LEBRIS QUINN

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expression
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Exp Gerontol 45:106-12. 2010
  2. ncbi Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Am J Physiol Endocrinol Metab 296:E191-202. 2009
  3. ncbi Muscle-specific overexpression of the type 1 IGF receptor results in myoblast-independent muscle hypertrophy via PI3K, and not calcineurin, signaling
    LeBris S Quinn
    Department of Gerontology, University of Washington, Seattle, WA 98493, USA
    Am J Physiol Endocrinol Metab 293:E1538-51. 2007
  4. ncbi Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition
    L S Quinn
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Anim Sci 86:E75-83. 2008
  5. ncbi Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, 151 American Lake Division, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Cell Biol Int 29:449-57. 2005
  6. ncbi Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders
    LeBris S Quinn
    Division of Gerontology and Geriatric Medicine, University of Washington, Seattle 98195, USA
    Exp Cell Res 280:55-63. 2002
  7. ncbi Interleukin-15 increases myosin accretion in human skeletal myogenic cultures
    Paul S Furmanczyk
    University of Washington, School of Medicine, Seattle, WA 98195, USA
    Cell Biol Int 27:845-51. 2003
  8. ncbi Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism
    Heather Marie P Wilson
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Cell Growth Differ 13:205-13. 2002
  9. ncbi Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Int J Mol Med 16:471-6. 2005
  10. ncbi Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue
    Belen Alvarez
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1570:33-7. 2002

Research Grants

  1. IL-15, Body Composition and Insulin Sensitivity in Aging
    LEBRIS QUINN; Fiscal Year: 2007
  2. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expression
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Exp Gerontol 45:106-12. 2010
    ....
  2. ncbi Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Am J Physiol Endocrinol Metab 296:E191-202. 2009
    ....
  3. ncbi Muscle-specific overexpression of the type 1 IGF receptor results in myoblast-independent muscle hypertrophy via PI3K, and not calcineurin, signaling
    LeBris S Quinn
    Department of Gerontology, University of Washington, Seattle, WA 98493, USA
    Am J Physiol Endocrinol Metab 293:E1538-51. 2007
    ....
  4. ncbi Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition
    L S Quinn
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Anim Sci 86:E75-83. 2008
    ..Modulation of the IL-15 signaling axis may be a novel mechanism to affect body composition in meat animal production...
  5. ncbi Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, 151 American Lake Division, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Cell Biol Int 29:449-57. 2005
    ..These findings provide support for the hypothesis that IL-15 functions in a muscle-to-fat endocrine axis which modulates fat:lean body composition and insulin sensitivity...
  6. ncbi Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders
    LeBris S Quinn
    Division of Gerontology and Geriatric Medicine, University of Washington, Seattle 98195, USA
    Exp Cell Res 280:55-63. 2002
    ..Administration of IL-15 or modulation of the IL-15 signaling pathway may represent an alternative strategy for maintaining skeletal muscle mass under these conditions...
  7. ncbi Interleukin-15 increases myosin accretion in human skeletal myogenic cultures
    Paul S Furmanczyk
    University of Washington, School of Medicine, Seattle, WA 98195, USA
    Cell Biol Int 27:845-51. 2003
    ....
  8. ncbi Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism
    Heather Marie P Wilson
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Cell Growth Differ 13:205-13. 2002
    ..These findings indicate that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism...
  9. ncbi Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Int J Mol Med 16:471-6. 2005
    ..The results suggest that the main mechanism involved in the anabolic effects of IL-15 in skeletal muscle relies on a decrease in the proteolytic rate...
  10. ncbi Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue
    Belen Alvarez
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1570:33-7. 2002
    ....
  11. ncbi Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells
    Belen Alvarez
    Cancer Research Group, , Universitat de Barcelona, Spain
    Biochim Biophys Acta 1542:66-72. 2002
    ..These findings indicate that the effects of TNF on muscle protein synthesis are mediated by IL-6, but that TNF exerts IL-6-independent effects on proliferation of murine skeletal myoblasts...
  12. ncbi TNF-alpha modulates cytokine and cytokine receptors in C2C12 myotubes
    Belen Alvarez
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
    Cancer Lett 175:181-5. 2002
    ..The results suggest that other cytokines may be involved in mediating TNF-alpha action in skeletal muscle and that anti-inflammatory cytokines may be released as a counter-regulatory mechanism...

Research Grants5

  1. IL-15, Body Composition and Insulin Sensitivity in Aging
    LEBRIS QUINN; Fiscal Year: 2007
    ..This research may lead to development of improved diagnostic, prevention, or treatment strategies for the common age-associated clinical conditions of frailty, sarcopenia, obesity, insulin resistance, and type-2 diabetes. ..
  2. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..abstract_text> ..