Gil D Rabinovici

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications
    Robert Laforce
    Memory and Aging Center, Department of Neurology, University of California San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Alzheimers Res Ther 3:31. 2011
  2. pmc Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management
    Gil D Rabinovici
    Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    CNS Drugs 24:375-98. 2010
  3. pmc Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo
    G D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Behav Neurol 21:117-28. 2009
  4. pmc Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Brain 133:512-28. 2010
  5. pmc Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 64:388-401. 2008
  6. pmc Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California, San Francisco, California 94143, USA
    Am J Alzheimers Dis Other Demen 22:474-88. 2007
  7. pmc Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD
    G D Rabinovici
    UCSF Memory and Aging Center, San Francisco, CA 94143, USA
    Neurology 77:2034-42. 2011
  8. ncbi request reprint 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California San Fransisco, San Francisco, CA 94117, USA
    Neurology 68:1205-12. 2007
  9. pmc Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals
    Miranka Wirth
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Neurosci 33:5553-63. 2013
  10. ncbi request reprint Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients
    Manja Lehmann
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA
    J Neurol Neurosurg Psychiatry 85:266-73. 2014

Detail Information

Publications32

  1. pmc Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications
    Robert Laforce
    Memory and Aging Center, Department of Neurology, University of California San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Alzheimers Res Ther 3:31. 2011
    ..We caution against screening asymptomatic individuals, and discuss the limited positive predictive value in older populations. Finally, we review limitations and unresolved questions related to this exciting new technique...
  2. pmc Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management
    Gil D Rabinovici
    Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    CNS Drugs 24:375-98. 2010
    ..However, recent advances in FTLD genetics and molecular pathology make the prospect of biologically driven, disease-specific therapies for FTLD seem closer than ever...
  3. pmc Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo
    G D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Behav Neurol 21:117-28. 2009
    ..In the future, amyloid imaging is likely to supplement clinical evaluation in selecting patients for anti-amyloid therapies, while MRI and FDG-PET may be more appropriate markers of clinical progression...
  4. pmc Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Brain 133:512-28. 2010
    ..Our data are consistent with a model in which both early amyloid-beta accumulation and increased vulnerability to amyloid-beta pathology play critical roles in the pathogenesis of Alzheimer's disease in young patients...
  5. pmc Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 64:388-401. 2008
    ....
  6. pmc Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California, San Francisco, California 94143, USA
    Am J Alzheimers Dis Other Demen 22:474-88. 2007
    ..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD...
  7. pmc Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD
    G D Rabinovici
    UCSF Memory and Aging Center, San Francisco, CA 94143, USA
    Neurology 77:2034-42. 2011
    ..To compare the diagnostic performance of PET with the amyloid ligand Pittsburgh compound B (PiB-PET) to fluorodeoxyglucose (FDG-PET) in discriminating between Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD)...
  8. ncbi request reprint 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California San Fransisco, San Francisco, CA 94117, USA
    Neurology 68:1205-12. 2007
    ..We hypothesized that PET imaging with (11)C-PIB would discriminate AD from frontotemporal lobar degeneration (FTLD), a non-Abeta dementia...
  9. pmc Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals
    Miranka Wirth
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Neurosci 33:5553-63. 2013
    ..The impact of neural integrity on cognitive functions is, however, enhanced in the presence of high Aβ burden for brain regions that are most affected in AD...
  10. ncbi request reprint Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients
    Manja Lehmann
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA
    J Neurol Neurosurg Psychiatry 85:266-73. 2014
    ..We aimed to assess the relationship between amyloid deposition, glucose metabolism and ApoE4 genotype in a clinically heterogeneous population of AD patients...
  11. ncbi request reprint Practical utility of amyloid and FDG-PET in an academic dementia center
    Pascual Sanchez-Juan
    From the Memory and Aging Center and Department of Neurology P S J, P M G, J H, B G, M H, L T G, M G T, W W S, A L B, H J R, J H K, B L M, W J J, G D R and Department of Pathology and Laboratory Medicine E J H, University of California, San Francisco University Hospital Marqués de Valdecilla, IFIMAV and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas P S J, Santander, Spain Helen Wills Neuroscience Institute P M G, W J J, G D R, University of California, Berkeley Lawrence Berkeley National Laboratory P M G, J P O, M J, W J J, G D R, Berkeley, CA Center for Neurodegenerative Research J Q T, University of Pennsylvania, Philadelphia and Department of Pathology and Laboratory Medicine H V V, University of California, Los Angeles
    Neurology 82:230-8. 2014
    ..To evaluate the effect of amyloid imaging on clinical decision making...
  12. pmc Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease
    Manja Lehmann
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 110:11606-11. 2013
    ..Our findings indicate that the posterior DMN and precuneus network are commonly affected in AD variants, whereas syndrome-specific neurodegenerative patterns are driven by the involvement of specific networks outside the DMN. ..
  13. pmc Association of lifetime cognitive engagement and low β-amyloid deposition
    Susan M Landau
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Arch Neurol 69:623-29. 2012
    ....
  14. pmc Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology
    Francesca Caso
    Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    Behav Neurol 26:95-106. 2013
    ..This patient demonstrates that biomarkers indicating brain amyloidosis should not be considered conclusive evidence that AD pathology accounts for a typical FTD clinical/anatomical syndrome...
