Research Topics
Genomes and Genes | L Darryl QuarlesSummaryAffiliation: University of Kansas Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin DShiguang Liu
Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
J Am Soc Nephrol 17:1305-15. 2006..The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D...
Endocrine functions of bone in mineral metabolism regulationL Darryl Quarles
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Clin Invest 118:3820-8. 2008....- Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp miceShiguang Liu
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
Am J Physiol Endocrinol Metab 293:E1636-44. 2007..In addition, systemic counterregulatory factors that attenuate the upregulation of FGF23 expression in Hyp mouse osteocytes are present in older mice... - Dose-dependent effects of Runx2 on bone developmentShiqin Zhang
Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
J Bone Miner Res 24:1889-904. 2009.... - Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralizationShiguang Liu
Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA
Curr Opin Nephrol Hypertens 16:329-35. 2007.... - Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney diseaseJason Stubbs
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Semin Dial 20:302-8. 2007.... - Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formationZhousheng Xiao
Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Biol Chem 285:1177-87. 2010..The conditional deletion of Pkd1 also resulted in increased adipogenesis in bone marrow and in osteoblast cultures. Thus, PKD1 directly functions in osteoblasts to regulate bone formation... - Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activityShiguang Liu
The Kidney Institute, University of Kansas Medical Center, MS 3018, Kansas City, KS 66160, USA
J Endocrinol 192:261-7. 2007..The resulting coordination of mineralization and release of a phosphaturic factor by MEPE may serve a physiological role in regulating systemic phosphate homeostasis to meet the needs for bone mineralization... - FGFR3 and FGFR4 do not mediate renal effects of FGF23Shiguang Liu
Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Am Soc Nephrol 19:2342-50. 2008..In summary, neither FGFR3 nor FGFR4 is the principal mediator of FGF23 effects in the proximal tubule, and co-localization of FGFR1 and Klotho suggests that the distal tubule may be an effector site of FGF23... - GPRC6A null mice exhibit osteopenia, feminization and metabolic syndromeMin Pi
The Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA
PLoS ONE 3:e3858. 2008..GPRC6A is a widely expressed orphan G-protein coupled receptor that senses extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological functions of GPRC6A are unknown... 
Economic analysis of cinacalcet in combination with low-dose vitamin D versus flexible-dose vitamin D in treating secondary hyperparathyroidism in hemodialysis patientsTheresa I Shireman
Department of Preventive Medicine and Public Health and the Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS, USA
Am J Kidney Dis 56:1108-16. 2010..The economic implications of these treatment regimens have not been explored...- Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRDJames B Wetmore
University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Clin J Am Soc Nephrol 5:110-6. 2010..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial... - Elevated FGF23 levels are associated with impaired calcium-mediated suppression of PTH in ESRDJames B Wetmore
Division of Nephrology and Hypertension, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
J Clin Endocrinol Metab 96:E57-64. 2011..The positive association of elevated fibroblast growth factor-23 (FGF23) with PTH levels in the setting of secondary hyperparathyroidism is paradoxical to the purported effects of FGF23 to suppress PTH secretion... - Inducible expression of Runx2 results in multiorgan abnormalities in miceNan He
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Cell Biochem 112:653-65. 2011..Use of tissue specific Cre mice will allow this model to be used to conditionally and inducibly overexpress Runx2 in different tissues and provide a means to study the post-natal tissue- and cell context-dependent functions of Runx2... - Calcimimetics as an adjuvant treatment for familial hypophosphatemic ricketsUri S Alon
Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children s Mercy Hospital, University of Missouri, Kansas City, MO 64108, USA
Clin J Am Soc Nephrol 3:658-64. 2008.... - Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null miceJason R Stubbs
The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Am Soc Nephrol 18:2116-24. 2007.... - Fibroblast growth factor 23: uremic toxin or innocent bystander in chronic kidney disease?Jason R Stubbs
Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS, USA
