M K Raghuraman

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Cell cycle-dependent establishment of a late replication program
    M K Raghuraman
    Department of Genetics, University of Washington, Box 35 7360, Seattle, WA 98195 7360, USA
    Science 276:806-9. 1997
  2. ncbi Molecular analysis of the replication program in unicellular model organisms
    M K Raghuraman
    Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA, 98133, USA
    Chromosome Res 18:19-34. 2010
  3. ncbi Replication dynamics of the yeast genome
    M K Raghuraman
    Department of Genetics, Department of Mathematics, University of Washington, Seattle, WA 98195, USA
    Science 294:115-21. 2001
  4. ncbi Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress
    Wenyi Feng
    Department of Genome Sciences, University of Washington, Box 355065 Foege Bldg, Room S041, 1705 NE Pacific St, Seattle, Washington 98195, USA
    Genetics 183:1249-60. 2009
  5. ncbi The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae
    Heather J McCune
    Department of Genomic Resources, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genetics 180:1833-47. 2008
  6. ncbi Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae
    Margaret L Hoang
    Department of Genome Sciences, University of Washington, Seattle, USA
    Mol Cell Biol 27:7594-602. 2007
  7. ncbi Maintaining replication origins in the face of genomic change
    Sara C Di Rienzi
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 22:1940-52. 2012
  8. ncbi Replication in hydroxyurea: it's a matter of time
    Gina M Alvino
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mol Cell Biol 27:6396-406. 2007
  9. ncbi CLB5-dependent activation of late replication origins in S. cerevisiae
    A D Donaldson
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell 2:173-82. 1998
  10. ncbi The dynamics of chromosome replication in yeast
    Isabelle A Lucas
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Curr Top Dev Biol 55:1-73. 2003

Collaborators

  • William S Noble
  • F R Cross
  • A D Donaldson
  • E A Winzeler
  • D J Lockhart
  • Bonita J Brewer
  • Sara C Di Rienzi
  • David Collingwood
  • Wenyi Feng
  • Gina M Alvino
  • Thomas J Pohl
  • Kimberly C Lindstrom
  • Heather J McCune
  • Walton L Fangman
  • Margaret L Hoang
  • Isabelle A Lucas
  • Tobias Mann
  • Lisa Rolczynski
  • Ragina Lancaster
  • Jeff Bachant
  • Laura S Danielson
  • Jeffrey J Delrow
  • Jeffrey Delrow
  • Sonia Hunt
  • Ronald P Leon
  • Luis Pessoa-Brandao
  • John M Murphy
  • Robert A Sclafani

Detail Information

Publications14

  1. ncbi Cell cycle-dependent establishment of a late replication program
    M K Raghuraman
    Department of Genetics, University of Washington, Box 35 7360, Seattle, WA 98195 7360, USA
    Science 276:806-9. 1997
    ..Once set, the signal can persist through the next S phase in the absence of the telomere. Establishment of the temporal program and of initiation competence of origins may be coincident events...
  2. ncbi Molecular analysis of the replication program in unicellular model organisms
    M K Raghuraman
    Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA, 98133, USA
    Chromosome Res 18:19-34. 2010
    ..But what exactly is a temporal program of replication, and how might it arise? In this article, we explore this question, drawing again on the wealth of experimental information in unicellular model organisms...
  3. ncbi Replication dynamics of the yeast genome
    M K Raghuraman
    Department of Genetics, Department of Mathematics, University of Washington, Seattle, WA 98195, USA
    Science 294:115-21. 2001
    ..The two ends of each of the 16 chromosomes are highly correlated in their times of replication. This microarray approach is readily applicable to other organisms, including humans...
  4. ncbi Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress
    Wenyi Feng
    Department of Genome Sciences, University of Washington, Box 355065 Foege Bldg, Room S041, 1705 NE Pacific St, Seattle, Washington 98195, USA
    Genetics 183:1249-60. 2009
    ..Our results highlight the importance of replicating yeast centromeres early and reveal different mechanisms of cell death due to differences in replication fork progression...
  5. ncbi The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae
    Heather J McCune
    Department of Genomic Resources, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genetics 180:1833-47. 2008
    ....
  6. ncbi Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae
    Margaret L Hoang
    Department of Genome Sciences, University of Washington, Seattle, USA
    Mol Cell Biol 27:7594-602. 2007
    ..Because similar mutations in mcm2 and mcm4 cannot bypass DDK, Mcm5 protein may be a unique Mcm protein that is the final target of DDK regulation...
  7. ncbi Maintaining replication origins in the face of genomic change
    Sara C Di Rienzi
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 22:1940-52. 2012
    ..We conclude that, over evolutionary time, origins maintain sequence, structure, and regulation, but are continually being created and destroyed, with the result that their locations are generally not conserved...
  8. ncbi Replication in hydroxyurea: it's a matter of time
    Gina M Alvino
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mol Cell Biol 27:6396-406. 2007
    ..We propose a revised model for the checkpoint response to HU that accounts for the continued but slowed pace of the temporal program of origin activation...
  9. ncbi CLB5-dependent activation of late replication origins in S. cerevisiae
    A D Donaldson
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell 2:173-82. 1998
    ..In clb5 clb6 mutants, the other B-type cyclins (Clb1-4p) promote an S phase during which both early and late replication origins fire...
  10. ncbi The dynamics of chromosome replication in yeast
    Isabelle A Lucas
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Curr Top Dev Biol 55:1-73. 2003
  11. ncbi Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae
    Thomas J Pohl
    Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 8:e1002677. 2012
    ..Our results constitute a direct link between establishment of the kinetochore and the replication initiation machinery, and suggest that the proposed higher-order structure of the pericentric chromatin influences replication initiation...
  12. ncbi Mapping yeast origins of replication via single-stranded DNA detection
    Wenyi Feng
    Department of Genome Sciences, Box 357730, University of Washington, Seattle, WA 98195, USA
    Methods 41:151-7. 2007
    ..We have also shown that this technique can identify origins in Schizosaccharomyces pombe, illustrating the utility of this method for origin mapping in other eukaryotes...
  13. ncbi Fragile genomic sites are associated with origins of replication
    Sara C Di Rienzi
    Department of Genome Sciences, University of Washington
    Genome Biol Evol 2009:350-63. 2009
    ..This study lays the groundwork for understanding the mechanisms by which origins of replication may impact genome architecture and disease...
  14. ncbi Genetic, genomic, and molecular tools for studying the protoploid yeast, L. waltii
    Sara C Di Rienzi
    Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA 98195, USA
    Yeast 28:137-51. 2011
    ..waltii. We hope that these tools will be used by the community to follow up on the ideas generated by sequence data and lead to a greater understanding of eukaryotic biology and genome evolution...