Debra C Quenelle

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Isolation and characterization of cidofovir resistant vaccinia viruses
    Marie N Becker
    University of Florida, Gainesville, FL, USA
    Virol J 5:58. 2008
  2. pmc Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice
    Debra C Quenelle
    Department of Pediatrics, The University of Alabama at Birmingham, School of Medicine, CHB 128, 1600 6th Avenue South, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 51:3940-7. 2007
  3. doi request reprint Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice
    Debra C Quenelle
    The University of Alabama at Birmingham, Birmingham, AL, USA
    Antivir Chem Chemother 22:131-7. 2011
  4. pmc Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies
    Debra C Quenelle
    The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35233 1711, USA
    J Infect Dis 202:1492-9. 2010
  5. pmc Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses
    Debra C Quenelle
    Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233 1711, USA
    Antimicrob Agents Chemother 51:4118-24. 2007
  6. pmc Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models
    Debra C Quenelle
    University of Alabama School of Medicine, Birmingham, AL, USA
    Antiviral Res 79:133-5. 2008
  7. pmc Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides
    Mark N Prichard
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 53:5251-8. 2009
  8. pmc Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections
    Earl R Kern
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, 35233, USA
    Antimicrob Agents Chemother 53:572-9. 2009
  9. pmc Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir
    Debra C Quenelle
    The University of Alabama School of Medicine, Birmingham, Alabama, USA
    Antimicrob Agents Chemother 48:404-12. 2004
  10. pmc Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir
    Earl R Kern
    Department of Pediatrics, The University of Alabama at Birmingham, School of Medicine, CHB 128, 1600 6th Ave South, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 48:3516-22. 2004

