Ya Wei Qiang

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Proteasome inhibitors and bone disease
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Semin Hematol 49:243-8. 2012
  2. pmc Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Br J Haematol 148:726-38. 2010
  3. doi request reprint Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Bone 42:669-80. 2008
  4. pmc Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 112:196-207. 2008
  5. pmc Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 113:4319-30. 2009
  6. pmc Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma
    Bo Hu
    Myeloma Institute for Research and Therapy, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 8:e74191. 2013
  7. pmc Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 77205, USA
    Blood 112:374-82. 2008
  8. ncbi request reprint Wnt signaling in B-cell neoplasia
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 22:1536-45. 2003
  9. pmc Wnts induce migration and invasion of myeloma plasma cells
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Blood 106:1786-93. 2005
  10. ncbi request reprint Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Blood 103:301-8. 2004

Detail Information

Publications11

  1. pmc Proteasome inhibitors and bone disease
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Semin Hematol 49:243-8. 2012
    ..This review will discuss the function of PIs in stimulating bone formation and suppression of bone resorption, and the mechanism underlying this process that leads to inhibition bone disease in MM patients...
  2. pmc Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Br J Haematol 148:726-38. 2010
    ....
  3. doi request reprint Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Bone 42:669-80. 2008
    ..Dkk1 inhibits this process and may be a key factor regulating pre-osteoblast differentiation and myeloma bone disease...
  4. pmc Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 112:196-207. 2008
    ....
  5. pmc Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 113:4319-30. 2009
    ....
  6. pmc Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma
    Bo Hu
    Myeloma Institute for Research and Therapy, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 8:e74191. 2013
    ..These results provide a novel molecular mechanism critical to understanding the anabolic role of carfilzomib on myeloma-induced bone disease. ..
  7. pmc Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 77205, USA
    Blood 112:374-82. 2008
    ..These results provide further support of the potential anabolic and anti-MM effects of enhancing Wnt signaling in the bone...
  8. ncbi request reprint Wnt signaling in B-cell neoplasia
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 22:1536-45. 2003
    ....
  9. pmc Wnts induce migration and invasion of myeloma plasma cells
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Blood 106:1786-93. 2005
    ..These results suggest that Wnt responsiveness of myeloma plasma cells may be a significant factor in disease progression...
  10. ncbi request reprint Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Blood 103:301-8. 2004
    ..The identification of IGF-I as both a proliferative and migratory factor provides a rational basis for the development of targeted therapeutic strategies directed at IGF-I in the treatment of MM...
  11. ncbi request reprint Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Blood 99:4138-46. 2002
    ..These results define important elements in IGF-I regulation of myeloma cell growth and provide biological correlates critical to an understanding of growth-factor modulation of proliferation and apoptosis...