H Qian

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Open-system nonequilibrium steady state: statistical thermodynamics, fluctuations, and chemical oscillations
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    J Phys Chem B 110:15063-74. 2006
  2. doi request reprint Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for sigmoidal responses
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Biophys 41:179-204. 2012
  3. pmc Linear analysis near a steady-state of biochemical networks: control analysis, correlation metrics and circuit theory
    William J Heuett
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Syst Biol 2:44. 2008
  4. ncbi request reprint Reducing intrinsic biochemical noise in cells and its thermodynamic limit
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 362:387-92. 2006
  5. ncbi request reprint Thermodynamic and kinetic analysis of sensitivity amplification in biological signal transduction
    Hong Qian
    Department of Applied Mathematics, University of Washington Seattle, WA 98195 2420, USA
    Biophys Chem 105:585-93. 2003
  6. pmc Fluorescence correlation spectroscopy with high-order and dual-color correlation to probe nonequilibrium steady states
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 101:2828-33. 2004
  7. pmc Cooperativity and specificity in enzyme kinetics: a single-molecule time-based perspective
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington, USA
    Biophys J 95:10-7. 2008
  8. doi request reprint Temporal cooperativity and sensitivity amplification in biological signal transduction
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 47:2211-20. 2008
  9. ncbi request reprint An asymptotic comparative analysis of the thermodynamics of non-covalent association
    H Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195 2420, USA
    J Math Biol 52:277-89. 2006
  10. ncbi request reprint Phosphorylation energy hypothesis: open chemical systems and their biological functions
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Annu Rev Phys Chem 58:113-42. 2007

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Open-system nonequilibrium steady state: statistical thermodynamics, fluctuations, and chemical oscillations
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    J Phys Chem B 110:15063-74. 2006
    ..The case studies illustrate an emerging theory for the isothermal nonequilibrium steady state of open systems...
  2. doi request reprint Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for sigmoidal responses
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Biophys 41:179-204. 2012
    ..The former gives rise to self-organized complexity, and the latter contains useful, albeit hidden, free energy that can be utilized for biological functions. There could be structures and energy in biochemical fluctuations...
  3. pmc Linear analysis near a steady-state of biochemical networks: control analysis, correlation metrics and circuit theory
    William J Heuett
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Syst Biol 2:44. 2008
    ..Here, we present a comprehensive theory of linear analysis for nonequilibrium steady-state (NESS) biochemical reaction networks that unites these disparate approaches in a common mathematical framework and thermodynamic basis...
  4. ncbi request reprint Reducing intrinsic biochemical noise in cells and its thermodynamic limit
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 362:387-92. 2006
    ..We also study an optimal kinetic network design that is capable of approaching the thermodynamic limit...
  5. ncbi request reprint Thermodynamic and kinetic analysis of sensitivity amplification in biological signal transduction
    Hong Qian
    Department of Applied Mathematics, University of Washington Seattle, WA 98195 2420, USA
    Biophys Chem 105:585-93. 2003
    ..Both utilize multiple kinetic cycles in time to gain temporal cooperativity, in contrast to allosteric cooperativity that utilizes multiple subunits in a protein...
  6. pmc Fluorescence correlation spectroscopy with high-order and dual-color correlation to probe nonequilibrium steady states
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 101:2828-33. 2004
    ....
  7. pmc Cooperativity and specificity in enzyme kinetics: a single-molecule time-based perspective
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington, USA
    Biophys J 95:10-7. 2008
    ..The theory unifies dynamic cooperativity and Hopfield-Ninio's kinetic proofreading mechanism for specificity amplification...
  8. doi request reprint Temporal cooperativity and sensitivity amplification in biological signal transduction
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 47:2211-20. 2008
    ..The theory is applicable to a wide range of processes in cell signaling including the specificity and sensitivity of T-cell activation...
  9. ncbi request reprint An asymptotic comparative analysis of the thermodynamics of non-covalent association
    H Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195 2420, USA
    J Math Biol 52:277-89. 2006
    ..This work provides a mathematical basis for modeling non-covalent association processes in biology...
