Hongwei Qin

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, 1918 University Blvd, MCLM 395, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Blood 106:3114-22. 2005
  2. ncbi request reprint Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5966-76. 2007
  3. ncbi request reprint SOCS3 deficiency promotes M1 macrophage polarization and inflammation
    Hongwei Qin
    Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 189:3439-48. 2012
  4. pmc Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:5004-9. 2012
  5. pmc Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3167-76. 2008
  6. pmc TGF-beta promotes Th17 cell development through inhibition of SOCS3
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    J Immunol 183:97-105. 2009
  7. ncbi request reprint IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Immunol 177:7761-71. 2006
  8. ncbi request reprint IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 1918 University Blvd, MCLM 395, Birmingham, Alabama 35294 0005, USA
    FASEB J 20:985-7. 2006
  9. pmc IL-17 enhancement of the IL-6 signaling cascade in astrocytes
    Xiangyu Ma
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:4898-906. 2010
  10. doi request reprint Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:5915-25. 2010

Collaborators

Detail Information

Publications23

  1. pmc LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, 1918 University Blvd, MCLM 395, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Blood 106:3114-22. 2005
    ..These results indicate that both LPS-induced NF-kappaB activation and endogenous production of IFN-beta that subsequently induces STAT-1alpha activation play critical roles in the transcriptional activation of the CD40 gene by LPS...
  2. ncbi request reprint Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5966-76. 2007
    ....
  3. ncbi request reprint SOCS3 deficiency promotes M1 macrophage polarization and inflammation
    Hongwei Qin
    Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 189:3439-48. 2012
    ..These findings collectively indicate that SOCS3 is involved in repressing the M1 proinflammatory phenotype, thereby deactivating inflammatory responses in macrophages...
  4. pmc Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:5004-9. 2012
    ..These findings indicate that myeloid cell SOCS3 provides protection from EAE through deactivation of neuroinflammatory responses...
  5. pmc Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3167-76. 2008
    ..These results indicate that IFN-beta induces SOCS-1 and SOCS-3 in primary astrocytes to attenuate its own chemokine-related inflammation in the CNS...
  6. pmc TGF-beta promotes Th17 cell development through inhibition of SOCS3
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    J Immunol 183:97-105. 2009
    ..Our data indicate that inhibition of SOCS3 and, thus, enhancement of STAT3 activation is at least one of the mechanisms of TGF-beta promotion of Th17 cell development...
  7. ncbi request reprint IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Immunol 177:7761-71. 2006
    ..These results indicate that SOCS-3 plays an important role in the negative regulation of LPS-induced CD40 gene expression by IL-10...
  8. ncbi request reprint IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 1918 University Blvd, MCLM 395, Birmingham, Alabama 35294 0005, USA
    FASEB J 20:985-7. 2006
    ..These novel results indicate that IFN-beta-induced SOCS-1 plays an important role in the negative regulation of IFN-beta-induced CD40 gene expression...
  9. pmc IL-17 enhancement of the IL-6 signaling cascade in astrocytes
    Xiangyu Ma
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:4898-906. 2010
    ..These results indicate that astrocytes can serve as a target of Th17 cells and IL-17 in the CNS, and SOCS3 participates in IL-17 functions in the CNS as a negative feedback regulator...
  10. doi request reprint Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:5915-25. 2010
    ..These data indicate that RA plays a critical role in the generation of mucosal DCs from bone marrow and in their functional activity...
  11. pmc IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia
    Brandi J Baker
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Glia 58:1082-93. 2010
    ..These studies are the first to demonstrate the proinflammatory effects of OSM in microglia, and also identify IL-27 as a novel inhibitor of inflammatory processes in these cells...
  12. doi request reprint Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages
    Lisa Nowoslawski Akhtar
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:2393-404. 2010
    ....
  13. ncbi request reprint Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis
    Yudong Liu
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294
    J Immunol 192:59-72. 2014
    ..Inhibition of the JAK/STAT pathway has clinical efficacy in multiple preclinical models of MS, suggesting the feasibility of the JAK/STAT pathway as a target for neuroinflammatory diseases. ..
  14. pmc AMP-activated protein kinase restricts IFN-γ signaling
    Gordon P Meares
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:372-80. 2013
    ..Overall, these findings provide the first link between AMPK and STAT1 and may provide important clues about how bioenergetics and inflammation are linked...
  15. pmc Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes
    Brandi J Baker
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Glia 56:1250-62. 2008
    ..These data indicate that OSM-induced activation of STAT-3 and the ERK1/2 and JNK pathways are critical for astrocytic expression of SOCS-3, which provides for feedback inhibition of cytokine-induced inflammatory responses in the CNS...
  16. doi request reprint Regulation of CCL20 expression in astrocytes by IL-6 and IL-17
    Gordon P Meares
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Glia 60:771-81. 2012
    ..Collectively, these results suggest that astrocytes, in response to IL-6, sIL-6R, and IL-17, may shift chemokine production to that favoring T cell recruitment to the CNS...
  17. pmc The IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins
    Sun J Lee
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Eur J Immunol 38:2325-36. 2008
    ..The recruitment of USF-1 to CIITA pIV is also reduced by statins, as is the recruitment of RNA polymerase II (Pol II), p300 and Brg-1. These data indicate that statins inhibit the transcriptional program of the CIITA gene...
  18. ncbi request reprint TRADD interacts with STAT1-alpha and influences interferon-gamma signaling
    Duane R Wesemann
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Nat Immunol 5:199-207. 2004
    ..These data indicate that TRADD may be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation...
  19. ncbi request reprint Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha
    Sun Jung Lee
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    J Leukoc Biol 82:436-47. 2007
    ..Collectively, these data indicate that SS inhibits IFN-gamma-induced CD40 expression by suppression of STAT-1alpha, and altering transcriptional events at the CD40 promoter...
  20. ncbi request reprint The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis
    Jeffrey C Edberg
    Departments of Medicine and Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue S, THT433A, Birmingham, AL 35294, USA
    J Biol Chem 277:41287-93. 2002
    ....
  21. ncbi request reprint Type I interferons as anti-inflammatory mediators
    Etty N Benveniste
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Sci STKE 2007:pe70. 2007
    ..Here, we discuss the molecular basis for the anti-inflammatory properties of type I IFNs and their therapeutic potential in autoimmune and inflammatory diseases...
  22. ncbi request reprint Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain
    Hongwei Qin
    Department of Medicine, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Immunol 173:6211-9. 2004
    ....
  23. doi request reprint ELISA methodology to quantify astrocyte production of cytokines/chemokines in vitro
    Hongwei Qin
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 814:235-49. 2012
    ..In this chapter, we describe our experience using ELISAs to detect and quantify cytokines and chemokines secreted by stimulated murine astrocytes, specifically IL-6 and CXCL10...