I Rahman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Antioxidant therapies in COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Int J Chron Obstruct Pulmon Dis 1:15-29. 2006
  2. ncbi Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease
    S Biswas
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Curr Med Chem 20:1496-530. 2013
  3. ncbi Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD
    Hongwei Yao
    Dept of Environmental Medicine, Lung Biology and Disease Program, Univ of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 303:L557-66. 2012
  4. ncbi Pharmacological antioxidant strategies as therapeutic interventions for COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, NY 14642, USA
    Biochim Biophys Acta 1822:714-28. 2012
  5. ncbi Antioxidant pharmacological therapies for COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Curr Opin Pharmacol 12:256-65. 2012
  6. ncbi SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Prev Med 54:S20-8. 2012
  7. ncbi Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Expert Rev Clin Pharmacol 5:293-309. 2012
  8. ncbi Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione
    Fabrizio Luppi
    Department of Pulmonology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands
    Respir Res 6:140. 2005
  9. ncbi Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells
    Aruna Kode
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Respir Res 7:132. 2006
  10. ncbi Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD
    Nobuhisa Ishikawa
    Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Respir Res 11:123. 2010

Research Grants

  1. Mechanisms of cigarette smoke-induced chromatin remodeling in lung inflammation
    Irfan Rahman; Fiscal Year: 2007
  2. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2009
  3. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2010
  4. Mechanisms of cigarette smoke-induced chromatin remodeling in lung inflammation
    Irfan Rahman; Fiscal Year: 2010
  5. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2010

Collaborators

Detail Information

Publications94

  1. ncbi Antioxidant therapies in COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Int J Chron Obstruct Pulmon Dis 1:15-29. 2006
    ..Various approaches to enhance lung antioxidant capacity and clinical trials of antioxidant compounds in COPD are discussed...
  2. ncbi Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease
    S Biswas
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Curr Med Chem 20:1496-530. 2013
    ..In this review, various pharmacological and dietary approaches to enhance lung antioxidant levels and beneficial effects of antioxidant therapeutics in treating or intervening the progression of COPD have been discussed...
  3. ncbi Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD
    Hongwei Yao
    Dept of Environmental Medicine, Lung Biology and Disease Program, Univ of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 303:L557-66. 2012
    ....
  4. ncbi Pharmacological antioxidant strategies as therapeutic interventions for COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, NY 14642, USA
    Biochim Biophys Acta 1822:714-28. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  5. ncbi Antioxidant pharmacological therapies for COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Curr Opin Pharmacol 12:256-65. 2012
    ..In this review the approaches to enhance lung antioxidants in COPD and the potential beneficial effects of antioxidant therapy on the course of the disease are discussed...
  6. ncbi SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Prev Med 54:S20-8. 2012
    ..The role of dietary polyphenols in regulation of SIRT1 in inflammaging is also discussed...
  7. ncbi Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Expert Rev Clin Pharmacol 5:293-309. 2012
    ..In this review, various novel approaches and problems associated with these approaches in COPD are reviewed...
  8. ncbi Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione
    Fabrizio Luppi
    Department of Pulmonology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands
    Respir Res 6:140. 2005
    ..We also studied whether modulation of intracellular glutathione/thiol levels could attenuate CSC-induced cell proliferation...
  9. ncbi Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells
    Aruna Kode
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Respir Res 7:132. 2006
    ....
  10. ncbi Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD
    Nobuhisa Ishikawa
    Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Respir Res 11:123. 2010
    ..They share the common denominators of a progressive nature and poor prognosis. The goal was to use non-biased proteomics to discover new markers for these diseases...
  11. ncbi Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
    John A Marwick
    National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:11. 2010
    ..However, the VEGFR2-mediated survival signaling in response to oxidants/cigarette smoke (CS) is not known. We hypothesized that CS exposure leads to disruption of VEGFR2-mediated endothelial survival signaling in rat lungs...