  10. ncbi request reprint Phosphorylation energy hypothesis: open chemical systems and their biological functions
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Annu Rev Phys Chem 58:113-42. 2007
    ....
  11. ncbi request reprint Metabolic futile cycles and their functions: a systems analysis of energy and control
    H Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Syst Biol (Stevenage) 153:192-200. 2006
    ..The possibility of different roles for the two major mechanisms within cellular biochemical regulation, namely reversible chemical modifications via futile cycles and shifting equilibrium by macromolecular binding, are discussed...
  12. ncbi request reprint Thermodynamics of stoichiometric biochemical networks in living systems far from equilibrium
    Hong Qian
    Departments of Applied Mathematics and Bioengineering, University of Washington, Seattle, 98195, USA
    Biophys Chem 114:213-20. 2005
    ..Energy conservation and the Second Law are established for steady-state and dynamic biochemical networks. The theory provides the physiochemical basis for analyzing large-scale metabolic networks in living organisms...
  13. ncbi request reprint Hydrogen exchange kinetics of proteins in denaturants: a generalized two-process model
    H Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 286:607-16. 1999
    ..This simple, minimalist's view of protein folding is consistent with various recent experimental observations on folding kinetics by HX...
  14. doi request reprint Stochastic bifurcation, slow fluctuations, and bistability as an origin of biochemical complexity
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Phys Chem Chem Phys 11:4861-70. 2009
    ..The implications of bistability to biochemical complexity are discussed...
  15. ncbi request reprint Stoichiometric network theory for nonequilibrium biochemical systems
    Hong Qian
    Department of Applied Mathematics and Bioengineering, University of Washington, Seattle, USA
    Eur J Biochem 270:415-21. 2003
    ..For sufficiently small flux a linear relationship between J and deltamu can be established as the linear flux-force relation in irreversible thermodynamics, analogous to Ohm's law in electrical circuits...
  16. pmc Quantitative study of polymer conformation and dynamics by single-particle tracking
    H Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Biophys J 76:1598-605. 1999
    ..Combining high precision measurements with the theoretical analysis presented here creates a powerful tool for studying conformational dynamics of biological and synthetic macromolecules at the single-molecule level...
  17. ncbi request reprint Terminal twist induced continuous writhe of a circular rod with intrinsic curvature
    H Qian
    Department of Applied Mathematics, University of Washington, Seattle 98195, USA
    J Biomol Struct Dyn 16:663-9. 1998
    ..The implication of this result on elastic models of circular DNA is discussed...
  18. pmc Single-particle tracking: Brownian dynamics of viscoelastic materials
    H Qian
    Departments of Applied Mathematics and Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Biophys J 79:137-43. 2000
    ....
  19. pmc From discrete protein kinetics to continuous Brownian dynamics: a new perspective
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195 2420, USA
    Protein Sci 11:1-5. 2002
    ..A semiquantitative analysis based on Brownian dynamics in a continuous energy landscape offers a more comprehensive description for motions of biological macromolecules...
  20. ncbi request reprint A mathematical analysis for the Brownian dynamics of a DNA tether
    H Qian
    Department of Applied Mathematics, University of Wahington, Seattle, WA 98195, USA
    J Math Biol 41:331-40. 2000
    ....
  21. ncbi request reprint Nonequilibrium thermodynamics and nonlinear kinetics in a cellular signaling switch
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Phys Rev Lett 94:028101. 2005
    ....
  22. doi request reprint Entropy demystified the "thermo"-dynamics of stochastically fluctuating systems
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington, USA
    Methods Enzymol 467:111-34. 2009
    ..Two examples from molecular biophysics, the efficiency of a motor protein ATPase and the substrate specificity of a phosphorylation-dephosphorylation cycle are discussed...
  23. pmc Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase
    Lisa M Bishop
    Department of Applied Mathematics, University of Washington, Seattle, Washington, USA
    Biophys J 98:1-11. 2010
    ..A previous reported noise-induced bistability in futile cycles is found to have originated from the kinase synchronization in a bistable system with slow transitions, as reported here...
