Research Topics
Genomes and Genes | L G RaiszSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
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Publications
Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivoXiaodong Li
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
Prostaglandins Other Lipid Mediat 67:173-80. 2002..This impaired response in EP2 -/- mice may be due to decreased ability to stimulate cyclic AMP and in part, to a smaller increase in the expression of RANKL mRNA...- Pathogenesis of osteoporosis: concepts, conflicts, and prospectsLawrence G Raisz
University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
J Clin Invest 115:3318-25. 2005..However, new and more effective approaches are likely to emerge from a better understanding of the regulators of bone cell function... - Short-term risedronate treatment in postmenopausal women: effects on biochemical markers of bone turnoverL Raisz
Division of Endocrinology Metabolism, University of Connecticut Health Center, Farmington 06032, USA
Osteoporos Int 11:615-20. 2000..This study demonstrates that the approved dose of risedonate (30 mg/day) for Paget's disease is effective at decreasing bone turnover after 2 weeks of treatment, as observed by the sensitive response of bone turnover markers... - Physiology and pathophysiology of bone remodelingL G Raisz
Lowell P Weicker, Jr General Clinical Research Center, University of Connecticut Health Center, MC 2806, 263 Farmington Ave, Farmington, CT 06030, USA
Clin Chem 45:1353-8. 1999..Local factors are implicated in the pathogenesis of the skeletal changes associated with immobilization, inflammation, and Paget disease of bone... - Clinical practice. Screening for osteoporosisLawrence G Raisz
Musculoskeletal Institute, University of Connecticut Health Center, Farmington 06030, USA
N Engl J Med 353:164-71. 2005 - The hunting of the snark: the elusive calcium receptor(s)Lawrence G Raisz
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
J Clin Invest 111:945-7. 2003 - Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ culturesLawrence G Raisz
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Prostaglandins Other Lipid Mediat 71:287-92. 2003..Only EP4A was effective in increasing 45Ca release. Both agonists increased [3H]-TdR incorporation and [3H]-proline incorporation into calvariae, particularly in the presence of cortisol... - Determinants of bone density in healthy older men with low testosterone levelsA M Kenny
Center on Aging, University of Connecticut Health Center, Farmington 06030 5215, USA
J Gerontol A Biol Sci Med Sci 55:M492-7. 2000..The purpose of this study was to define the predictors of bone mass ill healthy older men with low testosterone levels but without symptomatic osteoporosis... - Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout miceX Li
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Bone 30:567-73. 2002..The major defect in the response to PGE2 in animals lacking either EP2 or EP4 receptors is a reduction in basal and stimulated RANKL levels. Loss of EP4 receptor appears to have a greater effect on basal RANKL expression than EP2... - Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitroM Tomita
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Bone 30:159-63. 2002..01 micromol/L PGE(2). This could be due to the limited efficacy of the antagonist at high concentrations of PGE(2), or an alternative pathway, such as activation of the EP2 receptor... - Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitroX Li
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
Endocrinology 141:2054-61. 2000..A major defect in EP2 -/- mice appears to be in the capacity of osteoblastic cells to stimulate osteoclast formation. In addition, there appears to be a defect in the response of cells of the osteoclastic lineage to PGE2 in EP2 -/- mice... - Short-term effects of intramuscular and transdermal testosterone on bone turnover, prostate symptoms, cholesterol, and hematocrit in men over age 70 with low testosterone levelsA M Kenny
University of Connecticut Health Center, Farmington 06030 5215, USA
Endocr Res 26:153-68. 2000..8 +/- 0.9 ng/dl following treatment. Cholesterol profiles were also not affected by either transdermal or intramuscular testosterone. Similarly hemoglobin and hematocrit remained unchanged in men receiving either testosterone preparation... - Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in cultureY Okada
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Clin Invest 105:823-32. 2000..Mice lacking PGHS-1 were similar to wild-type mice in all of these parameters. These data suggest that PGHS-2 is not necessary for wild-type bone development but plays a critical role in bone resorption stimulated by 1,25-D and PTH... - A comparison of the effects of raloxifene and estrogen on bone in postmenopausal womenK M Prestwood
