Clive R Pullinger

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion
    Shu Fen Wung
    College of Nursing, University of Arizona, Tucson, AZ, USA
    Lipids Health Dis 5:19. 2006
  2. pmc An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients
    Clive R Pullinger
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    J Lipid Res 49:1846-54. 2008
  3. pmc Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults
    Clive R Pullinger
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Metab Syndr Relat Disord 8:279-86. 2010
  4. pmc Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia
    Mary B Engler
    Department of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143, USA
    Metabolism 57:1719-24. 2008
  5. pmc Types of sleep problems in adults living with HIV/AIDS
    Kathryn A Lee
    Department of Family Health Care Nursing, University of California, San Francisco, CA 94143 0606, USA
    J Clin Sleep Med 8:67-75. 2012
  6. pmc Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects
    Sinan Tanyolac
    Diabetes Center and Department of Medicine, University of California, San Francisco, California 94115, USA
    Metab Syndr Relat Disord 7:543-8. 2009
  7. pmc Symptom experience in HIV-infected adults: a function of demographic and clinical characteristics
    Kathryn A Lee
    Department of Family Health Care Nursing, University of California, San Francisco, California 94143 0606, USA
    J Pain Symptom Manage 38:882-93. 2009
  8. ncbi Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, San Francisco, California 94143 0130, USA
    Biochemistry 43:1626-32. 2004
  9. doi Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population
    Clive R Pullinger
    1 Cardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, California
    Metab Syndr Relat Disord 12:25-30. 2014
  10. pmc Risk factors and symptoms associated with pain in HIV-infected adults
    Bradley E Aouizerat
    Department of Physiological Nursing and Institute for Human Genetics, University of California, San Francisco, USA
    J Assoc Nurses AIDS Care 21:125-33. 2010

