- Crosstalk between G protein-coupled receptors and tyrosine kinase signaling: Src take centre stage
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
Arch Immunol Ther Exp (Warsz) 48:27-30. 2000
..In the past few years several groups have found that G protein-coupled receptors utilize non-receptor tyrosine kinases, mostly that of Src family, and some adapter proteins, to regulate tyrosine kinase cascades in cells...
- [Regulation of cellular differentiation and cellular function by phosphatidylinositol 3-kinase]
University of Pennsylvania Medical Center, Philadelphia 19104 6100, USA
Postepy Hig Med Dosw 54:609-18. 2000
..Thus, the role of PI3Ks in the regulation of differentiation is clearly a very complex process implicating integration between different receptor systems and cell type-specific responses...
- Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
Division of Hematology Oncology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Med 10:1187-9. 2004
..This increased dependence on Lyn signaling for BCR-ABL1(+) blast survival provides the basis for rational treatment of drug-resistant CML blast crisis, particularly when lymphoid in nature...
- BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells
Ying Yu Chen
Divisions of Hematology and Oncology, University of Pennsylvania School of Medicine, Philadelphia, USA
Blood 111:5182-6. 2008
..These data provide a novel, LFA-1-mediated mechanism whereby BCR-ABL1 inhibits SDF-1 action in malignant progenitors...
- Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
Am J Pathol 168:1631-41. 2006
..Furthermore, our results indicate that Brk may play a key role in lymphomagenesis, hence identifying the kinase as a potential therapeutic target in lymphomas...
- The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Blood 108:1145-50. 2006
- Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Blood 107:4234-9. 2006
..This cross talk may allow chemokine receptors to modulate the arrest of rolling hematopoietic precursors on the surface of bone marrow stromal cells...
- Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Lab Invest 85:1544-54. 2005
..The above results represent the 'proof-of-principle' experiments with regard to the ALK enzymatic activity as an attractive therapeutic target in T-cell lymphomas and other malignancies that express the kinase in an active form...
- Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells
Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
J Exp Med 196:667-78. 2002
..These results define a Src tyrosine kinases-dependent mechanism whereby BCR/ABL (and potentially other oncoproteins) dysregulates G protein-coupled receptor signaling and function of mammalian precursors...
- Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages
Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 180:6675-84. 2008
..This study identifies a novel signaling mechanism for HIV-1-induced IL-1beta production by primary human macrophages that may be involved in the neuropathogenesis of HIV-associated dementia...