M Raghavan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens
    Natasha Del Cid
    Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e41727. 2012
  2. doi request reprint Calreticulin in the immune system: ins and outs
    Malini Raghavan
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 5620, USA
    Trends Immunol 34:13-21. 2013
  3. doi request reprint TAP-inhibitors from old world primate 1-herpesviruses and their use: WO2009008713
    Malini Raghavan
    University of Michigan Medical School, Department of Microbiology and Immunology, 5641 Medical Science Building II, Ann Arbor, MI 48109 5620, USA
    Expert Opin Ther Pat 20:277-82. 2010
  4. pmc MHC class I assembly: out and about
    Malini Raghavan
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Immunol 29:436-43. 2008
  5. ncbi request reprint Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding
    P E Lapinski
    Department of Microbiology and Immunology and Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0620, USA
    J Biol Chem 276:7526-33. 2001
  6. doi request reprint Evolution of bubble clouds induced by pulsed cavitational ultrasound therapy - histotripsy
    Zhen Xu
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 55:1122-32. 2008
  7. pmc Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503
    Vilasack Thammavongsa
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109 0620, USA
    Immunogenetics 61:703-16. 2009
  8. pmc Mechanisms of function of tapasin, a critical major histocompatibility complex class I assembly factor
    Syed Monem Rizvi
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109 5620, USA
    Traffic 11:332-47. 2010
  9. pmc Direct peptide-regulatable interactions between MHC class I molecules and tapasin
    Syed Monem Rizvi
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 103:18220-5. 2006
  10. pmc Use of chimeric proteins to investigate the role of transporter associated with antigen processing (TAP) structural domains in peptide binding and translocation
    S Arora
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA
    Proc Natl Acad Sci U S A 98:7241-6. 2001

Collaborators

  • Kathleen L Collins
  • Zhen Xu
  • Naveen Bangia
  • Syed Monem Rizvi
  • Vilasack Thammavongsa
  • Natasha Del Cid
  • Laura Mancino
  • Gayatri Raghuraman
  • P E Lapinski
  • Christopher L Perria
  • Philip Edward Lapinski
  • Janice Belleisle
  • S Arora
  • Lianjun Shen
  • Chester Provoda
  • William Clay Brown
  • Larry Robert Peters
  • Ericca Stamper
  • Elise Jeffery
  • Malinda Schaefer
  • Mary Carrington
  • Tracey Filzen
  • Philip E Lapinski
  • Tracy M Filzen
  • Vijayalakshmi Rajamanickam
  • Richard Louis Cantley
  • R R Neubig