Center on Aging and Division of Endocrinology and Metabolism, University of Connecticut Health Center, Farmington 06030 5215, USA
J Clin Endocrinol Metab 85:2197-202. 2000..Thus, raloxifene is an alternative to CEE for the prevention and treatment of osteoporosis in postmenopausal women... - Effect of norethindrone acetate on hormone levels and markers of bone turnover in estrogen-treated postmenopausal womenO A Onobrakpeya
Division of Endocrinology and Metabolism, Lowell P. Weicker, General Clinical Research Center, University of Connecticut Health Center, Farmington, USA
Endocr Res 27:473-80. 2001..These results indicate that NETA does not have a potent short-term anabolic effect on bone but does have effects that are likely to be mediated through the estrogen and androgen receptors... - Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levelsA M Kenny
Center on Aging, University of Connecticut Health Center, Farmington, 06030 5215, USA
J Gerontol A Biol Sci Med Sci 56:M266-72. 2001..The impact of this on musculoskeletal health and the potential for improvement in function in this group with testosterone supplementation require investigation... - Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ cultureL G Raisz
University of Connecticut Health Center, Farmington 06032
Endocrinology 122:1083-6. 1988..HTS was more potent as an inhibitor when the CO2 concentration in the gas phase was reduced from 5% to 2% and the pH was increased from 7.2 to 7.5, consistent with an effect on CA-mediated hydrogen ion generation... - Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot studyP Taxel
Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 5456, USA
Osteoporos Int 19:193-9. 2008..E(2) treatment inhibited the ability of hematopoietic cells to form OCLs in response to RANKL, and decreased RANKL production. These changes are likely involved in the ability of E(2) to influence the development of osteoporosis... - The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older menP Taxel
Division of Endocrinology and Metabolism, Center on Aging, University of Connecticut Health Center, Farmington, Connecticut 06030 1317, USA
J Clin Endocrinol Metab 86:2869-74. 2001.... - Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cellsY K Min
Department of Medicine, University of Connecticut Health Center, Farmington, USA
J Bone Miner Res 13:1066-75. 1998..In summary, we show that IL-1 is a potent inducer of PGHS-2 expression and PGE2 production in human osteosarcoma cells as well as in osteoblastic cells derived from normal human bone... - Effects of selective prostaglandins E2 receptor agonists on cultured calvarial murine osteoblastic cellsCynthia B Alander
University of Connecticut Health Center, 263 Farmington Avenue, MC5456, Farmington, CT 06030, United States
Prostaglandins Other Lipid Mediat 81:178-83. 2006..We conclude that the anabolic effect of PGE(2) in calvarial osteoblastic cell cultures is largely mediated by activation of the EP4 receptor, while activation of the EP2 receptor is less effective... - Femoral bone mineral density in patients with heart failureA M Kenny
Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030 5215, USA
Osteoporos Int 17:1420-7. 2006..Heart failure and osteoporosis are common conditions in older, frail individuals. It is important to investigate interactions of the common problems in the aging population to devise relevant interventions... - Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged miceQi Gao
New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, CT 06030, USA
Bone 45:98-103. 2009..We conclude that expression of the EP4 receptor in osteoblasts is critical for anabolic responses to PGE(2) in cell culture but may not be essential for maintenance of bone remodeling in vivo... - Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: impaired responsiveness in heterozygotesPeili Zhan
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Prostaglandins Other Lipid Mediat 78:19-26. 2005..These results suggest that the EP4 receptor may be rate limiting not only for PGE2 stimulated resorption but also for resorption stimulated by other agonists, like PTH that induce PGE2 production... - Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathwayShilpa Choudhary
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Bone Miner Res 18:1813-24. 2003..Inhibition of PGE2 production inhibited the [Ca2+]e stimulation of osteoblastic differentiation but not the increase in cell number. Hence, some effects of [Ca2+]e on bone may be mediated by COX-2... - Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian menK Kuruvilla
General Clinical Research Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
