Richard D Rabbitt

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Evidence of piezoelectric resonance in isolated outer hair cells
    R D Rabbitt
    Department of Bioengineering, University of Utah, 506 BPRB 20 South, 2030 East Salt Lake City, UT 84112, USA
    Biophys J 88:2257-65. 2005
  2. pmc Hair-cell versus afferent adaptation in the semicircular canals
    R D Rabbitt
    University of Utah, Dept of Bioengineering, 20 South, 2030 East Room 506 BPRB, Salt Lake City, UT 84112, USA
    J Neurophysiol 93:424-36. 2005
  3. pmc Ionic composition of endolymph and perilymph in the inner ear of the oyster toadfish, Opsanus tau
    Tamer A Ghanem
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    Biol Bull 214:83-90. 2008
  4. pmc Mechanical amplification by hair cells in the semicircular canals
    Richard D Rabbitt
    University of Utah, Salt Lake City, UT 84013, USA
    Proc Natl Acad Sci U S A 107:3864-9. 2010
  5. ncbi request reprint How endolymph pressure modulates semicircular canal primary afferent discharge
    R D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 942:313-21. 2001
  6. ncbi request reprint Physiology of the semicircular canals after surgical plugging
    R D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 942:274-86. 2001
  7. pmc Dynamic displacement of normal and detached semicircular canal cupula
    Richard D Rabbitt
    Department of Bioengineering, University of Utah, 72 South Central Campus Dr, Rm 2646, Salt Lake City, UT, 84112, USA
    J Assoc Res Otolaryngol 10:497-509. 2009
  8. pmc Afferent responses during experimentally induced semicircular canalithiasis
    Suhrud M Rajguru
    Department of Bioengineering, University of Utah, 20 South 2030 East, Rm 506, Salt Lake City, UT 84112, USA
    J Neurophysiol 97:2355-63. 2007
  9. pmc The passive cable properties of hair cell stereocilia and their contribution to somatic capacitance measurements
    Kathryn D Breneman
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    Biophys J 96:1-8. 2009
  10. pmc Monitoring voltage-dependent charge displacement of Shaker B-IR K+ ion channels using radio frequency interrogation
    Sameera Dharia
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e17363. 2011

Research Grants

  1. Micro-Electric Impedance Spectroscopy of Hair Cells
    Richard Rabbitt; Fiscal Year: 2009
  2. Biomechanics of the Semicircular Canals
    Richard Rabbitt; Fiscal Year: 2007
  3. Micro-Electric Impedance Spectroscopy of Hair Cells
    Richard Rabbitt; Fiscal Year: 2004
  4. Biomechanics of the Semicircular Canals
    Richard D Rabbitt; Fiscal Year: 2010

