Research Topics
| B PuschnerSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Diagnosis of anatoxin-a poisoning in dogs from North AmericaBirgit Puschner
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Sciences Drive, Davis, CA 95616, USA
J Vet Diagn Invest 20:89-92. 2008....
Toxicosis caused by melamine and cyanuric acid in dogs and cats: uncovering the mystery and subsequent global implicationsBirgit Puschner
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 95616, USA
Clin Lab Med 31:181-99. 2011..Management of these outbreaks depends on the collaboration of veterinary and human laboratories and clinics, government agencies, academic institutions, and food industries, along with prompt communication and sharing of data...- Diagnosis and approach to poisoning in the horseB Puschner
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, California, USA
Vet Clin North Am Equine Pract 17:399-409. 2001..Consultation with a veterinary toxicologist aids in the follow-up of a poisoning case and can help to provide a thorough background to assist in preventing reoccurrence... - Mushroom poisoning cases in dogs and cats: diagnosis and treatment of hepatotoxic, neurotoxic, gastroenterotoxic, nephrotoxic, and muscarinic mushroomsBirgit Puschner
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, 1120 Haring Hall, Davis, CA 95616, USA
Vet Clin North Am Small Anim Pract 42:375-87, viii. 2012..Mushroom intoxications require tremendous efforts from clinicians and toxicologists in terms of making a diagnosis and treatment, and management is challenging... - Thallium toxicosis in a dog consequent to ingestion of Mycoplasma agar platesBirgit Puschner
Department of Molecular Biosciences and California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, 1120 Haring Hall, Davis, CA 95616, USA
J Vet Diagn Invest 24:227-30. 2012..The postexposure blood and hair thallium concentrations reported in this case are useful data for diagnosticians investigating dogs with potential thallium poisoning... - Treatment and diagnosis of a dog with fulminant neurological deterioration due to anatoxin--a intoxicationBirgit Puschner
California Animal Health and Food Safety Laboratory System Toxicology Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Vet Emerg Crit Care (San Antonio) 20:518-22. 2010..To describe the clinical features, treatment, diagnostic work-up, and outcome of a dog with acute neurologic signs subsequent to algal toxin exposure... - Assessment of melamine and cyanuric acid toxicity in catsBirgit Puschner
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Science Drive, Davis, CA, USA
J Vet Diagn Invest 19:616-24. 2007..The results demonstrate that the combination of melamine and cyanuric acid is responsible for acute renal failure in cats... - MycotoxinsBirgit Puschner
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Sciences Drive, Davis, CA 95616, USA
Vet Clin North Am Small Anim Pract 32:409-19. 2002..In most cases, clinical examination, clinical pathologic testing, and analytical chemistry analysis of suspect feed are necessary to reach a diagnosis... - Diagnosis of Amanita toxicosis in a dog with acute hepatic necrosisBirgit Puschner
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, School of Veterinary Medicine, University of California, West Health Science Drive, Davis, CA 95616, USA
J Vet Diagn Invest 19:312-7. 2007..Although hepatotoxic mushroom poisoning has been documented in dogs before, confirmatory techniques for biologic specimens have not been used previously in diagnostic investigations... - Copper toxicosis in a dairy goat herdJennifer Cornish
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 231:586-9. 2007..A closed herd of 400 mixed-breed dairy goats was examined because of a decrease in milk production and increase in mortality rate. Nine animals had died within a 1-month period... - Multiresidue screen for cardiotoxins by two-dimensional thin-layer chromatographyD M Holstege
Toxicology Laboratory, California Veterinary Diagnostic Laboratory System, University of California, Davis, California 95616, USA
J Agric Food Chem 48:60-4. 2000..The diagnostic utility of the method was tested by analyzing samples submitted to the veterinary toxicology laboratory... - Diagnosis of zinc phosphide poisoning in chickens using a new analytical approachAsheesh K Tiwary
California Animal Health and Food Safety Laboratory System, University of California, Davis, CA 95616, USA
Avian Dis 49:288-91. 2005..It was also found that the determination of zinc concentrations in liver or kidney tissue or stomach contents is not a reliable indicator of zinc phosphide poisoning... - Evaluation of the toxicity of Adonis aestivalis in sheepL W Woods
