Krishnan Raghavendran

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Pharmacotherapy of acute lung injury and acute respiratory distress syndrome
    Krishnan Raghavendran
    Department of Surgery, State University of New York SUNY at Buffalo, Buffalo, NY 14214, USA
    Curr Med Chem 15:1911-24. 2008
  2. pmc Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model
    Krishnan Raghavendran
    Department of Surgery, State University of New York at Buffalo, New York 14214, USA
    Shock 30:508-17. 2008
  3. pmc Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Trauma 67:1182-90. 2009
  4. ncbi request reprint A rat model for isolated bilateral lung contusion from blunt chest trauma
    Krishnan Raghavendran
    Department of Surgery Division of Trauma and Critical Care, SUNY at Buffalo, David K Miller Building, Suite 316, 462 Grider St, Suite 316, Buffalo, NY 14215, USA
    Anesth Analg 101:1482-9. 2005
  5. pmc Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Surg Res 155:273-82. 2009
  6. ncbi request reprint Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles
    Alan D Hutson
    Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Anesthesiology 104:73-9. 2006
  7. pmc Effect of high advanced glycation end-product diet on pulmonary inflammatory response and pulmonary function following gastric aspiration
    Weidun Alan Guo
    Department of Surgery, University at Buffalo State University of New York, Buffalo, NY 14215, USA
    Shock 38:677-84. 2012
  8. pmc Increased phospholipase A2 and lyso-phosphatidylcholine levels are associated with surfactant dysfunction in lung contusion injury in mice
    David Machado-Aranda
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Surgery 153:25-35. 2013
  9. pmc Lung contusion: inflammatory mechanisms and interaction with other injuries
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Shock 32:122-30. 2009
  10. pmc The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses
    Krishnan Raghavendran
    Department of Surgery, State University of New York, Buffalo 14215, USA
    Shock 24:132-8. 2005