Detail Information

Publications34

  1. pmc The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion
    Shu Fen Wung
    College of Nursing, University of Arizona, Tucson, AZ, USA
    Lipids Health Dis 5:19. 2006
    ..A case-control design was employed. The polymorphism was assessed by restriction assay in 212 cases and 161 controls. Genotypic, allelic, and phenotypic associations were examined...
  2. pmc An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients
    Clive R Pullinger
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    J Lipid Res 49:1846-54. 2008
    ..This specific apoA-V variant has a pronounced effect on TG metabolism, the mechanism of which remains to be elucidated...
  3. pmc Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults
    Clive R Pullinger
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Metab Syndr Relat Disord 8:279-86. 2010
    ..Metabolic syndrome is a combination of risk factors for cardiovascular disease and diabetes, It has been reported to be increased in human immunodeficiency virus (HIV)-infected individuals...
  4. pmc Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia
    Mary B Engler
    Department of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143, USA
    Metabolism 57:1719-24. 2008
    ..Linear regression models predict that possession of the rs2294213 minor allele increases HDL-C independent of triglycerides. These findings extend the association of rs2294213 with HDL-C levels into the extremes of the HDL distribution...
  5. pmc Types of sleep problems in adults living with HIV/AIDS
    Kathryn A Lee
    Department of Family Health Care Nursing, University of California, San Francisco, CA 94143 0606, USA
    J Clin Sleep Med 8:67-75. 2012
    ..To characterize specific types of sleep problems experienced by adults with HIV...
  6. pmc Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects
    Sinan Tanyolac
    Diabetes Center and Department of Medicine, University of California, San Francisco, California 94115, USA
    Metab Syndr Relat Disord 7:543-8. 2009
    ..Membrane glycoprotein PC-1 (also termed ENPP1) is a direct insulin receptor inhibitor, and certain polymorphisms of the ENPP1/PC-1 gene have been associated with insulin resistance, type 2 diabetes, obesity, and diabetic complications...
  7. pmc Symptom experience in HIV-infected adults: a function of demographic and clinical characteristics
    Kathryn A Lee
    Department of Family Health Care Nursing, University of California, San Francisco, California 94143 0606, USA
    J Pain Symptom Manage 38:882-93. 2009
    ..Because high symptom burden is more likely to precipitate self-care strategies that may potentially be ineffective, strategies for symptom management would be better guided by tailored interventions from health care providers...
  8. ncbi Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, San Francisco, California 94143 0130, USA
    Biochemistry 43:1626-32. 2004
    ..These data identify a novel regulatory mechanism for ABCA1 and suggest new strategies to modify its expression...
  9. doi Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population
    Clive R Pullinger
    1 Cardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, California
    Metab Syndr Relat Disord 12:25-30. 2014
    ..The aim of this study was to measure the frequency of this variant and to determine the degree of the association with T2DM and other features of the metabolic syndrome in a replication cohort of Hispanic Americans...
  10. pmc Risk factors and symptoms associated with pain in HIV-infected adults
    Bradley E Aouizerat
    Department of Physiological Nursing and Institute for Human Genetics, University of California, San Francisco, USA
    J Assoc Nurses AIDS Care 21:125-33. 2010
    ..Pain was highly prevalent (55%) and was associated with immune status (CD4+ T-cell count), race, and sleep disturbance, but not with age, gender, or symptoms of fatigue, depression, or anxiety...
  11. ncbi Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007
    ..Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia...
  12. ncbi Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors
    Christian Zellner
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Hum Mutat 25:18-21. 2005
    ..Haplotype analysis suggests four SNPs can define the five major haplotypes that lie within a single haplotype block encompassing these two genes...
  13. pmc Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study
    Melissa A Calton
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 18:1140-7. 2009
    ..However, our data suggest that MC3R mutations are not associated with severe obesity in this population...
  14. pmc WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 83:180-92. 2008
    ..In conclusion, analyses of 9,798 subjects show significant association between HDL-C and a WWOX variant with an allele-specific cis-regulatory function...
  15. ncbi Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery
    Jacqueline M Leung
    Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 107:406-11. 2007
    ..Whether patients who subsequently develop early postoperative delirium have a genetic predisposition that renders them at risk for postoperative delirium has not been determined...
  16. pmc Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy
    Ting Ting Hong
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA
    Heart Rhythm 9:961-7. 2012
    ..We hypothesized that BIN1 could be released into the circulation and that blood-available BIN1 can provide useful data on the cardiac status of patients whose hearts are failing secondary to ARVC...
  17. pmc Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study
    Steven G DuBois
    Department of Pediatrics, UCSF School of Medicine, San Francisco, California 94143 0106, USA
    Pediatr Blood Cancer 59:52-6. 2012
    ..Ewing sarcoma is a malignant bone tumor characterized by a high frequency of somatic EWSR1 translocations. Ewing sarcoma is less common in people of African or African-American ancestry, suggesting a genetic etiology...
  18. ncbi Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia
    Bradley E Aouizerat
    Department of Physiological Nursing, School of Nursing, University of California San Francisco, San Francisco, CA 94143, USA
    J Lipid Res 47:787-93. 2006
    ..R235W) of four (p.E72G, p.S119A, p.S124Y, and p.R235W) mutations in an in vitro activity assay. These findings indicate that PLTP gene variation is an important determinant of plasma lipoproteins and affects disorders of HDL metabolism...
  19. ncbi Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus
    Kathryn A Lee
    Department of Family Health Care Nursing, University of California at San Francisco, San Francisco, CA
    Sleep 37:157-66. 2014
    ..This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness...
  20. doi Epigenetic regulation and measurement of epigenetic changes
    Kimberly E Stephens
    1Department of Physiological Nursing, University of California, San Francisco, CA, USA
    Biol Res Nurs 15:373-81. 2013
    ....
  21. ncbi Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids
    Bradley E Aouizerat
    Department of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143, USA
    J Lipid Res 44:1167-73. 2003
    ..These findings indicate that APOAV is an important determinant of plasma TG and lipoprotein cholesterol, and is potentially a risk factor for cardiovascular disease...
  22. pmc Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
    Clive R Pullinger
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    J Clin Invest 110:109-17. 2002
    ..Study of the kindred, which is of English and Celtic background, revealed that individuals heterozygous for the mutation are also hyperlipidemic, indicating that this is a codominant disorder...
  23. ncbi Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation
    Jason D Roberts
    Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    J Cardiovasc Electrophysiol 25:271-7. 2014
    ..We sought to characterize the association between rs2200733 and prevalent Afl and to determine if the variant could predict AF after cavotricuspid isthmus ablation...
  24. ncbi Cytokine polymorphisms are associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome
    Kathryn A Lee
    Department of Family Health Care Nursing, University of California at San Francisco, San Francisco, CA
    Sleep 37:453-63. 2014
    ....
  25. pmc Identification of four gene variants associated with myocardial infarction
    Dov Shiffman
    Celera Diagnostics, Alameda, CA, USA
    Am J Hum Genet 77:596-605. 2005
    ..58] and OR13G1 [OR 1.40]); all ORs are for carriers of two versus zero risk alleles. These findings could lead to a better understanding of MI pathophysiology and improved patient risk assessment...
  26. ncbi Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders
    Clive R Pullinger
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Expert Rev Cardiovasc Ther 1:107-19. 2003
    ..This review relates the mechanisms underlying these five disorders with specific therapeutic interventions...
  27. ncbi Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Biochem Biophys Res Commun 306:463-8. 2003
    ..In both cell lines class 3 transcript levels were minimal and unchanged. It is shown here for the first time that the regulation of ABCA1 mRNA levels exploits the use of alternative transcription start sites...
  28. pmc Lack of support for the association between GAD2 polymorphisms and severe human obesity
    Michael M Swarbrick
    Diabetes Center, University of California, San Francisco, California, USA
    PLoS Biol 3:e315. 2005
    ....
  29. ncbi Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL
    Timothy S E Albert
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 46:469-74. 2005
    ..In conclusion, we found TG and HG to be the strongest predictors of apoL-I within a dyslipidemic CAD population. These data provide further characterization of the novel HDL-associated apoL-I...
  30. pmc Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia
    Jeroen B van der Net
    Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Eur Heart J 29:2195-201. 2008
    ..We performed a replication study of 10 polymorphisms and CHD in a population with familial hypercholesterolemia (FH), individuals at extreme risk of CHD...
  31. ncbi Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction
    Dov Shiffman
    Celera Inc, 1401 Harbor Bay Pkwy, Alameda, California 94502, USA
    Arterioscler Thromb Vasc Biol 26:1613-8. 2006
    ..Identify gene variants associated with early-onset myocardial infarction (MI)...
  32. ncbi A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease
    May M Luke
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 27:2030-6. 2007
    ..The purpose of this study was to identify genetic variants associated with severe coronary artery disease (CAD)...
  33. pmc A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    ..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)...
  34. ncbi Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding
    Dairena Gaffney
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, North Glasgow Hospital University NHS Trust, Fourth Floor, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Clin Chim Acta 321:113-21. 2002
    ..Previously, undescribed mutations were sought...