Sigrid A Rajasekaran

Summary

Affiliation: University of Delaware
Country: USA

Publications

  1. ncbi request reprint Na,K-ATPase and epithelial tight junctions
    Sigrid A Rajasekaran
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Front Biosci (Landmark Ed) 14:2130-48. 2009
  2. pmc Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis
    Sigrid A Rajasekaran
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Mol Cancer Ther 9:1515-24. 2010
  3. pmc Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo
    Seung Joon Lee
    Nemours Center for Childhood Cancer Research, Alfred I, duPont Hospital for Children, 1701 Rockland Road, Wilmington, DE 19803, USA
    BMC Cancer 11:144. 2011
  4. pmc Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit
    Sonali P Barwe
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Rockland Center One, 1701 Rockland Road, Wilmington, DE 19803, USA
    J Mol Cell Cardiol 47:552-60. 2009
  5. pmc Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability
    Sigrid A Rajasekaran
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Rockland Center I, 1701 Rockland Road, Wilmington, DE 19803, USA
    Mol Cancer Ther 7:2142-51. 2008
  6. pmc alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling
    LANDON J INGE
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, 1701 Rockland Road, Wilmington, DE 19803, USA
    Mol Cancer Ther 7:1386-97. 2008

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Na,K-ATPase and epithelial tight junctions
    Sigrid A Rajasekaran
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Front Biosci (Landmark Ed) 14:2130-48. 2009
    ..In this review, we have attempted to compile these new reports and suggest a model for a conserved role of Na,K-ATPase in the regulation of tight junction structure and functions...
  2. pmc Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis
    Sigrid A Rajasekaran
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Mol Cancer Ther 9:1515-24. 2010
    ..These findings reveal for the first time that Na,K-ATPase is a target of TGF-beta(1)-mediated EMT and is associated with the progression of EMT in cancer and fibrosis...
  3. pmc Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo
    Seung Joon Lee
    Nemours Center for Childhood Cancer Research, Alfred I, duPont Hospital for Children, 1701 Rockland Road, Wilmington, DE 19803, USA
    BMC Cancer 11:144. 2011
    ..In this study we evaluated the anti-cancer potential of curcumin in medulloblastoma by testing its ability to induce apoptosis and inhibit tumor growth in vitro and in vivo using established medulloblastoma models...
  4. pmc Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit
    Sonali P Barwe
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Rockland Center One, 1701 Rockland Road, Wilmington, DE 19803, USA
    J Mol Cell Cardiol 47:552-60. 2009
    ..In conclusion, our results demonstrate that Na,K-beta(1) plays an essential role in regulating cardiac contractility and that its loss is associated with significant pathophysiology of the heart...
  5. pmc Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability
    Sigrid A Rajasekaran
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, Rockland Center I, 1701 Rockland Road, Wilmington, DE 19803, USA
    Mol Cancer Ther 7:2142-51. 2008
    ..Thus, these findings provide the first evidence that PSMA has a causal role in the induction of aneuploidy and might play an etiologic role in the progression of prostate cancer...
  6. pmc alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling
    LANDON J INGE
    Nemours Center for Childhood Cancer Research, Alfred I duPont Hospital for Children, 1701 Rockland Road, Wilmington, DE 19803, USA
    Mol Cancer Ther 7:1386-97. 2008
    ..This study reveals for the first time that alpha-catenin is a key regulator of beta-catenin transcriptional activity and that the status of alpha-catenin expression in tumor tissues might have prognostic value for Src targeted therapy...