Research Topics
Species | Gil D RabinoviciSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applicationsRobert Laforce
Memory and Aging Center, Department of Neurology, University of California San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
Alzheimers Res Ther 3:31. 2011..We caution against screening asymptomatic individuals, and discuss the limited positive predictive value in older populations. Finally, we review limitations and unresolved questions related to this exciting new technique...- Amyloid vs FDG-PET in the differential diagnosis of AD and FTLDG D Rabinovici
UCSF Memory and Aging Center, San Francisco, CA 94143, USA
Neurology 77:2034-42. 2011..To compare the diagnostic performance of PET with the amyloid ligand Pittsburgh compound B (PiB-PET) to fluorodeoxyglucose (FDG-PET) in discriminating between Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD)... - Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burdenGil D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Brain 133:512-28. 2010..Our data are consistent with a model in which both early amyloid-beta accumulation and increased vulnerability to amyloid-beta pathology play critical roles in the pathogenesis of Alzheimer's disease in young patients... - Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivoG D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Behav Neurol 21:117-28. 2009..In the future, amyloid imaging is likely to supplement clinical evaluation in selecting patients for anti-amyloid therapies, while MRI and FDG-PET may be more appropriate markers of clinical progression... - Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and managementGil D Rabinovici
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
CNS Drugs 24:375-98. 2010..However, recent advances in FTLD genetics and molecular pathology make the prospect of biologically driven, disease-specific therapies for FTLD seem closer than ever... - Abeta amyloid and glucose metabolism in three variants of primary progressive aphasiaGil D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Ann Neurol 64:388-401. 2008.... - Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degenerationG D Rabinovici
Memory and Aging Center, University of California, San Francisco, California 94143, USA
Am J Alzheimers Dis Other Demen 22:474-88. 2007..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD... 
11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degenerationG D Rabinovici
Memory and Aging Center, University of California San Fransisco, San Francisco, CA 94117, USA
Neurology 68:1205-12. 2007..We hypothesized that PET imaging with (11)C-PIB would discriminate AD from frontotemporal lobar degeneration (FTLD), a non-Abeta dementia...- Association of lifetime cognitive engagement and low β-amyloid depositionSusan M Landau
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Arch Neurol 69:623-29. 2012.... - Cognition, glucose metabolism and amyloid burden in Alzheimer's diseaseAnsgar J Furst
Helen Wills Neuroscience Institute, 132 Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
Neurobiol Aging 33:215-25. 2012..Finally, there were no associations between regional PIB and FDG uptake. We conclude that regional and global amyloid burden does not correlate with clinical status or glucose metabolism in AD... - Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's diseaseManja Lehmann
UCSF Memory and Ageing Centre, Department of Neurology, Box 1207, San Francisco, CA 94158 1207, USA
Brain 136:844-58. 2013.... - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - Clinicopathological correlations in corticobasal degenerationSuzee E Lee
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Ann Neurol 70:327-40. 2011..To characterize cognitive and behavioral features, physical findings, and brain atrophy patterns in pathology-proven corticobasal degeneration (CBD) and corticobasal syndrome (CBS) with known histopathology... - Sporadic corticobasal syndrome due to FTLD-TDPMaria Carmela Tartaglia
Memory and Aging Center, Department of Neurology, University of California, 1207, 350 Parnassus Ave, Ste 905, San Francisco, CA 94143 1207, USA
Acta Neuropathol 119:365-74. 2010..These findings confirm that FTLD-TDP should be included in the pathological differential diagnosis for sporadic CBS... - ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron diseaseKeith A Vossel
a Department of Neurology, University of California, San Francisco, CA, USA
Neurocase . 2012..Although differences seen in a sibling pair could arise due to chance, these findings raise the possibility that apoE4 exacerbates brain pathology in FTLD through formation of neurotoxic apoE fragments and interactions with TDP-43... - Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's diseaseJuan Zhou
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
Brain 133:1352-67. 2010..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring... - Seizures in corticobasal degeneration: a case reportVanja C Douglas
University of California Department of Neurology Box 0114 400 Parnassus Ave, 8th Floor Neurology Clinic San Franciso, CA 94143 0114, USA
Neurocase 15:352-6. 2009..Thus, the occurrence of seizures in a patient with dementia should not exclude the diagnosis of CBD... - Amyloid imaging in distinguishing atypical prion disease from Alzheimer diseaseA L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 69:283-90. 2007..To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD)... 
White matter atrophy in Alzheimer's disease variantsRaffaella Migliaccio
Memory and Aging Center, Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Alzheimers Dement 8:S78-87.e1-2. 2012..Severe hemispheric gray matter (GM) atrophy associated with EOAD, lv-PPA, and PCA has been described, but regional patterns of white matter (WM) damage are still poorly understood...- Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not β-Amyloid in Cognitively Normal Older IndividualsMiranka Wirth
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, and Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94117
J Neurosci 33:5553-63. 2013..The impact of neural integrity on cognitive functions is, however, enhanced in the presence of high Aβ burden for brain regions that are most affected in AD... - Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathologyFrancesca Caso
Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
Behav Neurol 26:95-106. 2013..This patient demonstrates that biomarkers indicating brain amyloidosis should not be considered conclusive evidence that AD pathology accounts for a typical FTD clinical/anatomical syndrome... - Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansionBaber K Khan
Department of Neurology, University of California San Francisco, San Francisco, CA, USA
J Neurol Neurosurg Psychiatry 83:358-64. 2012..Here, two patients with bvFTD-SP with chromosome 9 open reading frame 72 (C9ORF72) hexanucleotide expansions are described... - Clinical syndromes associated with posterior atrophy: early age at onset AD spectrumR Migliaccio
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 73:1571-8. 2009..We compared PCA and LPA to each other and to an age-matched group of patients with early age at onset of Alzheimer disease (EO-AD). We hypothesized that these 3 syndromes are part of a single clinical and biologic continuum... - Donepezil-associated bradyarrhythmia in a patient with dementia with Lewy bodies (DLB)Michael H Rosenbloom
Department of Neurology, University of California, San Francisco Memory and Aging Center, San Francisco, CA, USA
Alzheimer Dis Assoc Disord 24:209-11. 2010..Owing to underlying autonomic dysfunction, patients with DLB may be at increased risk of bradyarrhythmia resulting from treatment with acetylcholinesterase inhibitors... - Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degenerationE J Kim
Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA
J Neurol Neurosurg Psychiatry 78:1375-8. 2007..Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo... - First symptom in sporadic Creutzfeldt-Jakob diseaseG D Rabinovici
Department of Neurology, University of California, San Francisco, CA, USA
Neurology 66:286-7. 2006