THIRUCHANDURAI RAJAN

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites
    N Paciorkowski
    University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    J Exp Med 191:731-6. 2000
  2. ncbi request reprint Superficial? Not us--we men are born molecular geneticists!
    Thiruchandurai V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    Perspect Biol Med 47:422-9. 2004
  3. ncbi request reprint Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses
    T V Rajan
    The University of Connecticut Health Center, 263 Farmington Avenue, 06030 3105, USA
    Exp Parasitol 100:235-47. 2002
  4. ncbi request reprint A double-blinded, placebo-controlled trial of garlic as a mosquito repellant: a preliminary study
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Med Vet Entomol 19:84-9. 2005
  5. ncbi request reprint East is East, etc
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 3105, USA
    Cancer Biol Ther 1:313-4. 2002
  6. ncbi request reprint The eye does not see what the mind does not know: the bacterium in the worm
    Thiruchandurai V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Perspect Biol Med 48:31-41. 2005
  7. ncbi request reprint Exogenous nucleosides are required for the morphogenesis of the human filarial parasite Brugia malayi
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Parasitol 90:1184-5. 2004
  8. ncbi request reprint Relationship of anti-microbial activity of tetracyclines to their ability to block the L3 to L4 molt of the human filarial parasite Brugia malayi
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
    Am J Trop Med Hyg 71:24-8. 2004
  9. ncbi request reprint The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation
    T V Rajan
    Department of Pathology, Room L 1037, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
    Trends Immunol 24:376-9. 2003
  10. ncbi request reprint Ascorbic acid is a requirement for the morphogenesis of the human filarial parasite Brugia malayi
    T V Rajan
    Department of Pathology, UCONN Health Center, Farmington, Connecticut 06030 3105, USA
    J Parasitol 89:868-70. 2003

Research Grants

  1. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
  2. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
  3. GROWTH OF B MALAYI IN MURINE MODELS--ROLE OF NK CELLS
    THIRUCHANDURAI RAJAN; Fiscal Year: 2001
  4. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2000
  5. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2006