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, PO Box 1770, Davis, CA 95617, USA
Vet Rec 168:49. 2011..No gross or microscopic lesions were seen when the ewes were examined postmortem at the end of the study... - Determination of grayanotoxins in biological samples by LC-MS/MSD M Holstege
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, CA 95616, USA
J Agric Food Chem 49:1648-51. 2001..The diagnostic utility of the method was tested by analyzing samples submitted to the veterinary toxicology laboratory... - Summer pheasant's eye (Adonis aestivalis) poisoning in three horsesL W Woods
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, PO Box 1770, Davis, CA 95617 1770, USA
Vet Pathol 41:215-20. 2004..Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America... - Ronidazole toxicosis in 3 society finches (Lonchura striata)L W Woods
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, Davis, CA 95617 1770, USA
Vet Pathol 47:231-5. 2010..Ronidazole was detected in the liver tissue at 2,700 ng/g (wet weight), and 2-hydroxymethyl-1-methyl-5-nitroimidazole was detected at 140 ng/g (wet weight)... - Death by caffeine: presumptive malicious poisoning of a dog by incorporation in ground meatS N Tawde
California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California Davis, West Health Sciences Drive, Davis, CA 95616, USA
J Med Toxicol 8:436-40. 2012..While few cases of accidental ingestion of caffeine by dogs have been described, the intentional use of a concentrated caffeine source to cause mortality in a dog has not been previously reported... - Using roquefortine C as a biomarker for penitrem A intoxicationAsheesh K Tiwary
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Science Drive, Davis, CA 95616, USA
J Vet Diagn Invest 21:237-9. 2009..In conclusion, roquefortine C can serve as a sensitive biomarker for penitrem A intoxication, but the clinical presentation needs to be considered for proper interpretation of its detection in the absence of penitrem A... - LC-MS/MS screen for penitrem A and roquefortine C in serum and urine samplesElizabeth R Tor
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, California 95616, USA
Anal Chem 78:4624-9. 2006..This is the first report of a positive mass spectrometric identification and quantitation of both compounds in urine and serum samples from dog intoxication cases... 
Cervical leiomyoma in an aged goat leading to massive hemorrhage and deathFrancisco A Uzal
California Animal Health and Food Safety Laboratory System, Faculty of Veterinary Medicine, University of California, San Bernardino, San Bernardino, California 92408, USA
Can Vet J 49:177-9. 2008..Necropsy, histologic examination, and immunohistochemical staining revealed the presence of a leiomyoma that originated from the uterine cervix, occupied most of the vaginal lumen, and had a bleeding, frayed artery in the caudal end...- Toxic mushroomsJohn H Tegzes
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Sciences Drive, Davis, CA 95616, USA
Vet Clin North Am Small Anim Pract 32:397-407. 2002..Collection of the toxicologic minimum database and gastrointestinal decontamination are important in all cases where mushroom ingestion is suspected... - Vitamin E and selenium concentrations in month-old beef calvesJohn Maas
Veterinary Medicine Extension, School of Veterinary Medicine, University of California, Davis, 1325 Surge III, Davis, CA, 95616, USA
J Vet Diagn Invest 20:86-9. 2008..965), and calf vitamin E was moderately correlated to cow vitamin E (r = 0.605). Calf vitamin E concentrations were consistently lower than cow vitamin E concentrations, and many values would be considered deficient... - The determination of melamine in muscle tissue by liquid chromatography/tandem mass spectrometryMichael S Filigenzi
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, CA 95616, USA
Rapid Commun Mass Spectrom 21:4027-32. 2007..The mean recovery for the seven replicates was 83% with 6.5% relative standard deviation and the calculated method detection limit was 1.7 ng/g... - Diagnosis of Taxus (yew) poisoning in a horseAsheesh K Tiwary
California Animal Health and Food Safety Laboratory System, University of California-Davis, West Health Science Drive, Davis, CA 95616, USA
J Vet Diagn Invest 17:252-5. 2005.... - Bilateral malacia associated with sodium poisoning in turkey poultsRocio Crespo
California Animal Health and Food Safety Laboratory System Fresno Branch, University of California, Davis, 2789 S Orange Avenue, Fresno, CA 93725, USA
Avian Dis 52:179-82. 2008..This case investigation demonstrated that sodium analysis of brain and liver are diagnostically useful when confirming sodium poisoning in young turkeys... - Rapid determination of domoic acid in serum and urine by liquid chromatography-electrospray tandem mass spectrometryElizabeth R Tor
