the pathophysiology of post-prostatectomy ED and discuss the experimental and available clinical evidence for administering PDE5 inhibitors after prostatectomy...
  12. ncbi request reprint Presence of NMDA receptor subunits in the male lower urogenital tract
    N F Gonzalez-Cadavid
    Department of Urology, University of California at Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    J Androl 21:566-78. 2000
    ..Further work is necessary to determine whether the NMDAR subunits form a fully active receptor and participate in the control of organ tone that is relevant to male sexual activity...
  13. ncbi request reprint The pleiotropic effects of inducible nitric oxide synthase (iNOS) on the physiology and pathology of penile erection
    N F Gonzalez-Cadavid
    LABioMed at Harbor UCLA Medical Center, Torrance, CA, and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Curr Pharm Des 11:4041-6. 2005
    ....
  14. ncbi request reprint Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography
    H H Davila
    Harbor University of California, Los Angeles, Research and Education Institute, Torrance, California 90502, USA
    Urology 64:1261-6. 2004
    ..To determine whether the rat develops corporal veno-occlusive dysfunction (CVOD) during the aging process...
  15. ncbi request reprint Gene expression in Peyronie's disease
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Los Angeles, California, USA
    Int J Impot Res 14:361-74. 2002
    ..Finally, possible therapeutic avenues for gene-based therapy in the treatment of PD are discussed that may eventually reduce the need for surgical intervention...
  16. ncbi request reprint Oral Bisphenol A (BPA) given to rats at moderate doses is associated with erectile dysfunction, cavernosal lipofibrosis and alterations of global gene transcription
    I Kovanecz
    1 Division of Urology, Department of Surgery, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA 2 Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Int J Impot Res 26:67-75. 2014
    ....
  17. ncbi request reprint Molecular pathophysiology and gene therapy of aging-related erectile dysfunction
    N F Gonzalez-Cadavid
    Harbor UCLA Research and Education Institute, Urology, Bldg F 6, 1124 West Carson Street, Torrance, CA 90502, USA
    Exp Gerontol 39:1705-12. 2004
    ..Gene transfer into the penis may soon translate to the clinic as a therapy aimed to cure the underlying conditions in ED, including fibrosis, as opposed to the facilitation of erection on demand offered by the current oral therapies...
  18. ncbi request reprint The efficacy and safety of tadalafil: an update
    C C Carson
    Department of Surgery, Division of Urology, University of North Carolina, Chapel Hill, NC, USA
    BJU Int 93:1276-81. 2004
    ..To provide an update on the efficacy and safety of tadalafil, a phosphodiesterase-5 inhibitor, in the treatment of erectile dysfunction (ED)...
  19. ncbi request reprint Early onset erectile dysfunction is usually not associated with abnormal cavernosal arterial Inflow
    J Rajfer
    1 Division of Urology, Department of Surgery, Harbor UCLA Medical Center, Torrance, CA, USA 2 Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Impot Res 25:217-20. 2013
    ..These observations suggest that the penile arterial system does not appear to be primarily involved in the etiology of the majority cases of ED that occur in young men. ..
  20. ncbi request reprint Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture
    A Qian
    Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Urology 64:399-404. 2004
    ..DD, a palmar fascia fibrosis, may be associated with PD...
  21. ncbi request reprint Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract
    T Magee
    Division of Urology, Harbor UCLA Medical Center, Torrance 90509, USA
    Biochem Biophys Res Commun 226:145-51. 1996
    ..The novel insert is present in human penile RNA and is transcribed from intron 16. The features and distribution of the penile nNOS suggest that it is may be regulated differentially from the cerebellar nNOS...
  22. ncbi request reprint Antifibrotic role of inducible nitric oxide synthase
    M G Ferrini
    Department of Urology, UCLA School of Medicine, Los Angeles, California, USA
    Nitric Oxide 6:283-94. 2002
    ....
  23. ncbi request reprint The evolving role of testosterone in the treatment of erectile dysfunction
    R Shabsigh
    Department of Urology, Columbia University, New York, NY 10032, USA
    Int J Clin Pract 60:1087-92. 2006
    ..Screening for hypogonadism may be useful in men with ED who fail prior PDE5 inhibitors, especially in populations at risk for hypogonadism such as type 2 diabetes and the metabolic syndrome...
  24. ncbi request reprint Protein inhibitor of nitric oxide synthase (NOS) and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOS
    T R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 68:478-88. 2003
    ..In conclusion, PIN and NMDAR colocalize with PnNOS in penile nerves, but the functional significance of these protein interactions for penile erection remains to be elucidated...
  25. ncbi request reprint Fibrin as an inducer of fibrosis in the tunica albuginea of the rat: a new animal model of Peyronie's disease
    H H Davila
    Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA
    BJU Int 91:830-8. 2003
    ..To investigate the role of fibrin in inducing fibrosis in the tunica albuginea (TA) of the rat penis, to develop a new animal model for Peyronie's disease (PD)...
  26. ncbi request reprint Improvement in emotional well-being and relationships of users of sildenafil
    N M Paige
    Division of General Internal Medicine, School of Medicine, University of California, Los Angeles, California, USA
    J Urol 166:1774-8. 2001
    ..001). CONCLUSIONS: Sildenafil users reported significant improvements in erectile and sexual function that were associated with positive changes in emotional well-being and the sexual partner relationships with their sexual partner...
  27. ncbi request reprint Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function
    M Ferrini
    Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA
    Neuroendocrinology 74:1-11. 2001
    ....