Detail Information

Publications25

  1. pmc Isolation and characterization of cidofovir resistant vaccinia viruses
    Marie N Becker
    University of Florida, Gainesville, FL, USA
    Virol J 5:58. 2008
    ..One mode of action for CDV has been demonstrated to be the inhibition of the viral DNA polymerase...
  2. pmc Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice
    Debra C Quenelle
    Department of Pediatrics, The University of Alabama at Birmingham, School of Medicine, CHB 128, 1600 6th Avenue South, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 51:3940-7. 2007
    ....
  3. doi request reprint Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice
    Debra C Quenelle
    The University of Alabama at Birmingham, Birmingham, AL, USA
    Antivir Chem Chemother 22:131-7. 2011
    ..In this investigation, the antiviral activity of N-MCT was assessed against herpes simplex virus type-2 (HSV-2) in BALB/c mice...
  4. pmc Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies
    Debra C Quenelle
    The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35233 1711, USA
    J Infect Dis 202:1492-9. 2010
    ..These studies indicate that CMX001 penetrates the blood-brain barrier, is a potent inhibitor of HSV replication in disseminated infections and central nervous system infections, and is superior to acyclovir...
  5. pmc Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses
    Debra C Quenelle
    Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233 1711, USA
    Antimicrob Agents Chemother 51:4118-24. 2007
    ....
  6. pmc Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models
    Debra C Quenelle
    University of Alabama School of Medicine, Birmingham, AL, USA
    Antiviral Res 79:133-5. 2008
    ..Cidofovir (CDV), at 20mg/kg given i.p., was used as a positive control. HDP-(S)-HPMPA or ODE-(S)-HPMPA significantly reduced viral replication compared to vehicle-treated mice, while oral (S)-HPMPA was ineffective...
  7. pmc Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides
    Mark N Prichard
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 53:5251-8. 2009
    ....
  8. pmc Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections
    Earl R Kern
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, 35233, USA
    Antimicrob Agents Chemother 53:572-9. 2009
    ....
  9. pmc Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir
    Debra C Quenelle
    The University of Alabama School of Medicine, Birmingham, Alabama, USA
    Antimicrob Agents Chemother 48:404-12. 2004
    ....
  10. pmc Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir
    Earl R Kern
    Department of Pediatrics, The University of Alabama at Birmingham, School of Medicine, CHB 128, 1600 6th Ave South, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 48:3516-22. 2004
    ..These results indicated that HDP-CDV or ODE-CDV given orally was as effective as parenteral CDV for the treatment of experimental MCMV infection and suggest that further evaluation for use in CMV infections in humans is warranted...
  11. pmc Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs
    Debra C Quenelle
    University of Alabama at Birmingham, Department of Pediatrics, Birmingham, AL 35233 1711, USA
    Antiviral Res 80:223-4. 2008
    ..Neither vaccine had any therapeutic effect if administered 24 h after viral infection...
  12. ncbi request reprint Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir
    Debra C Quenelle
    The University of Alabama School of Medicine, Birmingham, AL, USA
    Antiviral Res 63:33-40. 2004
    ..These models may provide a means for evaluating efficacy of new therapies directed against orthopoxvirus diseases and further confirm the topical activity of CDV against cutaneous infections...
  13. pmc Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine
    Mark N Prichard
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA
    Virol J 5:39. 2008
    ..Although the crystal structure for this enzyme has been determined, its potential as a target for antiviral therapy is unclear...
  14. pmc Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice
    Mark N Prichard
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL, USA
    Virol J 3:18. 2006
    ..These data are consistent with minimal defects observed in cell culture, but are not consistent with an important role for UL27 in vivo. We conclude that UL27 is not required for viral replication in vivo...
  15. ncbi request reprint In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections
    Debra C Quenelle
    University of Alabama School of Medicine, Birmingham, USA
    Antiviral Res 71:24-30. 2006
    ..These results suggest that this class of compound has little therapeutic potential for orthopoxvirus infections since the in vivo activity against CV, a surrogate virus for variola, is lacking...
  16. pmc CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections
    Mark N Prichard
    University of Alabama at Birmingham, Department of Pediatrics, 128 Children s Harbor Building, 1600 6th Avenue South, Birmingham, AL 35233 1711, USA
    Antimicrob Agents Chemother 55:4728-34. 2011
    ..These results suggest that CMX001 may be effective in the treatment of ACV-resistant HSV infections and as an adjunct therapy in individuals with suboptimal responses to ACV...
  17. pmc Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice
    Debra C Quenelle
    University of Alabama at Birmingham, School of Medicine, Department of Pediatrics, 128 Children s Harbor Building, 1600 6th Avenue South, Birmingham, AL 35233 1711, USA
    Antimicrob Agents Chemother 51:689-95. 2007
    ..Viral replication in target organs of ECTV-infected mice was also reduced...
  18. pmc Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections
    Earl R Kern
    University of Alabama School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Birmingham, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 48:4745-53. 2004
    ..These data indicate that the methylenecyclopropane analog, CPV, was highly efficacious in these four animal models and should be evaluated for use in HCMV infections in humans...
  19. pmc Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice
    Debra C Quenelle
    The University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 47:3275-80. 2003
    ....
  20. pmc Preclinical evaluation of a genetically engineered herpes simplex virus expressing interleukin-12
    James M Markert
    Department of Surgery, Division of Neurosurgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 86:5304-13. 2012
    ..nancymae lymphocytes in vitro. We conclude that the safety and preclinical efficacy of M002 warrants the advancement of a Δγ(1)34.5 virus expressing IL-12 to phase I clinical trials for patients with recurrent malignant glioma...
  21. pmc Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections
    Mark N Prichard
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 50:1336-41. 2006
    ..These results indicate that (N)-MCT is active in vitro and in vivo, and its mechanism of action suggests that the molecule may be an effective therapeutic for orthopoxvirus and herpesvirus infections, thus warranting further development...
  22. ncbi request reprint Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2
    Debra C Quenelle
    University of Alabama at Birmingham, Department of Pediatrics, CHB 128, 1600 6th Avenue South, Birmingham, AL 35233 1711, USA
    Vaccine 24:1515-22. 2006
    ..There was, however, a significant improvement in clinical herpetic genital disease with the combination of gD plus the immune enhancer GPI-0100...
  23. pmc Treatment of Vaccinia and Cowpox Virus Infections in Mice with CMX001 and ST-246
    Debra C Quenelle
    Department of Pediatrics, School of Medicine, The University of Alabama, 170 Children s Harbor Building, 1600 6th Avenue South, Birmingham, Birmingham, AL 35233, USA E mail
    Viruses 2:2681-95. 2010
    ....
  24. pmc Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs
    Mark N Prichard
    Medlmmune Vaccines Inc, 297 N Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 23:5424-31. 2005
    ..Results presented here support the concept of a rationally engineered live attenuated vaccine for the prevention of the genital disease associated with infection by HSV-2...
  25. ncbi request reprint Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides
    Nigel J Temperton
    Department of Virology, Royal Free and University College Medical School, London, United Kingdom
    J Med Virol 70:86-90. 2003
    ..The results provide a rationale for evaluating combinations of other HCMV proteins for incorporation into a multi-target DNA vaccine, and for the optimization of adjuvant usage, to elicit enhanced levels of neutralizing antibodies. 2003...