Wenchao Qu

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, United States
    Bioorg Med Chem Lett 19:3382-5. 2009
  2. pmc Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA)
    Zhihao Zha
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    J Med Chem 54:8085-98. 2011
  3. doi request reprint PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine
    Brian P Lieberman
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 52:1947-55. 2011
  4. doi request reprint Synthesis and comparative biological evaluation of L- and D-isomers of 18F-labeled fluoroalkyl phenylalanine derivatives as tumor imaging agents
    Limin Wang
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 38:301-12. 2011
  5. pmc 5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression
    Ann Marie Chacko
    Institute for Environmental Medicine, Targeted Therapeutics Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 36:29-38. 2009
  6. pmc Synthesis and evaluation of 18F labeled alanine derivatives as potential tumor imaging agents
    Limin Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 39:933-43. 2012
  7. doi request reprint Comparative evaluation of 18F-labeled glutamic acid and glutamine as tumor metabolic imaging agents
    Karl Ploessl
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 53:1616-24. 2012
  8. doi request reprint Preparation and characterization of L-[5-11C]-glutamine for metabolic imaging of tumors
    Wenchao Qu
    Departments of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 53:98-105. 2012
  9. pmc Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 18:4823-7. 2008
  10. pmc Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 17:3581-4. 2007

Collaborators

Detail Information

Publications19

  1. doi request reprint Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, United States
    Bioorg Med Chem Lett 19:3382-5. 2009
    ..In vitro enzyme assays indicated that the molecules, 5c-e, are potent inhibitors. Thus, they deserve further evaluation as potential radioactive probes for tumor imaging...
  2. pmc Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA)
    Zhihao Zha
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    J Med Chem 54:8085-98. 2011
    ..The results suggest that [(18)F]8a may be a useful PET imaging agent for selectively detecting Aβ plaques associated with cerebral vessels in the living human brain...
  3. doi request reprint PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine
    Brian P Lieberman
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 52:1947-55. 2011
    ..Recent studies suggest that several tumors may use glutamine as the key nutrient for survival. As an alternative metabolic tracer for tumors, (18)F-(2S,4R)4-fluoroglutamine was developed as a PET tracer for mapping glutaminolytic tumors...
  4. doi request reprint Synthesis and comparative biological evaluation of L- and D-isomers of 18F-labeled fluoroalkyl phenylalanine derivatives as tumor imaging agents
    Limin Wang
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 38:301-12. 2011
    ....
  5. pmc 5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression
    Ann Marie Chacko
    Institute for Environmental Medicine, Targeted Therapeutics Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 36:29-38. 2009
    ....
  6. pmc Synthesis and evaluation of 18F labeled alanine derivatives as potential tumor imaging agents
    Limin Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 39:933-43. 2012
    ..This paper reports the synthesis and labeling of (18)F alanine derivatives. We also investigate their biological characteristics as potential tumor imaging agents mediated by alanine-serine-cysteine preferring (ASC) transporter system...
  7. doi request reprint Comparative evaluation of 18F-labeled glutamic acid and glutamine as tumor metabolic imaging agents
    Karl Ploessl
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 53:1616-24. 2012
    ..Here, we report the preparation and comparative evaluation of (18)F-(2S,4R)4F-GLN and (18)F-(2S,4R)4F-GLU as tumor metabolic imaging agents...
  8. doi request reprint Preparation and characterization of L-[5-11C]-glutamine for metabolic imaging of tumors
    Wenchao Qu
    Departments of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 53:98-105. 2012
    ....
  9. pmc Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 18:4823-7. 2008
    ..These preliminary results identified that indolylphenylacetylene, 14, may be a good lead for further structural modification to develop a useful Abeta plaque imaging agent...
  10. pmc Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 17:3581-4. 2007
    ..Taken together, these preliminary results strongly suggest that these novel iodinated aza-diphenylacetylenes may be potentially useful for imaging Abeta plaques in the living human brain...
  11. doi request reprint Facile synthesis [5-(13)C-4-(2)H(2)]-L-glutamine for hyperpolarized MRS imaging of cancer cell metabolism
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Radiol 18:932-9. 2011
    ..This suggests that hyperpolarized (13)C glutamine may be useful as a magnetic resonance spectroscopy (MRS) imaging agent for detecting changes in glutamine metabolism in cancerous cells or tissues...
  12. doi request reprint Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents
    Limin Wang
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 20:3482-5. 2010
    ..The uptake of tracers followed the order of FET ([18F]1) > FEAT([18F]3) > FEMT ([18F]2) approximately FETA ([18F]4)...
  13. pmc Synthesis, uptake mechanism characterization and biological evaluation of (18)F labeled fluoroalkyl phenylalanine analogs as potential PET imaging agents
    Limin Wang
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 38:53-62. 2011
    ....
  14. doi request reprint Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression
    Ann Marie Chacko
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 51:5690-701. 2008
    ....
  15. pmc Quick assembly of 1,4-diphenyltriazoles as probes targeting beta-amyloid aggregates in Alzheimer's disease
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:3380-7. 2007
    ....
  16. doi request reprint Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors
    Wenchao Qu
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    J Am Chem Soc 133:1122-33. 2011
    ....
  17. pmc A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent
    Karl Plossl
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 35:83-90. 2008
    ..In conclusion, the new N(2)S(2) ligand was readily prepared and labeled with radioactive (67)Ga. Biodistribution in rats revealed high initial heart uptake and relatively high retention reflecting regional myocardial perfusion...
  18. ncbi request reprint Novel styrylpyridines as probes for SPECT imaging of amyloid plaques
    Wenchao Qu
    Department of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:2157-65. 2007
    ..Taken together, these results strongly suggest that these styrylpyridines are useful for imaging Abeta plaques in the living human brain...
  19. doi request reprint Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling
    Ann Marie Chacko
    Department of Pharmacology, University of Pennsylvania, 3700 Market Street, Suite 305, Philadelphia, Pennsylvania 19104, USA
    J Org Chem 73:4874-81. 2008
    ..Furthermore, this methodology has been extended to create a series of 13 5-alkyl-substituted nucleosides, including the target nucleosides 5 and 5-silyloxypropyl and 5-cyanobutyl derivatives...