Detail Information

Publications17

  1. pmc Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens
    Natasha Del Cid
    Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e41727. 2012
    ..non-glycosylated forms of ovalbumin. Together, these results point to the redundancies in pathways for uptake of soluble and bead-associated antigens...
  2. doi request reprint Calreticulin in the immune system: ins and outs
    Malini Raghavan
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 5620, USA
    Trends Immunol 34:13-21. 2013
    ..Further investigations are important towards advancing basic knowledge of glycoprotein-folding pathways, and towards developing new cancer therapeutic strategies...
  3. doi request reprint TAP-inhibitors from old world primate 1-herpesviruses and their use: WO2009008713
    Malini Raghavan
    University of Michigan Medical School, Department of Microbiology and Immunology, 5641 Medical Science Building II, Ann Arbor, MI 48109 5620, USA
    Expert Opin Ther Pat 20:277-82. 2010
    ..However, significant optimization of therapy conditions and characterizations of eligible tumor types will be needed to further develop therapeutic use of TAP inhibitors...
  4. pmc MHC class I assembly: out and about
    Malini Raghavan
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Immunol 29:436-43. 2008
    ..We discuss recent developments relating to interactions and mechanisms of function of the various assembly factors and pathways by which exogenous antigens access MHC class I molecules...
  5. ncbi request reprint Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding
    P E Lapinski
    Department of Microbiology and Immunology and Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0620, USA
    J Biol Chem 276:7526-33. 2001
    ..Taken together, these results also suggest the possibility of distinct functions for TAP1 and TAP2 NBD during a single translocation cycle...
  6. doi request reprint Evolution of bubble clouds induced by pulsed cavitational ultrasound therapy - histotripsy
    Zhen Xu
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 55:1122-32. 2008
    ..This study furthers our understanding of the dynamics of bubble clouds induced by histotripsy...
  7. pmc Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503
    Vilasack Thammavongsa
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109 0620, USA
    Immunogenetics 61:703-16. 2009
    ..These findings suggest that compared to HLA-B*3501, a reduced intracellular peptide repertoire for HLA-B*3503 could contribute to its slower intracellular trafficking and stronger association with rapid AIDS progression...
  8. pmc Mechanisms of function of tapasin, a critical major histocompatibility complex class I assembly factor
    Syed Monem Rizvi
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109 5620, USA
    Traffic 11:332-47. 2010
    ..Furthermore, tapasin or the TAP/tapasin complex has an intrinsic ability to recruit MHC class I molecules and promote assembly, but also uses generic folding factors to enhance MHC class I recruitment and assembly...
  9. pmc Direct peptide-regulatable interactions between MHC class I molecules and tapasin
    Syed Monem Rizvi
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 103:18220-5. 2006
    ..In cells, Tpn is likely to be a direct mediator of peptide-regulated binding and release of MHC class I from the TAP complex...
  10. pmc Use of chimeric proteins to investigate the role of transporter associated with antigen processing (TAP) structural domains in peptide binding and translocation
    S Arora
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA
    Proc Natl Acad Sci U S A 98:7241-6. 2001
    ..However, our observations that TAP complexes containing two identical TAP NBDs can mediate translocation indicate that distinct properties of the nucleotide binding site per se are not essential for the TAP catalytic cycle...
  11. ncbi request reprint Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes
    Gayatri Raghuraman
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109 0620, USA
    J Biol Chem 277:41786-94. 2002
    ..The enhanced structural stability of TAP1.TAP2 complexes in the presence of tapasin might explain the observations that tapasin increases TAP protein expression levels in mammalian cells...
  12. ncbi request reprint Catalytic site modifications of TAP1 and TAP2 and their functional consequences
    Christopher L Perria
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    J Biol Chem 281:39839-51. 2006
    ..A mechanistic model involving one main active site is likely to apply to other ABC transporters that have an asymmetric distribution of catalytic site residues within the two nucleotide binding sites...
  13. ncbi request reprint HLA-B44 polymorphisms at position 116 of the heavy chain influence TAP complex binding via an effect on peptide occupancy
    Vilasack Thammavongsa
    Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor 48109 0620, USA
    J Immunol 177:3150-61. 2006
    ..Relative to HLA-B*4405, inefficient peptide loading of HLA-B*4402 is likely to underlie its stronger tapasin dependence for cell surface expression and thermostability, and its enhanced susceptibility to pathogen interference strategies...
  14. ncbi request reprint Polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein
    Vilasack Thammavongsa
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    J Biol Chem 280:33497-505. 2005
    ....
  15. ncbi request reprint A polypeptide binding conformation of calreticulin is induced by heat shock, calcium depletion, or by deletion of the C-terminal acidic region
    Syed Monem Rizvi
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Cell 15:913-23. 2004
    ..Thus, cell stress conditions that generate nonnative substrates of calreticulin also affect the conformational properties of calreticulin itself, and enhance its binding to substrates, independent of substrate glucosylation...
  16. pmc Modes of calreticulin recruitment to the major histocompatibility complex class I assembly pathway
    Natasha Del Cid
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:4520-35. 2010
    ..However, such binding sites could contribute to substrate stabilization in a step that follows the glycan and ERp57-dependent recruitment of calreticulin to the PLC...
  17. pmc Calreticulin recognizes misfolded HLA-A2 heavy chains
    Laura Mancino
    Department of Microbiology and Immunology and Immunology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 99:5931-6. 2002
    ..However, in the absence of other endoplasmic reticulum components, calreticulin by itself does not enhance the assembly of misfolded MHC class I heavy chains with beta2m and peptides...

Research Grants20

  1. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 1999
    ..Finally, analysis of TAP interactions with HLA-B27 that are proposed will provide insight into the molecular mechanisms that underlie the association of B27 with autoimmune arthritic diseases. ..
  2. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2009
    ....
  3. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2009
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
  4. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2010
    ....
  5. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2010
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
  6. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2009
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
  7. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2009
    ....
  8. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2007
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
  9. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2000
    ..Finally, analysis of TAP interactions with HLA-B27 that are proposed will provide insight into the molecular mechanisms that underlie the association of B27 with autoimmune arthritic diseases. ..
  10. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2001
    ..Finally, analysis of TAP interactions with HLA-B27 that are proposed will provide insight into the molecular mechanisms that underlie the association of B27 with autoimmune arthritic diseases. ..
  11. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2002
    ..Finally, analysis of TAP interactions with HLA-B27 that are proposed will provide insight into the molecular mechanisms that underlie the association of B27 with autoimmune arthritic diseases. ..
  12. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2003
    ..Finally, analysis of TAP interactions with HLA-B27 that are proposed will provide insight into the molecular mechanisms that underlie the association of B27 with autoimmune arthritic diseases. ..
  13. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2004
    ..Taken together, these studies will provide insights into how peptide transport into the ER, and peptide assembly with MHC class I molecules, are orchestrated within the cell ..
  14. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2005
    ..Taken together, these studies will provide insights into how peptide transport into the ER, and peptide assembly with MHC class I molecules, are orchestrated within the cell ..
  15. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2006
    ..Taken together, these studies will provide insights into how peptide transport into the ER, and peptide assembly with MHC class I molecules, are orchestrated within the cell ..
  16. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2007
    ..Taken together, these studies will provide insights into how peptide transport into the ER, and peptide assembly with MHC class I molecules, are orchestrated within the cell ..
  17. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2009
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..