Detail Information

Publications28

  1. pmc Pharmacotherapy of acute lung injury and acute respiratory distress syndrome
    Krishnan Raghavendran
    Department of Surgery, State University of New York SUNY at Buffalo, Buffalo, NY 14214, USA
    Curr Med Chem 15:1911-24. 2008
    ..However, many of these agents have complementary biological/biochemical activities with the potential for synergy or additivity in combination therapy as discussed in this article...
  2. pmc Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model
    Krishnan Raghavendran
    Department of Surgery, State University of New York at Buffalo, New York 14214, USA
    Shock 30:508-17. 2008
    ..These results show that surfactant dysfunction is important in the pathophysiology of LC with or without concurrent gastric aspiration and provides a rationale for surfactant replacement therapy in these prevalent clinical conditions...
  3. pmc Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Trauma 67:1182-90. 2009
    ....
  4. ncbi request reprint A rat model for isolated bilateral lung contusion from blunt chest trauma
    Krishnan Raghavendran
    Department of Surgery Division of Trauma and Critical Care, SUNY at Buffalo, David K Miller Building, Suite 316, 462 Grider St, Suite 316, Buffalo, NY 14215, USA
    Anesth Analg 101:1482-9. 2005
    ..We concluded that an impact energy of 2.45 J induces isolated, bilateral lung contusion and provides a useful model for future mechanistic pathophysiological assessments...
  5. pmc Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Surg Res 155:273-82. 2009
    ....
  6. ncbi request reprint Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles
    Alan D Hutson
    Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Anesthesiology 104:73-9. 2006
    ..The authors hypothesized that inflammatory mediator profiles could be used to help diagnose different types of gastric aspiration...
  7. pmc Effect of high advanced glycation end-product diet on pulmonary inflammatory response and pulmonary function following gastric aspiration
    Weidun Alan Guo
    Department of Surgery, University at Buffalo State University of New York, Buffalo, NY 14215, USA
    Shock 38:677-84. 2012
    ..This is the first evidence implicating exacerbation of acute inflammatory lung injury by dietary AGEs. Targeting AGEs in the circulatory system may offer a therapeutic strategy for limiting lung injury following gastric aspiration...
  8. pmc Increased phospholipase A2 and lyso-phosphatidylcholine levels are associated with surfactant dysfunction in lung contusion injury in mice
    David Machado-Aranda
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Surgery 153:25-35. 2013
    ..This is extended here to a mouse model of unilateral LC with a focus on compositional and functional changes in surfactant associated with permeability injury and increases in activity of secretory phospholipase A2...
  9. pmc Lung contusion: inflammatory mechanisms and interaction with other injuries
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Shock 32:122-30. 2009
    ....
  10. pmc The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses
    Krishnan Raghavendran
    Department of Surgery, State University of New York, Buffalo 14215, USA
    Shock 24:132-8. 2005
    ..Inflammatory injury from isolated bilateral lung contusion in rats is most severe in the acute period (8 min-24 h) after initial blunt trauma, and includes a component of neutrophil-dependent pathology...
  11. pmc Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, NY, USA
    Shock 39:278-85. 2013
    ..Collectively, these data suggest that consumption of NO due to excess superoxide resulting in peroxynitrite formation leads to diminished vascular reactivity following LC...
  12. doi request reprint American College of Surgeons' Committee on Trauma Performance Improvement and Patient Safety program: maximal impact in a mature trauma center
    Bedabrata Sarkar
    Division of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Trauma 71:1447-53; discussion 1453-4. 2011
    ....
  13. doi request reprint Hepcidin in trauma: linking injury, inflammation, and anemia
    Kristen C Sihler
    Division of Acute Care Surgery Trauma, Burn, Surgical Critical Care, Emergency Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Trauma 69:831-7. 2010
    ..We sought to define the link between traumatic injury, hepcidin, and inflammation...
  14. ncbi request reprint The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome
    Weidun Alan Guo
    Department of Surgery, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
    Intensive Care Med 38:1588-98. 2012
    ..Additionally, the review explores the potential of RAGE as an important therapeutic target in ALI/ARDS...
  15. pmc NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury
    Bruce A Davidson
    Department of Anesthesiology, University at Buffalo School of Medicine, Buffalo, NY 14214, USA
    J Immunol 190:1714-24. 2013
    ..These results also point to Nrf2 as a therapeutic target to limit ALI by attenuating neutrophil-induced cellular injury...
  16. pmc Host susceptibility to gram-negative pneumonia after lung contusion
    Vladislav A Dolgachev
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109 5033, USA
    J Trauma Acute Care Surg 72:614-22; discussion 622-3. 2012
    ..We hypothesize that LC creates acute changes in the host pulmonary innate immune system that leads to vulnerability from a "second" hit bacterial infection...
  17. doi request reprint Nontrauma emergency surgery: optimal case mix for general surgery and acute care surgery training
    Jill R Cherry-Bukowiec
    Division of Acute Care Surgery and Section of General Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Trauma 71:1422-6; discussion 1426-7. 2011
    ..To examine the case mix and patient characteristics and outcomes of the nontrauma emergency (NTE) service in an academic Division of Acute Care Surgery...
  18. pmc Electroporation-mediated in vivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion
    David A Machado-Aranda
    Division of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Trauma Acute Care Surg 72:32-9; discussion 39-40. 2012
    ..We hypothesized that restoring the activity of the pump will result in removal of excess alveolar fluid and additionally reduce inflammation...
  19. ncbi request reprint The role of alveolar macrophages in the pathogenesis of aspiration pneumonitis
    Nader D Nader
    Department of Anesthesiology, University at Buffalo, State University of New York, Buffalo, New York 14215, USA
    Immunol Invest 36:457-71. 2007
    ..A robust TNFalpha response is seen following aspiration of food particles, while there is only a modest response to acid...
  20. pmc Aspiration-induced lung injury
    Krishnan Raghavendran
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 39:818-26. 2011
    ..Additionally, a review of current and potential biomarkers that have been tested clinically in humans is provided...
  21. ncbi request reprint Pharmacokinetics and pharmacodynamics of enoxaparin in multiple trauma patients
    Curtis E Haas
    Department of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, USA
    J Trauma 59:1336-43; discussion 1343-4. 2005
    ..Recent reports have suggested that the pharmacokinetics (PK) and pharmacodynamics of LMWH products may be altered in critically ill patients...
  22. pmc A randomized trial of chlorhexidine gluconate on oral bacterial pathogens in mechanically ventilated patients
    Frank A Scannapieco
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, 3435 Main St, Buffalo, NY 14214, USA
    Crit Care 13:R117. 2009
    ..12% chlorhexidine gluconate application necessary to reduce oral colonization by pathogens in 175 intubated patients in a trauma intensive care unit...
  23. ncbi request reprint Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1
    Krishnan Raghavendran
    Department of Surgery, University at Buffalo State University of New York, 14214, USA
    Am J Physiol Lung Cell Mol Physiol 289:L134-43. 2005
    ..These results indicate that MCP-1 is important for survival in murine aspiration pneumonitis and appears to act partly to protect uninjured lung regions by promoting isolation and compartmentalization of tissue with active inflammation...
  24. pmc Definition of ALI/ARDS
    Krishnan Raghavendran
    Division of Acute Care Surgery, Department of Surgery, University of Michigan Health System, 1500 East Medical Center Drive, 1C340A UH, SPC 5033, Ann Arbor, MI 48109 5033, USA
    Crit Care Clin 27:429-37. 2011
    ..In this article, definitions that have been recently used for ALI/ARDS in various clinical studies are discussed individually...
  25. doi request reprint Nonventilatory strategies for patients with life-threatening 2009 H1N1 influenza and severe respiratory failure
    Lena M Napolitano
    Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA
    Crit Care Med 38:e74-90. 2010
    ..Pharmacologic strategies (including steroids) investigated for the treatment of severe respiratory failure are also reviewed...
  26. ncbi request reprint Predictive value of sputum gram stain for the determination of appropriate antibiotic therapy in ventilator-associated pneumonia
    Krishnan Raghavendran
    Department of Surgery, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14215, USA
    J Trauma 62:1377-82; discussion 1382-3. 2007
    ..This study was conducted to analyze the predictive value of sputum Gram stain for selecting appropriate early antibiotic therapy for VAP as confirmed by a BAL quantitative culture (>10 CFU/mL considered diagnostic)...
  27. pmc Surfactant therapy for acute lung injury and acute respiratory distress syndrome
    Krishnan Raghavendran
    Division of Acute Care Surgery, Department of Surgery, University of Michigan Health System, 1500 East Medical Center Drive, 1C340A UH, SPC 5033, Ann Arbor, MI 48109 5033, USA
    Crit Care Clin 27:525-59. 2011
    ..This article reviews clinical studies of surfactant therapy in pediatric and adult patients with ALI/ARDS, focusing on its potential advantages in patients with direct pulmonary forms of these syndromes...
  28. ncbi request reprint Respiratory distress syndrome: principles and current therapy
    Krishnan Raghavendran
    Department of Surgery, Erie County Medical Center, State University of New York at Buffalo, New York, USA
    J Med 33:147-65. 2002
    ..Over the years a variety of "lung protective" treatment modalities have been introduced and proved as effective and safe in the treatment of this syndrome..