Affiliation: University of Cincinnati
SÃ¡nchez MartÃn F, Fan Y, Carreira V, Ovesen J, Vonhandorf A, Xia Y, et al
. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. Toxicol Sci. 2015;146:52-64 pubmed publisher
..Tissue specificity may be particularly critical in cases of extended exposure to mixtures of these agents, as may happen in the occupational setting or in areas where drinking water contains elevated levels of Cr(VI). ..
Puga A. Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease. Toxicol Sci. 2011;120:256-61 pubmed publisher
..Research to define the mechanisms responsible for the lifelong cardiovascular malformations resulting from TCDD exposure during embryonic development will be highly significant to the prevention of environmental cardiovascular injury. ..
Carreira V, Fan Y, Wang Q, Zhang X, Kurita H, Ko C, et al
. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. Toxicol Sci. 2015;147:425-35 pubmed publisher
Puga A, Ma C, Marlowe J. The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol. 2009;77:713-22 pubmed publisher
..Ultimately, the effect of a particular AHR ligand may depend as much on the adaptive interactions that it established with pathways and proteins expressed in a specific cell or tissue as on the toxic responses that it raises. ..
Wang Q, Kurita H, Carreira V, Ko C, Fan Y, Zhang X, et al
. Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions. Toxicol Sci. 2016;149:346-57 pubmed publisher
..Sustained AHR activation during ES cell differentiation appears to disrupt the expression of signals critical to the ontogeny of cardiac mesoderm and cause the loss of contractility in the resulting cardiomyocyte lineage. ..
Kurita H, Carreira V, Fan Y, Jiang M, Naticchioni M, Koch S, et al
. Ah receptor expression in cardiomyocytes protects adult female mice from heart dysfunction induced by TCDD exposure. Toxicology. 2016;355-356:9-20 pubmed publisher
..TCDD exposure appears to cause sexually dimorphic effects on heart function and induce fibrosis and changes in calcium signaling in both males and females through activation of the cardiomyocyte-specific Ahr. ..
Puga A, Barnes S, Dalton T, Chang C, Knudsen E, Maier M. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem. 2000;275:2943-50 pubmed
Puga A, Xia Y, Elferink C. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact. 2002;141:117-30 pubmed
..We have attempted to provide the reader with a balanced interpretation of the evidence, highlighting areas of consensus as well as areas still being contested. ..
Ovesen J, Fan Y, Chen J, Medvedovic M, Xia Y, Puga A. Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene. Toxicology. 2014;316:14-24 pubmed publisher
..We conclude that the combined effect of these two toxicants appears to be neither synergistic nor additive, generating a toxic/adaptive condition that cannot be predicted from the effect of each toxicant alone...