Christine Queitsch

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, Illinois, United States of America Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
    PLoS ONE 2:e648. 2007
  2. pmc Lessons from model organisms: phenotypic robustness and missing heritability in complex disease
    Christine Queitsch
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 8:e1003041. 2012
  3. pmc HSP90-buffered genetic variation is common in Arabidopsis thaliana
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2969-74. 2008
  4. pmc HSP90 affects the expression of genetic variation and developmental stability in quantitative traits
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2963-8. 2008
  5. ncbi Hsp90 as a capacitor of phenotypic variation
    Christine Queitsch
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 417:618-24. 2002
  6. ncbi The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity
    Todd A Sangster
    Committee on Genetics, University of Chicago, 920 E 58th Street Chicago, Illinois 60637, USA
    Curr Opin Plant Biol 8:86-92. 2005
  7. pmc Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3
    Soledad Francisca Undurraga
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:19363-7. 2012
  8. ncbi Hsp90 and chromatin: where is the link?
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, Illinois, USA
    Cell Cycle 2:166-8. 2003
  9. pmc Molecular mechanisms of robustness in plants
    Janne Lempe
    Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA
    Curr Opin Plant Biol 16:62-9. 2013
  10. pmc The protein chaperone HSP90 can facilitate the divergence of gene duplicates
    Jennifer Lachowiec
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Genetics 193:1269-77. 2013

Collaborators

  • Susan Lindquist
  • Jennifer L Nemhauser
  • Hui Wang
  • Orjan Carlborg
  • Jay Shendure
  • Matthew T Weirauch
  • Evan E Eichler
  • Neeraj Salathia
  • Seth J Davis
  • Kevin J Verstrepen
  • Xia Shen
  • Ron Milo
  • James H Thomas
  • Todd A Sangster
  • Jennifer Lachowiec
  • Maximilian O Press
  • Keisha D Carlson
  • Alessandra M Sullivan
  • Janne Lempe
  • Kurt Schellenberg
  • Pauline Rival
  • Jacob Bale
  • Soledad Francisca Undurraga
  • Soledad Undurraga
  • Etsuko Watanabe
  • Peter H Sudmant
  • Andrew B Stergachis
  • Audra K Johnson
  • Soledad F Undurraga
  • Eric Haugen
  • Robert E Thurman
  • Fidencio V Neri
  • Shane Neph
  • Andrej A Arsovski
  • Sanie Mnaimneh
  • Alex P Reynolds
  • Tanya Grancharova
  • Kerry L Bubb
  • Richard Sandstrom
  • Agnieszka Thompson
  • Benjamin Vernot
  • Morgan Diegel
  • Molly Weaver
  • Ally Yang
  • Shawn T Sullivan
  • John A Stamatoyannopoulos
  • Peter J Sabo
  • Timothy R Hughes
  • Tzitziki Lemus
  • Patrick J M Murphy
  • Matthieu Legendre
  • Maximilian Oliver Press
  • Nora Bujdoso
  • Keith Morneau
  • Hana N Lee
  • Sek Won Kong
  • Alicia Kelley
  • Amity Wilczek
  • Adam Bahrami
  • Catherine McLellan

Detail Information

Publications15

  1. pmc Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, Illinois, United States of America Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
    PLoS ONE 2:e648. 2007
    ..The comprehensive set of HSP90-reduced lines described here is a vital instrument to further examine the role of HSP90 as a central interface between organism, development, and environment...
  2. pmc Lessons from model organisms: phenotypic robustness and missing heritability in complex disease
    Christine Queitsch
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 8:e1003041. 2012
    ..We propose feasible approaches to measure robustness in large human populations, proof-of-principle experiments for robustness markers in model organisms, and a new GWAS design that takes differences in robustness into account...
  3. pmc HSP90-buffered genetic variation is common in Arabidopsis thaliana
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2969-74. 2008
    ..Hence, HSP90 is likely to occupy a central position in the translation of genotypic variation into phenotypic differences...
  4. pmc HSP90 affects the expression of genetic variation and developmental stability in quantitative traits
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2963-8. 2008
    ..Thus, HSP90 may centrally influence canalization, assimilation, and the rapid evolutionary alteration of phenotype through the concealment and exposure of cryptic genetic variation...
  5. ncbi Hsp90 as a capacitor of phenotypic variation
    Christine Queitsch
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 417:618-24. 2002
    ..Manipulating Hsp90's buffering capacity offers a tool for harnessing cryptic genetic variation and for elucidating the interplay between genotypes, environments and stochastic events in the determination of phenotype...
  6. ncbi The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity
    Todd A Sangster
    Committee on Genetics, University of Chicago, 920 E 58th Street Chicago, Illinois 60637, USA
    Curr Opin Plant Biol 8:86-92. 2005
    ..Plants have emerged as powerful tools that complement other model systems in attempts to extend our knowledge of the myriad impacts of protein folding and chaperone function...
  7. pmc Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3
    Soledad Francisca Undurraga
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:19363-7. 2012
    ..In fact, the Col-ELF3 allele, encoding the shortest known ELF3 polyQ tract, was haploinsufficient in Ws × Col F(1) hybrids. Our data support a model in which variable polyQ tracts drive adaptation to internal genetic environments...
  8. ncbi Hsp90 and chromatin: where is the link?
    Todd A Sangster
    Committee on Genetics, University of Chicago, Chicago, Illinois, USA
    Cell Cycle 2:166-8. 2003
  9. pmc Molecular mechanisms of robustness in plants
    Janne Lempe
    Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA
    Curr Opin Plant Biol 16:62-9. 2013
    ..Here, we review recent advances in identifying molecular robustness mechanisms in plants that have been enabled by a combination of classical genetics and population genetics with genome-scale data...
  10. pmc The protein chaperone HSP90 can facilitate the divergence of gene duplicates
    Jennifer Lachowiec
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Genetics 193:1269-77. 2013
    ..Our data provide evidence that HSP90 influences selection on genes encoding its clients and facilitates divergence between gene duplicates...
  11. pmc MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals
    Keisha D Carlson
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 25:750-61. 2015
    ..MIPSTR is applicable to any organism with a high-quality reference genome and is scalable to genotyping many thousands of STR loci in thousands of individuals...
  12. pmc The overdue promise of short tandem repeat variation for heritability
    Maximilian O Press
    Department of Genome Sciences, University of Washington, Foege Building S 250, Box 355065, 3720 15th Avenue NE, Seattle, WA 98195 5065, USA
    Trends Genet 30:504-12. 2014
    ..Lastly, we suggest that somatic STR variation within individuals may serve as a read-out of disease susceptibility, and is thus potentially a valuable covariate for future association studies. ..
  13. pmc A Genome-Wide Association Analysis Reveals Epistatic Cancellation of Additive Genetic Variance for Root Length in Arabidopsis thaliana
    Jennifer Lachowiec
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 11:e1005541. 2015
    ....
  14. doi Mapping and dynamics of regulatory DNA and transcription factor networks in A. thaliana
    Alessandra M Sullivan
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Cell Rep 8:2015-30. 2014
    ..Our results provide an extensive resource for the study of A. thaliana gene regulation and functional biology...
  15. pmc The conserved PFT1 tandem repeat is crucial for proper flowering in Arabidopsis thaliana
    Pauline Rival
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195
    Genetics 198:747-54. 2014
    ..Our study implies that there is strong selection on STRs not only to generate allelic diversity, but also to maintain certain lengths pursuant to optimal molecular function. ..