  24. doi request reprint Ultrasensitive dual phosphorylation dephosphorylation cycle kinetics exhibits canonical competition behavior
    Qingdao Huang
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Chaos 19:033109. 2009
    ..A stochastic interpretation is also provided that further gives intuitive understanding of the bistable behavior inside the cells...
  25. pmc Stochastic dynamics and non-equilibrium thermodynamics of a bistable chemical system: the Schlögl model revisited
    Melissa Vellela
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    J R Soc Interface 6:925-40. 2009
    ..Finally, in the appendix section is an illustration of how the diffusion approximation of the chemical master equation can fail to represent correctly the mesoscopically interesting steady-state behaviour of the system...
  26. pmc Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences
    Yi Y Shi
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:11527-32. 2006
    ..This result is consistent with the evolution of increased protein unfoldedness and challenges the dogma that only specific protein-protein interactions can be biologically functional...
  27. ncbi request reprint A stochastic model of oscillatory blood testosterone levels
    William J Heuett
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195 2420, USA
    Bull Math Biol 68:1383-99. 2006
    ..The Gillespie algorithm is used to simulate the hormone secretion model. Important parameters of the model are discussed and results from the model are compared to experimental observations...
  28. pmc Multiscale modeling of cardiac cellular energetics
    James B Bassingthwaighte
    Bioengineering Department, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Ann N Y Acad Sci 1047:395-424. 2005
    ..Currently there is to this end no established methodology from computational sciences...
  29. ncbi request reprint Chromatin looping and the probability of transcription
    Qiliang Li
    Division of Medical Genetics, Department of Medicine, Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Trends Genet 22:197-202. 2006
    ..This model can explain gene expression changes in the Hoxd gene cluster and the beta-globin locus...
  30. ncbi request reprint Grand canonical Markov model: a stochastic theory for open nonequilibrium biochemical networks
    William J Heuett
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    J Chem Phys 124:044110. 2006
    ..We are also able to suggest novel methods for experimentally determining reaction fluxes and biochemical affinities at nonequilibrium steady state as well as the overall network connectivity...
  31. ncbi request reprint A quasistationary analysis of a stochastic chemical reaction: Keizer's paradox
    Melissa Vellela
    Department of Applied Mathematics, University of Washington Seattle, Seattle, WA 98195, USA
    Bull Math Biol 69:1727-46. 2007
    ..The appropriate system size that can be considered sufficiently large, an important parameter in numerical computation, is also discussed...
  32. pmc Energy balance for analysis of complex metabolic networks
    Daniel A Beard
    Department of Bioengineering, University of Washington, Seattle, Washington 98915, USA
    Biophys J 83:79-86. 2002
    ..We show that EBA eliminates thermodynamically infeasible results associated with FBA...
  33. doi request reprint A perturbation analysis of rate theory of self-regulating genes and signaling networks
    Pei Zhe Shi
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    J Chem Phys 134:065104. 2011
    ..Generalization of the present approach can be included in multiple time-scale numerical computations for large biochemical networks...
  34. doi request reprint Open-system thermodynamic analysis of DNA polymerase fidelity
    Field Cady
    Department of Applied Mathematics, University of Washington, Seattle, 98195, USA
    Phys Biol 6:036011. 2009
    ..The mechanism discussed in the present paper is not limited to DNA replication alone; it may be applicable to other biochemical systems...
  35. ncbi request reprint Motor protein with nonequilibrium potential: Its thermodynamics and efficiency
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 69:012901. 2004
    ..dS, representing the energy input. In terms of micro and h(d) the thermodynamic energy conservation in the mesoscopic stochastic system can be rigorously established and various types of motor efficiency are elucidated...
  36. ncbi request reprint A stochastic analysis of a Brownian ratchet model for actin-based motility
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Mech Chem Biosyst 1:267-78. 2004
    ..For comparison, a continuous diffusion formalism of the BR model with great analytical simplicity is also studied...
  37. ncbi request reprint Single-molecule enzymology: stochastic Michaelis-Menten kinetics
    Hong Qian
    Department of Applied Mathematics, University of Washington, WA Seattle 98195, USA
    Biophys Chem 101:565-76. 2002
    ..We suggest that in addition to fluctuating enzyme conformation, the stochastic nature of substrate concentration fluctuations is another possible source of the complex behavior of single-molecule enzyme kinetics...
