DAVID MENASSAH RAIZEN

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Lethargus is a Caenorhabditis elegans sleep-like state
    David M Raizen
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 451:569-72. 2008
  2. ncbi A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans
    David M Raizen
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genetics 173:177-87. 2006
  3. ncbi Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 27:337-50. 2006
  4. ncbi A video method to study Drosophila sleep
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 125 South 31st St, Suite 2100, Philadelphia, PA 19104 3403, USA
    Sleep 31:1587-98. 2008
  5. ncbi Conservation of sleep: insights from non-mammalian model systems
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Trends Neurosci 31:371-6. 2008
  6. ncbi Genetic basis for sleep regulation and sleep disorders
    David M Raizen
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Neurol 26:467-83. 2006
  7. ncbi Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety
    Young jai You
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 7:249-57. 2008
  8. ncbi eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx
    James P McKay
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genetics 166:161-9. 2004

Research Grants

  1. Studies of behavioral quiescence in C. elegans
    David Raizen; Fiscal Year: 2007
  2. Regulation of sleep-like behavior in C. elegans
    DAVID MENASSAH RAIZEN; Fiscal Year: 2010
  3. Regulation of sleep-like behavior in C. elegans
    David Raizen; Fiscal Year: 2009

Collaborators

Detail Information

Publications8

  1. ncbi Lethargus is a Caenorhabditis elegans sleep-like state
    David M Raizen
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 451:569-72. 2008
    ..The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes...
  2. ncbi A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans
    David M Raizen
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genetics 173:177-87. 2006
    ..In a genetic screen we have identified extragenic suppressors of this gain-of-function mutant. Thus, this mutant promises to be a useful tool for identifying downstream targets of PKG...
  3. ncbi Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 27:337-50. 2006
    ....
  4. ncbi A video method to study Drosophila sleep
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 125 South 31st St, Suite 2100, Philadelphia, PA 19104 3403, USA
    Sleep 31:1587-98. 2008
    ..To use video to determine the accuracy of the infrared beam-splitting method for measuring sleep in Drosophila and to determine the effect of time of day, sex, genotype, and age on sleep measurements...
  5. ncbi Conservation of sleep: insights from non-mammalian model systems
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Trends Neurosci 31:371-6. 2008
    ....
  6. ncbi Genetic basis for sleep regulation and sleep disorders
    David M Raizen
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Neurol 26:467-83. 2006
    ..We anticipate such identification will increase our ability to assess risk for disease before symptom onset and by doing so will shift the focus from treatment to prevention of disease...
  7. ncbi Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety
    Young jai You
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 7:249-57. 2008
    ..The EGL-4 cGMP-dependent protein kinase functions downstream of insulin and TGF-beta in sensory neurons including ASI to control quiescence in response to food intake...
  8. ncbi eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx
    James P McKay
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genetics 166:161-9. 2004
    ..In eat-18 mutants, the gross localization of EAT-2 at the MC synapse is normal, suggesting that it is not required for trafficking. These data indicate that eat-18 could be a novel component of the pharyngeal nicotinic receptor...

Research Grants5

  1. Studies of behavioral quiescence in C. elegans
    David Raizen; Fiscal Year: 2007
    ..Raizen while he learns the scientific field of sleep and chronobiology and develops C. elegans as a model system for the study of behavioral quiescence and its relationship to development. ..
  2. Regulation of sleep-like behavior in C. elegans
    DAVID MENASSAH RAIZEN; Fiscal Year: 2010
    ..This proposal aims to add to our understanding of sleep regulation, in order to enhance the diagnosis and treatment of patients with sleep disorders. ..
  3. Regulation of sleep-like behavior in C. elegans
    David Raizen; Fiscal Year: 2009
    ..This proposal aims to add to our understanding of sleep regulation, in order to enhance the diagnosis and treatment of patients with sleep disorders. ..