  12. ncbi Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages
    Hadi Sarir
    Division of Pharmacology and Pathophysiology, Departement of Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, The Netherlands
    J Inflamm (Lond) 6:12. 2009
    ..Cigarette smoke contains high concentration of oxidants which can stimulate immune cells to produce reactive oxygen species, cytokines and chemokines...
  13. ncbi Current concepts of redox signaling in the lungs
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 8:681-9. 2006
    ..Furthermore, this also provides information as to how antioxidants are involved in redox signaling to control inflammatory and oxidative stress in the lung...
  14. ncbi Oxidative stress and redox regulation of lung inflammation in COPD
    I Rahman
    Dept of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, MRBX 3 11106, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur Respir J 28:219-42. 2006
    ..Various approaches to enhance lung antioxidant capacity and clinical trials of antioxidant compounds in chronic obstructive pulmonary disease are also discussed...
  15. ncbi Antioxidant therapeutic advances in COPD
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Ther Adv Respir Dis 2:351-74. 2008
    ..This article will review the various approaches adopted to enhance lung antioxidant levels, antioxidant therapeutic advances and recent past clinical trials of antioxidant compounds in COPD...
  16. ncbi Glutathione, stress responses, and redox signaling in lung inflammation
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Antioxid Redox Signal 7:42-59. 2005
    ..This forum article features the current knowledge on the role of GSH in redox signaling, particularly the regulation of transcription factors and downstream signaling in lung inflammation...
  17. ncbi Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, USA
    Redox Rep 9:125-43. 2004
    ..It is expected that EBC can be exploited to detect specific levels of biomarkers and monitor disease severity in response to appropriate prescribed therapy/treatment...
  18. ncbi The role of oxidative stress in the pathogenesis of COPD: implications for therapy
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    Treat Respir Med 4:175-200. 2005
    ..Various approaches to enhance the lung antioxidant screen and the clinical effectiveness of antioxidant compounds in the treatment of COPD are discussed...
  19. ncbi Antioxidant therapeutic targets in COPD
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Curr Drug Targets 7:707-20. 2006
    ..Various approaches to enhance lung antioxidant capacity and clinical trials of antioxidant compounds in COPD are discussed...
  20. ncbi Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, MRBX 3 11106, 601 Elmwood Avenue, Box 850, Rochester, NY 14642, USA
    Cell Biochem Biophys 43:167-88. 2005
    ..Oxidative stress may have a role in the poor efficacy of corticosteroids in COPD. This review discusses cellular and molecular changes that occur in response to smoking and oxidative stress in the pathogenesis of COPD...
  21. ncbi Regulation of glutathione in inflammation and chronic lung diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mutat Res 579:58-80. 2005
    ..This article describes the role of AP-1 and ARE in the regulation of cellular GSH biosynthesis and assesses the potential protective and therapeutic role of glutathione in oxidant-induced lung injury and inflammation...
  22. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
    ..Aberrations in oxidant: antioxidant balance can lead to a variety of airway diseases, such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis which is the topic of discussion in this review...
  23. ncbi Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, USA
    Nat Protoc 1:3159-65. 2006
    ....
  24. ncbi Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, NY, USA
    Biochem Pharmacol 68:1255-67. 2004
    ..Thus, oxidative stress regulates both signal transduction and chromatin remodeling which in turn impacts on pro-inflammatory responses in the lungs...
  25. ncbi Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD
    Gnanapragasam Arunachalam
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    J Inflamm (Lond) 7:34. 2010
    ..We studied the molecular mechanisms involved in development of emphysema in atherosclerosis-prone apolipoprotein E-deficient (ApoE-/-) mice in response to CS exposure...
  26. ncbi Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice
    Hongwei Yao
    Lung Biology and Disease Program, Deptartment of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1174-86. 2008
    ..Identification of sensitive and resistant mouse strains could be useful for studying the molecular mechanisms of effects of CS on inflammation and pharmacological interventional studies in CS-exposure mouse models...