Collaborators

Detail Information

Publications44

  1. pmc B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites
    N Paciorkowski
    University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    J Exp Med 191:731-6. 2000
    ..These data raise the possibility that the identification of molecule(s) recognized by humoral immune mechanisms might help generate prophylactic vaccines...
  2. ncbi request reprint Superficial? Not us--we men are born molecular geneticists!
    Thiruchandurai V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    Perspect Biol Med 47:422-9. 2004
  3. ncbi request reprint Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses
    T V Rajan
    The University of Connecticut Health Center, 263 Farmington Avenue, 06030 3105, USA
    Exp Parasitol 100:235-47. 2002
    ..These granulomas may represent an important mechanism by which worms are eliminated...
  4. ncbi request reprint A double-blinded, placebo-controlled trial of garlic as a mosquito repellant: a preliminary study
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Med Vet Entomol 19:84-9. 2005
    ..The data did not provide evidence of significant systemic mosquito repellence. A limitation of the study is that more prolonged ingestion of garlic may be needed to accomplish repellence...
  5. ncbi request reprint East is East, etc
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 3105, USA
    Cancer Biol Ther 1:313-4. 2002
  6. ncbi request reprint The eye does not see what the mind does not know: the bacterium in the worm
    Thiruchandurai V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Perspect Biol Med 48:31-41. 2005
    ..Intriguingly, the intense recent interest in Wolbachia is in complete contrast with the virtually complete indifference evoked by the original discovery of these organisms...
  7. ncbi request reprint Exogenous nucleosides are required for the morphogenesis of the human filarial parasite Brugia malayi
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Parasitol 90:1184-5. 2004
    ..malayi and B. pahangi depend on an exogenous source of at least 1 purine and 1 pyrimidine nucleoside to complete the L3 to L4 molt. The requirement for exogenous nucleosides opens the door for possible chemotherapeutic intervention...
  8. ncbi request reprint Relationship of anti-microbial activity of tetracyclines to their ability to block the L3 to L4 molt of the human filarial parasite Brugia malayi
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
    Am J Trop Med Hyg 71:24-8. 2004
    ..This study shows that chemically modified tetracycline, which does not to have anti-microbial activity, also blocks molting...
  9. ncbi request reprint The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation
    T V Rajan
    Department of Pathology, Room L 1037, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
    Trends Immunol 24:376-9. 2003
    ..I further propose that there is a fifth strategy that was not envisioned in the Gell and Coombs classification...
  10. ncbi request reprint Ascorbic acid is a requirement for the morphogenesis of the human filarial parasite Brugia malayi
    T V Rajan
    Department of Pathology, UCONN Health Center, Farmington, Connecticut 06030 3105, USA
    J Parasitol 89:868-70. 2003
    ..Brugia malayi apparently belongs to a small group of living organisms that depend on an exogenous source of vitamin C. This group includes only primates (including man) and guinea pigs among mammals...
  11. ncbi request reprint Effect of ingestion of honey on symptoms of rhinoconjunctivitis
    T V Rajan
    Department of Pathology, UCONN Health Center, Farmington 06030 3105, USA
    Ann Allergy Asthma Immunol 88:198-203. 2002
    ..Despite this high prevalence, relatively few sufferers seek professional medical help, presumably because of a widespread reliance on complementary remedies...
  12. ncbi request reprint Critical role for IgM in host protection in experimental filarial infection
    Bhargavi Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Immunol 175:1827-33. 2005
    ..Peritoneal exudate cells from primed mice, especially activated macrophages, carry high levels of IgM on their surfaces. Our observations suggest that an IgM-mediated reaction initiates the formation of host-protective granulomas...
  13. pmc Natural course of lymphatic filariasis: insights from epidemiology, experimental human infections, and clinical observations
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
    Am J Trop Med Hyg 73:995-8. 2005
    ..The intensity of transmission may underlie the differences in clinical presentation seen in diverse global pockets of endemicity...
  14. ncbi request reprint Neonatal tolerance and patent filarial infection
    T V Rajan
    Department of Pathology, 263 Farmington Avenue, Farmington, CT 06032, USA
    Trends Parasitol 23:459-62. 2007
    ..If the model is correct, there are profound implications for global eradication...
  15. ncbi request reprint Inflammatory bowel disease: maladaptation of the vigilant genotype in a hyper-clean world?
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Ave, 06032, USA
    Perspect Biol Med 49:171-7. 2006
    ..One manifestation of such dysregulation is organ-specific autoimmunity, such as IBD...
  16. pmc Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient mice
    Thirumalai Ramalingam
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    Infect Immun 71:4361-7. 2003
