Research Topics
| Charles T QuinnSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Acute silent cerebral infarction in children with sickle cell anemiaMichael M Dowling
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
Pediatr Blood Cancer 54:461-4. 2010..Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events...- Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemiaCharles T Quinn
Hematology Oncology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
Br J Haematol 145:500-5. 2009..In conclusion, Hb saturation is a determinant of TCD velocity and a risk factor for stroke in children with Hb SS... 
Writing and publishing your research findingsCharles T Quinn
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390 9063, USA
J Investig Med 57:634-9. 2009..We review the process of choosing what to write, how to write it clearly, and how to navigate the process of submission and publication...- Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemiaCharles T Quinn
Center for Cancer and Blood Disorders, Children s Medical Center Dallas, Dallas, TX, USA
Br J Haematol 140:336-9. 2008..Decline in SpO(2) over time further increases this risk. Hb desaturation is easily measured, potentially modifiable, and could be used to identify children with SS at increased risk of stroke... - Prediction of adverse outcomes in children with sickle cell anemia: a study of the Dallas Newborn CohortCharles T Quinn
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75390 9063, USA
Blood 111:544-8. 2008..The sensitivity of the model did not rise above 20% until specificity fell below 60%. We suggest that this model not be used as a criterion to initiate early interventions for SCD... - Prognostic significance of early vaso-occlusive complications in children with sickle cell anemiaCharles T Quinn
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Blood 109:40-5. 2007..Although we still lack a useful prognostic framework for young children with SS, those who experience early ACS might be candidates for higher risk interventions to mitigate or cure their disease... - Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell diseaseCharles T Quinn
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
Br J Haematol 131:129-34. 2005..We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia... 
Risk factors and prediction of outcomes in children and adolescents who have sickle cell anemiaCharles T Quinn
Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
Hematol Oncol Clin North Am 18:1339-54, ix. 2004..This article discusses risk factors and prediction in children and adolescents who have sickle cell anemia...- Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluidCharles T Quinn
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
J Pediatr Hematol Oncol 26:386-8. 2004..No sulfur-containing excitatory amino acids were detected. This study demonstrates multiple profound effects of MTX on CNS metabolism and provides insight to the pathogenesis of MTX neurotoxicity... - Survival of children with sickle cell diseaseCharles T Quinn
University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Blood 103:4023-7. 2004..5% by 18 years of age. No SCD-related deaths or strokes occurred in SC or Sbeta(+) subjects (n = 263). Childhood mortality from SCD is decreasing, the mean age at death is increasing, and a smaller proportion of deaths are from infection... - Prevalence of intracardiac shunting in children with sickle cell disease and strokeMichael M Dowling
Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
J Pediatr 156:645-50. 2010..To determine the prevalence of potential intracardiac shunts, including patent foramen ovale (PFO), in children with sickle cell disease (SCD) and stroke... - Improved survival of children and adolescents with sickle cell diseaseCharles T Quinn
Division of Hematology Oncology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Blood 115:3447-52. 2010..In summary, most children with SCD now survive the childhood years, but young adults who transition to adult medical care are at high risk for early death... - Hospitalization for invasive pneumococcal disease in a national sample of children with sickle cell disease before and after PCV7 licensureTimothy L McCavit
University of Texas Southwestern Medical Center, Dallas, TX, USA
Pediatr Blood Cancer 58:945-9. 2012..To estimate national hospitalization rates for invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) before and after the 2000 licensure of the heptavalent pneumococcal conjugate vaccine (PCV7)... - Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensureTimothy L McCavit
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
J Pediatr 158:505-7. 2011..We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease... - Hospital volume, hospital teaching status, patient socioeconomic status, and outcomes in patients hospitalized with sickle cell diseaseTimothy L McCavit
Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, and Children s Medical Center Dallas, TX 75390, USA
Am J Hematol 86:377-80. 2011..36; 95% CI, 1.05, 1.76) and [2] decreased LOS (quintiles 1–4 vs. quintile 5, effect estimate 20.08; 95%CI, 20.12, 20.04). These are the first data describing associations between lower SCD-specific hospital volumes and poorer outcomes... - Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisisJosh Koch
Division of Critical Care, Department of Pediatrics, University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75390 9063, USA
Am J Hematol 83:728-31. 2008..A quantitative pruritus score allowed us to systematically measure pruritus. Further evaluation by randomized, placebo-controlled study of 1 mcg/kg x hr naloxone in this setting is required... - Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusionTeresa Fu
Department of Pediatrics, Division of Hematology-Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, USA
Pediatr Blood Cancer 45:43-7. 2005..A randomized clinical trial to compare transfusion with no transfusion for minor surgical procedures is needed... - Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressureMichael R Debaun
Department of Pediatrics, Division of Hematology Oncology, Vanderbilt University, Nashville, TN, USA
Blood 119:3684-90. 2012..Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761... - Stroke in sickle cell anemia: alternative etiologiesMichael M Dowling
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Pediatr Neurol 41:124-6. 2009..The present case suggests that the more traditional etiologies for pediatric stroke may also cause stroke in children with sickle cell anemia... - Bordetella holmesii bacteremia in sickle cell diseaseTimothy L McCavit
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Pediatr Blood Cancer 51:814-6. 2008..holmesii infection from other invasive bacterial infections in SCD. Providers for patients with SCD should be aware of this pathogen and ensure that their microbiology laboratories are capable of isolating and identifying this organism... - Tapered oral dexamethasone for the acute chest syndrome of sickle cell diseaseCharles T Quinn
Cincinnati Children s Hospital Medical Center, Hematology Oncology, Cincinnati, OH 45220, USA
Br J Haematol 155:263-7. 2011..This ACS assessment tool was feasibly applied, and sL-selectin is a promising biomarker of ACS therapy... - Renal dysfunction in patients with thalassaemiaCharles T Quinn
U T Southwestern Medical Center, Dallas, TX, USA
Br J Haematol 153:111-7. 2011..The transfusion effect needs to be better understood. Awareness of underlying renal dysfunction in thalassaemia can inform decisions now about the use and monitoring of iron chelation... - Predictors of outcome in sickle cell diseaseCharles T Quinn
Department of Pediatrics, Division of Hematology-Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Pediatr Hematol Oncol 24:244-5. 2002 - Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North AmericaMaria G Vogiatzi
Department of Pediatrics, Pediatric Endocrinology, New York Presbyterian Hospital Weill Medical College of Cornell, New York, NY 10065, USA
Br J Haematol 146:546-56. 2009..Compared to patients with other thalassemia syndromes, those with beta TM suffered from higher rates of multiple endocrinopathies, abnormal calcium metabolism and hypercalciuria. Vitamin D abnormalities were high among adolescents... - Bone disease in thalassemia: a frequent and still unresolved problemMaria G Vogiatzi
Department of Pediatrics, Weill Medical College of Cornell, New York, New York, USA
J Bone Miner Res 24:543-57. 2009..Peak bone mass is suboptimal. Low BMD is associated with hypogonadism, increased bone turnover, and an increased risk for fractures...