R Quigley

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Dialysis disequilibrium syndrome
    Diana Zepeda-Orozco
    Department of Pediatrics, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Pediatr Nephrol 27:2205-11. 2012
  2. doi request reprint Developmental changes in renal function
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 24:184-90. 2012
  3. ncbi request reprint Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    J Membr Biol 204:109-16. 2005
  4. ncbi request reprint Proximal renal tubular acidosis
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Nephrol 19:S41-5. 2006
  5. ncbi request reprint Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activity
    Raymond Quigley
    Department of Pediatrics, Univeristy of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 286:F317-22. 2004
  6. ncbi request reprint Ontogeny of water transport in the rabbit proximal tubule
    Raymond Quigley
    Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9063 USA
    Pediatr Nephrol 18:1089-94. 2003
  7. doi request reprint Evaluation of hematuria and proteinuria: how should a pediatrician proceed?
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 20:140-4. 2008
  8. doi request reprint Androgens stimulate proximal tubule transport
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Gend Med 5:S114-20. 2008
  9. ncbi request reprint Diagnosis of urinary tract infections in children
    Raymond Quigley
    Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Curr Opin Pediatr 21:194-8. 2009
  10. ncbi request reprint Ontogeny of rabbit proximal tubule urea permeability
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1713-8. 2001

Collaborators

Detail Information

Publications33

  1. pmc Dialysis disequilibrium syndrome
    Diana Zepeda-Orozco
    Department of Pediatrics, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Pediatr Nephrol 27:2205-11. 2012
    ..Thus, measures to avoid its development are crucial. In this review, we will examine the pathophysiology of this syndrome and discuss the factors to consider in avoiding its development...
  2. doi request reprint Developmental changes in renal function
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 24:184-90. 2012
    ..These differences are greatly exaggerated in the preterm infant, making it more difficult to determine if there is a pathophysiologic problem...
  3. ncbi request reprint Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    J Membr Biol 204:109-16. 2005
    ..Botulinum toxins A and C also decreased the rate of rise of P(f). Thus, SNARE proteins are involved in the insertion of the water channels in the collecting duct...
  4. ncbi request reprint Proximal renal tubular acidosis
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Nephrol 19:S41-5. 2006
    ..This review will discuss the mechanisms that cause defects in proximal tubule bicarbonate transport as well as the common causes of isolated proximal renal tubular acidosis and the Fanconi syndrome...
  5. ncbi request reprint Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activity
    Raymond Quigley
    Department of Pediatrics, Univeristy of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 286:F317-22. 2004
    ..Hence, one of the key factors in the decreased ability of neonates to concentrate their urine is overactivity of phosphodiesterase in the cortical collecting duct that blunts the neonatal collecting duct Pf response to ADH...
  6. ncbi request reprint Ontogeny of water transport in the rabbit proximal tubule
    Raymond Quigley
    Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9063 USA
    Pediatr Nephrol 18:1089-94. 2003
    ..This review will discuss postnatal maturation of proximal tubule water transport...
  7. doi request reprint Evaluation of hematuria and proteinuria: how should a pediatrician proceed?
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 20:140-4. 2008
    ..The review will discuss the major causes of hematuria and proteinuria in the pediatric population, and discuss a rational approach to the evaluation of these conditions...
  8. doi request reprint Androgens stimulate proximal tubule transport
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Gend Med 5:S114-20. 2008
    ..Androgens are known to increase expression of angiotensinogen,but the effect of androgens on proximal tubule transport is unknown...
  9. ncbi request reprint Diagnosis of urinary tract infections in children
    Raymond Quigley
    Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Curr Opin Pediatr 21:194-8. 2009
    ..Thus, prompt diagnosis and initiation of treatment of urinary tract infections are paramount objectives...
  10. ncbi request reprint Ontogeny of rabbit proximal tubule urea permeability
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1713-8. 2001
    ..The lower P(urea) in neonatal proximal tubules may play a role in overall urea excretion and in developing and maintaining a high medullary urea concentration and thus in the ability to concentrate the urine during renal maturation...
  11. pmc Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Nephron Physiol 113:p23-8. 2009
    ..Because the Cyp4a14 enzyme is located in the proximal tubule of the kidney, we hypothesized that there could be dysregulation of transport in this segment that could contribute to the hypertension...
  12. ncbi request reprint Water transport in neonatal and adult rabbit proximal tubules
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 283:F280-5. 2002
    ..01 vs. 40.49 +/- 13.89 microm/s, P < 0.05). Thus the intracellular compartment of the neonatal PCT has a lower resistance for water transport than the adult PCT and is responsible for the higher than expected P(f) in the neonatal PCT...
  13. ncbi request reprint Diffusional water permeability (PDW) of adult and neonatal rabbit renal brush border membrane vesicles
    J Mulder
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 9063, USA
    J Membr Biol 187:167-74. 2002
    ..There are significant changes in water transport across the apical membrane during postnatal development, consistent with a maturational increase in channel-mediated water transport...
  14. ncbi request reprint Developmental changes in rabbit proximal straight tubule paracellular permeability
    Raymond Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Am J Physiol Renal Physiol 283:F525-31. 2002
