- Inhibition of lysosomal functions reduces proteasomal activityLiyan Qiao
Department of Pathology, 930 Sparks Center, 1530 3rd Ave S, University of Alabama at Birmingham, Birmingham, AL 35294 0017, United States
Neurosci Lett 456:15-9. 2009..Inhibition of lysosomal or proteasomal activities led to higher levels of chaperone heat shock cognate protein Hsc70, suggesting an attempt to compensate protein degradation deficiency by enhancing chaperone-mediated autophagy...
- Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicityLiyan Qiao
Department of Pathology, University of Alabama at Birmingham, USA
Mol Brain 1:17. 2008..Our data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics...