Paul M Quinton

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Salivary secretion assay for drug efficacy for cystic fibrosis in mice
    John Adam Best
    University of California, San Diego, Department of Pediatrics, 9500 Gilman Drive, La Jolla, CA 92093 0831, USA
    Exp Physiol 90:189-93. 2005
  2. doi request reprint Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis
    Paul M Quinton
    Department of Pediatrics, University of California, San Diego School of Medicine, and Biomedical Sciences, University of California, Riverside UCR, La Jolla, CA 92093, USA
    Lancet 372:415-7. 2008
  3. pmc Surface fluid absorption and secretion in small airways
    A K M Shamsuddin
    Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0830, USA
    J Physiol 590:3561-74. 2012
  4. ncbi request reprint Too much salt, too little soda: cystic fibrosis
    Paul M Quinton
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0831, USA
    Sheng Li Xue Bao 59:397-415. 2007
  5. ncbi request reprint Cystic fibrosis: lessons from the sweat gland
    Paul M Quinton
    Biomedical Sciences, University of California, Riverside, USA
    Physiology (Bethesda) 22:212-25. 2007
  6. pmc Predominant constitutive CFTR conductance in small airways
    Xiaofei Wang
    Dept, Pediatrics, Medical School, University of California, San Diego, San Diego, CA USA
    Respir Res 6:7. 2005
  7. ncbi request reprint Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts
    X F Wang
    Department of Pediatrics, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0831, USA
    Exp Physiol 89:417-25. 2004
  8. pmc Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis
    Paul M Quinton
    Department of Pediatrics, Rady Children s Hospital, University of California San Diego School of Medicine, La Jolla, California 92093 0830, USA
    Am J Physiol Cell Physiol 299:C1222-33. 2010
  9. pmc A new role for bicarbonate secretion in cervico-uterine mucus release
    Ruth W Muchekehu
    Department of Pediatrics 0830, School of Medicine, University of California San Diego, La Jolla, CA 92093 0830, USA
    J Physiol 588:2329-42. 2010
  10. pmc Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion
    Mary Abigail S Garcia
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California School of Medicine, San Diego, California 92093 0831, USA
    J Clin Invest 119:2613-22. 2009

