K Rahmouni

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi The concept of selective leptin resistance: evidence from agouti yellow obese mice
    Marcelo L G Correia
    Hypertension Genetics Specialized Center of Research and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1101, USA
    Diabetes 51:439-42. 2002
  2. pmc Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
    Seongjin Seo
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa, IA 52242, USA
    Hum Mol Genet 18:1323-31. 2009
  3. pmc Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice
    Zhongming Zhang
    Dpartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Diabetes 60:1063-71. 2011
  4. pmc Amylin acts in the central nervous system to increase sympathetic nerve activity
    Caroline Fernandes-Santos
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Endocrinology 154:2481-8. 2013
  5. ncbi Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics and the Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 41:763-7. 2003
  6. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
  7. ncbi Brain effects of leptin: what intracellular mechanism?
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Cardiovascular Center, 524 MRC, Iowa City, IA 52242, USA
    Curr Diab Rep 3:427-9. 2003
  8. ncbi Obesity-associated hypertension: new insights into mechanisms
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 45:9-14. 2005
  9. pmc Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
    Kamal Rahmouni
    Center on Functional Genomics of Hypertension, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Diabetes 58:536-42. 2009
  10. ncbi Role of selective leptin resistance in diet-induced obesity hypertension
    Kamal Rahmouni
    Cardiovascular Research Center, 524 MRC, University of Iowa, Iowa City, IA 52242, USA
    Diabetes 54:2012-8. 2005