Detail Information

Publications29

  1. pmc Evidence of piezoelectric resonance in isolated outer hair cells
    R D Rabbitt
    Department of Bioengineering, University of Utah, 506 BPRB 20 South, 2030 East Salt Lake City, UT 84112, USA
    Biophys J 88:2257-65. 2005
    ..These resonance data further support the piezoelectric theory of OHC function, and implicate piezoelectricity in the broad-band electromechanical behavior of OHCs underlying mammalian cochlear function...
  2. pmc Hair-cell versus afferent adaptation in the semicircular canals
    R D Rabbitt
    University of Utah, Dept of Bioengineering, 20 South, 2030 East Room 506 BPRB, Salt Lake City, UT 84112, USA
    J Neurophysiol 93:424-36. 2005
    ....
  3. pmc Ionic composition of endolymph and perilymph in the inner ear of the oyster toadfish, Opsanus tau
    Tamer A Ghanem
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    Biol Bull 214:83-90. 2008
    ....
  4. pmc Mechanical amplification by hair cells in the semicircular canals
    Richard D Rabbitt
    University of Utah, Salt Lake City, UT 84013, USA
    Proc Natl Acad Sci U S A 107:3864-9. 2010
    ..The biophysical basis of the motor(s) remains hypothetical, but a key discriminating question may involve how changes in somatic electrical impedance evoked by efferent synaptic action alter function of the motor(s)...
  5. ncbi request reprint How endolymph pressure modulates semicircular canal primary afferent discharge
    R D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 942:313-21. 2001
    ..Results demonstrate that the semicircular canals are indeed sensitive to small changes in translabyrinthine pressure in addition to head-movement-related changes in transcupular pressure...
  6. ncbi request reprint Physiology of the semicircular canals after surgical plugging
    R D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 942:274-86. 2001
    ..Plug-canal responses are quantitatively described in terms of biomechanics of the deformable labyrinth...
  7. pmc Dynamic displacement of normal and detached semicircular canal cupula
    Richard D Rabbitt
    Department of Bioengineering, University of Utah, 72 South Central Campus Dr, Rm 2646, Salt Lake City, UT, 84112, USA
    J Assoc Res Otolaryngol 10:497-509. 2009
    ..Partially detached cupulae reattached and normal afferent discharge patterns were recovered 5-7 h following detachment. This regeneration process may have relevance to the recovery of semicircular canal function following head trauma...
  8. pmc Afferent responses during experimentally induced semicircular canalithiasis
    Suhrud M Rajguru
    Department of Bioengineering, University of Utah, 20 South 2030 East, Rm 506, Salt Lake City, UT 84112, USA
    J Neurophysiol 97:2355-63. 2007
    ..The magnitude and time course of the responses reported here are sufficient to explain the symptoms of BPPV...
  9. pmc The passive cable properties of hair cell stereocilia and their contribution to somatic capacitance measurements
    Kathryn D Breneman
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    Biophys J 96:1-8. 2009
    ..This potential drop is proportional to the intracellular resistance and stereocilium tip conductance and can produce a maximum capacitance error on the order of fF for single stereocilia and pF for the bundle...
  10. pmc Monitoring voltage-dependent charge displacement of Shaker B-IR K+ ion channels using radio frequency interrogation
    Sameera Dharia
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e17363. 2011
    ....
  11. pmc Power efficiency of outer hair cell somatic electromotility
    Richard D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Comput Biol 5:e1000444. 2009
    ..The high power efficiency, tuning, and efferent control of outer hair cells are the direct result of biophysical properties of the cells, thus providing the physical basis for the remarkable sensitivity and selectivity of hearing...
  12. pmc Biomechanics of horizontal canal benign paroxysmal positional vertigo
    Suhrud M Rajguru
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Vestib Res 15:203-14. 2005
    ..The model was further applied to assess the efficacy of a 360 degrees -rotation CRP for the treatment of canalithiasis HC-BPPV...
  13. pmc The role of 3-canal biomechanics in angular motion transduction by the human vestibular labyrinth
    Marytheresa A Ifediba
    Department of Bioengineering, University of Utah, 20 South 2030 East, Salt Lake City, UT 84112, USA
    Ann Biomed Eng 35:1247-63. 2007
    ..Finally, parameter studies indicate that changes in canal cross-sectional area and shape only moderately affect canal temporal and directional coding, while three-canal orientation is critical to directional coding...
  14. pmc Single cell electric impedance topography: mapping membrane capacitance
    Sameera Dharia
    Department of Bioengineering, University of Utah, 72 South Central Campus Dr, Salt Lake City, UT 84112, USA
    Lab Chip 9:3370-7. 2009
    ..In addition, the same circumferential array was used to map the size of the extracellular electrical shunt path around the cell, providing a means to estimate the location and shape of the cell in the recording chamber...
  15. doi request reprint Monitoring voltage-sensitive membrane impedance change using radio frequency interrogation
    Sameera Dharia
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:889-94. 2010
    ....
  16. pmc Relationship between inner-ear fluid pressure and semicircular canal afferent nerve discharge
    A Yamauchi
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    J Assoc Res Otolaryngol 3:26-44. 2002