Nephrol News Issues 23:33-4, 36-7. 2009.... - Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolismJian Q Feng
Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
Nat Genet 38:1310-5. 2006..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism... - Parathyroid-specific interaction of the calcium-sensing receptor and G alpha qMin Pi
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Kidney Int 74:1548-56. 2008..These studies demonstrate the feasibility of selectively targeting the parathyroid gland to investigate signaling mechanisms downstream of the calcium receptor... - Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift?James B Wetmore
Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66160, USA
Nat Clin Pract Nephrol 5:24-33. 2009..Finally, we propose a novel treatment framework in which calcimimetics are the primary therapy for suppressing parathyroid hormone production in patients with end-stage renal disease... - How fibroblast growth factor 23 worksShiguang Liu
Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
J Am Soc Nephrol 18:1637-47. 2007..Further understanding of this primary phosphate homeostatic pathway has the potential to have a significant impact on the diagnosis and treatment of disorders of bone and mineral metabolism... - Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRDJason R Stubbs
3901 Rainbow Boulevard, MS 3002, Kansas City, KS 66160, USA
J Am Soc Nephrol 21:353-61. 2010..These data suggest that nutritional vitamin D therapy has a biologic effect on circulating monocytes and associated inflammatory markers in patients with ESRD... - Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptorsMin Pi
Department of Internal Medicine, The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Cell Biochem 95:1081-92. 2005.... - Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-IIZhousheng Xiao
Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Biol Chem 283:12624-34. 2008..The overall function of the primary cilium-polycystin complex may be to sense and transduce environmental clues into signals regulating osteoblast differentiation and bone development... - Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemiaShiguang Liu
Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, MS 3018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
J Am Soc Nephrol 16:1645-53. 2005..These results demonstrate that MEPE elevation in Hyp mice does not contribute to the hypophosphatemia associated with inactivating Phex mutations and is therefore not phosphatonin... - Pathogenic role of Fgf23 in Hyp miceShiguang Liu
The Kidney Institute, The University of Kansas Medical Center, Kansas City, KS 66160, USA
Am J Physiol Endocrinol Metab 291:E38-49. 2006..These results suggest that Fgf23 acts downstream of Phex to cause both the renal and bone phenotypes in Hyp mice... - Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitizationMin Pi
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Mol Endocrinol 19:1078-87. 2005..We conclude that GRKs and beta-arrestins play key roles in regulating CASR responsiveness in parathyroid glands... - Treatment of secondary hyperparathyroidism in kidney disease: what we know and do not know about use of calcimimetics and vitamin D analogsJames B Wetmore
Department of Medicine, Division of Nephrology, University of Kansas Medical Center, Kansas City, KS, USA
Int J Nephrol Renovasc Dis 1:5-17. 2008.... - Identification of a novel extracellular cation-sensing G-protein-coupled receptorMin Pi
Kidney Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Biol Chem 280:40201-9. 2005.... - Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null backgroundQisheng Tu
Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 111:1029-37. 2003..Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR... - The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal diseaseL Darryl Quarles
Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Soc Nephrol 14:575-83. 2003..AMG 073 represents a novel and promising therapy to improve the management of secondary hyperparathyroidism... - FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationL Darryl Quarles
Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Endocrinol Metab 285:E1-9. 2003.... - Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotypeShiguang Liu
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:3686-97. 2002.... - Serum FGF23 levels in normal and disordered phosphorus homeostasisThomas J Weber
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Bone Miner Res 18:1227-34. 2003..In contrast, FGF23 levels were markedly increased in subjects with ESRD and correlated inversely with the degree of hyperphosphatemia... - Inhibition of MEPE cleavage by PhexRong Guo
Department of Medicine, The Center for Bone and Mineral Disorders, Duke University Medical Center, Box 3036, Durham, NC 27710, USA
Biochem Biophys Res Commun 297:38-45. 2002.... - Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiationXiaowei Chen