Toxicology Laboratory, California Animal Health and Food Safety Laboratory System, University of California, Davis, California 95616, USA
J Agric Food Chem 51:1791-6. 2003..The diagnostic utility of the method was tested by analyzing samples from live animals showing clinical signs suggestive of domoic acid poisoning submitted to the veterinary toxicology laboratory... - Determination of alpha-amanitin in serum and liver by multistage linear ion trap mass spectrometryMichael S Filigenzi
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, California 95616, USA
J Agric Food Chem 55:2784-90. 2007..50 ng/g. This is the first report of a positive mass spectrometric identification and quantitation of alpha-amanitin in serum and liver from suspect human and animal intoxications... - Interaction of ionophore and vitamin E in knockdown syndrome of turkeysRocio Crespo
California Animal Health and Food Safety Laboratory, University of California Davis, Fresno, CA 93725, USA
J Vet Diagn Invest 20:472-6. 2008..The current study also suggests that monensin in the feed could induce lower concentrations of vitamin E in the liver of turkeys and can predispose the turkeys to knockdown syndrome... - Diagnostic determination of melamine and related compounds in kidney tissue by liquid chromatography/tandem mass spectrometryMichael S Filigenzi
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory University of California, Davis, California 95616, USA
J Agric Food Chem 56:7593-9. 2008..This method was successfully used for routine postmortem diagnosis of melamine toxicosis in animals. Melamine was also detected by this method in paraffin-embedded tissue from animals suspected to have died of melamine toxicosis... - In vitro study of the effectiveness of three commercial adsorbents for binding oleander toxinsAsheesh K Tiwary
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, West Health Sciences Drive, Davis, CA 95616, USA
Clin Toxicol (Phila) 47:213-8. 2009..Bio-Sponge has been used to prevent gastrointestinal absorption of oleander toxins in livestock but the efficacy of activated charcoal and Bio-Sponge for adsorbing oleandrin and oleandrigenin has not yet been studied... - Coronary artery rupture in male commercial turkeysH L Shivaprasad
Fresno Branch, University of California, Davis, Fresno CA 93725, USA
Avian Pathol 33:226-32. 2004..Genetic diseases such as connective tissue disorders of the elastin and/or collagen were also considered as possible causes... - Amanita mushroom poisoning: efficacy of aggressive treatment of two dogsJohn H Tegzes
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory University of California, Davis 95617, USA
Vet Hum Toxicol 44:96-9. 2002..Death occurred in 1 dog despite aggressive treatment measures including hemoperfusion, while aggressive measures resulted in a favorable outcome in the other dog... - Determination of strophanthidin in ingesta and plant material by LC-MS/MSMichael S Filigenzi
California Animal Health and Food Safety Laboratory System, University of California, Davis, California 95616, USA
J Agric Food Chem 52:2174-8. 2004..075 microg/g, and the limit of quantitation was calculated to be 0.24 microg/g for strophanthidin in control rumen samples. This method was used in diagnostic investigations to confirm fatal strophanthidin glycoside poisonings in horses... - Determination of oleandrin in tissues and biological fluids by liquid chromatography-electrospray tandem mass spectrometryElizabeth R Tor
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, California 95616, USA
J Agric Food Chem 53:4322-5. 2005..The sensitivity and specificity of the LC-MS/MS analysis enables it to be the method of choice for toxicological investigations of oleander poisoning... - Grayanotoxin poisoning in three goatsB Puschner
California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis 95616, USA
J Am Vet Med Assoc 218:573-5, 527-8. 2001..Rhododendron poisoning should be considered in animals with clinical evidence of gastrointestinal tract irritation, cardiac arrhythmias, and neurologic signs... - Influence of age, sex, and production class on liver zinc concentration in calvesBirgit Puschner
Toxicology Laboratory, California Animal Health and Food Safety Laboratory System, University of California, Davis, CA 95616, USA
J Vet Diagn Invest 16:278-82. 2004.... - Gossypol toxicosis in a dog consequent to ingestion of cottonseed beddingFrancisco A Uzal
California Animal Health and Food Safety Laboratory System, University of California, San Bernadino, USA