Collaborators

Detail Information

Publications46

  1. ncbi The concept of selective leptin resistance: evidence from agouti yellow obese mice
    Marcelo L G Correia
    Hypertension Genetics Specialized Center of Research and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1101, USA
    Diabetes 51:439-42. 2002
    ..If leptin resistance is selective in obese humans, then leptin could contribute to sympathetic overactivity and its adverse consequences in human obesity...
  2. pmc Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
    Seongjin Seo
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa, IA 52242, USA
    Hum Mol Genet 18:1323-31. 2009
    ..Our data indicate that BBS proteins mediate LepR trafficking and that impaired LepR signaling underlies energy imbalance in BBS. These findings represent a novel mechanism for leptin resistance and obesity...
  3. pmc Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice
    Zhongming Zhang
    Dpartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Diabetes 60:1063-71. 2011
    ....
  4. pmc Amylin acts in the central nervous system to increase sympathetic nerve activity
    Caroline Fernandes-Santos
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Endocrinology 154:2481-8. 2013
    ..Our data demonstrate that CNS action of amylin regulates sympathetic nerve outflow to peripheral tissues involved in energy balance and cardiovascular function. ..
  5. ncbi Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics and the Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 41:763-7. 2003
    ..Our data demonstrate that PI3K appears to play an important role in the transduction of leptin-induced changes in renal sympathetic outflow...
  6. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
    ..In addition, the renal sympathoexcitatory responses to leptin and insulin are dependent on the MC-4R, demonstrating an important role for the MC-4R in the regulation of renal sympathetic nerve outflow by leptin and insulin...
  7. ncbi Brain effects of leptin: what intracellular mechanism?
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Cardiovascular Center, 524 MRC, Iowa City, IA 52242, USA
    Curr Diab Rep 3:427-9. 2003
  8. ncbi Obesity-associated hypertension: new insights into mechanisms
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 45:9-14. 2005
    ..These recent discoveries should lead to novel strategies for treatment of obesity and hypertension...
  9. pmc Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
    Kamal Rahmouni
    Center on Functional Genomics of Hypertension, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Diabetes 58:536-42. 2009
    ..Here, we tested the hypothesis that extracellular signal-regulated kinase (ERK) is mediating leptin action in the hypothalamus...
  10. ncbi Role of selective leptin resistance in diet-induced obesity hypertension
    Kamal Rahmouni
    Cardiovascular Research Center, 524 MRC, University of Iowa, Iowa City, IA 52242, USA
    Diabetes 54:2012-8. 2005
    ..However, there is preservation of the renal sympathetic and arterial pressure responses to leptin, which represent a potential mechanism for the adverse cardiovascular consequences of obesity...
  11. pmc Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
    Kamal Rahmouni
    Department of Internal Medicine, Center on Functional Genomics of Hypertension, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Invest 118:1458-67. 2008
    ..Furthermore, we found that BBS mice had a decreased hypothalamic expression of proopiomelanocortin, which suggests that BBS genes play an important role in maintaining leptin sensitivity in proopiomelanocortin neurons...
  12. ncbi Leptin and the central neural mechanisms of obesity hypertension
    Kamal Rahmouni
    Department of Internal Medicine, University of Iowa and VAMC, Iowa City, IA 52242, USA
    Drugs Today (Barc) 38:807-17. 2002
    ..The understanding of neuronal signaling pathways involved in leptin signaling and energy balance has opened new research possibilities for the treatment of obesity...
  13. ncbi Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin
    Kamal Rahmouni
    Center on Functional Genomics of Hypertension, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 49:647-52. 2007
    ..These results also suggest that the cardiovascular effects of leptin might be evoked by the action of this hormone in the arcuate nucleus of the hypothalamus...
  14. ncbi Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats
    K Rahmouni
    Institut de Pharmacologie, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    Hypertension 38:902-6. 2001
    ..This dose of the antagonist was without effect after subcutaneous administration. Thus, brain MRs appear to participate in the maintenance of hypertension in conscious adult SHR sensitized by sodium loading...
  15. ncbi Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension
    Kamal Rahmouni
    Institut de Pharmacologie, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    Eur J Pharmacol 436:207-16. 2002
    ..In conclusion, these results demonstrate that in rats with hypertension induced by DOCA-salt, brain mineralocorticoid receptor blockade affects renal function and blood pressure regulation...
  16. ncbi Cardiovascular and sympathetic effects of leptin
    Kamal Rahmouni
    SCOR Hypertension Genetics and Department of Internal Medicine, University of Iowa, 524 MRC, Iowa City, IA 52242, USA
    Curr Hypertens Rep 4:119-25. 2002
    ..A detailed understanding of the multitude and complexity of integrated neuronal circuits and neuropeptide-containing pathways in leptin action will help in understanding the pathogenesis of obesity and related disorders...
  17. ncbi Influence of sodium intake on the cardiovascular and renal effects of brain mineralocorticoid receptor blockade in normotensive rats
    Kamal Rahmouni
    Institut de Pharmacologie, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    J Hypertens 20:1829-34. 2002
    ..We hypothesize that modulation of sodium intake affects the cardiovascular and renal effects of brain MR blockade...
  18. ncbi Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats
    K Rahmouni
    Institut de Pharmacologie, Laboratoire de Pharmacologie Physiologie Rénovasculaire, Faculte de Medecine, Universite Louis Pasteur, 11 rue Humann, 67085, Strasbourg, France
    Eur J Pharmacol 385:199-202. 1999
    ..Heart rate, food intake and water consumption were not affected at either dose. In conclusion, in conscious female rats, brain mineralocorticoid receptors participate in blood pressure and renal function control...
  19. pmc Mechanisms mediating renal sympathetic activation to leptin in obesity
    Donald A Morgan
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1730-6. 2008
    ..Our results demonstrate the importance of PI3K and melanocortin receptors in the transduction of leptin-induced renal sympathetic activation in obesity...
  20. ncbi [Brain mineralocorticoid receptor and blood pressure control in the conscious normotensive rat]
    K Rahmouni
    Institut de Pharmacologie, , , Strasbourg
    Arch Mal Coeur Vaiss 91:1009-12. 1998
    ..It is possible that increased sympathetic outflow and renal mechanisms are involved. Interference with brain MR not only affects blood pressure but it also has effect on renal function...
  21. pmc Differential effects of insulin on sympathetic nerve activity in agouti obese mice
    Donald A Morgan
    Center on Functional Genomics of Hypertension, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    J Hypertens 28:1913-9. 2010
    ..Here, we examined the effect of insulin on regional sympathetic nerve activity (SNA) in obesity...
  22. ncbi Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins
    K Rahmouni
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Bioessays 23:1095-9. 2001
