Alexander Rabchevsky

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Efficacy of methylprednisolone therapy for the injured rat spinal cord
    Alexander G Rabchevsky
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci Res 68:7-18. 2002
  2. pmc Latest approaches for the treatment of spasticity and autonomic dysreflexia in chronic spinal cord injury
    Alexander G Rabchevsky
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Neurotherapeutics 8:274-82. 2011
  3. pmc Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury
    A G Rabchevsky
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Spinal Cord 49:99-105. 2011
  4. doi request reprint Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward?
    Alexander G Rabchevsky
    Spinal Cord and Brain Injury Research Center, Lexington, University of Kentucky, KY 40536 0509, USA
    Pharmacol Ther 132:15-29. 2011
  5. ncbi request reprint Temporal-spatial dynamics in oligodendrocyte and glial progenitor cell numbers throughout ventrolateral white matter following contusion spinal cord injury
    Alexander G Rabchevsky
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    Glia 55:831-43. 2007
  6. ncbi request reprint Creatine diet supplement for spinal cord injury: influences on functional recovery and tissue sparing in rats
    Alexander G Rabchevsky
    Sanders Brown Center on Aging, Department of Physiology, University of Kentucky, 236 Health Sciences Research Building, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 20:659-69. 2003
  7. pmc Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury
    Alexander G Rabchevsky
    University of Kentucky, Spinal Cord and Brain Injury Research Center and Department of Physiology, 741 South Limestone Street, B371 BBSRB, Lexington, KY 40536 0509, USA
    Prog Brain Res 152:265-74. 2006
  8. pmc Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia
    Adrian A Cameron
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 26:2923-32. 2006
  9. ncbi request reprint Temporal characterization of mitochondrial bioenergetics after spinal cord injury
    Patrick G Sullivan
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 24:991-9. 2007
  10. pmc Noxious colorectal distention in spinalized rats reduces pseudorabies virus labeling of sympathetic neurons
    Hanad Duale
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 27:1369-78. 2010