  15. pmc Cognition, glucose metabolism and amyloid burden in Alzheimer's disease
    Ansgar J Furst
    Helen Wills Neuroscience Institute, 132 Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Neurobiol Aging 33:215-25. 2012
    ..Finally, there were no associations between regional PIB and FDG uptake. We conclude that regional and global amyloid burden does not correlate with clinical status or glucose metabolism in AD...
  16. pmc Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease
    Suzee E Lee
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, ON, Canada Department of Neurology and Neurosciences, Brain Dynamics Research Center, Dokuz Eylul University, Izmir, Turkey BEYINMER, Istanbul Kultur University, Istanbul, Turkey Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Marques de Valdecilla University Hospital, Institute for Formation and Research of the Foundation Marqués de Valdecilla IFIMAV, University of Cantabria, Cantabria, Spain Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian, Gipuzkoa, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Area 6, Institute Carlos III, Spain Neuroscience Area, Institute Biodonostia, San Sebastian, Gipuzkoa, Spain Department of Neurology, Neurobehavior Division, University of California, Los Angeles Department of Psychiatry and Neurology, University of California, Los Angeles, CA Department of Neuroscience, Mayo Clinic, Rochester, MN Department of Medicine, Weill Medical College of Cornell University
    Alzheimer Dis Assoc Disord 27:302-9. 2013
    ..These data warrant larger studies with clinicopathologic correlation to elucidate the influence of this genetic variant on neurodegenerative disease. ..
  17. pmc Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
    Manja Lehmann
    UCSF Memory and Ageing Centre, Department of Neurology, Box 1207, San Francisco, CA 94158 1207, USA
    Brain 136:844-58. 2013
    ....
  18. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  19. pmc ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease
    Keith A Vossel
    Department of Neurology, University of California, San Francisco, CA, USA
    Neurocase 19:295-301. 2013
    ..Although differences seen in a sibling pair could arise due to chance, these findings raise the possibility that apoE4 exacerbates brain pathology in FTLD through formation of neurotoxic apoE fragments and interactions with TDP-43...
  20. ncbi request reprint Seizures and epileptiform activity in the early stages of Alzheimer disease
    Keith A Vossel
    Gladstone Institute of Neurological Disease, San Francisco, California2Memory and Aging Center, Department of Neurology, University of California, San Francisco, California
    JAMA Neurol 70:1158-66. 2013
    ..We report key features of AD-related seizures and epileptiform activity that are instructive for clinical practice and highlight similarities between AD and transgenic animal models of the disease...
  21. pmc Sporadic corticobasal syndrome due to FTLD-TDP
    Maria Carmela Tartaglia
    Memory and Aging Center, Department of Neurology, University of California, 1207, 350 Parnassus Ave, Ste 905, San Francisco, CA 94143 1207, USA
    Acta Neuropathol 119:365-74. 2010
    ..These findings confirm that FTLD-TDP should be included in the pathological differential diagnosis for sporadic CBS...
  22. pmc Clinicopathological correlations in corticobasal degeneration
    Suzee E Lee
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 70:327-40. 2011
    ..To characterize cognitive and behavioral features, physical findings, and brain atrophy patterns in pathology-proven corticobasal degeneration (CBD) and corticobasal syndrome (CBS) with known histopathology...
  23. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  24. pmc Seizures in corticobasal degeneration: a case report
    Vanja C Douglas
    University of California Department of Neurology Box 0114 400 Parnassus Ave, 8th Floor Neurology Clinic San Franciso, CA 94143 0114, USA
    Neurocase 15:352-6. 2009
    ..Thus, the occurrence of seizures in a patient with dementia should not exclude the diagnosis of CBD...
  25. ncbi request reprint Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease
    A L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Neurology 69:283-90. 2007
    ..To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD)...
  26. pmc White matter atrophy in Alzheimer's disease variants
    Raffaella Migliaccio
    Memory and Aging Center, Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Alzheimers Dement 8:S78-87.e1-2. 2012
    ..Severe hemispheric gray matter (GM) atrophy associated with EOAD, lv-PPA, and PCA has been described, but regional patterns of white matter (WM) damage are still poorly understood...
  27. pmc Handedness and language learning disability differentially distribute in progressive aphasia variants
    Zachary A Miller
    1 Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Brain 136:3461-73. 2013
    ..Taken together, this study suggests that neurodevelopmental signatures impart differential trajectories towards neurodegenerative disease. ..
  28. pmc Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion
    Baber K Khan
    Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    J Neurol Neurosurg Psychiatry 83:358-64. 2012
    ..Here, two patients with bvFTD-SP with chromosome 9 open reading frame 72 (C9ORF72) hexanucleotide expansions are described...
  29. pmc Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum
    R Migliaccio
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Neurology 73:1571-8. 2009
    ..We compared PCA and LPA to each other and to an age-matched group of patients with early age at onset of Alzheimer disease (EO-AD). We hypothesized that these 3 syndromes are part of a single clinical and biologic continuum...
  30. pmc Donepezil-associated bradyarrhythmia in a patient with dementia with Lewy bodies (DLB)
    Michael H Rosenbloom
    Department of Neurology, University of California, San Francisco Memory and Aging Center, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:209-11. 2010
    ..Owing to underlying autonomic dysfunction, patients with DLB may be at increased risk of bradyarrhythmia resulting from treatment with acetylcholinesterase inhibitors...
  31. pmc Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration
    E J Kim
    Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA
    J Neurol Neurosurg Psychiatry 78:1375-8. 2007
    ..Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo...
  32. ncbi request reprint First symptom in sporadic Creutzfeldt-Jakob disease
    G D Rabinovici
    Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 66:286-7. 2006