Arshad Rahman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration
    Arshad Rahman
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Antioxid Redox Signal 11:823-39. 2009
  2. ncbi request reprint cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells
    Arshad Rahman
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1017-24. 2004
  3. pmc Blocking NF-κB: an inflammatory issue
    Arshad Rahman
    Department of Pediatrics, Box 850, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Proc Am Thorac Soc 8:497-503. 2011
  4. pmc Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65
    Kaiser M Bijli
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Biol Chem 283:14674-84. 2008
  5. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
  6. pmc Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells
    Fabeha Fazal
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:21047-56. 2009
  7. pmc Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 12:1355-69. 2010
  8. pmc Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 8:e59965. 2013
  9. ncbi request reprint Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Immunol 174:5823-9. 2005
  10. pmc Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 47:660-8. 2012

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration
    Arshad Rahman
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Antioxid Redox Signal 11:823-39. 2009
    ..This review summarizes our current understanding of the "ICAM-1 paradigm" of TEM with an emphasis on the signaling events mediating ICAM-1 expression and activated by ICAM-1 engagement in endothelial cells...
  2. ncbi request reprint cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells
    Arshad Rahman
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1017-24. 2004
    ....
  3. pmc Blocking NF-κB: an inflammatory issue
    Arshad Rahman
    Department of Pediatrics, Box 850, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Proc Am Thorac Soc 8:497-503. 2011
    ....
  4. pmc Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65
    Kaiser M Bijli
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Biol Chem 283:14674-84. 2008
    ....
  5. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
    ..Thus, these data reveal an important role of PKC-delta and PI3K/Akt pathways in activating mTOR as an endogenous modulator to ensure a tight regulation of NF-kappaB signaling of ICAM-1 expression in endothelial cells...
  6. pmc Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells
    Fabeha Fazal
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:21047-56. 2009
    ..Together, these data show that cofilin-1 occupies a central position in RhoA-actin pathway mediating nuclear translocation of RelA/p65 and expression of ICAM-1 in endothelial cells...
  7. pmc Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 12:1355-69. 2010
    ....
  8. pmc Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 8:e59965. 2013
    ..These results provide mechanistic insight into lung inflammatory response associated with intravascular coagulation and identify nmMLCK as a critical target for modulation of lung inflammation...
  9. ncbi request reprint Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Immunol 174:5823-9. 2005
    ..These data define a novel role of mTOR in down-regulating thrombin-induced ICAM-1 expression in endothelial cells by controlling a delayed and transient activation of NF-kappaB...
  10. pmc Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 47:660-8. 2012
    ..Thus, specific targeting of Pyk2 may be an effective anti-inflammatory strategy in vascular diseases associated with EC inflammation and intravascular coagulation...
  11. ncbi request reprint Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 282:3940-50. 2007
    ....
  12. ncbi request reprint c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L396-404. 2007
    ..These data implicate an important role of c-Src in phosphorylating RelA/p65 to promote the transcriptional activity of NF-kappaB and thereby ICAM-1 expression in endothelial cells...
  13. pmc Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation
    Antony Leonard
    Dept of Pediatrics, Lung Biology and Disease Program, Univ of Rochester School of Medicine, 601 Elmwood Ave Box 850, Rochester, NY
    Am J Physiol Lung Cell Mol Physiol 305:L651-64. 2013
    ..Thus this study provides evidence for a novel role of LIMK1 and SSH-1L in selectively regulating EC inflammation associated with intravascular coagulation. ..
  14. ncbi request reprint RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65
    Khandaker N Anwar
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Immunol 173:6965-72. 2004
    ....
  15. doi request reprint VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    FASEB J 22:2297-310. 2008
    ..This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases...
  16. pmc GPR56 Regulates VEGF production and angiogenesis during melanoma progression
    Liquan Yang
    Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, USA
    Cancer Res 71:5558-68. 2011
    ..We propose that components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma...
