Affiliation: University of California
- CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activationL Pulliam
Departments of Laboratory Medicine and Medicine, University of California, San Francisco, CA 94143, USA
Brain Res 893:95-103. 2001..These findings may have implications for other neurological diseases where apoptotic cell death contributes to neurodegeneration...
- Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral loadLynn Pulliam
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
J Neuroimmunol 157:93-8. 2004..We concluded that there is a circulating CD14+ macrophage hybrid phenotype in subjects with HVL...
- A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrationsLynn Pulliam
Department of Laboratory Medicine, Veterans Affairs Medical Center, San Francisco, 94121, USA
AIDS 25:1721-6. 2011..In spite of effective antiretroviral therapy (ART), cognition is impaired in upwards of 35% of the HIV-infected population. We investigated a possible link between peripheral immune activation and brain metabolite concentrations...
- Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometryBing Sun
Department of Laboratory Medicine, University of California, and Veterans Affairs Medical Center, San Francisco, USA
AIDS 18:1009-12. 2004..The protein was identified as lysozyme, a major macrophage defense protein. This further demonstrates macrophage dysfunction as a significant consequence of HAD...
- Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementiaLeonard Kusdra
Department of Laboratory Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
AIDS 16:31-8. 2002..Changes in neural cell signaling, structural and functional proteins may represent more subtle neurotoxicity, manifested in cell dysfunction rather than frank cell death...
- Suppressed monocyte gene expression profile in men versus women with PTSDThomas C Neylan
Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain Behav Immun 25:524-31. 2011..Changes in immune cell gene expression may contribute to medical morbidity in PTSD...
- Intranasal tat alters gene expression in the mouse brainLynn Pulliam
Department of Laboratory Medicine, Veterans Affairs Medical Center, 4150 Clement St 113A, San Francisco, CA 94121, USA
J Neuroimmune Pharmacol 2:87-92. 2007..This IN Tat model of neuroinflammation may be useful to study HIV-1-induced neurodegeneration...
- HIV regulation of amyloid beta productionLynn Pulliam
Veterans Affair Medical Center, San Francisco, University of California, San Francisco, CA 94121, USA
J Neuroimmune Pharmacol 4:213-7. 2009..These findings may explain the continued cognitive dysfunction found in HIV-infected individuals controlled on antiviral therapy...
- Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infectionHans Rempel
Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
AIDS 24:1415-23. 2010..The objectives were two fold: to characterize the impact of HIV-1 infection on peripheral monocyte gene expression and to identify the predominant factor(s) responsible for altered gene expression...
- HIV-1 Tat inhibits neprilysin and elevates amyloid betaHans C Rempel
Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
AIDS 19:127-35. 2005....
- Transcriptional control of monocyte gene expression in post-traumatic stress disorderAoife O'Donovan
Veteran s Affairs Medical Center, San Francisco, CA 94121, USA
Dis Markers 30:123-32. 2011..Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD...
- HIV-1 Infection Increases Brain Amyloid BetaLynn Pulliam; Fiscal Year: 2006..We believe that mechanisms derived from these experiments will have implications for long term survivors of HIV-1 infection and hopefully give us new clues for therapeutic strategies against HIV-associated dementia. ..