  27. ncbi Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
    Aruna Kode
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 294:L478-88. 2008
    ..These data may have implications in dietary modulation of antioxidants in treatment of chronic obstructive pulmonary disease...
  28. ncbi Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
    Se-Ran Yang
    Dept. of Environmental Medicine, Lung Biology and Disease Program, Univ. of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L46-57. 2006
    ..Moreover, cigarette smoke-mediated proinflammatory events are regulated by the redox status of the cells...
  29. ncbi Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications
    Hongwei Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:5405-16. 2010
    ..These data provide new insights into the molecular mechanisms underlying the pathogenesis of chronic inflammatory lung diseases...
  30. ncbi Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 12:1355-69. 2010
    ....
  31. ncbi Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema
    Carolyn J Baglole
    Univ. of Rochester School of Medicine and Dentistry, Dept. of Environmental Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L19-29. 2006
    ..Variations in the sensitivity of fibroblasts to cigarette smoke may account for the fact that only some smokers develop emphysema...
  32. ncbi IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 38:689-98. 2008
    ..Taken together, these data suggest that IKK alpha plays a key role in CS-induced pro-inflammatory gene transcription through phospho-acetylation of both RelA/p65 and histone H3...
  33. ncbi Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD
    Saravanan Rajendrasozhan
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Antioxid Redox Signal 10:799-811. 2008
    ....
  34. ncbi Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice
    Hongwei Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Pathol 172:1222-37. 2008
    ..Thus, these data suggest that genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage...
  35. ncbi RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 40:147-58. 2009
    ..Rapid degradation of RelB signals for RelA/p65 activation and loss of its protective ability to suppress the proinflammatory cytokine release in lymphoid B cells...
  36. ncbi Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation
    Sangwoon Chung
    Dept of Environmental Medicine, Univ of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 299:L192-203. 2010
    ....
  37. ncbi Current perspectives on role of chromatin modifications and deacetylases in lung inflammation in COPD
    Saravanan Rajendrasozhan
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, USA
    COPD 6:291-7. 2009
    ..Knowledge on molecular mechanisms of epigenetic changes in abnormal lung inflammation will help in understanding the pathophysiology of COPD which may lead to the development of novel epigenetic therapies in the near future...
  38. ncbi Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging
    Se Ran Yang
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, MRBX 3 11106, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L567-76. 2007
    ..Thus our data show that SIRT1 regulates cigarette smoke-mediated proinflammatory mediator release via NF-kappaB, implicating a role of SIRT1 in sustained inflammation and aging of the lungs...
  39. ncbi Lysine deacetylation in ischaemic preconditioning: the role of SIRT1
    Sergiy M Nadtochiy
    Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 604, Rochester, NY 14642, USA
    Cardiovasc Res 89:643-9. 2011
    ..Lysine (Lys) acetylation is an important regulator of protein function, but this type of modification has not been studied in the context of IPC. We investigated Lys acetylation in IPC and its upstream regulation by SIRT1...
  40. ncbi Regulation of SIRT1 in cellular functions: role of polyphenols
    Sangwoon Chung
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Arch Biochem Biophys 501:79-90. 2010
    ..In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli...
  41. ncbi SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
    Saravanan Rajendrasozhan
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 177:861-70. 2008
    ..Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein/histone deacetylase that regulates proinflammatory mediators by deacetylating histone and nonhistone proteins...
  42. ncbi Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin
    Saibal Biswas
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Nutr Food Res 52:987-94. 2008
    ..Thus, curcumin may be a potential antioxidant and anti-inflammatory therapeutic agent against chronic inflammatory lung diseases...
  43. ncbi Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
    Saravanan Rajendrasozhan
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, USA
    Am J Physiol Lung Cell Mol Physiol 298:L197-209. 2010
    ....
  44. ncbi Current concepts on the role of inflammation in COPD and lung cancer
    Hongwei Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA
    Curr Opin Pharmacol 9:375-83. 2009
    ..Understanding the cellular and molecular mechanisms underlying these processes will provide novel avenues for halting the chronic inflammation in COPD and devising therapeutic strategies against lung cancer...
