L G Raisz

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo
    Xiaodong Li
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Prostaglandins Other Lipid Mediat 67:173-80. 2002
  2. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
  3. ncbi request reprint Short-term risedronate treatment in postmenopausal women: effects on biochemical markers of bone turnover
    L Raisz
    Division of Endocrinology Metabolism, University of Connecticut Health Center, Farmington 06032, USA
    Osteoporos Int 11:615-20. 2000
  4. ncbi request reprint Physiology and pathophysiology of bone remodeling
    L G Raisz
    Lowell P Weicker, Jr General Clinical Research Center, University of Connecticut Health Center, MC 2806, 263 Farmington Ave, Farmington, CT 06030, USA
    Clin Chem 45:1353-8. 1999
  5. ncbi request reprint Clinical practice. Screening for osteoporosis
    Lawrence G Raisz
    Musculoskeletal Institute, University of Connecticut Health Center, Farmington 06030, USA
    N Engl J Med 353:164-71. 2005
  6. pmc The hunting of the snark: the elusive calcium receptor(s)
    Lawrence G Raisz
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Clin Invest 111:945-7. 2003
  7. ncbi request reprint Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures
    Lawrence G Raisz
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 71:287-92. 2003
  8. ncbi request reprint Determinants of bone density in healthy older men with low testosterone levels
    A M Kenny
    Center on Aging, University of Connecticut Health Center, Farmington 06030 5215, USA
    J Gerontol A Biol Sci Med Sci 55:M492-7. 2000
  9. ncbi request reprint Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice
    X Li
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:567-73. 2002
  10. ncbi request reprint Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitro
    M Tomita
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:159-63. 2002

Research Grants

  1. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 1993
  2. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 2002
  3. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 2007

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo
    Xiaodong Li
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Prostaglandins Other Lipid Mediat 67:173-80. 2002
    ..This impaired response in EP2 -/- mice may be due to decreased ability to stimulate cyclic AMP and in part, to a smaller increase in the expression of RANKL mRNA...
  2. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
    ..However, new and more effective approaches are likely to emerge from a better understanding of the regulators of bone cell function...
  3. ncbi request reprint Short-term risedronate treatment in postmenopausal women: effects on biochemical markers of bone turnover
    L Raisz
    Division of Endocrinology Metabolism, University of Connecticut Health Center, Farmington 06032, USA
    Osteoporos Int 11:615-20. 2000
    ..This study demonstrates that the approved dose of risedonate (30 mg/day) for Paget's disease is effective at decreasing bone turnover after 2 weeks of treatment, as observed by the sensitive response of bone turnover markers...
  4. ncbi request reprint Physiology and pathophysiology of bone remodeling
    L G Raisz
    Lowell P Weicker, Jr General Clinical Research Center, University of Connecticut Health Center, MC 2806, 263 Farmington Ave, Farmington, CT 06030, USA
    Clin Chem 45:1353-8. 1999
    ..Local factors are implicated in the pathogenesis of the skeletal changes associated with immobilization, inflammation, and Paget disease of bone...
  5. ncbi request reprint Clinical practice. Screening for osteoporosis
    Lawrence G Raisz
    Musculoskeletal Institute, University of Connecticut Health Center, Farmington 06030, USA
    N Engl J Med 353:164-71. 2005
  6. pmc The hunting of the snark: the elusive calcium receptor(s)
    Lawrence G Raisz
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Clin Invest 111:945-7. 2003
  7. ncbi request reprint Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures
    Lawrence G Raisz
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 71:287-92. 2003
    ..Only EP4A was effective in increasing 45Ca release. Both agonists increased [3H]-TdR incorporation and [3H]-proline incorporation into calvariae, particularly in the presence of cortisol...
  8. ncbi request reprint Determinants of bone density in healthy older men with low testosterone levels
    A M Kenny
    Center on Aging, University of Connecticut Health Center, Farmington 06030 5215, USA
    J Gerontol A Biol Sci Med Sci 55:M492-7. 2000
    ..The purpose of this study was to define the predictors of bone mass ill healthy older men with low testosterone levels but without symptomatic osteoporosis...
  9. ncbi request reprint Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice
    X Li
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:567-73. 2002
    ..The major defect in the response to PGE2 in animals lacking either EP2 or EP4 receptors is a reduction in basal and stimulated RANKL levels. Loss of EP4 receptor appears to have a greater effect on basal RANKL expression than EP2...
  10. ncbi request reprint Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitro
    M Tomita
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:159-63. 2002
    ..01 micromol/L PGE(2). This could be due to the limited efficacy of the antagonist at high concentrations of PGE(2), or an alternative pathway, such as activation of the EP2 receptor...
