Research Topics
Species | THIRUCHANDURAI RAJANSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
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Publications
B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasitesN Paciorkowski
University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
J Exp Med 191:731-6. 2000..These data raise the possibility that the identification of molecule(s) recognized by humoral immune mechanisms might help generate prophylactic vaccines...
Superficial? Not us--we men are born molecular geneticists!Thiruchandurai V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
Perspect Biol Med 47:422-9. 2004- Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responsesT V Rajan
The University of Connecticut Health Center, 263 Farmington Avenue, 06030 3105, USA
Exp Parasitol 100:235-47. 2002..These granulomas may represent an important mechanism by which worms are eliminated... - A double-blinded, placebo-controlled trial of garlic as a mosquito repellant: a preliminary studyT V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
Med Vet Entomol 19:84-9. 2005..The data did not provide evidence of significant systemic mosquito repellence. A limitation of the study is that more prolonged ingestion of garlic may be needed to accomplish repellence... - East is East, etcT V Rajan
Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-3105, USA
Cancer Biol Ther 1:313-4. 2002 - The eye does not see what the mind does not know: the bacterium in the wormThiruchandurai V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
Perspect Biol Med 48:31-41. 2005..Intriguingly, the intense recent interest in Wolbachia is in complete contrast with the virtually complete indifference evoked by the original discovery of these organisms... - Exogenous nucleosides are required for the morphogenesis of the human filarial parasite Brugia malayiT V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA
J Parasitol 90:1184-5. 2004..malayi and B. pahangi depend on an exogenous source of at least 1 purine and 1 pyrimidine nucleoside to complete the L3 to L4 molt. The requirement for exogenous nucleosides opens the door for possible chemotherapeutic intervention... - Relationship of anti-microbial activity of tetracyclines to their ability to block the L3 to L4 molt of the human filarial parasite Brugia malayiT V Rajan
Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
Am J Trop Med Hyg 71:24-8. 2004..This study shows that chemically modified tetracycline, which does not to have anti-microbial activity, also blocks molting... - The Gell-Coombs classification of hypersensitivity reactions: a re-interpretationT V Rajan
Department of Pathology, Room L 1037, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
Trends Immunol 24:376-9. 2003..I further propose that there is a fifth strategy that was not envisioned in the Gell and Coombs classification... - Ascorbic acid is a requirement for the morphogenesis of the human filarial parasite Brugia malayiT V Rajan
Department of Pathology, UCONN Health Center, Farmington, Connecticut 06030 3105, USA
J Parasitol 89:868-70. 2003..Brugia malayi apparently belongs to a small group of living organisms that depend on an exogenous source of vitamin C. This group includes only primates (including man) and guinea pigs among mammals... - Effect of ingestion of honey on symptoms of rhinoconjunctivitisT V Rajan
Department of Pathology, UCONN Health Center, Farmington 06030 3105, USA
Ann Allergy Asthma Immunol 88:198-203. 2002..Despite this high prevalence, relatively few sufferers seek professional medical help, presumably because of a widespread reliance on complementary remedies... - Critical role for IgM in host protection in experimental filarial infectionBhargavi Rajan
Department of Pathology, University of Connecticut Health Center, Farmington, CT 06032, USA
J Immunol 175:1827-33. 2005..Peritoneal exudate cells from primed mice, especially activated macrophages, carry high levels of IgM on their surfaces. Our observations suggest that an IgM-mediated reaction initiates the formation of host-protective granulomas... 