  45. ncbi Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells
    Elizabeth P Ryan
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 850, Rochester, NY 14642, USA
    Cancer Immunol Immunother 57:347-58. 2008
    ..These observations also support the concept that certain Cox-2 selective inhibitors may have therapeutic value in combination with other drugs to kill malignant B lineage cells...
  46. ncbi Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
    John A Marwick
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L897-908. 2006
    ..However, targeted therapies to restore VEGF(165)-VEGFR-2 complex may promote endothelial cell survival and help to ameliorate emphysema...
  47. ncbi Environmental toxicity, redox signaling and lung inflammation: the role of glutathione
    Saibal K Biswas
    Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 850, Rochester, NY 14642, USA
    Mol Aspects Med 30:60-76. 2009
    ..We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease...
  48. ncbi Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling
    H Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY, U S A
    Biochem Soc Trans 35:1151-5. 2007
    ....
  49. ncbi Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM
    Hongwei Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:15571-6. 2010
    ..In conclusion, SOD3 attenuates emphysema and reduces oxidative fragmentation of ECM in mouse lung. Thus, pharmacological augmentation of SOD3 in the lung may have a therapeutic potential in the intervention of COPD/emphysema...
  50. ncbi Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD
    Jae Woong Hwang
    Department of Environmental Medicine, University of Rochester Medical Center, NY, USA
    Arch Biochem Biophys 500:203-9. 2010
    ..These data suggest that the SIRT1-PARP-1 axis plays a critical role in the regulation of CS-induced autophagy and have important implications in understanding the mechanisms of CS-induced cell death and senescence...
  51. ncbi Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke
    David Adenuga
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 40:464-73. 2009
    ....
  52. ncbi Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke
    Saravanan Rajendrasozhan
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Pulm Pharmacol Ther 23:172-81. 2010
    ....
  53. ncbi SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    Samuel Caito
    Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    FASEB J 24:3145-59. 2010
    ..Our data suggest that oxidants/aldehydes covalently modify SIRT1, decreasing enzymatic activity and marking the protein for proteasomal degradation, which has implications in inflammatory conditions...
  54. ncbi VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    FASEB J 22:2297-310. 2008
    ..This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases...
  55. ncbi Regulation of inflammation and redox signaling by dietary polyphenols
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, MRBX 3.11106, 601 Elmwood Avenue, Box 850, Rochester, NY 14642, USA
    Biochem Pharmacol 72:1439-52. 2006
    ..This commentary discusses the recent data on dietary polyphenols in the control of signaling and inflammation particularly during oxidative stress, their metabolism and bioavailability...
  56. ncbi Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages
    Samuel Caito
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642 USA
    Antioxid Redox Signal 10:253-60. 2008
    ..These data have implications in designing therapies for treatment of COPD and pulmonary fibrosis...
  57. ncbi SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
    Gnanapragasam Arunachalam
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 393:66-72. 2010
    ..These findings suggest that CS- and oxidant-mediated reduction of SIRT1 is associated with acetylation of eNOS which have implications in endothelial dysfunction...
  58. ncbi Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes
    David Adenuga
    Department of Environmental Medicine, University of Rochester Medical Center, NY 14642, USA
    Arch Biochem Biophys 498:62-73. 2010
    ..Thus, phospho-acetylation of HDAC2 negatively regulates its deacetylase activity which has implications in steroid resistance in chronic inflammatory conditions...
  59. ncbi Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice
    Hongwei Yao
    Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 39:7-18. 2008
    ..These data may have ramifications in CS-induced senescence in the pathogenesis of chronic obstructive pulmonary disease/emphysema...
  60. ncbi Oxidative stress, thiol redox signaling methods in epigenetics
    Isaac K Sundar
    Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Methods Enzymol 474:213-44. 2010
    ....
  61. ncbi PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
    Samuel Caito
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Biochem Biophys Res Commun 392:264-70. 2010
    ..Overall, these data suggest that environmental/oxidant stress-induced SIRT1 down-regulation and PARP-1 activation are independent events despite both enzymes sharing the same cofactor...
