L Darryl Quarles

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:1305-15. 2006
  2. pmc Endocrine functions of bone in mineral metabolism regulation
    L Darryl Quarles
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Clin Invest 118:3820-8. 2008
  3. ncbi request reprint Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Am J Physiol Endocrinol Metab 293:E1636-44. 2007
  4. pmc Dose-dependent effects of Runx2 on bone development
    Shiqin Zhang
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Bone Miner Res 24:1889-904. 2009
  5. ncbi request reprint Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization
    Shiguang Liu
    Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA
    Curr Opin Nephrol Hypertens 16:329-35. 2007
  6. pmc Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease
    Jason R Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Bone Miner Res 27:38-46. 2012
  7. pmc Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation
    Zhousheng Xiao
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 285:1177-87. 2010
  8. ncbi request reprint Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease
    Jason Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Dial 20:302-8. 2007
  9. pmc FGFR3 and FGFR4 do not mediate renal effects of FGF23
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 19:2342-50. 2008
  10. pmc Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, MS 3018, Kansas City, KS 66160, USA
    J Endocrinol 192:261-7. 2007

Research Grants

Detail Information

Publications51

  1. ncbi request reprint Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:1305-15. 2006
    ..The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D...
  2. pmc Endocrine functions of bone in mineral metabolism regulation
    L Darryl Quarles
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Clin Invest 118:3820-8. 2008
    ....
  3. ncbi request reprint Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Am J Physiol Endocrinol Metab 293:E1636-44. 2007
    ..In addition, systemic counterregulatory factors that attenuate the upregulation of FGF23 expression in Hyp mouse osteocytes are present in older mice...
  4. pmc Dose-dependent effects of Runx2 on bone development
    Shiqin Zhang
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Bone Miner Res 24:1889-904. 2009
    ....
  5. ncbi request reprint Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization
    Shiguang Liu
    Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA
    Curr Opin Nephrol Hypertens 16:329-35. 2007
    ....
  6. pmc Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease
    Jason R Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Bone Miner Res 27:38-46. 2012
    ..Elevations in FGF23 and PTH coincide with an increase in urinary phosphate excretion that likely prevents the early onset of hyperphosphatemia in the face of increased bone turnover and a progressive decline in functional renal mass...
  7. pmc Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation
    Zhousheng Xiao
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 285:1177-87. 2010
    ..The conditional deletion of Pkd1 also resulted in increased adipogenesis in bone marrow and in osteoblast cultures. Thus, PKD1 directly functions in osteoblasts to regulate bone formation...
  8. ncbi request reprint Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease
    Jason Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Dial 20:302-8. 2007
    ....
  9. pmc FGFR3 and FGFR4 do not mediate renal effects of FGF23
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 19:2342-50. 2008
    ..In summary, neither FGFR3 nor FGFR4 is the principal mediator of FGF23 effects in the proximal tubule, and co-localization of FGFR1 and Klotho suggests that the distal tubule may be an effector site of FGF23...
  10. pmc Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, MS 3018, Kansas City, KS 66160, USA
    J Endocrinol 192:261-7. 2007
    ..The resulting coordination of mineralization and release of a phosphaturic factor by MEPE may serve a physiological role in regulating systemic phosphate homeostasis to meet the needs for bone mineralization...
  11. pmc GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome
    Min Pi
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA
    PLoS ONE 3:e3858. 2008
    ..GPRC6A is a widely expressed orphan G-protein coupled receptor that senses extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological functions of GPRC6A are unknown...
  12. pmc Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
    ..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial...
  13. ncbi request reprint Economic analysis of cinacalcet in combination with low-dose vitamin D versus flexible-dose vitamin D in treating secondary hyperparathyroidism in hemodialysis patients
    Theresa I Shireman
    Department of Preventive Medicine and Public Health and the Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS, USA
    Am J Kidney Dis 56:1108-16. 2010
    ..The economic implications of these treatment regimens have not been explored...
  14. doi request reprint Inducible expression of Runx2 results in multiorgan abnormalities in mice
    Nan He
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Cell Biochem 112:653-65. 2011
    ..Use of tissue specific Cre mice will allow this model to be used to conditionally and inducibly overexpress Runx2 in different tissues and provide a means to study the post-natal tissue- and cell context-dependent functions of Runx2...
  15. pmc Elevated FGF23 levels are associated with impaired calcium-mediated suppression of PTH in ESRD