Research Grants

  1. CL-/HCO3- EXCHANGE IN CYSTIC FIBROSIS SWEAT GLANDS
    Paul Quinton; Fiscal Year: 2001
  2. Electroyte Transport in Small Airways
    Paul Quinton; Fiscal Year: 2007
  3. Electroyte Transport in Small Airways
    Paul Quinton; Fiscal Year: 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Salivary secretion assay for drug efficacy for cystic fibrosis in mice
    John Adam Best
    University of California, San Diego, Department of Pediatrics, 9500 Gilman Drive, La Jolla, CA 92093 0831, USA
    Exp Physiol 90:189-93. 2005
    ..The data indicate that salivary secretory rates in CF mice could be used to assay potential drugs for their effectiveness in correcting the secretory defect in cystic fibrosis...
  2. doi request reprint Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis
    Paul M Quinton
    Department of Pediatrics, University of California, San Diego School of Medicine, and Biomedical Sciences, University of California, Riverside UCR, La Jolla, CA 92093, USA
    Lancet 372:415-7. 2008
    ..If the hypothesis is valid, pathogenesis in cystic fibrosis could be due as much to defective transport of HCO(3)(-) as to defective Cl(-) transport...
  3. pmc Surface fluid absorption and secretion in small airways
    A K M Shamsuddin
    Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0830, USA
    J Physiol 590:3561-74. 2012
    ....
  4. ncbi request reprint Too much salt, too little soda: cystic fibrosis
    Paul M Quinton
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0831, USA
    Sheng Li Xue Bao 59:397-415. 2007
    ..Consequently, we conclude by considering possible mechanisms by which defects in anion transport might predispose the CF lung to chronic infections...
  5. ncbi request reprint Cystic fibrosis: lessons from the sweat gland
    Paul M Quinton
    Biomedical Sciences, University of California, Riverside, USA
    Physiology (Bethesda) 22:212-25. 2007
    ..The sweat gland has taught us much...
  6. pmc Predominant constitutive CFTR conductance in small airways
    Xiaofei Wang
    Dept, Pediatrics, Medical School, University of California, San Diego, San Diego, CA USA
    Respir Res 6:7. 2005
    ....
  7. ncbi request reprint Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts
    X F Wang
    Department of Pediatrics, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0831, USA
    Exp Physiol 89:417-25. 2004
    ..Results also suggest that CFTR Cl- conductance (GCl) was blocked in both apical and basal membranes. The inhibitor appears to exert some effect on Na+ transport as well...
  8. pmc Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis
    Paul M Quinton
    Department of Pediatrics, Rady Children s Hospital, University of California San Diego School of Medicine, La Jolla, California 92093 0830, USA
    Am J Physiol Cell Physiol 299:C1222-33. 2010
    ....
  9. pmc A new role for bicarbonate secretion in cervico-uterine mucus release
    Ruth W Muchekehu
    Department of Pediatrics 0830, School of Medicine, University of California San Diego, La Jolla, CA 92093 0830, USA
    J Physiol 588:2329-42. 2010
    ....
  10. pmc Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion
    Mary Abigail S Garcia
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California School of Medicine, San Diego, California 92093 0831, USA
    J Clin Invest 119:2613-22. 2009
    ....
  11. ncbi request reprint Effect of anion transport blockers on CFTR in the human sweat duct
    M M Reddy
    Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, CA 92093 0831, USA
    J Membr Biol 189:15-25. 2002
    ..All the inhibitors studied primarily blocked CFTR from the cytoplasmic side and all inhibition appeared to be independent of metabolic and phosphorylation processes...
  12. ncbi request reprint Apical heterotrimeric g-proteins activate CFTR in the native sweat duct
    M M Reddy
    University of California, San Diego, School of Medicine, Department of Pediatrics-0831, La Jolla, CA 92093-0831, USA
    J Membr Biol 179:51-61. 2001
    ..We conclude that heterotrimeric G-proteins are present in the apical membrane of the native human sweat duct which may help regulate salt absorption by controlling CFTR G(Cl) activity...
  13. pmc PKA mediates constitutive activation of CFTR in human sweat duct
    M M Reddy
    Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, 9500 Gilman Drive 0830, La Jolla, CA 92093, USA
    J Membr Biol 231:65-78. 2009
    ..We conclude that the phosphorylation by PKA alone appears to be primarily responsible for constitutive activation of gCFTR in vivo...
  14. doi request reprint Effect of cytosolic pH on epithelial Na+ channel in normal and cystic fibrosis sweat ducts
    M M Reddy
    Department of Pediatrics 0831, School of Medicine, University of California San Diego, La Jolla, CA 92093 0831, USA
    J Membr Biol 225:1-11. 2008
    ..These changes may play a role in coordinating the activities of ENaC and CFTR during transepithelial salt transport...
  15. ncbi request reprint Cytosolic potassium controls CFTR deactivation in human sweat duct
    M M Reddy
    Department of Pediatrics, 0831 University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, 92093 0831, USA
    Am J Physiol Cell Physiol 291:C122-9. 2006
    ..We surmise that [K(+)](c) stabilizes when Na(+) influx decreases to a level equal to its efflux through the basolateral Na(+)-K(+) pump thereby preventing disruptive changes in cell volume...
  16. ncbi request reprint ENaC activity requires CFTR channel function independently of phosphorylation in sweat duct
    M M Reddy
    Department of Pediatrics, University of California, San Diego, UCSD School of Medicine, 9500 Gillman Drive, La Jolla, CA 92103 0831, USA
    J Membr Biol 207:23-33. 2005
    ..However, reversing I(Cl-) through CFTR in the direction of secretion (Cl- gradient from cell to lumen) prevents ENaC activation even in the presence of I(Cl-) through CFTR...
  17. ncbi request reprint Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells
    M M Reddy
    Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, California 92093 0831, USA
    Nature 423:756-60. 2003
    ..The loss of this uniquely regulated HCO3- conductance is most probably responsible for the more severe forms of cystic fibrosis pathology...
  18. ncbi request reprint Functional interaction of CFTR and ENaC in sweat glands
    M M Reddy
    Department of Pediatrics, 0831, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Pflugers Arch 445:499-503. 2003
    ..Not only are CFTR and ENaC activated together in duct salt absorption, but ENaC activation depends on functioning CFTR. NaCl is poorly absorbed in the CF duct because CFTR activity appears to impose a loss of ENaC activity as well...
  19. ncbi request reprint Selective activation of cystic fibrosis transmembrane conductance regulator Cl- and HCO3- conductances
    M M Reddy
    Department of Pediatrics, UCSD School of Medicine, La Jolla, CA 92093 0831, USA
    JOP 2:212-8. 2001
    ..We also surmise that the severity of the pathogenesis in CF is closely related to the phenotypic ability of a mutant CFTR to express a HCO(3)(-) conductance...
  20. ncbi request reprint cAMP-independent phosphorylation activation of CFTR by G proteins in native human sweat duct
    M M Reddy
    Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093-0831, USA
    Am J Physiol Cell Physiol 280:C604-13. 2001
    ..We concluded that heterotrimeric G proteins activate CFTR G(Cl) endogenously via a cAMP-independent pathway in this native absorptive epithelium...
  21. pmc Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis
    Ning Yang
    N Yang Division of Respiratory Medicine, Department of Pediatrics, University of California School of Medicine, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0830, USA
    J Physiol 591:4581-93. 2013
    ....
  22. doi request reprint Iontophoretic beta-adrenergic stimulation of human sweat glands: possible assay for cystic fibrosis transmembrane conductance regulator activity in vivo
    A K M Shamsuddin
    Department of Pediatrics, UC San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0831, USA
    Exp Physiol 93:969-81. 2008
    ..beta-Adrenergic secretion can be stimulated in vivo by concurrent iontophoresis of these drugs in normal, but not in CF, subjects...
  23. ncbi request reprint Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism
    M M Reddy
    Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, 92093 0831, USA mmr ucsd edu
    J Membr Biol 203:151-9. 2005
    ..We conclude that virtual lack of ENaC in PHA-1 ducts had little effect on CFTR activity and that the positive skin potentials could potentially serve as a diagnostic tool to identify type-1 pseudohypoaldosteronism...

Research Grants8

  1. CL-/HCO3- EXCHANGE IN CYSTIC FIBROSIS SWEAT GLANDS
    Paul Quinton; Fiscal Year: 2001
    ..Defining HCO3 ion-transport and its relevance to CFTR function should lend much to explaining, and hopefully, ameliorating these problems. ..
  2. Electroyte Transport in Small Airways
    Paul Quinton; Fiscal Year: 2007
    ..Correctly understanding this fundamental structure/function is critical to developing effective therapies. ..
  3. Electroyte Transport in Small Airways
    Paul Quinton; Fiscal Year: 2009
    ..Correctly understanding this fundamental structure/function is critical to developing effective therapies. ..