  62. ncbi 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
    Irfan Rahman
    Respiratory Medicine Unit, ELEGI Laboratory, University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Respir Crit Care Med 166:490-5. 2002
    ..01). The elevated levels of 4-HNE may play a role in the signaling events in lung inflammation leading to the imbalance of the expression of both proinflammatory mediators and protective antioxidant genes in COPD...
  63. ncbi Glutathione and p53 independently mediate responses against oxidative stress in ES cells
    Jonathan P Coe
    CRC Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, UK
    Free Radic Biol Med 32:187-96. 2002
    ..Thus, in the absence of p53 ES cells bearing genotoxic damage are less likely to be propagated, suggesting that p53-dependent apoptosis acts to limit the deleterious effects of oxidative stress during early development...
  64. ncbi Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets
    Irfan Rahman
    ELEGI Laboratory, MRC Centre for Inflammation Research, Medical School, University of Edinburgh, Edinburgh, UK
    Curr Drug Targets Inflamm Allergy 1:291-315. 2002
    ..In addition, development of such novel antioxidant compounds would be therapeutically useful in monitoring the oxidative and inflammatory biomarkers in the progression/severity of asthma and COPD...
  65. ncbi Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10)
    Ken Donaldson
    Colt ELEGI Laboratories, Centre for Inflammation Research, The University of Edinburgh Medical School, Edinburgh EH8 9AG, Scotland, UK
    Free Radic Biol Med 34:1369-82. 2003
    ..Oxidative stress from particles is also likely to play an important role in the carcinogenic effects associated with PM(10) and hydroxyl radicals from PM(10) cause DNA damage in vitro...
  66. ncbi Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1
    Hazel Jardine
    Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 277:21158-66. 2002
    ..The findings of this study provide important information, which may be used for the modulation of glutathione biosynthesis in inflammation...
  67. ncbi 2nd International Meeting on Free Radicals in Health and Disease. The role of oxidants and antioxidants in the regulation of chronic diseases, may 8-12, 2002, Istanbul, Turkey
    Irfan Rahman
    Respiratory Medicine Unit, ELEGI Laboratory University of Edinburgh Medical School, Teviok Place, Edinburgh EH8 9AG, UK
    Free Radic Res 37:349-54. 2003
  68. ncbi Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles
    Peter S Gilmour
    Edinburgh Lung and the Environment Group Initiative Colt Laboratory, The University of Edinburgh, Department of Medicine and Radiological Sciences, Medical School, Edinburgh EH8 9AG, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 284:L533-40. 2003
    ..Acetylation of H4 mediated by PM(10) was associated with the promoter region of the IL-8 gene. These data suggest that remodeling of chromatin by histone acetylation plays a role in PM(10)-mediated responses in the lungs...
  69. ncbi Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells
    Irfan Rahman
    ELEGI and Colt Research Laboratory, Respiratory Medicine Unit, Wilkie Building, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Biophys Res Commun 302:860-4. 2003
    ..This indicates a molecular mechanism for the anti-inflammatory effects of ergothioneine...
  70. ncbi Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells
    Frank Antonicelli
    Department of Medical and Radiological Sciences, Respiratory Medicine Unit, ELEGI/Colt Research Laboratories, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Free Radic Biol Med 32:492-502. 2002
    ..These data indicate that NAL may be used to modulate pro-inflammatory process by inhibiting cytokine release in the lungs and thus has therapeutic potential in inflammatory lung diseases...
  71. ncbi Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases
    Irfan Rahman
    Respiratory Medicine, ELEGI Laboratory, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    J Biochem Mol Biol 36:95-109. 2003
    ....
  72. ncbi Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation
    Irfan Rahman
    ELEGI Colt Research Laboratory, University of Edinburgh, Medical School, Scotland, UK
    Mol Cell Biochem 234:239-48. 2002
    ..This indicates a mechanism for the pro-inflammatory effects of oxidative stress...