    James B Wetmore
    Division of Nephrology and Hypertension, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    J Clin Endocrinol Metab 96:E57-64. 2011
    ..The positive association of elevated fibroblast growth factor-23 (FGF23) with PTH levels in the setting of secondary hyperparathyroidism is paradoxical to the purported effects of FGF23 to suppress PTH secretion...
  16. pmc Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets
    Uri S Alon
    Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children s Mercy Hospital, University of Missouri, Kansas City, MO 64108, USA
    Clin J Am Soc Nephrol 3:658-64. 2008
    ....
  17. ncbi request reprint Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
    Jason R Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:2116-24. 2007
    ....
  18. pmc Parathyroid-specific interaction of the calcium-sensing receptor and G alpha q
    Min Pi
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Kidney Int 74:1548-56. 2008
    ..These studies demonstrate the feasibility of selectively targeting the parathyroid gland to investigate signaling mechanisms downstream of the calcium receptor...
  19. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  20. ncbi request reprint Fibroblast growth factor 23: uremic toxin or innocent bystander in chronic kidney disease?
    Jason R Stubbs
    Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS, USA
    Nephrol News Issues 23:33-4, 36-7. 2009
    ....
  21. pmc Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptors
    Min Pi
    Department of Internal Medicine, The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Cell Biochem 95:1081-92. 2005
    ....
  22. ncbi request reprint How fibroblast growth factor 23 works
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:1637-47. 2007
    ..Further understanding of this primary phosphate homeostatic pathway has the potential to have a significant impact on the diagnosis and treatment of disorders of bone and mineral metabolism...
  23. pmc Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift?
    James B Wetmore
    Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Nat Clin Pract Nephrol 5:24-33. 2009
    ..Finally, we propose a novel treatment framework in which calcimimetics are the primary therapy for suppressing parathyroid hormone production in patients with end-stage renal disease...
  24. pmc Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD
    Jason R Stubbs
    3901 Rainbow Boulevard, MS 3002, Kansas City, KS 66160, USA
    J Am Soc Nephrol 21:353-61. 2010
    ..These data suggest that nutritional vitamin D therapy has a biologic effect on circulating monocytes and associated inflammatory markers in patients with ESRD...
  25. pmc Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II
    Zhousheng Xiao
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 283:12624-34. 2008
    ..The overall function of the primary cilium-polycystin complex may be to sense and transduce environmental clues into signals regulating osteoblast differentiation and bone development...
  26. pmc Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, MS 3018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Am Soc Nephrol 16:1645-53. 2005
    ..These results demonstrate that MEPE elevation in Hyp mice does not contribute to the hypophosphatemia associated with inactivating Phex mutations and is therefore not phosphatonin...
  27. ncbi request reprint Pathogenic role of Fgf23 in Hyp mice
    Shiguang Liu
    The Kidney Institute, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 291:E38-49. 2006
    ..These results suggest that Fgf23 acts downstream of Phex to cause both the renal and bone phenotypes in Hyp mice...
  28. pmc Identification of a novel extracellular cation-sensing G-protein-coupled receptor
    Min Pi
    Kidney Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 280:40201-9. 2005
    ....
  29. ncbi request reprint Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization
    Min Pi
    Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Endocrinol 19:1078-87. 2005
    ..We conclude that GRKs and beta-arrestins play key roles in regulating CASR responsiveness in parathyroid glands...
  30. pmc Treatment of secondary hyperparathyroidism in kidney disease: what we know and do not know about use of calcimimetics and vitamin D analogs
    James B Wetmore
    Department of Medicine, Division of Nephrology, University of Kansas Medical Center, Kansas City, KS, USA
    Int J Nephrol Renovasc Dis 1:5-17. 2008
    ....
  31. ncbi request reprint The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease
    L Darryl Quarles
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Soc Nephrol 14:575-83. 2003
    ..AMG 073 represents a novel and promising therapy to improve the management of secondary hyperparathyroidism...
  32. ncbi request reprint Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    Shiguang Liu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:3686-97. 2002
    ....
  33. ncbi request reprint Inhibition of MEPE cleavage by Phex
    Rong Guo
    Department of Medicine, The Center for Bone and Mineral Disorders, Duke University Medical Center, Box 3036, Durham, NC 27710, USA
    Biochem Biophys Res Commun 297:38-45. 2002
    ....
  34. pmc Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
    Qisheng Tu
    Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 111:1029-37. 2003
    ..Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR...
  35. ncbi request reprint FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization
    L Darryl Quarles
    Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Endocrinol Metab 285:E1-9. 2003