    ....
  17. ncbi request reprint Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice
    L Ganley
    University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut, 06030 3105, USA
    Exp Parasitol 98:35-43. 2001
    ..In contrast, NOS2-/- mice demonstrate an early rise in IgG2a titers compared to B6 +/+ mice. Our data suggest that NO is not an obligate requirement for the elimination of B. malayi from the peritoneal cavities of mice...
  18. pmc Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite
    L Spencer
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    Infect Immun 69:7743-52. 2001
    ....
  19. ncbi request reprint Acute but not chronic macrophage recruitment in filarial infections in mice is dependent on C-C chemokine ligand 2
    M Ramesh
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
    Parasite Immunol 29:395-404. 2007
    ..We further report that larval clearance and the in vitro adhesion of PECs to larvae were unimpaired in these mice...
  20. ncbi request reprint Endogenous testosterone levels do not affect filarial worm burdens in mice
    L Ganley
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, 06003-3105, USA
    Exp Parasitol 98:29-34. 2001
    ....
  21. ncbi request reprint Impaired clearance of primary but not secondary Brugia infections in IL-5 deficient mice
    Thirumalai Ramalingam
    Department of Pathology, University of Connecticut Health Center, Farmington, CT, USA
    Exp Parasitol 105:131-9. 2003
    ..These observations suggest that IL-5 induced eosinophilia is more important in the control of a primary infection in naïve mice than a secondary infection in primed mice...
  22. ncbi request reprint Determinants of memory in experimental filarial infections in mice
    Y Dash
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Parasite Immunol 29:567-74. 2007
    ..pahangi L3. The gap between the priming and second injections of larvae ranged between 4 and 60 weeks. We found that the memory responses in BALB/cByJ mice lasted over a year whereas those in C57BL/6 mice waned more rapidly...
  23. ncbi request reprint Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice
    S Babu
    Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
    J Immunol 161:1428-32. 1998
    ..Furthermore, these data suggest that the interaction of the host immune system with the filarial parasite is double edged, with both host protective and parasite growth-promoting activities emanating from the former...
  24. pmc T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4
    L Spencer
    Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
    Infect Immun 71:3097-106. 2003
    ..Instead, our data imply that T cells may be required for eosinophil accumulation at the site of infection...
  25. ncbi request reprint A hypothesis for the tissue specificity of nematode parasites
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    Exp Parasitol 89:140-2. 1998
    ....
  26. pmc Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice
    Natalia Paciorkowski
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    Infect Immun 71:1370-8. 2003
    ..pahangi infection. The data demonstrate a critical role of B lymphocytes in antifilarial immunity in naïve mice and in the memory response in primed mice...
  27. ncbi request reprint CD8+ T lymphocytes are not required for murine resistance to human filarial parasites
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington 06030
    J Parasitol 78:744-6. 1992
    ..We find that these mice are completely resistant to B. malayi, indicating that the CD8+ T lymphocyte subset is not an obligate requirement for murine resistance to human filarial parasites...
  28. ncbi request reprint Inhibitors of the lipoxygenase pathway block development of Brugia malayi L3 in vitro
    H L Smith
    Department of Pathology, University of Connecticut Health Center, Farmington 06032, USA
    J Parasitol 87:242-9. 2001
    ..immitis development. These results demonstrate that a lipoxygenase pathway product is required for molting of the infective stage larvae of filarial parasites...
  29. ncbi request reprint CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington 06030
    Exp Parasitol 78:352-60. 1994
    ..malayi infective-stage larvae demonstrated that mice lacking CD4+ T-lymphocytes were resistant to infection. These data indicate that CD4+ T-cells are not an obligate requirement for murine resistance to B. malayi...
  30. pmc Mice genetically deficient in immunoglobulin E are more permissive hosts than wild-type mice to a primary, but not secondary, infection with the filarial nematode Brugia malayi
    L A Spencer
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    Infect Immun 71:2462-7. 2003
    ..These data imply that deficiencies other than IgE production (i.e., IgG1 production) deficiency may be responsible for the increased permissiveness of IgE(-/-) mice as hosts following infection with B. malayi...
  31. pmc Cellular immunity, but not gamma interferon, is essential for resolution of Babesia microti infection in BALB/c mice
    Michael L Clawson
    Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030 3710, USA
    Infect Immun 70:5304-6. 2002
    ..These data indicate that cellular immunity is critical for the clearance of B. microti in BALB/c mice but that disease resolution can occur even in the absence of IFN-gamma...
