Li Qian

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599, USA
    J Neural Transm 117:971-9. 2010
  2. pmc beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599 7455, USA
    Glia 57:1600-9. 2009
  3. pmc Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Immunol 181:660-8. 2008
  4. pmc Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neuroinflammation 4:23. 2007
  5. ncbi request reprint NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Parkinsonism Relat Disord 13:S316-20. 2007
  6. pmc β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway
    Li Qian
    North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 186:4443-54. 2011
  7. ncbi request reprint Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 179:1198-209. 2007
  8. doi request reprint Microglial cells and Parkinson's disease
    Li Qian
    Department of Microbiology, The University of North Carolina Schools of Medicine and Dentistry, Chapel Hill, NC 27599 7455, USA
    Immunol Res 41:155-64. 2008
  9. pmc Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
    Inna E Tchivileva
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Mol Pain 5:13. 2009
  10. ncbi request reprint The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production
    Kai Soo Tan
    Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, 404 Brauer Hall, CB 7450, Chapel Hill, NC 27511, USA
    Biomaterials 27:5170-7. 2006

Detail Information

Publications12

  1. pmc Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599, USA
    J Neural Transm 117:971-9. 2010
    ....
  2. pmc beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599 7455, USA
    Glia 57:1600-9. 2009
    ..Together, these findings indicate that beta2AR activation induces microglial PHOX activation and DA neurotoxicity through an ERK-dependent/PKA-independent pathway...
  3. pmc Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Immunol 181:660-8. 2008
    ....
  4. pmc Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neuroinflammation 4:23. 2007
    ..Microglia-mediated inflammation has recently been implicated as a critical mechanism responsible for progressive neurodegeneration...
  5. ncbi request reprint NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Parkinsonism Relat Disord 13:S316-20. 2007
    ..Taken together, our results demonstrate that femtomolar concentrations of DPI exert potent anti-inflammatory and neuroprotective effects by inhibiting microglial activation through the inhibition of ERK-regulated PHOX activity...
  6. pmc β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway
    Li Qian
    North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 186:4443-54. 2011
    ....
  7. ncbi request reprint Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 179:1198-209. 2007
    ..Furthermore, our study reveals that inhibition of PHOX is a novel site of action for the mu-opioid receptor-independent effect of morphine...
  8. doi request reprint Microglial cells and Parkinson's disease
    Li Qian
    Department of Microbiology, The University of North Carolina Schools of Medicine and Dentistry, Chapel Hill, NC 27599 7455, USA
    Immunol Res 41:155-64. 2008
    ..The work on our lab is concerned with understanding the mechanisms of activation, response, and therapeutic targets of microglial cells, with the aim to provide more effective treatments for PD and other inflammatory diseases of the CNS...
  9. pmc Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
    Inna E Tchivileva
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Mol Pain 5:13. 2009
    ..Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased experimental pain sensitivity in rodents...
  10. ncbi request reprint The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production
    Kai Soo Tan
    Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, 404 Brauer Hall, CB 7450, Chapel Hill, NC 27511, USA
    Biomaterials 27:5170-7. 2006
    ..The responses of J744A.1 cells to surface and superimposed LPS stimulation suggest only modest effects of the modeled endosseous implant surface on adherent cell pro-inflammatory cytokine expression and NO signaling...
  11. pmc Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease
    Patrick M Flood
    Department of Periodontology and the Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7454, USA
    Parkinsons Dis 2011:216298. 2011
    ..These studies suggest that targeting the classical pathway of NF-κB through the inhibition of the IKK complex can serve as a useful therapeutic approach to the treatment of PD...
  12. ncbi request reprint Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase
    Li Qian
    The Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Pharmacol Exp Ther 319:44-52. 2006
    ..Together, our results suggest that IL-10 inhibits LPS-induced DA neurotoxicity through the inhibition of PHOX activity in a JAK1-dependent mechanism...