Charles T Quinn

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Acute silent cerebral infarction in children with sickle cell anemia
    Michael M Dowling
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Pediatr Blood Cancer 54:461-4. 2010
  2. doi request reprint Writing and publishing your research findings
    Charles T Quinn
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390 9063, USA
    J Investig Med 57:634-9. 2009
  3. pmc Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemia
    Charles T Quinn
    Center for Cancer and Blood Disorders, Children s Medical Center Dallas, Dallas, TX, USA
    Br J Haematol 140:336-9. 2008
  4. pmc Prediction of adverse outcomes in children with sickle cell anemia: a study of the Dallas Newborn Cohort
    Charles T Quinn
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75390 9063, USA
    Blood 111:544-8. 2008
  5. pmc Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Blood 109:40-5. 2007
  6. pmc Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Br J Haematol 131:129-34. 2005
  7. ncbi request reprint Risk factors and prediction of outcomes in children and adolescents who have sickle cell anemia
    Charles T Quinn
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Hematol Oncol Clin North Am 18:1339-54, ix. 2004
  8. ncbi request reprint Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid
    Charles T Quinn
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    J Pediatr Hematol Oncol 26:386-8. 2004
  9. pmc Survival of children with sickle cell disease
    Charles T Quinn
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Blood 103:4023-7. 2004
  10. pmc Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia
    Charles T Quinn
    Hematology Oncology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Br J Haematol 145:500-5. 2009

