FREDERICK QUELLE

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Cytokine signaling to the cell cycle
    Frederick W Quelle
    Department of Pharmacology and The Graduate Program in Immunology, The University of Iowa, Carver College of Medicine, 2 210 Bowen Science Bld, Iowa City, IA 52242, USA
    Immunol Res 39:173-84. 2007
  2. ncbi request reprint Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells
    Paula Chakravarti
    Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Int J Oncol 26:509-14. 2005
  3. doi request reprint FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage
    Hong Lei
    Department of Pharmacology, The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Mol Cancer Res 7:1294-303. 2009
  4. ncbi request reprint Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells
    Matthew K Henry
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Exp Cell Res 299:257-66. 2004
  5. ncbi request reprint Cytokine activation of phosphoinositide 3-kinase sensitizes hematopoietic cells to cisplatin-induced death
    Dipali Nimbalkar
    Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cancer Res 63:1034-9. 2003
  6. pmc Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function
    Chandrashekhar Korgaonkar
    Department of Pharmacology, The University of Iowa, College of Medicine, Iowa City, IA 52242, USA
    Mol Cell Biol 25:1258-71. 2005
  7. ncbi request reprint Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage
    Dipali Nimbalkar
    Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cell Cycle 7:2877-85. 2008

Research Grants

Collaborators

  • Dipali Nimbalkar
  • Matthew K Henry
  • Hong Lei
  • Paula Chakravarti
  • Chandrashekhar Korgaonkar
  • Dawn E Quelle
  • April A Frazier
  • Van Tompkins
  • Jussara Hagen
  • Chantal Allamargot
  • Raymond J Hohl

Detail Information

Publications7

  1. ncbi request reprint Cytokine signaling to the cell cycle
    Frederick W Quelle
    Department of Pharmacology and The Graduate Program in Immunology, The University of Iowa, Carver College of Medicine, 2 210 Bowen Science Bld, Iowa City, IA 52242, USA
    Immunol Res 39:173-84. 2007
    ..Evidence for how these signaling pathways promote hematopoietic cell proliferation is considered along with their likely targets among the cell cycle regulators...
  2. ncbi request reprint Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells
    Paula Chakravarti
    Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Int J Oncol 26:509-14. 2005
    ..These observations also suggest that selective activation of PI3K-dependent signaling can enhance radiosensitivity in breast cancer cells...
  3. doi request reprint FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage
    Hong Lei
    Department of Pharmacology, The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Mol Cancer Res 7:1294-303. 2009
    ..Inhibition of FOXO activity by cytokine-induced PI3K/AKT signaling is sufficient to override these DNA damage-induced cell cycle checkpoints, but may negatively impact hematopoietic cell viability...
  4. ncbi request reprint Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells
    Matthew K Henry
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Exp Cell Res 299:257-66. 2004
    ..Together, these observations identify a mechanism through which cytokine-activated PI3K contributes to G1 to S phase progression in factor-dependent hematopoietic cells by enhancing the phosphorylation and activation of Cdk2...
  5. ncbi request reprint Cytokine activation of phosphoinositide 3-kinase sensitizes hematopoietic cells to cisplatin-induced death
    Dipali Nimbalkar
    Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cancer Res 63:1034-9. 2003
    ..These data suggest that cytokine activation of PI3K signaling pathways overrides cisplatin-induced growth arrest checkpoints, thereby sensitizing hematopoietic cells to DNA damage-induced death...
  6. pmc Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function
    Chandrashekhar Korgaonkar
    Department of Pharmacology, The University of Iowa, College of Medicine, Iowa City, IA 52242, USA
    Mol Cell Biol 25:1258-71. 2005
    ..Conversely, NPM overexpression antagonized ARF function while increasing its nucleolar localization. These data suggest that NPM inhibits ARF's p53-dependent activity by targeting it to nucleoli and impairing ARF-Mdm2 association...
  7. ncbi request reprint Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage
    Dipali Nimbalkar
    Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cell Cycle 7:2877-85. 2008
    ..While this activity can rescue irradiated cells from permanent G(1) phase arrest, it results in aberrant cell cycling and death when activated in hematopoietic cells arrested at the G(2) phase DNA damage checkpoint...

Research Grants5

  1. CYTOKINE SIGNALING PATHWAYS REGULATING A G1 CHECKPOINT
    FREDERICK QUELLE; Fiscal Year: 2003
    ..Finally, we will directly assay the status of G/1 cell cycle regulators, including cyclin D-dependent kinases and their inhibitors, and correlate their activities with the UV-induction and cytokine release of the G/1 checkpoint. ..