Haohua Qian

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina
    Haohua Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, IL 60612, USA
    Brain Res Mol Brain Res 103:62-70. 2002
  2. pmc GABAC receptor binding of quantum-dot conjugates of variable ligand valency
    Hélène A Gussin
    Departments of Ophthalmology and Visual Sciences, Bioengineering, Neurology and Rehabilitation, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL 60612, USA
    Bioconjug Chem 21:1455-64. 2010
  3. ncbi request reprint Interactions between rho and gamma2 subunits of the GABA receptor
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurochem 94:482-90. 2005
  4. ncbi request reprint Random assembly of GABA rho1 and rho2 subunits in the formation of heteromeric GABA(C) receptors
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, USA
    Cell Mol Neurobiol 26:289-305. 2006
  5. ncbi request reprint Pharmacology of GABAC receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Neurosci Lett 376:60-5. 2005
  6. pmc Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46
    Quan V Hoang
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Vis 16:1343-52. 2010
  7. doi request reprint Pharmacological characterization, localization, and regulation of ionotropic glutamate receptors in skate horizontal cells
    Matthew A Kreitzer
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Vis Neurosci 26:375-87. 2009
  8. ncbi request reprint Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate
    Andrea D Birnbaum
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Vis Neurosci 22:211-23. 2005
  9. doi request reprint Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue
    Lan Yue
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, Illinois 60612, USA
    Nat Commun 3:1095. 2012
  10. pmc A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance
    Yujie Zhu
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Neurosci Lett 418:205-9. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina
    Haohua Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, IL 60612, USA
    Brain Res Mol Brain Res 103:62-70. 2002
    ..These results suggest that the gamma(2) subunit can co-assemble only with one (rho(1B)), but not with other white perch GABA rho subunits...
  2. pmc GABAC receptor binding of quantum-dot conjugates of variable ligand valency
    Hélène A Gussin
    Departments of Ophthalmology and Visual Sciences, Bioengineering, Neurology and Rehabilitation, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL 60612, USA
    Bioconjug Chem 21:1455-64. 2010
    ....
  3. ncbi request reprint Interactions between rho and gamma2 subunits of the GABA receptor
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurochem 94:482-90. 2005
    ..Taken together, these findings suggest that a heteromeric rho(gamma2) receptor could represent one form of GABA(C) receptor on retinal neurons...
  4. ncbi request reprint Random assembly of GABA rho1 and rho2 subunits in the formation of heteromeric GABA(C) receptors
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, USA
    Cell Mol Neurobiol 26:289-305. 2006
    ....
  5. ncbi request reprint Pharmacology of GABAC receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Neurosci Lett 376:60-5. 2005
    ..These results indicate that, in addition to the characteristic response properties identified previously, there is a pattern of pharmacological reactions that further distinguishes the A- and B-subtypes of GABA rho receptor...
  6. pmc Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46
    Quan V Hoang
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Vis 16:1343-52. 2010
    ..Specifically, we examined the response kinetics of GJs formed by pairing cells expressing Cx43 or Cx46, or those expressing both, i.e., designated as Cx43*Cx46...
  7. doi request reprint Pharmacological characterization, localization, and regulation of ionotropic glutamate receptors in skate horizontal cells
    Matthew A Kreitzer
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Vis Neurosci 26:375-87. 2009
    ....
  8. ncbi request reprint Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate
    Andrea D Birnbaum
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Vis Neurosci 22:211-23. 2005
    ..Antibodies for both transporters showed labeling in the outer and inner plexiform layers, and staining extended from the outer to inner limiting membranes...
  9. doi request reprint Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue
    Lan Yue
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, Illinois 60612, USA
    Nat Commun 3:1095. 2012
    ..The findings demonstrate photocontrol of GABA(A)Rs by an allosteric ligand, and open new avenues for fundamental and clinically oriented research on GABA(A)Rs, a major class of neurotransmitter receptors in the central nervous system...