Research Grants

  1. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander Rabchevsky; Fiscal Year: 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Efficacy of methylprednisolone therapy for the injured rat spinal cord
    Alexander G Rabchevsky
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci Res 68:7-18. 2002
    ..Equally important, our results caution the use of lesion volume dimensions or percent tissue sparing at the epicenter as indicators of therapeutic efficacy because neither reflects the actual amount of tissue sparing...
  2. pmc Latest approaches for the treatment of spasticity and autonomic dysreflexia in chronic spinal cord injury
    Alexander G Rabchevsky
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Neurotherapeutics 8:274-82. 2011
    ....
  3. pmc Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury
    A G Rabchevsky
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Spinal Cord 49:99-105. 2011
    ....
  4. doi request reprint Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward?
    Alexander G Rabchevsky
    Spinal Cord and Brain Injury Research Center, Lexington, University of Kentucky, KY 40536 0509, USA
    Pharmacol Ther 132:15-29. 2011
    ....
  5. ncbi request reprint Temporal-spatial dynamics in oligodendrocyte and glial progenitor cell numbers throughout ventrolateral white matter following contusion spinal cord injury
    Alexander G Rabchevsky
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    Glia 55:831-43. 2007
    ....
  6. ncbi request reprint Creatine diet supplement for spinal cord injury: influences on functional recovery and tissue sparing in rats
    Alexander G Rabchevsky
    Sanders Brown Center on Aging, Department of Physiology, University of Kentucky, 236 Health Sciences Research Building, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 20:659-69. 2003
    ..The relationship between the efficacy of creatine and the magnitude of the insults is discussed...
  7. pmc Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury
    Alexander G Rabchevsky
    University of Kentucky, Spinal Cord and Brain Injury Research Center and Department of Physiology, 741 South Limestone Street, B371 BBSRB, Lexington, KY 40536 0509, USA
    Prog Brain Res 152:265-74. 2006
    ..These responses are manifested as autonomic dysreflexia...
  8. pmc Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia
    Adrian A Cameron
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 26:2923-32. 2006
    ..These results demonstrate that site-directed genetic manipulation of axon guidance molecules after complete spinal cord injury can alter endogenous circuitry to modulate plasticity-induced autonomic pathophysiology...
  9. ncbi request reprint Temporal characterization of mitochondrial bioenergetics after spinal cord injury
    Patrick G Sullivan
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 24:991-9. 2007
    ..Based on the present results, the temporal profile of mitochondrial dysfunction indicates that interventions targeting mitochondrial oxidative damage and dysfunction may serve as a beneficial pharmacological treatment for acute SCI...
  10. pmc Noxious colorectal distention in spinalized rats reduces pseudorabies virus labeling of sympathetic neurons
    Hanad Duale
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 27:1369-78. 2010
    ....
  11. pmc Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transection
    Shaoping Hou
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Comp Neurol 509:382-99. 2008
    ....
  12. ncbi request reprint Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions
    Patrick G Sullivan
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Comp Neurol 474:524-34. 2004
    ....
  13. ncbi request reprint Rat models of traumatic spinal cord injury to assess motor recovery
    Stephen M Onifer
    Spinal Cord and Brain Injury Research Center, Biomedical and Biological Sciences Research Building, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536 0509, USA
    ILAR J 48:385-95. 2007
    ....
  14. ncbi request reprint Experimental modeling of spinal cord injury: characterization of a force-defined injury device
    Stephen W Scheff
    The Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neurotrauma 20:179-93. 2003
    ..This novel rodent model of SCI provides a significant improvement over existing devices for SCI by reducing variability with a constant preset force to define the injury...
  15. pmc Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury
    Samir P Patel
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neurochem 114:291-301. 2010
    ..05) spared gray matter. In summary, ALC treatment maintains mitochondrial bioenergetics following contusion SCI and, thus, holds great potential as a neuroprotective therapy for acute SCI...
  16. pmc Spinal cord injury reduces the efficacy of pseudorabies virus labeling of sympathetic preganglionic neurons
    Hanad Duale
    Spinal Cord and Brain Injury Research Center, and Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neuropathol Exp Neurol 68:168-78. 2009
    ..These results question whether spinal cord injury exclusively retards PRV expression and/or transport or whether this injury broadly affects host cell-viral interactions...
  17. doi request reprint Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury
    Samir P Patel
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    J Neurosci Res 87:130-40. 2009
    ..Moreover, they indicate that combinatorial therapeutic approaches targeting different populations of mitochondria holds great potential in fostering neuroprotection after acute SCI...
  18. ncbi request reprint Role of peroxynitrite in secondary oxidative damage after spinal cord injury
    Yiqin Xiong
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Lexington, KY 40536, USA
    J Neurochem 100:639-49. 2007
    ..Scavengers of PON, or its derived free radical species, may provide an improved antioxidant neuroprotective approach for the treatment of post-traumatic oxidative damage in the injured spinal cord...
  19. doi request reprint Targeting axon growth from neuronal transplants along preformed guidance pathways in the adult CNS
    Kristine S Ziemba
    Spinal Cord and Brain Injury Research Center, and Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 28:340-8. 2008
    ..These results show that judicious expression of neuron-specific chemoattractant and chemorepellant molecules using viral vectors can support and target axon growth from neuronal transplants in the adult CNS...
  20. pmc Electrophysiological characteristics of identified kidney-related neurons in adult rat spinal cord slices
    Andrei V Derbenev
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 474:168-72. 2010
    ..Combined PRV-152 pre-labeling and whole-cell patch-clamp recordings may allow more effective analysis of synaptic plasticity seen in adult models of injury or chronic disease...

Research Grants5

  1. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander Rabchevsky; Fiscal Year: 2007
    ..This information will form the basis for developing potential treatments for this common and debilitating complication of SCI. ..