  73. ncbi Oxidative stress, transcription factors and chromatin remodelling in lung inflammation
    Irfan Rahman
    ELEGI and Colt Research Laboratory, MRC Centre for Inflammation Research, Medical School, University of Edinburgh, Wilkie Building, Teviot Place, Edinburgh, UK
    Biochem Pharmacol 64:935-42. 2002
    ..This suggests that the remodelling of chromatin by histone acetylation plays a role in the oxidant-mediated pro-inflammatory responses in the lungs...
  74. ncbi The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro
    Monica Deiana
    Dipartimento di Biologia Sperimentale, Sez. Patologia Sperimentale, , Cittadella Universitaria SS 554, 09042 Monserrato, Cagliari, Italy
    Biochem Biophys Res Commun 296:1148-51. 2002
    ..A TEAC value of 0.10+/-0.05mM was obtained for EM-X, indicating antioxidant potential. We suggest that the anti-inflammatory and antioxidant properties of EM-X are dependent on the flavonoid contents of the beverage...
  75. ncbi Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells
    John A Marwick
    Respiratory Medicine Unit, ELEGI and Colt Laboratory, University of Edinburgh, Medical School, Edinburgh, UK
    Ann N Y Acad Sci 973:278-83. 2002
    ..This may be important in the growth arrest and cell survival of alveolar type II cells in the G(1) phase...
  76. ncbi Biomarkers in breath condensate: a promising new non-invasive technique in free radical research
    Irfan Rahman
    Respiratory Medicine, ELEGI, Colt Research Laboratories, MRC Centre for Inflammation Research, The University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, UK
    Free Radic Res 37:1253-66. 2003
    ..By assessing the nature of oxidative stress in this manner, the most appropriate therapy can be selected and the response to treatment monitored...
  77. ncbi Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products
    Paul A Kirkham
    Novartis Institute for Biomedical Research Horsham, West Sussex, UK
    Biochem Biophys Res Commun 318:32-7. 2004
    ....
  78. ncbi Future therapeutic treatment of COPD: struggle between oxidants and cytokines
    Willem I de Boer
    Netherlands Asthma Foundation, Leusden, The Netherlands
    Int J Chron Obstruct Pulmon Dis 2:205-28. 2007
    ....
  79. ncbi Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy
    Paul Kirkham
    Respiratory Diseases, Novartis Institutes for BioMedical Research, Horsham, West Sussex, RH12 5AB, UK
    Pharmacol Ther 111:476-94. 2006
    ..It is likely, therefore, that a combination of antioxidants may be effective in the treatment of asthma and COPD. Various approaches to enhance the lung antioxidant screen and clinical trials of antioxidant compounds are discussed...
  80. ncbi Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone
    Douglas Morrison
    Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH3 9YW, Scotland, UK
    Respir Med 100:2227-34. 2006
    ..Ozone exposure did not increase epithelial permeability, but was associated with neutrophil influx into the airspaces, without evidence of increased oxidative stress...
  81. ncbi Redox modifications of protein-thiols: emerging roles in cell signaling
    Saibal Biswas
    Department of Biochemistry, Dr. Ambedkar College, Nagpur, Maharashtra State, India
    Biochem Pharmacol 71:551-64. 2006
    ....
  82. ncbi Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2
    Koremu K Meja
    Novartis Institutes for BioMedical Research, Respiratory Disease, Horsham, UK
    Am J Respir Cell Mol Biol 39:312-23. 2008
    ..Curcumin may therefore have potential to reverse steroid resistance, which is common in patients with COPD and asthma...
  83. ncbi Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation
    Romain Debret
    Laboratoire de Biochimie, Universite de Reims Champagne Ardenne, CNRS UMR 6237, 51095 Reims Cedex, France
    Biochim Biophys Acta 1783:1718-27. 2008
    ....