  10. pmc A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance
    Yujie Zhu
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Neurosci Lett 418:205-9. 2007
    ..These results indicate that a single amino acid in the TMII region plays an important role in determining the single channel conductance of the GABAC receptors...
  11. pmc Binding of muscimol-conjugated quantum dots to GABAC receptors
    Hélène A Gussin
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, and Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Am Chem Soc 128:15701-13. 2006
    ....
  12. ncbi request reprint Activation of membrane receptors by neurotransmitter released from temperature-sensitive hydrogels
    Niraj J Muni
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W Taylor Street, Chicago, IL 60612, USA
    J Neurosci Methods 151:97-105. 2006
    ..The data indicate that the present system affords a temperature-regulated release of GABA from the hydrogel and a resulting activation of the expressed GABA(C) receptors...
  13. pmc Subunit-specific polyclonal antibody targeting human ρ1 GABA(C) receptor
    Hélène A Gussin
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL 60612, USA
    Exp Eye Res 93:59-64. 2011
    ..Immunostaining of human retinal sections shows preferential staining within the inner plexiform layer. GABA(C) Ab N-14 appears well suited for investigative studies of GABA(C) ρ1 subunit in retina and other neural tissues...
  14. pmc Harmonic analysis of the cone flicker ERG of rabbit
    Haohua Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Eye Res 91:811-7. 2010
    ..These findings provide a basis for formulating protocols to evaluate the effect of pharmacologic agents and/or disease on the cone flicker ERG of rabbit...
  15. pmc Structural model of rho1 GABAC receptor based on evolutionary analysis: Testing of predicted protein-protein interactions involved in receptor assembly and function
    Larisa Adamian
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Protein Sci 18:2371-83. 2009
    ....
  16. pmc 2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors
    An Xie
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612, USA
    Mol Pharmacol 80:965-78. 2011
    ..Structure-activity relationships are discussed in the context of molecular modeling of ligand binding to the antagonist binding site of the GABA(A)-ρ1 receptor...
  17. pmc Characteristics of period doubling in the rat cone flicker ERG
    Manthan R Shah
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Eye Res 90:196-202. 2010
    ..The period doubling properties we observed in the flicker ERG response of the rat cone system provide constraints on the nature of the nonlinear feedback mechanism presumed to underlie the period doubling phenomenon...
  18. pmc Potentiating action of propofol at GABAA receptors of retinal bipolar cells
    Lan Yue
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Invest Ophthalmol Vis Sci 52:2497-509. 2011
    ..The authors investigated the action of propofol on GABA-elicited membrane current responses of retinal bipolar cells, which have both GABA(A) and GABA(C) receptors...
  19. pmc Cyclothiazide: a subunit-specific inhibitor of GABAC receptors
    An Xie
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W Taylor Street, Chicago, IL 60612, USA
    J Physiol 586:2743-52. 2008
    ..4 s, but the kinetics were approximately 10-fold slower when GABA is absent. The ability of CTZ to interact with various types of neurotransmitter receptors indicates that the drug has multiple actions in the CNS...
  20. ncbi request reprint Blockade of an inward sodium current facilitates pharmacological study of hemi-gap-junctional currents in Xenopus oocytes
    Harris Ripps
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, UIC College of Medicine, Chicago, Illinois 60612, USA
    Biol Bull 203:192-4. 2002
  21. pmc Streptozotocin-induced diabetes modulates GABA receptor activity of rat retinal neurons
    David J Ramsey
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Exp Eye Res 85:413-22. 2007
    ..Taken together, the results suggest that diabetes modifies the subunit composition of the GABA(C) receptor on retinal neurons, most likely through its effect on the efficacy of gene transcription...
  22. ncbi request reprint Properties of connexin26 hemichannels expressed in Xenopus oocytes
    Harris Ripps
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, Illinois, USA
    Cell Mol Neurobiol 24:647-65. 2004
    ..4. These findings provide a basis with which to evaluate the in situ pharmacological studies that attempt to assess the putative role of Cx26 hemichannels in the feedback pathway in the distal retina...
