Ishtiaq Qadri

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells
    Garret R Anderson
    Department of Medicine, School of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Mol Pharmacol 70:1062-70. 2006
  2. ncbi Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3
    Ishtiaq Qadri
    Department of Medicine, Division of Gastroenterology and Hepatology, Hepatobiliary Center, University of Colorado Health Sciences Center, B 145, 4200 E, 9th Avenue, Denver 80262, USA
    Biochim Biophys Acta 1592:193-204. 2002
  3. ncbi Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression
    Ishtiaq Qadri
    Department of Pediatrics, University of Colorado Health Sciences Center, Mail Stop 8106, 12801 East 17th Ave, L 18 7403, RC 1 South, P O Box 6511, Aurora, CO 80045, USA
    Mol Pharmacol 70:627-36. 2006
  4. pmc Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1
    Ishtiaq Qadri
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Biochem J 378:919-28. 2004
  5. pmc Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β
    Ishtiaq Qadri
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 287:37340-51. 2012
  6. pmc Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Lipid Res 50:2193-202. 2009
  7. pmc C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells
    Mahua Choudhury
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Cell Endocrinol 331:102-8. 2011
  8. ncbi Hormonal regulation of hepatic multidrug resistance-associated protein 2 (Abcc2) primarily involves the pattern of growth hormone secretion
    Francis R Simon
    Department of Medicine, Division of Gastroenterolgy and Hepatology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Am J Physiol Gastrointest Liver Physiol 290:G595-608. 2006
  9. ncbi Multihormonal regulation of hepatic sinusoidal Ntcp gene expression
    Francis R Simon
    Univ of Colorado Health Sciences Center, Dept of Medicine B 145 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Gastrointest Liver Physiol 287:G782-94. 2004
  10. doi Hepatitis C virus infection: molecular pathways to metabolic syndrome
    Muhammad Y Sheikh
    Division of Gastroenterology and Hepatology, University of California San Francisco Fresno Education Program, Community Regional Medical Center, Fresno, CA 93721, USA
    Hepatology 47:2127-33. 2008

Collaborators

Detail Information

Publications13

  1. pmc Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells
    Garret R Anderson
    Department of Medicine, School of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Mol Pharmacol 70:1062-70. 2006
    ..These findings demonstrate that TCDD-mediated AhR signaling is impaired in hepatocytes in which HCV is present and that NS5A alone or in the presence of other nonstructural proteins of the subgenomic replicon is in part responsible...
  2. ncbi Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3
    Ishtiaq Qadri
    Department of Medicine, Division of Gastroenterology and Hepatology, Hepatobiliary Center, University of Colorado Health Sciences Center, B 145, 4200 E, 9th Avenue, Denver 80262, USA
    Biochim Biophys Acta 1592:193-204. 2002
    ..This could explain one of the possible mechanism(s) by which NS5A is able to exert its effect on cellular gene expression and cell growth regulation...
  3. ncbi Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression
    Ishtiaq Qadri
    Department of Pediatrics, University of Colorado Health Sciences Center, Mail Stop 8106, 12801 East 17th Ave, L 18 7403, RC 1 South, P O Box 6511, Aurora, CO 80045, USA
    Mol Pharmacol 70:627-36. 2006
    ..In conclusion, we describe a novel mechanism by which HCV gene expression may induce adaptive responses involving MRP2 via HNF1 activation. This may constitute, in part, the cellular detoxification task force during HCV infection...
  4. pmc Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1
    Ishtiaq Qadri
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Biochem J 378:919-28. 2004
    ....
  5. pmc Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β
    Ishtiaq Qadri
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 287:37340-51. 2012
    ....
  6. pmc Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Lipid Res 50:2193-202. 2009
    ....
  7. pmc C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells
    Mahua Choudhury
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Cell Endocrinol 331:102-8. 2011
    ..Understanding how ER stress suppresses AMPK activation and increases C/EBPβ expression could lead to a potentially novel pathway for treatment of diabetes...
  8. ncbi Hormonal regulation of hepatic multidrug resistance-associated protein 2 (Abcc2) primarily involves the pattern of growth hormone secretion
    Francis R Simon
    Department of Medicine, Division of Gastroenterolgy and Hepatology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Am J Physiol Gastrointest Liver Physiol 290:G595-608. 2006
    ..In conclusion, Mrp2 levels are regulated by the combination of thyroxine and different growth hormone secretory patterns...
  9. ncbi Multihormonal regulation of hepatic sinusoidal Ntcp gene expression
    Francis R Simon
    Univ of Colorado Health Sciences Center, Dept of Medicine B 145 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Gastrointest Liver Physiol 287:G782-94. 2004
    ..These findings demonstrate the essential role that pituitary hormones play in the sexually dimorphic control of Ntcp expression in adult rat liver and in the mediation of estrogen effects...
  10. doi Hepatitis C virus infection: molecular pathways to metabolic syndrome
    Muhammad Y Sheikh
    Division of Gastroenterology and Hepatology, University of California San Francisco Fresno Education Program, Community Regional Medical Center, Fresno, CA 93721, USA
    Hepatology 47:2127-33. 2008
    ..This chain of events may be initiated by HCV-associated IR and provides a direction for future research in the areas of therapeutic intervention...
  11. ncbi CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Hepatology 45:1108-17. 2007
    ....
  12. ncbi Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability
    Andrew P Feranchak
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:44632-8. 2003
    ....
  13. pmc Inhibition of cellular responses to insulin in a rat liver cell line. A role for PKC in insulin resistance
    Livia Puljak
    Department of Internal Medicine, University of Texas South Western Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8887, USA
    J Physiol 563:471-82. 2005
    ..These results suggest that stimulation of PKC activity in insulin resistance contributes to the inhibition of cellular responses to insulin in liver cells...