  84. ncbi Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice
    Saibal K Biswas
    Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, EH16 4TJ Edinburgh, UK
    Biochem Biophys Res Commun 338:1368-73. 2005
    ..Modification of the glutathione pathway may present a novel and important therapeutic target in the prevention and treatment of atherosclerosis...
  85. ncbi Biomarkers in risk assessment of asbestos exposure
    Kunal Bhattacharya
    Industrial Toxicology Research Centre, P.O. Box 80, M.G. Marg, Lucknow 226001, India
    Mutat Res 579:6-21. 2005
    ..The present review article covers in detail possible biomarkers for risk assessment of morbidity due to fibers/particles in exposed population...
  86. ncbi Lack of systemic oxidative stress during PAF challenge in mild asthma
    Andrés L Echazarreta
    Servei de Pneumologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Respir Med 99:519-23. 2005
    ..Unlike PAF, L-PAF-induced changes were negligible. We conclude that there is no systemic oxidant-antioxidant imbalance during acute bronchoconstriction induced by PAF in these patients with mild asthma...
  87. ncbi Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity
    Saibal K Biswas
    Centre for Cardiovascular Sciences, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Medical School, Edinburgh, UK
    Antioxid Redox Signal 7:32-41. 2005
    ..This suggests that curcumin has multiple properties: as an oxygen radical scavenger, antioxidant through modulation of glutathione levels, and antiinflammatory agent through inhibition of IL-8 release in lung cells...
  88. ncbi Redox signaling in the lungs
    Irfan Rahman
    Antioxid Redox Signal 7:1-5. 2005
  89. ncbi Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells
    Fiona M Moodie
    ELEGI and Colt Research Laboratories, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK
    FASEB J 18:1897-9. 2004
    ..Thus, H2O2 and CSC enhance acetylation of histone proteins and decrease histone deacetylase activity but differentially regulate proinflammatory cytokine release in alveolar epithelial cells...
  90. ncbi Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    John A Marwick
    MRC Centre for Inflammation Research, Department of Environmental Medicine, University of Edinburgh, UK
    Am J Respir Cell Mol Biol 31:633-42. 2004
    ..These findings suggest a possible molecular mechanism by which cigarette smoke drives proinflammatory gene transcription and an inflammatory response in the lungs...
  91. ncbi 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis
    So-Young Lim
    College of Pharmacy, Seoul National University, Seoul 151-742, Korea
    J Biol Chem 279:46263-70. 2004
    ..The above findings suggest that 15d-PGJ(2) may act as a survival mediator capable of augmenting cellular thiol antioxidant capacity through up-regulation of the intracellular GSH synthesis in response to the nitrosative insult...
  92. ncbi Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn
    Frank Antonicelli
    Edinburgh Lung and Environment Group Initiative/Colt Research Laboratories, Department of Medical and Radiological Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Am J Physiol Lung Cell Mol Physiol 286:L1319-27. 2004
    ....
  93. ncbi Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation
    Christopher S Stevenson
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 293:L1183-93. 2007
    ..As such, it appears that metabolic pathways are central to dealing with the stress of CS exposure; however, over time, inflammation and stress response gene sets become the most significantly affected in the chronic response to CS...
  94. ncbi Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke
    Hui Jung Kim
    Pulmonary Division, Department of Internal Medicine, Seoul Adventist Hospital, Seoul 130-650, Korea
    Am J Physiol Lung Cell Mol Physiol 283:L409-17. 2002
    ..In conclusion, smoke inhibition of fibroblast repair, as reflected by collagen gel contraction and fibronectin production, may be modulated by intracellular GSH levels...

Research Grants7

  1. Mechanisms of cigarette smoke-induced chromatin remodeling in lung inflammation
    Irfan Rahman; Fiscal Year: 2007
    ....
  2. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2009
    ..End of Abstract) ..
  3. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2010
    ....
  4. Mechanisms of cigarette smoke-induced chromatin remodeling in lung inflammation
    Irfan Rahman; Fiscal Year: 2010
    ....
  5. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2010
    ..End of Abstract) ..