Detail Information

Publications27

  1. pmc Acute silent cerebral infarction in children with sickle cell anemia
    Michael M Dowling
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Pediatr Blood Cancer 54:461-4. 2010
    ..Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events...
  2. doi request reprint Writing and publishing your research findings
    Charles T Quinn
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390 9063, USA
    J Investig Med 57:634-9. 2009
    ..We review the process of choosing what to write, how to write it clearly, and how to navigate the process of submission and publication...
  3. pmc Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemia
    Charles T Quinn
    Center for Cancer and Blood Disorders, Children s Medical Center Dallas, Dallas, TX, USA
    Br J Haematol 140:336-9. 2008
    ..Decline in SpO(2) over time further increases this risk. Hb desaturation is easily measured, potentially modifiable, and could be used to identify children with SS at increased risk of stroke...
  4. pmc Prediction of adverse outcomes in children with sickle cell anemia: a study of the Dallas Newborn Cohort
    Charles T Quinn
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75390 9063, USA
    Blood 111:544-8. 2008
    ..The sensitivity of the model did not rise above 20% until specificity fell below 60%. We suggest that this model not be used as a criterion to initiate early interventions for SCD...
  5. pmc Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Blood 109:40-5. 2007
    ..Although we still lack a useful prognostic framework for young children with SS, those who experience early ACS might be candidates for higher risk interventions to mitigate or cure their disease...
  6. pmc Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Br J Haematol 131:129-34. 2005
    ..We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia...
  7. ncbi request reprint Risk factors and prediction of outcomes in children and adolescents who have sickle cell anemia
    Charles T Quinn
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Hematol Oncol Clin North Am 18:1339-54, ix. 2004
    ..This article discusses risk factors and prediction in children and adolescents who have sickle cell anemia...
  8. ncbi request reprint Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid
    Charles T Quinn
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    J Pediatr Hematol Oncol 26:386-8. 2004
    ..No sulfur-containing excitatory amino acids were detected. This study demonstrates multiple profound effects of MTX on CNS metabolism and provides insight to the pathogenesis of MTX neurotoxicity...
  9. pmc Survival of children with sickle cell disease
    Charles T Quinn
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Blood 103:4023-7. 2004
    ..5% by 18 years of age. No SCD-related deaths or strokes occurred in SC or Sbeta(+) subjects (n = 263). Childhood mortality from SCD is decreasing, the mean age at death is increasing, and a smaller proportion of deaths are from infection...
  10. pmc Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia
    Charles T Quinn
    Hematology Oncology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Br J Haematol 145:500-5. 2009
    ..In conclusion, Hb saturation is a determinant of TCD velocity and a risk factor for stroke in children with Hb SS...
  11. pmc Improved survival of children and adolescents with sickle cell disease
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Blood 115:3447-52. 2010
    ..In summary, most children with SCD now survive the childhood years, but young adults who transition to adult medical care are at high risk for early death...
  12. doi request reprint Prevalence of intracardiac shunting in children with sickle cell disease and stroke
    Michael M Dowling
    Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    J Pediatr 156:645-50. 2010
    ..To determine the prevalence of potential intracardiac shunts, including patent foramen ovale (PFO), in children with sickle cell disease (SCD) and stroke...
  13. doi request reprint National trends in incidence rates of hospitalization for stroke in children with sickle cell disease
    Timothy L McCavit
    Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 60:823-7. 2013
    ..Therefore, we aimed to generate national incidence rates of hospitalization for stroke in children with sickle cell disease (SCD) before and after publication of the Stroke Prevention Trial in Sickle Cell Anemia (STOP trial) in 1998...
  14. doi request reprint Hospitalization for invasive pneumococcal disease in a national sample of children with sickle cell disease before and after PCV7 licensure
    Timothy L McCavit
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Pediatr Blood Cancer 58:945-9. 2012
    ..To estimate national hospitalization rates for invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) before and after the 2000 licensure of the heptavalent pneumococcal conjugate vaccine (PCV7)...
  15. pmc Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell disease
    Michael M Dowling
    Departments of Pediatrics, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX 75390 9063, USA
    Blood 120:3891-7. 2012
    ..Some ASCIE (1 of 4 in our study) may be reversible. Alterations in management may be warranted for children with severe anemia to identify unrecognized ischemic brain injury that may have permanent neurocognitive sequelae...
  16. pmc Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure
    Timothy L McCavit
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Pediatr 158:505-7. 2011
    ..We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease...
  17. ncbi request reprint Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusion
    Teresa Fu
    Department of Pediatrics, Division of Hematology Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 45:43-7. 2005
    ..In particular, the merits of transfusion prior to minor or low-risk surgical procedures in children with SCD have not been demonstrated...
  18. doi request reprint Hospital volume, hospital teaching status, patient socioeconomic status, and outcomes in patients hospitalized with sickle cell disease
    Timothy L McCavit
    Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, and Children s Medical Center Dallas, TX 75390, USA
    Am J Hematol 86:377-80. 2011
    ..36; 95% CI, 1.05, 1.76) and [2] decreased LOS (quintiles 1–4 vs. quintile 5, effect estimate 20.08; 95%CI, 20.12, 20.04). These are the first data describing associations between lower SCD-specific hospital volumes and poorer outcomes...
  19. doi request reprint Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisis
    Josh Koch
    Division of Critical Care, Department of Pediatrics, University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75390 9063, USA
    Am J Hematol 83:728-31. 2008
    ..A quantitative pruritus score allowed us to systematically measure pruritus. Further evaluation by randomized, placebo-controlled study of 1 mcg/kg x hr naloxone in this setting is required...
  20. pmc Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
    Michael R Debaun
    Department of Pediatrics, Division of Hematology Oncology, Vanderbilt University, Nashville, TN, USA
    Blood 119:3684-90. 2012
    ..Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761...
  21. pmc Stroke in sickle cell anemia: alternative etiologies
    Michael M Dowling
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Neurol 41:124-6. 2009
    ..The present case suggests that the more traditional etiologies for pediatric stroke may also cause stroke in children with sickle cell anemia...
  22. pmc Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease
    Charles T Quinn
    Cincinnati Children s Hospital Medical Center, Hematology Oncology, Cincinnati, OH 45220, USA
    Br J Haematol 155:263-7. 2011
    ..This ACS assessment tool was feasibly applied, and sL-selectin is a promising biomarker of ACS therapy...
  23. doi request reprint Bordetella holmesii bacteremia in sickle cell disease
    Timothy L McCavit
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 51:814-6. 2008
    ..holmesii infection from other invasive bacterial infections in SCD. Providers for patients with SCD should be aware of this pathogen and ensure that their microbiology laboratories are capable of isolating and identifying this organism...
  24. doi request reprint Renal dysfunction in patients with thalassaemia
    Charles T Quinn
    U T Southwestern Medical Center, Dallas, TX, USA
    Br J Haematol 153:111-7. 2011
    ..The transfusion effect needs to be better understood. Awareness of underlying renal dysfunction in thalassaemia can inform decisions now about the use and monitoring of iron chelation...
  25. ncbi request reprint Predictors of outcome in sickle cell disease
    Charles T Quinn
    Department of Pediatrics, Division of Hematology Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Pediatr Hematol Oncol 24:244-5. 2002
  26. pmc Bone disease in thalassemia: a frequent and still unresolved problem
    Maria G Vogiatzi
    Department of Pediatrics, Weill Medical College of Cornell, New York, New York, USA
    J Bone Miner Res 24:543-57. 2009
    ..Peak bone mass is suboptimal. Low BMD is associated with hypogonadism, increased bone turnover, and an increased risk for fractures...
  27. pmc Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America
    Maria G Vogiatzi
    Department of Pediatrics, Pediatric Endocrinology, New York Presbyterian Hospital Weill Medical College of Cornell, New York, NY 10065, USA
    Br J Haematol 146:546-56. 2009
    ..Compared to patients with other thalassemia syndromes, those with beta TM suffered from higher rates of multiple endocrinopathies, abnormal calcium metabolism and hypercalciuria. Vitamin D abnormalities were high among adolescents...