Ya Wei Qiang

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi Proteasome inhibitors and bone disease
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Semin Hematol 49:243-8. 2012
  2. ncbi Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Br J Haematol 148:726-38. 2010
  3. ncbi Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Bone 42:669-80. 2008
  4. ncbi Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 112:196-207. 2008
  5. ncbi Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 113:4319-30. 2009
  6. ncbi Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 77205, USA
    Blood 112:374-82. 2008
  7. ncbi Wnt signaling in B-cell neoplasia
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 22:1536-45. 2003
  8. ncbi Wnts induce migration and invasion of myeloma plasma cells
    Ya-Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
    Blood 106:1786-93. 2005
  9. ncbi Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells
    Ya-Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
    Blood 103:301-8. 2004
  10. ncbi Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk
    Ya-Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
    Blood 99:4138-46. 2002

Detail Information

Publications10

  1. ncbi Proteasome inhibitors and bone disease
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Semin Hematol 49:243-8. 2012
    ..This review will discuss the function of PIs in stimulating bone formation and suppression of bone resorption, and the mechanism underlying this process that leads to inhibition bone disease in MM patients...
  2. ncbi Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Br J Haematol 148:726-38. 2010
    ....
  3. ncbi Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Bone 42:669-80. 2008
    ..Dkk1 inhibits this process and may be a key factor regulating pre-osteoblast differentiation and myeloma bone disease...
  4. ncbi Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 112:196-207. 2008
    ....
  5. ncbi Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 113:4319-30. 2009
    ....
  6. ncbi Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    Ya Wei Qiang
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 77205, USA
    Blood 112:374-82. 2008
    ..These results provide further support of the potential anabolic and anti-MM effects of enhancing Wnt signaling in the bone...
  7. ncbi Wnt signaling in B-cell neoplasia
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 22:1536-45. 2003
    ....
  8. ncbi Wnts induce migration and invasion of myeloma plasma cells
    Ya-Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
    Blood 106:1786-93. 2005
    ..These results suggest that Wnt responsiveness of myeloma plasma cells may be a significant factor in disease progression...
  9. ncbi Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells
    Ya-Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
    Blood 103:301-8. 2004
    ..The identification of IGF-I as both a proliferative and migratory factor provides a rational basis for the development of targeted therapeutic strategies directed at IGF-I in the treatment of MM...
  10. ncbi Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk
    Ya-Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
    Blood 99:4138-46. 2002
    ..These results define important elements in IGF-I regulation of myeloma cell growth and provide biological correlates critical to an understanding of growth-factor modulation of proliferation and apoptosis...