Lynn Pulliam

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation
    L Pulliam
    Departments of Laboratory Medicine and Medicine, University of California, San Francisco, CA 94143, USA
    Brain Res 893:95-103. 2001
  2. ncbi Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load
    Lynn Pulliam
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Neuroimmunol 157:93-8. 2004
  3. ncbi A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations
    Lynn Pulliam
    Department of Laboratory Medicine, Veterans Affairs Medical Center, San Francisco, 94121, USA
    AIDS 25:1721-6. 2011
  4. ncbi Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometry
    Bing Sun
    Department of Laboratory Medicine, University of California, and Veterans Affairs Medical Center, San Francisco, USA
    AIDS 18:1009-12. 2004
  5. ncbi Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia
    Leonard Kusdra
    Department of Laboratory Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    AIDS 16:31-8. 2002
  6. ncbi Suppressed monocyte gene expression profile in men versus women with PTSD
    Thomas C Neylan
    Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Behav Immun 25:524-31. 2011
  7. ncbi Intranasal tat alters gene expression in the mouse brain
    Lynn Pulliam
    Department of Laboratory Medicine, Veterans Affairs Medical Center, 4150 Clement St 113A, San Francisco, CA 94121, USA
    J Neuroimmune Pharmacol 2:87-92. 2007
  8. ncbi HIV regulation of amyloid beta production
    Lynn Pulliam
    Veterans Affair Medical Center, San Francisco, University of California, San Francisco, CA 94121, USA
    J Neuroimmune Pharmacol 4:213-7. 2009
  9. ncbi Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection
    Hans Rempel
    Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    AIDS 24:1415-23. 2010
  10. ncbi HIV-1 Tat inhibits neprilysin and elevates amyloid beta
    Hans C Rempel
    Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    AIDS 19:127-35. 2005

Research Grants

  1. HIV-1 Infection Increases Brain Amyloid Beta
    Lynn Pulliam; Fiscal Year: 2006

Collaborators

Detail Information

Publications11

  1. ncbi CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation
    L Pulliam
    Departments of Laboratory Medicine and Medicine, University of California, San Francisco, CA 94143, USA
    Brain Res 893:95-103. 2001
    ..These findings may have implications for other neurological diseases where apoptotic cell death contributes to neurodegeneration...
  2. ncbi Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load
    Lynn Pulliam
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Neuroimmunol 157:93-8. 2004
    ..We concluded that there is a circulating CD14+ macrophage hybrid phenotype in subjects with HVL...
  3. ncbi A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations
    Lynn Pulliam
    Department of Laboratory Medicine, Veterans Affairs Medical Center, San Francisco, 94121, USA
    AIDS 25:1721-6. 2011
    ..In spite of effective antiretroviral therapy (ART), cognition is impaired in upwards of 35% of the HIV-infected population. We investigated a possible link between peripheral immune activation and brain metabolite concentrations...
  4. ncbi Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometry
    Bing Sun
    Department of Laboratory Medicine, University of California, and Veterans Affairs Medical Center, San Francisco, USA
    AIDS 18:1009-12. 2004
    ..The protein was identified as lysozyme, a major macrophage defense protein. This further demonstrates macrophage dysfunction as a significant consequence of HAD...
  5. ncbi Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia
    Leonard Kusdra
    Department of Laboratory Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    AIDS 16:31-8. 2002
    ..Changes in neural cell signaling, structural and functional proteins may represent more subtle neurotoxicity, manifested in cell dysfunction rather than frank cell death...
  6. ncbi Suppressed monocyte gene expression profile in men versus women with PTSD
    Thomas C Neylan
    Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Behav Immun 25:524-31. 2011
    ..Changes in immune cell gene expression may contribute to medical morbidity in PTSD...
  7. ncbi Intranasal tat alters gene expression in the mouse brain
    Lynn Pulliam
    Department of Laboratory Medicine, Veterans Affairs Medical Center, 4150 Clement St 113A, San Francisco, CA 94121, USA
    J Neuroimmune Pharmacol 2:87-92. 2007
    ..This IN Tat model of neuroinflammation may be useful to study HIV-1-induced neurodegeneration...
  8. ncbi HIV regulation of amyloid beta production
    Lynn Pulliam
    Veterans Affair Medical Center, San Francisco, University of California, San Francisco, CA 94121, USA
    J Neuroimmune Pharmacol 4:213-7. 2009
    ..These findings may explain the continued cognitive dysfunction found in HIV-infected individuals controlled on antiviral therapy...
  9. ncbi Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection
    Hans Rempel
    Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    AIDS 24:1415-23. 2010
    ..The objectives were two fold: to characterize the impact of HIV-1 infection on peripheral monocyte gene expression and to identify the predominant factor(s) responsible for altered gene expression...
  10. ncbi HIV-1 Tat inhibits neprilysin and elevates amyloid beta
    Hans C Rempel
    Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    AIDS 19:127-35. 2005
    ....
  11. ncbi Transcriptional control of monocyte gene expression in post-traumatic stress disorder
    Aoife O'Donovan
    Veteran s Affairs Medical Center, San Francisco, CA 94121, USA
    Dis Markers 30:123-32. 2011
    ..Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD...

Research Grants3

  1. HIV-1 Infection Increases Brain Amyloid Beta
    Lynn Pulliam; Fiscal Year: 2006
    ..We believe that mechanisms derived from these experiments will have implications for long term survivors of HIV-1 infection and hopefully give us new clues for therapeutic strategies against HIV-associated dementia. ..