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr Biochem 14:342-9. 2003.... - Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HClSharon M Moe
Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Kidney Int 67:760-71. 2005.... - Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow cultureWei Pan
Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
J Cell Biochem 94:307-16. 2005..Gen has estrogen-like activity and stimulates the proliferation and osteoblastic differentiation of mouse BMSCs at least in part through NO/cGMP pathway... - Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34)Liming Wang
Division of Nephrology, Department of Medicine, Duke University, Durham VA Medical Centers, Durham, North Carolina, USA
J Bone Miner Res 19:1661-70. 2004..CONCLUSIONS: These data suggest that the anabolic effects of GRK inhibition are age dependent. The osteoinductive actions of the GRK inhibitor are, however, unmasked by treatment with PTH(1-34)... - A novel cation-sensing mechanism in osteoblasts is a molecular target for strontiumMin Pi
Box 3036, 00570 Blue Zone, Duke Hospital South, Duke University Medical Center, Durham, NC 27710, USA
J Bone Miner Res 19:862-9. 2004..These findings are consistent with strontium activation of a novel Galphaq-coupled extracellular cation-sensing receptor in osteoblasts with distinct cation specificity... - Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanismQisheng Tu
Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
J Bone Miner Res 18:1825-33. 2003..Further understanding of calcyclin function in osteoblasts may identify novel targets for regulating bone formation... - Regulation of fibroblastic growth factor 23 expression but not degradation by PHEXShiguang Liu
Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:37419-26. 2003.... - Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone lossLiming Wang
Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina, USA
Am J Physiol Endocrinol Metab 288:E826-34. 2005..Taken together, these data suggest that enhancing GRK2 activity and consequently reducing GPCR activity in osteoblasts produces a low bone-turnover state that reduces bone mass... - Evidence for a bone-kidney axis regulating phosphate homeostasisL Darryl Quarles
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 112:642-6. 2003 - Guidelines for disorders of mineral metabolism and secondary hyperparathyroidism should not yet be modifiedJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, CA 94143 0532, USA
Nat Clin Pract Nephrol 2:337-9. 2006..The focus should be on evaluating the effects of alternative strategies on survival, as well as clinical manifestations of cardiovascular and bone disease... - Hyperphosphatemia in end-stage renal diseaseOlafur S Indridason
Department of Medicine, Division of Nephrology, University Hospital, Reykjavik, Iceland
Adv Ren Replace Ther 9:184-92. 2002..The development of new phosphate binders and efforts to find new ways to inhibit gastrointestinal absorption of phosphate will lead to improvements in the control of serum phosphate levels in ESRD... - Introduction: emerging therapies derived from the molecular pathogenesis of secondary hyperparathyroidism in ESRD patientsL Darryl Quarles
Adv Ren Replace Ther 9:153-8. 2002 - Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblastsRobert F Spurney
Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Administration Medical Centers, North Carolina 27710, USA
J Clin Invest 109:1361-71. 2002..The predominant effect of the transgene, however, was anabolic, as evidenced by an increase in bone density and trabecular bone volume in the transgenic mice compared with nontransgenic littermate controls... - IRES-dependent translational control of Cbfa1/Runx2 expressionZhou Sheng Xiao
Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
J Cell Biochem 88:493-505. 2003..These findings suggest that Cbfa1 UTRs have IRES-dependent translational activities that may permit continued Cbfa1 expression under conditions that are not optimal for cap-dependent translation... - Extracellular calcium-sensing receptors in the parathyroid gland, kidney, and other tissuesL Darryl Quarles
Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina, USA
Curr Opin Nephrol Hypertens 12:349-55. 2003..In the present review, I discuss the function of CasR as well as provide evidence for the presence of additional calcium-sensing mechanisms in the skeleton and possibly other tissues...
Research Grants
- EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTSL Quarles; Fiscal Year: 2006..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
- University of Kansas Training Grant in NephrologyL Quarles; Fiscal Year: 2007..Individuals who complete the program will be capable of independent investigation and translating research accomplishments into important advances with clinical relevance. ..