Osteoporos Int 22:217-21. 2011..A majority of our subjects were either osteopenic or osteoporotic, and their fracture risk increased when FRAX® was used in conjunction with femur neck T-scores... - Lack of association between androgen receptor polymorphisms and bone mineral density or physical function in older menA M Kenny
Center on Aging, MC 5215, University of Connecticut Health Center, Farmingham, CT 06030 5215, USA
Endocr Res 31:285-93. 2005..Men with osteoporosis or fracture had lower BioT, physical performance, and physical activity than controls. This study found no association between CA G repeats and FN BMD in older men with normal or low BMD or FX... - Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cellsT Sobue
University of Connecticut School of Medicine, Farmington, USA
J Bone Miner Res 17:502-12. 2002..These data show that TGF-beta regulates FGF-2 gene expression in human osteosarcoma cells. Furthermore, TGF-beta modulates the cellular localization of FGF-2 and its receptors... - Basic fibroblast growth factor induces osteoclast formation in murine bone marrow culturesM M Hurley
The University of Connecticut Health Center, Farmington 06030 1850, USA
Bone 22:309-16. 1998..We conclude that bFGF stimulates OCL formation in C57BL/6 bone marrow cultures by mechanisms that require prostaglandin synthesis. This pathway is likely to be one mechanism by which bFGF stimulates resorption... - The effect of micronized estradiol on bone turnover and calciotropic hormones in older men receiving hormonal suppression therapy for prostate cancerPamela Taxel
Division of Endocrinology and Metabolism, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1317, USA
J Clin Endocrinol Metab 87:4907-13. 2002..We conclude that E(2) inhibits bone resorption in hypogonadal men through a direct skeletal effect that is independent of PTH. Low dose estrogen may be an option for the prevention and/or treatment of bone loss in this population... - Mechanisms of bone remodeling: implications for clinical practiceAnne M Kenny
Center on Aging, Department of Medicine, Lowell P. Weicker, Jr, General Clinical Research Center, University of Connecticut Health Center, Farmington, USA
J Reprod Med 47:63-70. 2002..These new approaches have allowed us to define more precisely the specific roles of androgens, estrogens and other regulatory hormones in human skeletal physiology and pathophysiology... - Prostaglandins in bone: bad cop, good cop?Katherine A Blackwell
New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, USA
Trends Endocrinol Metab 21:294-301. 2010..Further analysis of COX-2 and PG receptors and their downstream G-protein signaling in bone could provide important clues to the regulation of skeletal cell growth in both health and disease... - Changes in urinary excretion of helical peptide during therapy for osteoporosis in older adultsPamela Taxel
Division of Endocrinology and Metabolism, University of Connecticut Health Center, Farmington, CT, USA
Clin Chem 50:747-50. 2004 - Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal womenAnne M Kenny
Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030 5215, USA
Osteoporos Int 15:290-4. 2004..05). Calcium citrate decreased markers of bone resorption significantly more than calcium carbonate in postmenopausal women, although no differences in their effects in calcium excretion or PTH were detected... - Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal womenFaryal S Mirza
University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Clin Endocrinol Metab 95:1991-7. 2010..Sclerostin is a negative regulator of bone formation... - Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal womenCheryl Oncken
Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington 06030, USA
Nicotine Tob Res 4:451-8. 2002..48; p = 0.004 and r = 0.36; p = 0.04, respectively). Six weeks of smoking abstinence produces reductions in SHBG and NTx. This may partly explain how smoking contributes to osteoporosis in postmenopausal women... - Prevention and treatment of osteoporosisKaren M Prestwood
Division of Geriatrics, University of Connecticut Center on Aging, University of Connecticut Health Center, Farmington, Connecticut, USA
Clin Cornerstone 4:31-41. 2002.... - Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtypeK Nemoto
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
Prostaglandins 54:713-25. 1997..Higher EP2 expression was found in fetal long bones and calvariae than in adult by RT-PCR and in situ hybridization, suggesting a role for this receptor in rapidly growing skeletal tissue... - Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariaeH Kawaguchi
Department of Medicine, University of Connecticut Health Center, Farmington 06030
