P Rai

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells
    Dominick G A Burton
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e68003. 2013
  2. pmc Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS
    Priyamvada Rai
    Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Small Gtpases 3:120-5. 2012
  3. pmc Creation and validation of a ligation-independent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells
    Asmita Patel
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    BMC Biotechnol 12:3. 2012
  4. pmc NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells
    Ricardo Parrondo
    Geriatric Research, Education, and Clinical Center and Research Service, Bruce W, Carter Veterans Affairs Medical Center, Miami, FL 33125, USA
    Mol Cancer 9:182. 2010
  5. doi request reprint Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house
    Priyamvada Rai
    Division of Gerontology and Geriatric Medicine, Department of Medicine, Rosenstiel Medical Sciences Building, Rm 7094 Locator Code D 503, 1600 NW 10th Ave, Miller School of Medicine, University of Miami, Miami, FL 33136, United States
    Mutat Res 703:71-81. 2010
  6. doi request reprint Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
    P Rai
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Oncogene 30:1489-96. 2011

Collaborators

Detail Information

Publications6

  1. pmc Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells
    Dominick G A Burton
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e68003. 2013
    ..Thus our study demonstrates that ADIS promotes outgrowth of androgen-refractory PC cells and is consequently a suboptimal tumor-suppressor response to AD. ..
  2. pmc Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS
    Priyamvada Rai
    Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Small Gtpases 3:120-5. 2012
    ..Accordingly, targeting MTH1 in RAS-transformed tumor cells will not only induce proliferative defects but also potentially enhance therapeutic cytotoxicity by shifting cellular response away from pro-survival mechanisms...
  3. pmc Creation and validation of a ligation-independent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells
    Asmita Patel
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    BMC Biotechnol 12:3. 2012
    ..However, the relatively small number of feasible restriction enzyme sequences in their cloning sites can hinder successful generation of overexpression constructs if these sequences are also present in the target cDNA insert...
  4. pmc NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells
    Ricardo Parrondo
    Geriatric Research, Education, and Clinical Center and Research Service, Bruce W, Carter Veterans Affairs Medical Center, Miami, FL 33125, USA
    Mol Cancer 9:182. 2010
    ..In prostate cancer, it is not clear in the different cell types (androgen-dependent and castration-resistant) if activation or inhibition of NF-kappaB is required for stimulation of apoptosis by chemotherapy...
  5. doi request reprint Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house
    Priyamvada Rai
    Division of Gerontology and Geriatric Medicine, Department of Medicine, Rosenstiel Medical Sciences Building, Rm 7094 Locator Code D 503, 1600 NW 10th Ave, Miller School of Medicine, University of Miami, Miami, FL 33136, United States
    Mutat Res 703:71-81. 2010
    ..This review will explore the role of oxidation in the nucleotide pool as a major effector of oxidative stress-induced genotoxic damage and DDR in the context of cellular senescence and tumorigenic transformation...
  6. doi request reprint Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
    P Rai
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Oncogene 30:1489-96. 2011
    ..These results indicate that the guanine nucleotide pool is a critical target for intracellular ROS produced by oncogenic RAS and that RAS-transformed cells require robust MTH1 expression to proliferate...