  38. pmc A mechanism for SRC kinase-dependent signaling by noncatalytic receptors
    Jonathan A Cooper
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochemistry 47:5681-8. 2008
    ..Other events that regulate signaling in specific cases may have evolved for fine-tuning of this basic mechanism...
  39. ncbi request reprint Quantitative model for binary measurements of protein-protein interactions
    Yi Y Shi
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    J Comput Biol 14:1011-23. 2007
    ..It is also shown that not only the association constants but also the protein abundance could be a factor in producing the power-law degree distribution of protein-protein interaction networks...
  40. ncbi request reprint Viscoelasticity of living materials: mechanics and chemistry of muscle as an active macromolecular system
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Mol Cell Biomech 5:107-17. 2008
    ..Some disparity between the mechanical and the chemical views of cross-bridges and motor proteins are noted, and a duality between force and energy in discrete states and transitions of macromolecular systems is discussed...
  41. ncbi request reprint Clustering coefficients of protein-protein interaction networks
    Gerald A Miller
    Department of Physics, University of Washington Seattle, Seattle, WA 98195, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 75:051910. 2007
    ..This shows that degree distributions are not sufficient to determine the properties of PINs...
  42. pmc DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1
    Manjusha Dixit
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Proc Natl Acad Sci U S A 104:18157-62. 2007
    ..Our results suggest that up-regulation of both DUX4 and PITX1 in FSHD muscles may play critical roles in the molecular mechanisms of the disease...
  43. ncbi request reprint Sensitivity and specificity amplification in signal transduction
    Guangpu Li
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Biochem Biophys 39:45-59. 2003
    ..These studies have provided insights into the sensitivity and specificity amplification of biological signals in integrated systems...
  44. ncbi request reprint Nonequilibrium steady state of a nanometric biochemical system: determining the thermodynamic driving force from single enzyme turnover time traces
    Wei Min
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Nano Lett 5:2373-8. 2005
    ..The statistical precisions of these three Deltamu estimators are analyzed and compared for experimental time traces with finite lengths...
  45. pmc Amplifying signal transduction specificity without multiple phosphorylation
    Hong Qian
    Biophys J 84:1410-1. 2003
  46. ncbi request reprint Kinetic timing: a novel mechanism that improves the accuracy of GTPase timers in endosome fusion and other biological processes
    Guangpu Li
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 940 SL Young Blvd, BMSB 853, Oklahoma City, OK 73104, USA
    Traffic 3:249-55. 2002
    ..It also explains the necessity for the existence of multiple GTP-bound intermediates identified by fluorescence spectroscopy and nuclear magnetic resonance studies...
  47. ncbi request reprint Powering a burnt bridges Brownian ratchet: a model for an extracellular motor driven by proteolysis of collagen
    Saveez Saffarian
    Cell Biology Department, Harvard Medical School CBR, 200 Longwood Avenue, Boston, MA 02115, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 73:041909. 2006
    ..1 pN stall force for individual collagenase molecules. A dimer, surprisingly, can generate a force in the range of 5 pN, suggesting that the motor can be of biological significance...
  48. ncbi request reprint Thermodynamic-based computational profiling of cellular regulatory control in hepatocyte metabolism
    Daniel A Beard
    Biotechnology and Bioengineering Center, Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Endocrinol Metab 288:E633-44. 2005
    ....
  49. ncbi request reprint Ab initio prediction of thermodynamically feasible reaction directions from biochemical network stoichiometry
    Feng Yang
    Biotechnology and Bioengineering Center, Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Metab Eng 7:251-9. 2005
    ..We show that for a reaction network of 44 internal reactions representing energy metabolism, the computed linear inequality constraints represent necessary and sufficient conditions for thermodynamic feasibility...