Endocrinology 135:1157-64. 1994.... - Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout miceManshan Xu
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Bone 47:341-52. 2010..It is possible that manipulation of endogenous PGs could have important clinical implications for anabolic therapy with PTH... - Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptorKatsuhiro Ono
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Bone Miner Res 20:23-9. 2005..A selective EP2 receptor agonist mimicked these effects. Deletion of the EP2 receptor or depletion of T-cells abrogated the increase in OC number... - Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivoDaichi Chikazu
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
J Bone Miner Res 17:1430-40. 2002.... - The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell linesKatsuhiro Ono
Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Bone 33:798-804. 2003.... - The osteoporosis revolution marches onLawrence G Raisz
UConn Center for Osteoporosis, University of Connecticut Health Center, Farmington, CT 06030-5456, USA
J Orthop Sci 12:405-12. 2007 - Pathogenesis of osteoporosisLawrence G Raisz
Division of Endocrinology and Metabolism, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, MC 1850, Farmington, CT 06030-1850, USA. raisznso.uchc.edu
Endocrinol Metab Clin North Am 32:15-24. 2003..Identification of specific pathogenetic mechanisms should lead to new approaches to the diagnosis and management of this disorder... - Effects of prostaglandin E2 on bone in mice in vivoQi Gao
New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Prostaglandins Other Lipid Mediat 89:20-5. 2009..Studies of PGE(2) in combination with an inhibitor of resorption could lead to development of a true anabolic model and permit assessment of the roles of specific PGE(2) receptors and signal transduction pathways... - Extracellular calcium induces COX-2 in osteoblasts via a PKA pathwayShilpa Choudhary
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Biochem Biophys Res Commun 322:395-402. 2004..Ca(+2)](e) also stimulated a 2- to 3-fold increase in cAMP production. Hence, the [Ca(+2)](e) induction of COX-2 mRNA expression and promoter activity was independent of the PKC pathway and dependent on the PKA signaling pathway... - Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathwaySunil Wadhwa
Department of Orthodontics, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
J Bone Miner Res 17:266-74. 2002..We conclude that FSS transcriptionally induces COX-2 gene expression in osteoblasts, that the maximum induction requires new protein synthesis, and that induction occurs largely via an ERK signaling pathway... - Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cellsYoko Sakuma
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Bone 34:827-34. 2004..We conclude that the PG induction of COX-2 in this system generally paralleled effects on cAMP production and was mediated predominantly via the PKA pathway... - Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow culturesKatherine A Blackwell
New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
Prostaglandins Other Lipid Mediat 90:76-80. 2009..Our results suggest that BMP-2 can increase osteoclast formation in response to PGE(2) by increasing the RANKL:OPG ratio in osteoblasts, which may have therapeutic implications for the use of BMP-2... - Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatmentSundeep Khosla
J Oral Maxillofac Surg 66:1320-1; author reply 1321-2. 2008 - Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002Daichi Chikazu
J Bone Miner Res 20:1888-98. 2005 - Osteoporosis panel summaryAlex Capron
University of Southern California, School of Law, Los Angeles, California, USA
J Bone Miner Res 18:1160-2. 2003 - Homocysteine and osteoporotic fractures--culprit or bystander?Lawrence G Raisz
N Engl J Med 350:2089-90. 2004 - Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinaseMaria Giovanna Sabbieti
Department of Comparative Morphology and Biochemistry, Via Gentile III da Varano, 62032 Camerino MC, Italy
Cell Tissue Res 319:267-78. 2005..We conclude that PGF(2alpha) stimulates nuclear translocation of FGF-2 and FGFR2 by a PKC-dependent pathway; we also suggest an involvement of MAPK/ERK2 in this process...
Research Grants
- FACTORS INFLUENCING BONE METABOLISMLawrence Raisz; Fiscal Year: 1993..We will attempt to find markers for bone resorption using in vitro models, which can then be used to assess resorption in vivo...
- FACTORS INFLUENCING BONE METABOLISMLawrence Raisz; Fiscal Year: 2002....
- FACTORS INFLUENCING BONE METABOLISMLawrence Raisz; Fiscal Year: 2007..In addition, signal transduction pathways for enhanced osteoclastogenesis will be examined. ..