  17. ncbi request reprint Regulation of lung neutrophil recruitment by VE-cadherin
    Janie Orrington-Myers
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 291:L764-71. 2006
    ..These results suggest that disassembly of VE-cadherin junctions serves as a negative signal for limiting transendothelial PMN migration secondary to decreased ICAM-1 expression in the mouse model of LPS-induced sepsis...
  18. ncbi request reprint Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells
    Randall S Frey
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 281:16128-38. 2006
    ..Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling NADPH oxidase-dependent oxidant production and subsequent NF-kappaB activation and ICAM-1 expression...
  19. ncbi request reprint Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis
    Randal A Skidgel
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 169:2093-101. 2002
    ..Thus, NO production in high quantities may be important in the mechanism of amplification of the lung inflammatory response associated with sepsis...
  20. ncbi request reprint Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells
    Arshad Rahman
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612 7343, USA
    Circ Res 91:398-405. 2002
    ..These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt...
  21. ncbi request reprint Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1
    Kamran Javaid
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, Ill 60612, USA
    Circ Res 92:1089-97. 2003
    ..The rapid ICAM-1 expression represents a novel mechanism for promoting the stable adhesion of PMN to endothelial cells that is needed to facilitate the early-onset transendothelial migration of PMN...
  22. ncbi request reprint Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:3404-11. 2002
    ..Thus, oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of TNFalpha-induced NF-kappaB activation and ICAM-1 expression in endothelial cells...
  23. ncbi request reprint Inhibition of activator protein-1 transcription factor activation by omega-3 fatty acid modulation of mitogen-activated protein kinase signaling kinases
    Tricia A Babcock
    Department of Surgery, University of Illinois at Chicago, 60612, USA
    JPEN J Parenter Enteral Nutr 27:176-80; discussion 181. 2003
    ....
  24. ncbi request reprint Activation of protein kinase C delta by IFN-gamma
    Dilip K Deb
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 171:267-73. 2003
    ..Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes...
  25. ncbi request reprint E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability
    Evan S Ong
    Dept of Pharmacology, College of Medicine, Univ of Illinois, 835 S Wolcott Ave, Chicago, IL 60612 7343, USA
    Am J Physiol Lung Cell Mol Physiol 285:L879-88. 2003
    ..The massive CD11/CD18-independent airway PMN influx occurring in the absence of lung vascular injury is indicative of an efficient host-defense response elicited by E. coli pneumonia...
  26. ncbi request reprint Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells
    Biman C Paria
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:37195-203. 2003
    ..The augmented Ca2+ entry secondary to TRPC1 expression may be an important mechanism of endothelial injury induced by TNF-alpha...
  27. ncbi request reprint PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells
    Randall S Frey
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612 7343, USA
    Circ Res 90:1012-9. 2002
    ..These data demonstrate a novel function of PKCzeta in signaling oxidant generation in endothelial cells by the activation of NADPH oxidase, which may be important in mediating endothelial activation responses...
  28. ncbi request reprint Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice
    Xiao Pei Gao
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 168:3974-82. 2002
    ....
  29. ncbi request reprint Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonist
    Ning Xu
    Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 282:L796-802. 2002
    ..The results support the model that initial engagement of CD18 integrins enables the further recruitment of additional PMN into lung tissues such that PMN continue to sequester and migrate after E. coli challenge...
  30. ncbi request reprint Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
    Shahab Uddin
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:14408-16. 2002
    ..Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses...

Research Grants8

  1. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2005
    ....
  2. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2007
    ..These studies may provide future directions for development of therapeutic strategies for inflammatory disease states such as Acute Respiratory Distress Syndrome (ARDS). ..
  3. G-protein-induced Signaling of PMN-mediated Lung Injury
    Arshad Rahman; Fiscal Year: 2010
    ..These studies may provide future directions for development of therapeutic strategies for inflammatory disease states such as Acute Respiratory Distress Syndrome (ARDS). ..