  23. ncbi request reprint An electrophysiological study of retinal function in the diabetic female rat
    David J Ramsey
    Departments of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, 1955 W Taylor Street, Chicago, IL 60612, USA
    Invest Ophthalmol Vis Sci 47:5116-24. 2006
    ..To examine retinal function in female Long-Evans rats with streptozotocin (STZ)-induced diabetes...
  24. ncbi request reprint Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment
    Tania Q Vu
    Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL 60612, USA
    Biomaterials 26:1895-903. 2005
    ....
  25. pmc Quantum dot conjugates of GABA and muscimol: binding to α1β2γ2 and ρ1 GABA(A) receptors
    Hélène A Gussin
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    ACS Chem Neurosci 4:435-43. 2013
    ....
  26. pmc Two distinct processes are evident in rat cone flicker ERG responses at low and high temporal frequencies
    Haohua Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Eye Res 87:71-5. 2008
    ....
  27. doi request reprint Restoration of electroretinogram activity in exenterated swine eyes following ophthalmic artery anastomosis
    Jun Shi
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Restor Neurol Neurosci 27:351-7. 2009
    ..To determine the feasibility of restoring electroretinogram (ERG) activity of exenterated swine eyes following in vivo arterial anastomosis...
  28. ncbi request reprint Potassium currents distinguish the two subtypes of morphologically distinct skate bipolar cells
    Haohua Qian
    Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    Biol Bull 207:191-4. 2004
  29. doi request reprint Distinctive patterns of alterations in proton efflux from goldfish retinal horizontal cells monitored with self-referencing H⁺-selective electrodes
    Matthew A Kreitzer
    Department of Biology, Indiana Wesleyan University, 4201 South Washington Street, Marion, IN 46953, USA
    Eur J Neurosci 36:3040-50. 2012
    ..These findings argue strongly against the hypothesis that H(+) release from horizontal cells mediates lateral inhibition in the outer retina...
  30. pmc Extracellular pH dynamics of retinal horizontal cells examined using electrochemical and fluorometric methods
    Jason Jacoby
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    J Neurophysiol 107:868-79. 2012
    ..Our results suggest that HAF is reporting intracellular pH changes and that depolarization of horizontal cells induces an extracellular alkalinization, which may relieve H(+)-mediated inhibition of photoreceptor synaptic transmission...
  31. pmc Taurine suppresses the spread of cell death in electrically coupled RPE cells
    Chandani Udawatte
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Mol Vis 14:1940-50. 2008
    ....
  32. ncbi request reprint Picrotoxin accelerates relaxation of GABAC receptors
    Haohua Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor St, Chicago, IL 60612, USA
    Mol Pharmacol 67:470-9. 2005
    ..These results support an allosteric mechanism of picrotoxin inhibition of ligand-gated chloride channels...
  33. pmc Neurovascular interaction and the pathophysiology of diabetic retinopathy
    Haohua Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Exp Diabetes Res 2011:693426. 2011
    ..We suggest that a similar situation arises in the diabetic retina, and we propose a logical strategy aimed at therapeutic intervention...
  34. ncbi request reprint Pharmacological enhancement of hemi-gap-junctional currents in Xenopus oocytes
    Harris Ripps
    Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    J Neurosci Methods 121:81-92. 2002
    ..These results provide a foundation upon which to further characterize the gating of hemichannel currents mediated by connexins expressed in Xenopus oocytes...
  35. ncbi request reprint Assembly and characterization of biofunctional neurotransmitter-immobilized surfaces for interaction with postsynaptic membrane receptors
    Uroosa Saifuddin
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biomed Mater Res A 66:184-91. 2003
    ..However, nonspecific anti-immunoglobulin G antibodies directed to these surfaces show low binding affinity. Taken together, the data support the idea that the synthesized surfaces are biofunctional...
  36. ncbi request reprint Histidine suppresses zinc modulation of connexin hemichannels
    Richard L Chappell
    Marine Biological Laboratory, Woods Hole, Massachusetts 10021, USA
    Biol Bull 207:188-90. 2004