J Vet Diagn Invest 17:626-9. 2005..This first documented case of gossypol poisoning in a dog, caused by the ingestion of cottonseed bedding, demonstrates how specific toxicological analysis is crucial in reaching an accurate diagnosis... - Oleander intoxication in New World camelids: 12 cases (1995-2006)Tania A Kozikowski
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 235:305-10. 2009..To characterize the clinical and clinicopathologic effects and evaluate outcome associated with oleander toxicosis in New World camelids... - Serum fluoride concentrations, biochemical and histopathological changes associated with prolonged sevoflurane anaesthesia in horsesB Driessen
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, 95616, USA
J Vet Med A Physiol Pathol Clin Med 49:337-47. 2002.... - Myopathy in brown pelicans (Pelicanus occidentalis) associated with rancid feedH L Shivaprasad
California Animal Health and Food Safety Laboratory System, University of California, Davis, Fresno 93725, USA
Vet Rec 150:307-11. 2002..5 iu/kg (normal 20 to 30 iu/kg). It was concluded that the myopathy was probably caused by vitamin E deficiency due to feeding the pelicans a rancid diet... - Cyanide toxicosis in goats after ingestion of California Holly (Heteromeles arbutifolia)John H Tegzes
California Animal Health and Food Safety Laboratory System-Toxicology Laboratory, University of California, Davis, CA 95616, USA
J Vet Diagn Invest 15:478-80. 2003..This study describes a case that resulted in significant morbidity and mortality in a herd of goats after exposure to California holly (Heteromeles arbutifolia)... - Influence of age and production type on liver copper concentrations in calvesBirgit Puschner
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Sciences Drive, Davis, CA 95616, USA
J Vet Diagn Invest 16:382-7. 2004.... - Necrotizing enterocolitis and death in a goat kid associated with enterotoxin (CPE)-producing Clostridium perfringens type AMariano E Fernandez Miyakawa
California Animal Health and Food Safety Laboratory System, University of California Davis, San Bernardino Branch, Calfornia 92408, USA
Can Vet J 48:1266-9. 2007..Isolation of Clostridium perfringens type A secreting enterotoxin (CPE) and presence of CPE in the small intestine suggest that CPE contributed to the death of this kid... - Evaluation of the toxicity of Adonis aestivalis in calvesLeslie W Woods
California Animal Health and Food Safety Laboratory System, University of California, Davis, CA, USA
J Vet Diagn Invest 19:581-5. 2007..Based on the results of this study, cattle do not appear to be as susceptible to toxicosis from A. aestivalis as other species, such as horses and pigs... - Assessment of vitamin E concentrations in serum and cerebrospinal fluid of horses following oral administration of vitamin EJamie K Higgins
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 69:785-90. 2008..To determine concentrations of alpha-tocopherol in serum and CSF of healthy horses following administration of supplemental vitamin E in feed... - Short communication: Attempts to identify Clostridium botulinum toxin in milk from three experimentally intoxicated Holstein cowsR B Moeller
California Animal Health and Food Safety Laboratory, University of California, Tulare 93274, USA
J Dairy Sci 92:2529-33. 2009..From these results, it appears that Clostridium botulinum type C toxin does not cross from the blood to the milk in detectable concentrations... - Effects of oral tetrachlorvinphos fly control (Equitrol) administration in horses: physiological and behavioural findingsJ Berger
Behaviour Service, Veterinary Medical Teaching Hospital, University of California, Davis, California 95616, USA
Vet Res Commun 32:75-92. 2008..No changes were detected in physiological or neurological parameters, immune markers or thyroid hormones in treated (n=6) or control (n=4) horses during the course of the study... - Vitamin A deficiency in turkey poultsP L Cortes
California Animal Health and Food Safety Laboratory System (CAHFS, University of California, Fresno Branch, 2789 South Orange Avenue, Fresno, CA 93725, USA
J Vet Diagn Invest 18:489-94. 2006.... - Screening and mass spectral confirmation of beta-lactam antibiotic residues in milk using LC-MS/MSD M Holstege
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, CA 95616, USA
J Agric Food Chem 50:406-11. 2002..2 ng/mL (ampicillin), 0.4 ng/mL (ceftiofur), 0.8 ng/mL (cephapirin), 1 ng/mL (amoxicillin and penicillin G), and 2 ng/mL (cloxacillin and penicillin V) using a nominal sample size of 5 mL... - Retinopathy associated with ivermectin toxicosis in two dogsPatrick J Kenny
