Research Topics
Species | R QuigleySummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Developmental changes in renal functionRaymond Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Curr Opin Pediatr 24:184-90. 2012..These differences are greatly exaggerated in the preterm infant, making it more difficult to determine if there is a pathophysiologic problem...
Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water PermeabilityR Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
J Membr Biol 204:109-16. 2005..Botulinum toxins A and C also decreased the rate of rise of P(f). Thus, SNARE proteins are involved in the insertion of the water channels in the collecting duct...- Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activityRaymond Quigley
Department of Pediatrics, Univeristy of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
Am J Physiol Renal Physiol 286:F317-22. 2004..Hence, one of the key factors in the decreased ability of neonates to concentrate their urine is overactivity of phosphodiesterase in the cortical collecting duct that blunts the neonatal collecting duct Pf response to ADH... - Ontogeny of water transport in the rabbit proximal tubuleRaymond Quigley
Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9063 USA
Pediatr Nephrol 18:1089-94. 2003..This review will discuss postnatal maturation of proximal tubule water transport... - Proximal renal tubular acidosisR Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Nephrol 19:S41-5. 2006..This review will discuss the mechanisms that cause defects in proximal tubule bicarbonate transport as well as the common causes of isolated proximal renal tubular acidosis and the Fanconi syndrome... - Evaluation of hematuria and proteinuria: how should a pediatrician proceed?Raymond Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
Curr Opin Pediatr 20:140-4. 2008..The review will discuss the major causes of hematuria and proteinuria in the pediatric population, and discuss a rational approach to the evaluation of these conditions... - Androgens stimulate proximal tubule transportRaymond Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
Gend Med 5:S114-20. 2008..Androgens are known to increase expression of angiotensinogen,but the effect of androgens on proximal tubule transport is unknown... - Diagnosis of urinary tract infections in childrenRaymond Quigley
Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
Curr Opin Pediatr 21:194-8. 2009..Thus, prompt diagnosis and initiation of treatment of urinary tract infections are paramount objectives... - Ontogeny of rabbit proximal tubule urea permeabilityR Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
Am J Physiol Regul Integr Comp Physiol 280:R1713-8. 2001..The lower P(urea) in neonatal proximal tubules may play a role in overall urea excretion and in developing and maintaining a high medullary urea concentration and thus in the ability to concentrate the urine during renal maturation... 
Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout miceRaymond Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
Nephron Physiol 113:p23-8. 2009..Because the Cyp4a14 enzyme is located in the proximal tubule of the kidney, we hypothesized that there could be dysregulation of transport in this segment that could contribute to the hypertension...- Water transport in neonatal and adult rabbit proximal tubulesRaymond Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Am J Physiol Renal Physiol 283:F280-5. 2002..01 vs. 40.49 +/- 13.89 microm/s, P < 0.05). Thus the intracellular compartment of the neonatal PCT has a lower resistance for water transport than the adult PCT and is responsible for the higher than expected P(f) in the neonatal PCT... - Diffusional water permeability (PDW) of adult and neonatal rabbit renal brush border membrane vesiclesJ Mulder
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9063, USA
J Membr Biol 187:167-74. 2002..There are significant changes in water transport across the apical membrane during postnatal development, consistent with a maturational increase in channel-mediated water transport... - Developmental changes in rabbit proximal straight tubule paracellular permeabilityRaymond Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235-9063, USA
Am J Physiol Renal Physiol 283:F525-31. 2002..3 +/- 1.4 Omega x cm(2) in neonatal PST (P < 0.01). In conclusion, there are significant maturational changes in the characteristics of the PST paracellular pathway affecting transport in this nephron segment... - Fibroblast growth factor-23 increases mouse PGE2 production in vivo and in vitroAshu Syal
Department of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
Am J Physiol Renal Physiol 290:F450-5. 2006..In conclusion, FGF-23 increases urinary and renal tubular PGE2 production via the MAP kinase pathway and PGE2 inhibits proximal tubule phosphate transport... - Androgens augment proximal tubule transportAlbert Quan
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, USA
Am J Physiol Renal Physiol 287:F452-9. 2004.... - Glucocorticoids increase osmotic water permeability (Pf) of neonatal rabbit renal brush border membrane vesiclesJaap Mulder
Dept. of Pediatrics, U. T. Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USA