    ..3 +/- 1.4 Omega x cm(2) in neonatal PST (P < 0.01). In conclusion, there are significant maturational changes in the characteristics of the PST paracellular pathway affecting transport in this nephron segment...
  15. ncbi request reprint Fibroblast growth factor-23 increases mouse PGE2 production in vivo and in vitro
    Ashu Syal
    Department of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 290:F450-5. 2006
    ..In conclusion, FGF-23 increases urinary and renal tubular PGE2 production via the MAP kinase pathway and PGE2 inhibits proximal tubule phosphate transport...
  16. ncbi request reprint Androgens augment proximal tubule transport
    Albert Quan
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 287:F452-9. 2004
    ....
  17. ncbi request reprint Glucocorticoids increase osmotic water permeability (Pf) of neonatal rabbit renal brush border membrane vesicles
    Jaap Mulder
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1417-21. 2005
    ..This mimics the maturational changes and suggests a physiological role for glucocorticoids in maturation of proximal tubule water transport...
  18. ncbi request reprint Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport
    R Quigley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Am J Physiol Renal Physiol 278:F949-53. 2000
    ..Endogenous production of 20-HETE may play a role in tonic suppression of transport and may therefore be an endogenous regulator of transport in the proximal tubule...
  19. ncbi request reprint Hypothyroidism increases osmotic water permeability (Pf) in the developing renal brush border membrane
    Jaap Mulder
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    Pediatr Res 53:1001-7. 2003
    ..The higher Pf in hypothyroid adult rabbits is due to a higher expression of AQP1 protein as well as a greater membrane fluidity than in euthyroid rabbits...
  20. ncbi request reprint Inhibition of proximal convoluted tubule transport by dopamine
    M Baum
    Departments of Pediatrics and Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Kidney Int 54:1593-600. 1998
    ..Dopamine can produce a natriuresis and diuresis independent of changes in renal hemodynamics. However, previous studies have failed to demonstrate an inhibition of transport by dopamine in intact proximal convoluted tubules...
  21. ncbi request reprint Renal replacement therapy and acute renal failure
    Albert Quan
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Curr Opin Pediatr 17:205-9. 2005
    ....
  22. ncbi request reprint Maturational changes in renal tubular transport
    Michel Baum
    Departments of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9063, USA
    Curr Opin Nephrol Hypertens 12:521-6. 2003
    ..This review examines the maturational changes that occur in renal tubules during postnatal development...
  23. pmc Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Proc Natl Acad Sci U S A 100:11098-103. 2003
    ..In conclusion, there is dysregulation of renal PG metabolism in Hyp mice, and indomethacin treatment normalizes the urinary excretion of phosphate by a direct tubular effect...
  24. ncbi request reprint Thyroid hormone modulates rabbit proximal straight tubule paracellular permeability
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 286:F477-82. 2004
    ..cm(2), or 7.0 +/- 0.7 Omega.cm(2) in hypothyroid animals that received thyroid replacement. Therefore, the maturational increase in thyroid hormone levels does not fully explain the developmental changes in the paracellular pathway...
  25. ncbi request reprint Role of prostaglandins in the pathogenesis of X-linked hypophosphatemia
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Pediatr Nephrol 21:1067-74. 2006
    ..In Hyp mice, indomethacin improves the phosphate transport defect in vitro and in vivo. Whether indomethacin has the same effect in patients with X-linked hypophosphatemia is unknown...
  26. ncbi request reprint Phosphatonin washout in Hyp mice proximal tubules: evidence for posttranscriptional regulation
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 288:F363-70. 2005
    ..These data are consistent with a rapidly reversible posttranscriptional defect in Hyp mice causing a reduction in phosphate transport...
  27. ncbi request reprint Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules
    Michel Baum
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Kidney Int 68:1148-53. 2005
    ..Fibroblast growth factor-23 (FGF-23) has been implicated in the renal phosphate wasting in tumor-induced osteomalacia, X-linked hypophosphatemia, and autosomal-dominant hypophosphatemic rickets...
  28. ncbi request reprint Maturation of rat proximal tubule chloride permeability
    Michel Baum
    Dept of Pediatrics, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235 9063, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1659-64. 2005
    ..2 +/- 0.8 vs. 4.6 +/- 0.1 ohms x cm2, P < 0.05). These studies demonstrate there are maturational changes in the rat paracellular pathway that impact net NaCl transport during development...
  29. ncbi request reprint Ontogeny of renal sodium transport
    Michel Baum
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Semin Perinatol 28:91-6. 2004
    ..This review focuses on how the neonatal kidney reabsorbs NaCl with a special emphasis on the differences between the neonatal and adult kidney...
  30. ncbi request reprint Effective removal of methotrexate by high-flux hemodialysis
    Jeffrey M Saland
    Department of Pediatrics, The Mount Sinai School of Medicine, One Gustave L Levy Place Box 1664, NY 10029 6574, USA
    Pediatr Nephrol 17:825-9. 2002
    ..Therapy is indicated in cases where compassionate use of CPDG(2) may not be available, or while awaiting its delivery...
  31. ncbi request reprint Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles
    Wei Zhong Zeng
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75390 8856, USA
    Am J Physiol Renal Physiol 283:F630-9. 2002
    ..These results provide compelling evidence for endocytosis of ROMK channels via clathrin-coated vesicles...
  32. ncbi request reprint Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct
    Po Yin Chu
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 285:F1179-87. 2003
    ..This decrease in the abundance of ROMK is likely important for maintaining K+ homeostasis during K+ deficiency...
  33. ncbi request reprint Proximal tubule water transport-lessons from aquaporin knockout mice
    Michel Baum
    Am J Physiol Renal Physiol 289:F1193-4. 2005