Natural course of lymphatic filariasis: insights from epidemiology, experimental human infections, and clinical observationsT V Rajan
Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
Am J Trop Med Hyg 73:995-8. 2005..The intensity of transmission may underlie the differences in clinical presentation seen in diverse global pockets of endemicity...- Neonatal tolerance and patent filarial infectionT V Rajan
Department of Pathology, 263 Farmington Avenue, Farmington, CT 06032, USA
Trends Parasitol 23:459-62. 2007..If the model is correct, there are profound implications for global eradication... - Inflammatory bowel disease: maladaptation of the vigilant genotype in a hyper-clean world?T V Rajan
Department of Pathology, University of Connecticut Health Center, 263 Farmington Ave, 06032, USA
Perspect Biol Med 49:171-7. 2006..One manifestation of such dysregulation is organ-specific autoimmunity, such as IBD... - Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient miceThirumalai Ramalingam
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA
Infect Immun 71:4361-7. 2003.... - Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- miceL Ganley
University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut, 06030 3105, USA
Exp Parasitol 98:35-43. 2001..In contrast, NOS2-/- mice demonstrate an early rise in IgG2a titers compared to B6 +/+ mice. Our data suggest that NO is not an obligate requirement for the elimination of B. malayi from the peritoneal cavities of mice... - Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasiteL Spencer
Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
Infect Immun 69:7743-52. 2001.... - Acute but not chronic macrophage recruitment in filarial infections in mice is dependent on C-C chemokine ligand 2M Ramesh
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
Parasite Immunol 29:395-404. 2007..We further report that larval clearance and the in vitro adhesion of PECs to larvae were unimpaired in these mice... - Endogenous testosterone levels do not affect filarial worm burdens in miceL Ganley
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, 06003-3105, USA
Exp Parasitol 98:29-34. 2001.... - Impaired clearance of primary but not secondary Brugia infections in IL-5 deficient miceThirumalai Ramalingam
Department of Pathology, University of Connecticut Health Center, Farmington, CT, USA
Exp Parasitol 105:131-9. 2003..These observations suggest that IL-5 induced eosinophilia is more important in the control of a primary infection in naïve mice than a secondary infection in primed mice... - Determinants of memory in experimental filarial infections in miceY Dash
Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA
Parasite Immunol 29:567-74. 2007..pahangi L3. The gap between the priming and second injections of larvae ranged between 4 and 60 weeks. We found that the memory responses in BALB/cByJ mice lasted over a year whereas those in C57BL/6 mice waned more rapidly... - Host NK cells are required for the growth of the human filarial parasite Brugia malayi in miceS Babu
Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
J Immunol 161:1428-32. 1998..Furthermore, these data suggest that the interaction of the host immune system with the filarial parasite is double edged, with both host protective and parasite growth-promoting activities emanating from the former... - T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4L Spencer
Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
Infect Immun 71:3097-106. 2003..Instead, our data imply that T cells may be required for eosinophil accumulation at the site of infection... - A hypothesis for the tissue specificity of nematode parasitesT V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
Exp Parasitol 89:140-2. 1998.... - Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in miceNatalia Paciorkowski
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA
Infect Immun 71:1370-8. 2003..pahangi infection. The data demonstrate a critical role of B lymphocytes in antifilarial immunity in naïve mice and in the memory response in primed mice... - CD8+ T lymphocytes are not required for murine resistance to human filarial parasitesT V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington 06030
J Parasitol 78:744-6. 1992..We find that these mice are completely resistant to B. malayi, indicating that the CD8+ T lymphocyte subset is not an obligate requirement for murine resistance to human filarial parasites... - Inhibitors of the lipoxygenase pathway block development of Brugia malayi L3 in vitroH L Smith
Department of Pathology, University of Connecticut Health Center, Farmington 06032, USA
J Parasitol 87:242-9. 2001..immitis development. These results demonstrate that a lipoxygenase pathway product is required for molting of the infective stage larvae of filarial parasites... - CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayiT V Rajan
Department of Pathology, University of Connecticut Health Center, Farmington 06030
Exp Parasitol 78:352-60. 1994..malayi infective-stage larvae demonstrated that mice lacking CD4+ T-lymphocytes were resistant to infection. These data indicate that CD4+ T-cells are not an obligate requirement for murine resistance to B. malayi... - Mice genetically deficient in immunoglobulin E are more permissive hosts than wild-type mice to a primary, but not secondary, infection with the filarial nematode Brugia malayiL A Spencer
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA
Infect Immun 71:2462-7. 2003..These data imply that deficiencies other than IgE production (i.e., IgG1 production) deficiency may be responsible for the increased permissiveness of IgE(-/-) mice as hosts following infection with B. malayi... - Cellular immunity, but not gamma interferon, is essential for resolution of Babesia microti infection in BALB/c miceMichael L Clawson
Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030-3710, USA
Infect Immun 70:5304-6. 2002..These data indicate that cellular immunity is critical for the clearance of B. microti in BALB/c mice but that disease resolution can occur even in the absence of IFN-gamma... - Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infectionThirumalai Ramalingam
Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
Infect Immun 73:8442-3. 2005..Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is... - The L3 to L4 molt of Brugia malayi: real time visualization by video microscopyManish Ramesh
Department of Pathology, University of Connecticut Health Center, Farmington 06030-3105, USA
J Parasitol 91:1028-33. 2005..Finally, it retracts out of the cap and extrudes the pharyngeal cuticle. Detachment of the pharyngeal cuticle is the final event in the process and continues up to an hour after the rest of the cuticle has been shed... - The immunodeficient scid mouse as a model for human lymphatic filariasisF K Nelson
Department of Pathology, University of Connecticut Health Center, Farmington 06030
J Exp Med 173:659-63. 1991..These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite... - Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigenYashodhara Dash
Department of Immunology, 263 Farmington Avenue, University of Connecticut Health Center, Farmington, CT 06032, USA
Infect Immun 79:838-45. 2011..Our data reinforce the work of others and also provide a possible mechanism by which immune responses to BmALT-2 may provide host protection... - Isolation and partial sequence of a collagen gene from the human filarial parasite Brugia malayiV R Caulagi
Department of Pathology, University of Connecticut Health Center, Farmington 06030
Mol Biochem Parasitol 45:57-64. 1991..BmCol1 is a single copy gene and appears to be present in several other parasitic nematodes examined... - Murine extramedullary erythropoiesis induced by tick infestationY Dash
Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, 06030, USA
Ann Trop Med Parasitol 99:518-31. 2005..These results indicate that, within 8 days of their initiation, the tick infestations induced extramedullary erythropoiesis in the spleens of their murine hosts... - Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancerEmily J Greenspan
Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA
Carcinogenesis 28:769-76. 2007..These lesions may be precursors to MSI-low CRC, providing a potential early biomarker to assess the effects of cancer prevention strategies... - Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humansDaniel W Rosenberg
Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Cancer Res 67:3551-4. 2007.... - Epigenetic alterations in RASSF1A in human aberrant crypt fociEmily J Greenspan
Center for Molecular Medicine, UCHC School of Medicine, University of Connecticut Health Center, Farmington, CT 06030-3101, USA
Carcinogenesis 27:1316-22. 2006..Importantly, CIM of RASSF1A is an early epigenetic aberration, occurring in the absence of synchronous colon tumors and is not accompanied by field effects into the surrounding epithelium... - Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma modelAnurag Singh
1Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA
Immunol Cell Biol 86:535-8. 2008..Thus, the resolution of airway inflammatory responses with chronic antigen inhalation is a localized response, not associated with loss of systemic responses to antigen... - Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancerRichard G Stevens
Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA
Cancer Lett 248:262-8. 2007..4; the mean was significantly higher in the patients with a positive family history of CRC (9.0, p<0.01; n=43) or a personal history of advanced adenoma (7.5, p<0.05; n=34)... - Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growthGlenn S Belinsky
Center for Molecular Medicine, The Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
Mol Carcinog 46:106-16. 2007..Mechanisms that may account for differences between the tumor explant model versus the Apc(Min) model of intestinal cancer are discussed... - Effects of the physico-chemical nature of two biomimetic crystals on the innate immune responseManish Ramesh
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
Int Immunopharmacol 7:1617-29. 2007..Proper utilization of the physico-chemical features of particulates offers a new direction for the development of more effective vaccine adjuvants...
Research Grants
- FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICETHIRUCHANDURAI RAJAN; Fiscal Year: 2005....
- Brugia Infections in Mice: Role of EosinophilsTHIRUCHANDURAI RAJAN; Fiscal Year: 2005..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
- GROWTH OF B MALAYI IN MURINE MODELS--ROLE OF NK CELLSTHIRUCHANDURAI RAJAN; Fiscal Year: 2001..Identification of the molecule(s) involved in the interaction could help us formulate a rationale approach to immunoprophylaxis, as well as pharmacology of lymphatic filarial parasites. ..
- FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICETHIRUCHANDURAI RAJAN; Fiscal Year: 2000..b) the influence of alleles at the Nramp and iNOS loci on murine susceptibility to B. malayi. (c). the role of cytokines controlling the induction of nitric oxide in the resistance of NOD/LtSz-scid mice to B. malayi. ..
- FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICETHIRUCHANDURAI RAJAN; Fiscal Year: 2006..More excitingly, they might help us identify the epitope that forms the target of host defense raising the possibility, long-term, of generating an immuno-prophylactic strategy against filarial infections. ..