  11. ncbi request reprint Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro
    X Li
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Endocrinology 141:2054-61. 2000
    ..A major defect in EP2 -/- mice appears to be in the capacity of osteoblastic cells to stimulate osteoclast formation. In addition, there appears to be a defect in the response of cells of the osteoclastic lineage to PGE2 in EP2 -/- mice...
  12. ncbi request reprint Short-term effects of intramuscular and transdermal testosterone on bone turnover, prostate symptoms, cholesterol, and hematocrit in men over age 70 with low testosterone levels
    A M Kenny
    University of Connecticut Health Center, Farmington 06030 5215, USA
    Endocr Res 26:153-68. 2000
    ..8 +/- 0.9 ng/dl following treatment. Cholesterol profiles were also not affected by either transdermal or intramuscular testosterone. Similarly hemoglobin and hematocrit remained unchanged in men receiving either testosterone preparation...
  13. pmc Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture
    Y Okada
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Clin Invest 105:823-32. 2000
    ..Mice lacking PGHS-1 were similar to wild-type mice in all of these parameters. These data suggest that PGHS-2 is not necessary for wild-type bone development but plays a critical role in bone resorption stimulated by 1,25-D and PTH...
  14. ncbi request reprint A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women
    K M Prestwood
    Center on Aging and Division of Endocrinology and Metabolism, University of Connecticut Health Center, Farmington 06030 5215, USA
    J Clin Endocrinol Metab 85:2197-202. 2000
    ..Thus, raloxifene is an alternative to CEE for the prevention and treatment of osteoporosis in postmenopausal women...
  15. ncbi request reprint Effect of norethindrone acetate on hormone levels and markers of bone turnover in estrogen-treated postmenopausal women
    O A Onobrakpeya
    Division of Endocrinology and Metabolism, Lowell P. Weicker, General Clinical Research Center, University of Connecticut Health Center, Farmington, USA
    Endocr Res 27:473-80. 2001
    ..These results indicate that NETA does not have a potent short-term anabolic effect on bone but does have effects that are likely to be mediated through the estrogen and androgen receptors...
  16. ncbi request reprint Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels
    A M Kenny
    Center on Aging, University of Connecticut Health Center, Farmington, 06030 5215, USA
    J Gerontol A Biol Sci Med Sci 56:M266-72. 2001
    ..The impact of this on musculoskeletal health and the potential for improvement in function in this group with testosterone supplementation require investigation...
  17. ncbi request reprint Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ culture
    L G Raisz
    University of Connecticut Health Center, Farmington 06032
    Endocrinology 122:1083-6. 1988
    ..HTS was more potent as an inhibitor when the CO2 concentration in the gas phase was reduced from 5% to 2% and the pH was increased from 7.2 to 7.5, consistent with an effect on CA-mediated hydrogen ion generation...
  18. ncbi request reprint Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study
    P Taxel
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 5456, USA
    Osteoporos Int 19:193-9. 2008
    ..E(2) treatment inhibited the ability of hematopoietic cells to form OCLs in response to RANKL, and decreased RANKL production. These changes are likely involved in the ability of E(2) to influence the development of osteoporosis...
  19. ncbi request reprint The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men
    P Taxel
    Division of Endocrinology and Metabolism, Center on Aging, University of Connecticut Health Center, Farmington, Connecticut 06030 1317, USA
    J Clin Endocrinol Metab 86:2869-74. 2001
    ....
  20. ncbi request reprint Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells
    Y K Min
    Department of Medicine, University of Connecticut Health Center, Farmington, USA
    J Bone Miner Res 13:1066-75. 1998
    ..In summary, we show that IL-1 is a potent inducer of PGHS-2 expression and PGE2 production in human osteosarcoma cells as well as in osteoblastic cells derived from normal human bone...
  21. pmc Effects of selective prostaglandins E2 receptor agonists on cultured calvarial murine osteoblastic cells
    Cynthia B Alander
    University of Connecticut Health Center, 263 Farmington Avenue, MC5456, Farmington, CT 06030, United States
    Prostaglandins Other Lipid Mediat 81:178-83. 2006
    ..We conclude that the anabolic effect of PGE(2) in calvarial osteoblastic cell cultures is largely mediated by activation of the EP4 receptor, while activation of the EP2 receptor is less effective...
  22. ncbi request reprint Femoral bone mineral density in patients with heart failure
    A M Kenny
    Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030 5215, USA
    Osteoporos Int 17:1420-7. 2006
    ..Heart failure and osteoporosis are common conditions in older, frail individuals. It is important to investigate interactions of the common problems in the aging population to devise relevant interventions...
  23. doi request reprint Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice
    Qi Gao
    New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 45:98-103. 2009
    ..We conclude that expression of the EP4 receptor in osteoblasts is critical for anabolic responses to PGE(2) in cell culture but may not be essential for maintenance of bone remodeling in vivo...