    ..This explanation is consistent with predictions of a finite element model of the end organ. Results have implications regarding the role of deltaP in angular motion transduction and the role of P0 under transient hydropic conditions...
  17. pmc Electrically evoking and electrochemically resolving quantal release on a microchip
    Gregory M Dittami
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84118, USA
    Lab Chip 10:30-5. 2010
    ..Analysis of spike population statistics suggested detection of catecholamines from multiple release sites around the cells. The potential for such a device to be used in flow cytometry to evoke and detect exocytosis was demonstrated...
  18. ncbi request reprint Directional coding of three-dimensional movements by the vestibular semicircular canals
    R D Rabbitt
    Department of Bioengineering, University of Utah Salt Lake City 84112, USA
    Biol Cybern 80:417-31. 1999
    ..Results may have implications regarding the central representation of angular head movements in space as well as the neuronal mappings between three-canal afferent inputs and motor outputs...
  19. ncbi request reprint Three-dimensional reconstruction of the membranous vestibular labyrinth in the toadfish, Opsanus tau
    T A Ghanem
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Hear Res 124:27-43. 1998
    ..Ten micrometer histological sections of the material were also prepared to measure wall thickness in various regions of the labyrinth...
  20. ncbi request reprint Determinants of semicircular canal afferent response dynamics in fish
    R D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 781:213-43. 1996
    ..HG afferents fall between these two extremes, and, other than the influence of the mechanical lower-corner, their response primarily reflects PTC processing...
  21. ncbi request reprint Three-dimensional biomechanical model of benign paroxysmal positional vertigo
    Suhrud M Rajguru
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Ann Biomed Eng 32:831-46. 2004
    ..Results further illustrate the effectiveness of the Epley CRP in repositioning the particles and relieving the symptoms of the canalithiasis type of BPPV...
  22. pmc Intracellular calcium transients evoked by pulsed infrared radiation in neonatal cardiomyocytes
    Gregory M Dittami
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Physiol 589:1295-306. 2011
    ..Results support the hypothesis that 1862 nm pulsed IR modulates mitochondrial Ca2+ transport primarily through actions on mCU and mNCX...
  23. pmc Hair cell bundles: flexoelectric motors of the inner ear
    Kathryn D Breneman
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 4:e5201. 2009
    ....
  24. pmc Efferent modulation of hair cell function
    Richard D Rabbitt
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA
    Curr Opin Otolaryngol Head Neck Surg 19:376-81. 2011
    ..This review covers the articles published between 2010 and early 2011 that presented new findings on inner-ear efferents and their ability to modulate hair cell function...
  25. pmc Photometric recording of transmembrane potential in outer hair cells
    Takashi Nakagawa
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Neural Eng 3:79-86. 2006
    ..Results are consistent with the hypothesis that OHCs exhibit inhomogeneous membrane potentials that vary with position in analogy with the voltage in nerve axons...
  26. pmc Determinants of spatial and temporal coding by semicircular canal afferents
    Stephen M Highstein
    Washington University School of Medicine, Department of Otolaryngology, St Louis, MO 63110, USA
    J Neurophysiol 93:2359-70. 2005
    ..The evidence for this conclusion is reviewed below...
  27. pmc Convergence of excitatory and inhibitory hair cell transmitters shapes vestibular afferent responses
    Gay R Holstein
    Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:15766-71. 2004
    ..Results demonstrate that gamma-aminobutyric acid participates in shaping the temporal dynamics of afferent responses...
  28. ncbi request reprint Gamma-aminobutyric acid is present in a spatially discrete subpopulation of hair cells in the crista ampullaris of the toadfish Opsanus tau
    Gay R Holstein
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 471:1-10. 2004
    ..These observations, together with the excitatory activity generally associated with 8th nerve afferent fibers, strongly suggest that GABA serves an important, specific, and complex role in determining primary afferent response dynamics...
  29. ncbi request reprint Strain measurement in coronary arteries using intravascular ultrasound and deformable images
    Alexander I Veress
    Department of Bioengineering, Department of Radiology, University of Utah, 50 South Central Campus Drive, Room 2480, Salt Lake City, Utah 84112 9202, USA
    J Biomech Eng 124:734-41. 2002
    ....

Research Grants15

  1. Micro-Electric Impedance Spectroscopy of Hair Cells
    Richard Rabbitt; Fiscal Year: 2009
    ..Dr. Rabbitt, Professor of Bioengineering at the University of Utah, will direct the BRP team. ..
  2. Biomechanics of the Semicircular Canals
    Richard Rabbitt; Fiscal Year: 2007
    ..abstract_text> ..
  3. Micro-Electric Impedance Spectroscopy of Hair Cells
    Richard Rabbitt; Fiscal Year: 2004
    ..Multi-electrode mu EIT systems will be fabricated, instrumented, tested and applied to image the spatio-temporal distribution and response dynamics of hair cell plasma and major organelle membranes by the end of year 4. ..
  4. Biomechanics of the Semicircular Canals
    Richard D Rabbitt; Fiscal Year: 2010
    ....