  50. ncbi request reprint Synchronized dynamics and non-equilibrium steady states in a stochastic yeast cell-cycle network
    Hao Ge
    School of Mathematical Sciences, Peking University, Beijing, PR China
    Math Biosci 211:132-52. 2008
    ..Such a large separation in the magnitude of the circulations, between a dominant, main cycle and the rest, gives rise to the stochastic synchronization phenomenon...
  51. ncbi request reprint Combining flux and energy balance analysis to model large-scale biochemical networks
    William J Heuett
    Department of Physics, University of Colorado, 390 UCB, Boulder, Colorado 80309 0390, USA
    J Bioinform Comput Biol 4:1227-43. 2006
    ..As a result, we suggest a novel optimization with respect to the heat dissipation rate of a system. We also emphasize the importance of incorporating interactions between a model network and its surroundings...
  52. ncbi request reprint Thermodynamic constraints for biochemical networks
    Daniel A Beard
    Biotechnology and Bioengineering Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Theor Biol 228:327-33. 2004
    ....
  53. ncbi request reprint Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection
    Ming Chieh Ma
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:16208-18. 2005
    ..Our findings demonstrate a novel mechanism of HPC neuroprotection (i.e. the intracellular up-regulation of DOR-regulated survival signals)...
  54. ncbi request reprint Regional differences in rates of plant speciation and molecular evolution: a comparison between eastern Asia and eastern North America
    Qiu Yun Jenny Xiang
    Department of Botany, North Carolina State University, Raleigh, North Carolina 27695 7612, USA
    Evolution 58:2175-84. 2004
    ..The close relationship between rates of ITS evolution and species richness further suggests that species production may be directly linked to rate of nucleotide substitution...
  55. ncbi request reprint In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials
    Wanda DePinto
    Discovery Oncology, Hoffmann La Roche, Inc, 340 Kingsland Street, Nutley, NJ 07110, USA
    Mol Cancer Ther 5:2644-58. 2006
    ..R547 is currently being evaluated in phase I clinical trials...
  56. pmc Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
    Natalija Buza-Vidas
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
    Genes Dev 20:2018-23. 2006
    ..Lnk(-/-) HSC expansion is dependent on THPO, and 12-wk-old Lnk(-/-)Thpo(-/-) mice have 65-fold fewer LT-HSCs than Lnk(-/-) mice. Expansions of multiple myeloid, but not lymphoid, progenitors in Lnk(-/-) mice also proved THPO-dependent...
  57. ncbi request reprint Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
    Robert Mansson
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 84 Lund, Sweden
    Immunity 26:407-19. 2007
    ....
  58. ncbi request reprint Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells
    Hong Qian
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 110:2399-407. 2007
    ....
  59. ncbi request reprint A latitudinal gradient in large-scale beta diversity for vascular plants in North America
    Hong Qian
    Research and Collections Center, Illinois State Museum, Springfield, IL 62703, USA
    Ecol Lett 10:737-44. 2007
    ..Therefore, decreasing beta diversity from south to north reflects decreasing climate differentiation within more northerly latitude zones, and primarily post-glacial dispersal limitation north of 50 degrees N...
  60. pmc Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data
    Agnes Baross
    Genome Sciences Centre, BC Cancer Agency, British Columbia Cancer Agency, Suite 100, 570 West 7th Avenue, Vancouver, BC, V5Z 4S6, Canada
    BMC Bioinformatics 8:368. 2007
    ..The popularity of this technology and its associated open source data format have resulted in the development of an increasing number of software packages for the analysis of copy number changes using these SNP arrays...
  61. ncbi request reprint Kit regulates maintenance of quiescent hematopoietic stem cells
    Lina A Thoren
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    J Immunol 180:2045-53. 2008
    ..Most notably, accelerated in vivo BrdU incorporation and cell cycle kinetics implicated a previously unrecognized role of Kit in maintaining quiescent HSCs in steady state adult hematopoiesis...
  62. ncbi request reprint A global evaluation of metabolic theory as an explanation for terrestrial species richness gradients
    Bradford A Hawkins
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
    Ecology 88:1877-88. 2007
    ..We conclude that metabolic theory, as currently formulated, is a poor predictor of observed diversity gradients in most terrestrial systems...