Am J Physiol Regul Integr Comp Physiol 288:R1417-21. 2005..This mimics the maturational changes and suggests a physiological role for glucocorticoids in maturation of proximal tubule water transport... - Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transportR Quigley
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
Am J Physiol Renal Physiol 278:F949-53. 2000..Endogenous production of 20-HETE may play a role in tonic suppression of transport and may therefore be an endogenous regulator of transport in the proximal tubule... - Hypothyroidism increases osmotic water permeability (Pf) in the developing renal brush border membraneJaap Mulder
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9063, USA
Pediatr Res 53:1001-7. 2003..The higher Pf in hypothyroid adult rabbits is due to a higher expression of AQP1 protein as well as a greater membrane fluidity than in euthyroid rabbits... - Inhibition of proximal convoluted tubule transport by dopamineM Baum
Departments of Pediatrics and Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Kidney Int 54:1593-600. 1998..Dopamine can produce a natriuresis and diuresis independent of changes in renal hemodynamics. However, previous studies have failed to demonstrate an inhibition of transport by dopamine in intact proximal convoluted tubules... - Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulationMichel Baum
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
Am J Physiol Renal Physiol 288:F363-70. 2005..These data are consistent with a rapidly reversible posttranscriptional defect in Hyp mice causing a reduction in phosphate transport... - Maturational changes in renal tubular transportMichel Baum
Departments of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9063, USA
Curr Opin Nephrol Hypertens 12:521-6. 2003..This review examines the maturational changes that occur in renal tubules during postnatal development... - Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacinMichel Baum
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
Proc Natl Acad Sci U S A 100:11098-103. 2003..In conclusion, there is dysregulation of renal PG metabolism in Hyp mice, and indomethacin treatment normalizes the urinary excretion of phosphate by a direct tubular effect... - Role of prostaglandins in the pathogenesis of X-linked hypophosphatemiaMichel Baum
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
Pediatr Nephrol 21:1067-74. 2006..In Hyp mice, indomethacin improves the phosphate transport defect in vitro and in vivo. Whether indomethacin has the same effect in patients with X-linked hypophosphatemia is unknown... - Thyroid hormone modulates rabbit proximal straight tubule paracellular permeabilityMichel Baum
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
Am J Physiol Renal Physiol 286:F477-82. 2004..cm(2), or 7.0 +/- 0.7 Omega.cm(2) in hypothyroid animals that received thyroid replacement. Therefore, the maturational increase in thyroid hormone levels does not fully explain the developmental changes in the paracellular pathway... - Effect of fibroblast growth factor-23 on phosphate transport in proximal tubulesMichel Baum
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
Kidney Int 68:1148-53. 2005..Fibroblast growth factor-23 (FGF-23) has been implicated in the renal phosphate wasting in tumor-induced osteomalacia, X-linked hypophosphatemia, and autosomal-dominant hypophosphatemic rickets... - Maturation of rat proximal tubule chloride permeabilityMichel Baum
Dept of Pediatrics, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235 9063, USA
Am J Physiol Regul Integr Comp Physiol 289:R1659-64. 2005..2 +/- 0.8 vs. 4.6 +/- 0.1 ohms x cm2, P < 0.05). These studies demonstrate there are maturational changes in the rat paracellular pathway that impact net NaCl transport during development... - Renal replacement therapy and acute renal failureAlbert Quan
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Curr Opin Pediatr 17:205-9. 2005.... - Ontogeny of renal sodium transportMichel Baum
Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
Semin Perinatol 28:91-6. 2004..This review focuses on how the neonatal kidney reabsorbs NaCl with a special emphasis on the differences between the neonatal and adult kidney... - Effective removal of methotrexate by high-flux hemodialysisJeffrey M Saland
Department of Pediatrics, The Mount Sinai School of Medicine, One Gustave L. Levy Place Box 1664, NY 10029-6574, USA
Pediatr Nephrol 17:825-9. 2002..Therapy is indicated in cases where compassionate use of CPDG(2) may not be available, or while awaiting its delivery... - Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesiclesWei-Zhong Zeng
Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75390-8856, USA
Am J Physiol Renal Physiol 283:F630-9. 2002..These results provide compelling evidence for endocytosis of ROMK channels via clathrin-coated vesicles... - Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting ductPo Yin Chu
Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 285:F1179-87. 2003..This decrease in the abundance of ROMK is likely important for maintaining K+ homeostasis during K+ deficiency... - Proximal tubule water transport-lessons from aquaporin knockout miceMichel Baum
Am J Physiol Renal Physiol 289:F1193-4. 2005