  24. ncbi request reprint Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: impaired responsiveness in heterozygotes
    Peili Zhan
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 78:19-26. 2005
    ..These results suggest that the EP4 receptor may be rate limiting not only for PGE2 stimulated resorption but also for resorption stimulated by other agonists, like PTH that induce PGE2 production...
  25. ncbi request reprint Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathway
    Shilpa Choudhary
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Bone Miner Res 18:1813-24. 2003
    ..Inhibition of PGE2 production inhibited the [Ca2+]e stimulation of osteoblastic differentiation but not the increase in cell number. Hence, some effects of [Ca2+]e on bone may be mediated by COX-2...
  26. doi request reprint Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men
    K Kuruvilla
    General Clinical Research Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
    Osteoporos Int 22:217-21. 2011
    ..A majority of our subjects were either osteopenic or osteoporotic, and their fracture risk increased when FRAX® was used in conjunction with femur neck T-scores...
  27. ncbi request reprint Lack of association between androgen receptor polymorphisms and bone mineral density or physical function in older men
    A M Kenny
    Center on Aging, MC 5215, University of Connecticut Health Center, Farmingham, CT 06030 5215, USA
    Endocr Res 31:285-93. 2005
    ..Men with osteoporosis or fracture had lower BioT, physical performance, and physical activity than controls. This study found no association between CA G repeats and FN BMD in older men with normal or low BMD or FX...
  28. ncbi request reprint Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells
    T Sobue
    University of Connecticut School of Medicine, Farmington, USA
    J Bone Miner Res 17:502-12. 2002
    ..These data show that TGF-beta regulates FGF-2 gene expression in human osteosarcoma cells. Furthermore, TGF-beta modulates the cellular localization of FGF-2 and its receptors...
  29. ncbi request reprint Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures
    M M Hurley
    The University of Connecticut Health Center, Farmington 06030 1850, USA
    Bone 22:309-16. 1998
    ..We conclude that bFGF stimulates OCL formation in C57BL/6 bone marrow cultures by mechanisms that require prostaglandin synthesis. This pathway is likely to be one mechanism by which bFGF stimulates resorption...
  30. ncbi request reprint The effect of micronized estradiol on bone turnover and calciotropic hormones in older men receiving hormonal suppression therapy for prostate cancer
    Pamela Taxel
    Division of Endocrinology and Metabolism, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1317, USA
    J Clin Endocrinol Metab 87:4907-13. 2002
    ..We conclude that E(2) inhibits bone resorption in hypogonadal men through a direct skeletal effect that is independent of PTH. Low dose estrogen may be an option for the prevention and/or treatment of bone loss in this population...
  31. ncbi request reprint Mechanisms of bone remodeling: implications for clinical practice
    Anne M Kenny
    Center on Aging, Department of Medicine, Lowell P Weicker, Jr, General Clinical Research Center, University of Connecticut Health Center, Farmington, USA
    J Reprod Med 47:63-70. 2002
    ..These new approaches have allowed us to define more precisely the specific roles of androgens, estrogens and other regulatory hormones in human skeletal physiology and pathophysiology...
  32. pmc Prostaglandins in bone: bad cop, good cop?
    Katherine A Blackwell
    New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, USA
    Trends Endocrinol Metab 21:294-301. 2010
    ..Further analysis of COX-2 and PG receptors and their downstream G-protein signaling in bone could provide important clues to the regulation of skeletal cell growth in both health and disease...
  33. ncbi request reprint Changes in urinary excretion of helical peptide during therapy for osteoporosis in older adults
    Pamela Taxel
    Division of Endocrinology and Metabolism, University of Connecticut Health Center, Farmington, CT, USA
    Clin Chem 50:747-50. 2004
  34. ncbi request reprint Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women
    Anne M Kenny
    Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030 5215, USA
    Osteoporos Int 15:290-4. 2004
    ..05). Calcium citrate decreased markers of bone resorption significantly more than calcium carbonate in postmenopausal women, although no differences in their effects in calcium excretion or PTH were detected...
  35. pmc Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women
    Faryal S Mirza
    University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Clin Endocrinol Metab 95:1991-7. 2010
    ..Sclerostin is a negative regulator of bone formation...
  36. ncbi request reprint Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women
    Cheryl Oncken
    Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington 06030, USA
    Nicotine Tob Res 4:451-8. 2002
    ..48; p = 0.004 and r = 0.36; p = 0.04, respectively). Six weeks of smoking abstinence produces reductions in SHBG and NTx. This may partly explain how smoking contributes to osteoporosis in postmenopausal women...
  37. ncbi request reprint Prevention and treatment of osteoporosis
    Karen M Prestwood
    Division of Geriatrics, University of Connecticut Center on Aging, University of Connecticut Health Center, Farmington, Connecticut, USA
    Clin Cornerstone 4:31-41. 2002
    ....
