Linghua Qiu

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi request reprint Specific gene silencing using RNAi in cell culture
    Chunxing Yang
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 793:457-77. 2011
  2. pmc Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01602, USA
    Mol Neurodegener 8:1. 2013
  3. pmc A construct with fluorescent indicators for conditional expression of miRNA
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    BMC Biotechnol 8:77. 2008
  4. pmc Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression
    Hongyan Wang
    Department of Biochemistry and Molecular Pharmacology, Chemical Biology Program, Cell Biology, and Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:15845-52. 2008
  5. pmc The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism
    Chunxing Yang
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e15878. 2010
  6. pmc A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e18778. 2011

Collaborators

Detail Information

Publications6

  1. doi request reprint Specific gene silencing using RNAi in cell culture
    Chunxing Yang
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 793:457-77. 2011
    ....
  2. pmc Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01602, USA
    Mol Neurodegener 8:1. 2013
    ..Furthermore, the amount of VAPB protein is reported to be reduced in sporadic ALS patients and mutant SOD1G93A mice, leading to the hypothesis that wild type VAPB plays a role in the pathogenesis of ALS without VAPB mutations...
  3. pmc A construct with fluorescent indicators for conditional expression of miRNA
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    BMC Biotechnol 8:77. 2008
    ..Furthermore, because microRNA (miRNA) targeting specific genes can be expressed simultaneously with protein coding genes, incorporation of fluorescent marker proteins can simplify the screening and analysis of transgenic RNAi animals...
  4. pmc Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression
    Hongyan Wang
    Department of Biochemistry and Molecular Pharmacology, Chemical Biology Program, Cell Biology, and Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:15845-52. 2008
    ..These results bring RNA interference therapy one step closer to its clinical application for treatment of chronic, devastating, and fatal CNS disorders...
  5. pmc The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism
    Chunxing Yang
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e15878. 2010
    ....
  6. pmc A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e18778. 2011
    ..Therefore, results from this Cre-loxP approach to generate inducible transgenic alleles must be interpreted with caution and conclusions drawn in previous reports may need reexamination...