Monte J Radeke

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
    Aaron M Newman
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, Biological Sciences 2 Building, University of California, Santa Barbara, CA 93106 5060, USA
    Genome Med 4:16. 2012
  2. ncbi request reprint Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid
    Monte J Radeke
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 85:366-80. 2007
  3. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010
  4. pmc Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 108:18277-82. 2011
  5. pmc The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93016, USA
    Proc Natl Acad Sci U S A 99:11830-5. 2002
  6. ncbi request reprint Evidence that ganglion cells react to retinal detachment
    Francie E Coblentz
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Exp Eye Res 76:333-42. 2003
  7. ncbi request reprint Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration
    Sergiu T Leu
    Department of Molecular, Cellular and Development Biology, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 74:141-54. 2002

Collaborators

Detail Information

Publications7

  1. pmc Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
    Aaron M Newman
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, Biological Sciences 2 Building, University of California, Santa Barbara, CA 93106 5060, USA
    Genome Med 4:16. 2012
    ..Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract..
  2. ncbi request reprint Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid
    Monte J Radeke
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 85:366-80. 2007
    ..These findings lay the groundwork for further studies into the roles of the corresponding gene products in the normal, aged, and diseased macula...
  3. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010
    ....
  4. pmc Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 108:18277-82. 2011
    ..This model system will facilitate the analysis of molecular and cellular aspects of AMD pathogenesis, and the testing of new therapeutic agents for its treatment...
  5. pmc The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93016, USA
    Proc Natl Acad Sci U S A 99:11830-5. 2002
    ..Thus, A beta deposition could be an important component of the local inflammatory events that contribute to atrophy of the retinal pigmented epithelium, drusen biogenesis, and the pathogenesis of AMD...
  6. ncbi request reprint Evidence that ganglion cells react to retinal detachment
    Francie E Coblentz
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Exp Eye Res 76:333-42. 2003
    ..Cellular remodelling of this type in response to detachment may explain the slow recovery of vision that often occurs after reattachment, or those changes that are often assumed to be permanent...
  7. ncbi request reprint Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration
    Sergiu T Leu
    Department of Molecular, Cellular and Development Biology, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 74:141-54. 2002
    ..The data lead to the speculation that high TIMP-3 concentrations within drusen could inhibit MMPs and as a result slow the proteolytic degradation of these deposits...