    ..These data add complexity to the mechanisms by which leptin achieves its effects in the central nervous system, but they also offer potential mechanisms to explain the phenomenon of leptin resistance observed in obesity...
  23. ncbi Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome
    Melissa A Fath
    Department of Pediatrics, Division of Medcal Genetics, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 14:1109-18. 2005
    ..These observations suggest that the complete absence of MKKS leads to BBS while the MKS phenotype is likely to be due to specific mutations...
  24. ncbi Selective resistance to central neural administration of leptin in agouti obese mice
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, and Department of Internal Medicine, University of Iowa, and the Veterans Administration Medical Center, Iowa City, Iowa 52242 1101, USA
    Hypertension 39:486-90. 2002
    ..It seems to result instead from alterations in the central neural pathways mediating effects of leptin...
  25. ncbi Leptin and the cardiovascular system
    Kamal Rahmouni
    Department of Internal Medicine, and General Clinical Research Center, University of Iowa, Iowa City, Iowa 52242, USA
    Recent Prog Horm Res 59:225-44. 2004
    ..Exploration of the sites and mechanisms of leptin resistance should provide novel therapeutic strategies for obesity, insulin resistance, and hypertension...
  26. ncbi Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Department of Internal Medical, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Endocrinol Metab 286:E891-5. 2004
    ..Our findings also suggest that 1.2 kb of regulatory sequences present in the hAGT transgene are sufficient to transcriptionally respond to a high-fat diet in an adipose-specific and depot-specific manner...
  27. pmc A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity
    Roger E Davis
    Department of Pediatrics, Anatomy and Cell Biology, Radiology, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 104:19422-7. 2007
    ....
  28. ncbi Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome
    Marcelo L G Correia
    Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Diabetes Obes Metab 8:603-10. 2006
    ..To review the potential role of leptin, hyperleptinaemia and leptin resistance in the cardiovascular and endocrine complications of metabolic syndrome...
  29. pmc Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney
    Allyn L Mark
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1101, USA
    Hypertension 53:375-80. 2009
    ..The study strengthens the concept of a distributed brain network of leptin action and demonstrates that these distributed brain sites can mediate contrasting sympathetic responses to leptin...
  30. pmc SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 12:78-87. 2010
    ..In summary, our results provide direct genetic evidence that SIRT1 in POMC neurons is required for normal autonomic adaptations against diet-induced obesity...
  31. ncbi Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
    Allyn L Mark
    Hypertension Genetics Specialized Center of Research, The Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Medical Center, Iowa City, Iowa, USA
    J Hypertens 20:1245-50. 2002
    ..If selective leptin resistance occurs in obese humans, then leptin could contribute to the sympathetic overactivity and hypertension despite resistance to its metabolic actions...
  32. pmc The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation
    Yongjun Lu
    Department of Internal Medicine and Cardiovascular Research Center, University of Iowa, Iowa City, IA 52242, USA
    Neuron 64:885-97. 2009
    ..The genetic disruption of ASIC2 recapitulates the pathological dysautonomia seen in heart failure and hypertension and defines a molecular defect that may be relevant to its development...
  33. pmc Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Research Center, and Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    J Clin Invest 114:652-8. 2004
    ..These data demonstrate that PI3K and MAPK are specific and regionally selective mediators of the action of insulin on the sympathetic nervous system...
  34. ncbi Loss of leptin actions in obesity: two concepts with cardiovascular implications
    Allyn L Mark
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Clin Exp Hypertens 26:629-36. 2004
    ....
  35. ncbi Endothelial effects of leptin: implications in health and diseases
    Kamal Rahmouni
    Department of Internal Medicine and General Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Curr Diab Rep 5:260-6. 2005
    ..Further characterization of the endothelial effects of leptin will, it is hoped, help in the understanding of the different pathophysiologic diseases associated with obesity...
  36. ncbi A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
    A L Mark
    Specialized Center of Research in Hypertension Genetics, The Department of Internal Medicine, Lucille A Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA 52242 1101, USA
    Acta Physiol Scand 177:345-9. 2003
    ..This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop...
  37. ncbi Lack of dilator effect of leptin in the hindlimb vascular bed of conscious rats
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, United States
    Eur J Pharmacol 518:175-81. 2005
    ..These findings are in accordance with our previous results and argue against a meaningful direct dilator action of leptin on resistance vessels in vivo...
  38. ncbi The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells
    Matthew E Dickson
    Interdisciplinary Genetics Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 49:631-9. 2007
    ..Therefore, our data support a hypothesis that polymorphisms in the angiotensinogen promoter may act cell specifically to differentially regulate the level of angiotensinogen transcription in angiotensin-producing tissues...
  39. pmc Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor
    Shannon M Harlan
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 57:627-32. 2011
    ..These findings provide important insight into the molecular mechanisms underlying leptin's effects on the sympathetic cardiovascular function and arterial pressure...
  40. pmc Inactivation of Bardet-Biedl syndrome genes causes kidney defects
    Deng Fu Guo
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Renal Physiol 300:F574-80. 2011
    ..These findings extend our understanding of the function of BBS proteins and emphasize the importance of these proteins in renal physiology...
  41. pmc Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes
    Andreas M Beyer
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Heart Circ Physiol 299:H1902-7. 2010
    ..In conclusion, these data implicate Bbs genes in the regulation of vascular function and demonstrate that disrupting Bbs2 and Bbs6 genes affect differentially the vascular function...
  42. pmc Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation
    Shannon M Harlan
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Circ Res 108:808-12. 2011
    ..The hypothalamic arcuate nucleus (ARC) is considered a major site for leptin signaling that regulates several physiological processes...
  43. ncbi Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation
    Leona Plum
    Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne CMMC, D 50674 Cologne, Germany
    Cell Metab 6:431-45. 2007
    ..These data provide direct genetic evidence that leptin-stimulated Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT...
  44. ncbi Does genetic variation in the leptin receptor influence the sympathetic tone in obesity?
    Kamal Rahmouni
    Hypertens Res 31:1057-9. 2008
  45. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  46. pmc Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression
    Kamal Rahmouni
    Circ Res 103:565-7. 2008