Affiliation: University of California
- Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic miceL Villasana
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
Radiats Biol Radioecol 48:167-70. 2008....
- Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of femalesJ Raber
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94141 9100, USA
Proc Natl Acad Sci U S A 95:10914-9. 1998..These results could be pertinent to cognitive impairments observed in human APOE epsilon4 carriers. NSE-apoE mice and similar models may facilitate the preclinical assessment of treatments for apoE-related cognitive deficits...
- Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterationsJ Raber
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
J Neurosci 20:2064-71. 2000..These results support a key role for apoE in the tonic inhibition of steroidogenesis and HPA axis activity and have important implications for the behavioral analysis of Apoe(-/-) mice...
- Apolipoprotein E and cognitive performanceJ Raber
Gladstone Institute of Neurological Disease, University of California, San Francisco 94141 9100, USA
Nature 404:352-4. 2000
- Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DgatS J Smith
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
Nat Genet 25:87-90. 2000..Our findings indicate that multiple mechanisms exist for triglyceride synthesis and suggest that the selective inhibition of Dgat-mediated triglyceride synthesis may be useful for treating obesity...
- Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effectsJ Raber
Gladstone Molecular Neurobiology Program and the Department of Neurology, University of California, San Francisco, California 94141 9100, USA
J Biol Chem 272:15057-60. 1997..An imbalance between the effects of OB on corticotropin-releasing factor release from the hypothalamus and on adrenocorticotrophic hormone release from the pituitary could contribute to obesity...
- Effects of sex and APOE epsilon4 on object recognition and spatial navigation in the elderlyF Berteau-Pavy
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Neuroscience 147:6-17. 2007..In men, salivary cortisol levels correlated with object recognition. These results show that object recognition and spatial navigation tests are useful to assess cognitive function in the elderly...
- Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivityT S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, 97239, USA
Neuroscience 137:413-23. 2006..Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice...
- Role of H(3) receptor-mediated signaling in cognitionG Bongers
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
Inflamm Res 53:S51-2. 2004
- Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthaseJ Raber
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Virology 226:362-73. 1996..These findings demonstrate that CNS expression of a viral envelope protein can activate the HPA axis and thereby alter peripheral levels of immunomodulatory hormones...
- Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuliX Xu
Gladstone Molecular Neurobiology Program and Department of Neurology, University of California, San Francisco, CA 94141, USA
Proc Natl Acad Sci U S A 94:12655-60. 1997..In contrast, the high baseline activity of JNK in the brain and the activation of the JNK cascade by environmental stimuli suggest that this kinase may play an important physiological role in neuronal function...
- Nitric oxide is not involved in the control of vasopressin release during acute forced swimming in ratsM Engelmann
Institut für Medizinische Neurobiologie, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
Amino Acids 26:37-43. 2004..Increased nNOS mRNA in the SON after forced swimming and the increase in AVP release in the presence of exogenous NO under forced swimming points to a possible role of NO in the regulation of the HNS under repeated stressor exposure...