  32. pmc Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection
    Thirumalai Ramalingam
    Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
    Infect Immun 73:8442-3. 2005
    ..Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is...
  33. ncbi request reprint The L3 to L4 molt of Brugia malayi: real time visualization by video microscopy
    Manish Ramesh
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    J Parasitol 91:1028-33. 2005
    ..Finally, it retracts out of the cap and extrudes the pharyngeal cuticle. Detachment of the pharyngeal cuticle is the final event in the process and continues up to an hour after the rest of the cuticle has been shed...
  34. pmc The immunodeficient scid mouse as a model for human lymphatic filariasis
    F K Nelson
    Department of Pathology, University of Connecticut Health Center, Farmington 06030
    J Exp Med 173:659-63. 1991
    ..These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite...
  35. pmc Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigen
    Yashodhara Dash
    Department of Immunology, 263 Farmington Avenue, University of Connecticut Health Center, Farmington, CT 06032, USA
    Infect Immun 79:838-45. 2011
    ..Our data reinforce the work of others and also provide a possible mechanism by which immune responses to BmALT-2 may provide host protection...
  36. ncbi request reprint Isolation and partial sequence of a collagen gene from the human filarial parasite Brugia malayi
    V R Caulagi
    Department of Pathology, University of Connecticut Health Center, Farmington 06030
    Mol Biochem Parasitol 45:57-64. 1991
    ..BmCol1 is a single copy gene and appears to be present in several other parasitic nematodes examined...
  37. ncbi request reprint Murine extramedullary erythropoiesis induced by tick infestation
    Y Dash
    Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, 06030, USA
    Ann Trop Med Parasitol 99:518-31. 2005
    ..These results indicate that, within 8 days of their initiation, the tick infestations induced extramedullary erythropoiesis in the spleens of their murine hosts...
  38. ncbi request reprint Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Carcinogenesis 28:769-76. 2007
    ..These lesions may be precursors to MSI-low CRC, providing a potential early biomarker to assess the effects of cancer prevention strategies...
  39. ncbi request reprint Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
    Daniel W Rosenberg
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Cancer Res 67:3551-4. 2007
    ....
  40. pmc Epigenetic alterations in RASSF1A in human aberrant crypt foci
    Emily J Greenspan
    Center for Molecular Medicine, UCHC School of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Carcinogenesis 27:1316-22. 2006
    ..Importantly, CIM of RASSF1A is an early epigenetic aberration, occurring in the absence of synchronous colon tumors and is not accompanied by field effects into the surrounding epithelium...
  41. pmc Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model
    Anurag Singh
    1Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA
    Immunol Cell Biol 86:535-8. 2008
    ..Thus, the resolution of airway inflammatory responses with chronic antigen inhalation is a localized response, not associated with loss of systemic responses to antigen...
  42. ncbi request reprint Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer
    Richard G Stevens
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA
    Cancer Lett 248:262-8. 2007
    ..4; the mean was significantly higher in the patients with a positive family history of CRC (9.0, p<0.01; n=43) or a personal history of advanced adenoma (7.5, p<0.05; n=34)...
  43. ncbi request reprint Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth
    Glenn S Belinsky
    Center for Molecular Medicine, The Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Mol Carcinog 46:106-16. 2007
    ..Mechanisms that may account for differences between the tumor explant model versus the Apc(Min) model of intestinal cancer are discussed...
  44. ncbi request reprint Effects of the physico-chemical nature of two biomimetic crystals on the innate immune response
    Manish Ramesh
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Int Immunopharmacol 7:1617-29. 2007
    ..Proper utilization of the physico-chemical features of particulates offers a new direction for the development of more effective vaccine adjuvants...

Research Grants20

  1. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  2. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ....
  3. GROWTH OF B MALAYI IN MURINE MODELS--ROLE OF NK CELLS
    THIRUCHANDURAI RAJAN; Fiscal Year: 2001
    ..Identification of the molecule(s) involved in the interaction could help us formulate a rationale approach to immunoprophylaxis, as well as pharmacology of lymphatic filarial parasites. ..
  4. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2000
    ..b) the influence of alleles at the Nramp and iNOS loci on murine susceptibility to B. malayi. (c). the role of cytokines controlling the induction of nitric oxide in the resistance of NOD/LtSz-scid mice to B. malayi. ..
  5. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2006
    ..More excitingly, they might help us identify the epitope that forms the target of host defense raising the possibility, long-term, of generating an immuno-prophylactic strategy against filarial infections. ..