William R Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 233:279-84. 2008..Both dogs had mild obtundation and mydriasis in both eyes. It was thought that dog 1 may have ingested ivermectin; dog 2 had been treated with ivermectin for demodectic mange... - Acute lead toxicosis in a harbor seal (Phoca vitulina richardsi) consequent to ingestion of a lead fishing sinkerTanja S Zabka
Anatomic Pathology Service, Veterinary Medical Teaching Hospital, University of California, Davis, California 95616, USA
J Wildl Dis 42:651-7. 2006..66 ppm), and postmortem tissues (84 ppm, wet weight liver). This first documented case of lead toxicosis in a wild marine mammal demonstrates an additional way in which human fishing activities can harm marine mammals... - Diterpenoid alkaloid toxicosis in cattle in the Swiss AlpsBirgit Puschner
California Animal Health and Food Safety Laboratory System-Toxicology Laboratory, University of California, Davis 95616, USA
Vet Hum Toxicol 44:8-10. 2002..The findings ofditerpenoid alkaloids in the gastrointestinal contents confirmed exposure to Delphinium and Aconitum spp, possibly resulting in sudden death... - Coma and apnea in a dog with hydroxyzine toxicosisJohn H Tegzes
California Animal Health and Food Safety Laboratory System, University of California, Davis 95617, USA
Vet Hum Toxicol 44:24-6. 2002..The positive outcome justifies critical care of similarly exposed animals. Veterinarians should be aware of the potential for coma and apnea secondary to hydroxyzine exposure... - The correlation of potassium content and moisture in bovine liver samples analyzed for trace mineral concentrationsTaylor P Ludwick
Agricultural and Environmental Chemistry Graduate Group, Department of Environmental Toxicology, University of California, Davis, CA, USA
J Vet Diagn Invest 20:314-20. 2008..4x(-0.952). An exponent of -1 is predicted by conservation of potassium mass. These findings have practical significance in maintaining and improving cattle growth, health, reproduction, and food safety... - Management of an ingested lead foreign body in an Amazon parrotShannon M Riggs
California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, One Shields Avenue, University of California, Davis, CA 95616, USA
Vet Hum Toxicol 44:345-8. 2002..However, this Amazon parrot was fed portions of game birds that contained lead shots within their muscles, which is a common source of secondary lead poisoning in raptors... - Determination of the median toxic dose of type C botulinum toxin in lactating dairy cowsRobert B Moeller
California Animal Health and Food Safety Laboratory System, Tulare Laboratory, University of California, 18830 Road 112, Tulare, CA 93274, USA
J Vet Diagn Invest 15:523-6. 2003..The mouse protection bioassay and the immunostick ELISA for type C botulinum toxin failed to identify the presence of the toxin in the serum, blood, and milk samples taken from all 7 animals... - Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horsesEugene P Steffey
Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 66:606-14. 2005.... - Effects of desflurane and mode of ventilation on cardiovascular and respiratory functions and clinicopathologic variables in horsesEugene P Steffey
Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 66:669-77. 2005..Desflurane is not metabolized to an important degree and does not appear to prominently influence renal function or hepatic cellular integrity or function... - Tissue heavy metal concentrations of stranded California sea lions (Zalophus californianus) in Southern CaliforniaErin R Harper
SeaWorld San Diego, San Diego, CA 92109, USA
Environ Pollut 147:677-82. 2007..This is the largest study of tissue heavy metal concentrations in California sea lions to date. These data demonstrate how passive monitoring of stranded animals can provide insight into environmental impacts on marine mammals... - Fatal ricin toxicosis in a puppy confirmed by liquid chromatography/mass spectrometry when using ricinine as a markerPamela Mouser
Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN, USA
J Vet Diagn Invest 19:216-20. 2007.... - Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007Cathy A Brown
Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
J Vet Diagn Invest 19:525-31. 2007..These results indicate that the pet food-associated renal failure outbreaks in 2004 and 2007 share identical clinical, histologic, and toxicologic findings, providing compelling evidence that they share the same causation... - Assessment of acute injuries, exposure to environmental toxins, and five-year health surveillance of New York Police Department working dogs following the September 11, 2001, World Trade Center terrorist attackPhilip R Fox
Caspary Institute of the Animal Medical Center, 510 E 62nd Street, New York, NY 10065, USA
J Am Vet Med Assoc 233:48-59. 2008....