  38. ncbi request reprint Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype
    K Nemoto
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Prostaglandins 54:713-25. 1997
    ..Higher EP2 expression was found in fetal long bones and calvariae than in adult by RT-PCR and in situ hybridization, suggesting a role for this receptor in rapidly growing skeletal tissue...
  39. ncbi request reprint Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae
    H Kawaguchi
    Department of Medicine, University of Connecticut Health Center, Farmington 06030
    Endocrinology 135:1157-64. 1994
    ....
  40. pmc Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice
    Manshan Xu
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 47:341-52. 2010
    ..It is possible that manipulation of endogenous PGs could have important clinical implications for anabolic therapy with PTH...
  41. ncbi request reprint Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptor
    Katsuhiro Ono
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Bone Miner Res 20:23-9. 2005
    ..A selective EP2 receptor agonist mimicked these effects. Deletion of the EP2 receptor or depletion of T-cells abrogated the increase in OC number...
  42. ncbi request reprint Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo
    Daichi Chikazu
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 17:1430-40. 2002
    ....
  43. ncbi request reprint The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines
    Katsuhiro Ono
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Bone 33:798-804. 2003
    ....
  44. pmc The osteoporosis revolution marches on
    Lawrence G Raisz
    UConn Center for Osteoporosis, University of Connecticut Health Center, Farmington, CT 06030 5456, USA
    J Orthop Sci 12:405-12. 2007
  45. ncbi request reprint Pathogenesis of osteoporosis
    Lawrence G Raisz
    Division of Endocrinology and Metabolism, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, MC 1850, Farmington, CT 06030 1850, USA raisznso uchc edu
    Endocrinol Metab Clin North Am 32:15-24. 2003
    ..Identification of specific pathogenetic mechanisms should lead to new approaches to the diagnosis and management of this disorder...
  46. doi request reprint Effects of prostaglandin E2 on bone in mice in vivo
    Qi Gao
    New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 89:20-5. 2009
    ..Studies of PGE(2) in combination with an inhibitor of resorption could lead to development of a true anabolic model and permit assessment of the roles of specific PGE(2) receptors and signal transduction pathways...
  47. ncbi request reprint Extracellular calcium induces COX-2 in osteoblasts via a PKA pathway
    Shilpa Choudhary
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biochem Biophys Res Commun 322:395-402. 2004
    ..Ca(+2)](e) also stimulated a 2- to 3-fold increase in cAMP production. Hence, the [Ca(+2)](e) induction of COX-2 mRNA expression and promoter activity was independent of the PKC pathway and dependent on the PKA signaling pathway...
  48. ncbi request reprint Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway
    Sunil Wadhwa
    Department of Orthodontics, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 17:266-74. 2002
    ..We conclude that FSS transcriptionally induces COX-2 gene expression in osteoblasts, that the maximum induction requires new protein synthesis, and that induction occurs largely via an ERK signaling pathway...
  49. ncbi request reprint Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells
    Yoko Sakuma
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 34:827-34. 2004
    ..We conclude that the PG induction of COX-2 in this system generally paralleled effects on cAMP production and was mediated predominantly via the PKA pathway...
  50. pmc Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow cultures
    Katherine A Blackwell
    New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 90:76-80. 2009
    ..Our results suggest that BMP-2 can increase osteoclast formation in response to PGE(2) by increasing the RANKL:OPG ratio in osteoblasts, which may have therapeutic implications for the use of BMP-2...
  51. doi request reprint Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment
    Sundeep Khosla
    J Oral Maxillofac Surg 66:1320-1; author reply 1321-2. 2008
  52. ncbi request reprint Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002
    Daichi Chikazu
    J Bone Miner Res 20:1888-98. 2005
  53. ncbi request reprint Osteoporosis panel summary
    Alex Capron
    University of Southern California, School of Law, Los Angeles, California, USA
    J Bone Miner Res 18:1160-2. 2003
  54. ncbi request reprint Homocysteine and osteoporotic fractures--culprit or bystander?
    Lawrence G Raisz
    N Engl J Med 350:2089-90. 2004
  55. ncbi request reprint Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase
    Maria Giovanna Sabbieti
    Department of Comparative Morphology and Biochemistry, Via Gentile III da Varano, 62032 Camerino MC, Italy
    Cell Tissue Res 319:267-78. 2005
    ..We conclude that PGF(2alpha) stimulates nuclear translocation of FGF-2 and FGFR2 by a PKC-dependent pathway; we also suggest an involvement of MAPK/ERK2 in this process...

Research Grants20

  1. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 1993
    ..We will attempt to find markers for bone resorption using in vitro models, which can then be used to assess resorption in vivo...
  2. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 2002
    ....
  3. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 2007
    ..In addition, signal transduction pathways for enhanced osteoclastogenesis will be examined. ..