    ....
  36. ncbi request reprint Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism
    Qisheng Tu
    Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1825-33. 2003
    ..Further understanding of calcyclin function in osteoblasts may identify novel targets for regulating bone formation...
  37. ncbi request reprint A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium
    Min Pi
    Box 3036, 00570 Blue Zone, Duke Hospital South, Duke University Medical Center, Durham, NC 27710, USA
    J Bone Miner Res 19:862-9. 2004
    ..The current studies demonstrate that a G-protein-mediated response to strontium persists in osteoblasts that lack CASR, suggesting a predominant role for a novel cation-sensing receptor in mediating the osseous response to strontium...
  38. ncbi request reprint Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34)
    Liming Wang
    Division of Nephrology, Department of Medicine, Duke University, Durham VA Medical Centers, Durham, North Carolina, USA
    J Bone Miner Res 19:1661-70. 2004
    ..We found that (1) GRK inhibition in osteoblasts has age-dependent effects on bone mass, and (2) the anabolic actions of GRK inhibition are revealed by treatment with PTH(1-34)...
  39. ncbi request reprint Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture
    Wei Pan
    Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
    J Cell Biochem 94:307-16. 2005
    ..Gen has estrogen-like activity and stimulates the proliferation and osteoblastic differentiation of mouse BMSCs at least in part through NO/cGMP pathway...
  40. ncbi request reprint Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss
    Liming Wang
    Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina, USA
    Am J Physiol Endocrinol Metab 288:E826-34. 2005
    ..Taken together, these data suggest that enhancing GRK2 activity and consequently reducing GPCR activity in osteoblasts produces a low bone-turnover state that reduces bone mass...
  41. ncbi request reprint Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
    Shiguang Liu
    Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:37419-26. 2003
    ....
  42. ncbi request reprint Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:760-71. 2005
    ....
  43. ncbi request reprint Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiation
    Xiaowei Chen
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    J Nutr Biochem 14:342-9. 2003
    ....
  44. ncbi request reprint Serum FGF23 levels in normal and disordered phosphorus homeostasis
    Thomas J Weber
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1227-34. 2003
    ..In contrast, FGF23 levels were markedly increased in subjects with ESRD and correlated inversely with the degree of hyperphosphatemia...
  45. pmc Evidence for a bone-kidney axis regulating phosphate homeostasis
    L Darryl Quarles
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 112:642-6. 2003
  46. ncbi request reprint Introduction: emerging therapies derived from the molecular pathogenesis of secondary hyperparathyroidism in ESRD patients
    L Darryl Quarles
    Adv Ren Replace Ther 9:153-8. 2002
  47. pmc Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts
    Robert F Spurney
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Administration Medical Centers, North Carolina 27710, USA
    J Clin Invest 109:1361-71. 2002
    ..The predominant effect of the transgene, however, was anabolic, as evidenced by an increase in bone density and trabecular bone volume in the transgenic mice compared with nontransgenic littermate controls...
  48. ncbi request reprint Hyperphosphatemia in end-stage renal disease
    Olafur S Indridason
    Department of Medicine, Division of Nephrology, University Hospital, Reykjavik, Iceland
    Adv Ren Replace Ther 9:184-92. 2002
    ..The development of new phosphate binders and efforts to find new ways to inhibit gastrointestinal absorption of phosphate will lead to improvements in the control of serum phosphate levels in ESRD...
  49. ncbi request reprint IRES-dependent translational control of Cbfa1/Runx2 expression
    Zhou Sheng Xiao
    Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biochem 88:493-505. 2003
    ..These findings suggest that Cbfa1 UTRs have IRES-dependent translational activities that may permit continued Cbfa1 expression under conditions that are not optimal for cap-dependent translation...
  50. ncbi request reprint Guidelines for disorders of mineral metabolism and secondary hyperparathyroidism should not yet be modified
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, CA 94143 0532, USA
    Nat Clin Pract Nephrol 2:337-9. 2006
    ..The focus should be on evaluating the effects of alternative strategies on survival, as well as clinical manifestations of cardiovascular and bone disease...
  51. ncbi request reprint Extracellular calcium-sensing receptors in the parathyroid gland, kidney, and other tissues
    L Darryl Quarles
    Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Nephrol Hypertens 12:349-55. 2003
    ..In the present review, I discuss the function of CasR as well as provide evidence for the presence of additional calcium-sensing mechanisms in the skeleton and possibly other tissues...

Research Grants3

  1. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2006
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
  2. University of Kansas Training Grant in Nephrology
    L Quarles; Fiscal Year: 2007
    ..Individuals who complete the program will be capable of independent investigation and translating research accomplishments into important advances with clinical relevance. ..