A Ptasznik

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Crosstalk between G protein-coupled receptors and tyrosine kinase signaling: Src take centre stage
    A Ptasznik
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Arch Immunol Ther Exp (Warsz) 48:27-30. 2000
  2. ncbi request reprint [Regulation of cellular differentiation and cellular function by phosphatidylinositol 3-kinase]
    A Ptasznik
    University of Pennsylvania Medical Center, Philadelphia 19104 6100, USA
    Postepy Hig Med Dosw 54:609-18. 2000
  3. ncbi request reprint Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
    Andrzej Ptasznik
    Division of Hematology Oncology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 10:1187-9. 2004
  4. pmc BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells
    Ying Yu Chen
    Divisions of Hematology and Oncology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 111:5182-6. 2008
  5. pmc Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes
    Monika Kasprzycka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Pathol 168:1631-41. 2006
  6. pmc The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages
    Brian Tomkowicz
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 108:1145-50. 2006
  7. pmc Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells
    Yuji Nakata
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 107:4234-9. 2006
  8. ncbi request reprint Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lab Invest 85:1544-54. 2005
  9. pmc Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells
    Andrzej Ptasznik
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
    J Exp Med 196:667-78. 2002
  10. pmc Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages
    Ricky Cheung
    Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 180:6675-84. 2008

Research Grants

Collaborators

  • Alan Gewirtz
  • Yuji Nakata
  • Ricky Cheung
  • Ronald G Collman
  • Monika Kasprzycka
  • Michal Marzec
  • Ying Yu Chen
  • Vipa Ravyn
  • Brian Tomkowicz
  • Mariusz A Wasik
  • Qian Zhang
  • Lingshu Wang
  • Mobeen Malik
  • Brian E Tomkowicz
  • Maria Wysocka
  • Phyllis Gimotty
  • Mark R Crompton
  • ChuHee Lee
  • Zhi Jong Wang
  • Miroslaw Majewski
  • Pawel Wlodarski
  • Niels Odum

Detail Information

Publications10

  1. ncbi request reprint Crosstalk between G protein-coupled receptors and tyrosine kinase signaling: Src take centre stage
    A Ptasznik
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Arch Immunol Ther Exp (Warsz) 48:27-30. 2000
    ..In the past few years several groups have found that G protein-coupled receptors utilize non-receptor tyrosine kinases, mostly that of Src family, and some adapter proteins, to regulate tyrosine kinase cascades in cells...
  2. ncbi request reprint [Regulation of cellular differentiation and cellular function by phosphatidylinositol 3-kinase]
    A Ptasznik
    University of Pennsylvania Medical Center, Philadelphia 19104 6100, USA
    Postepy Hig Med Dosw 54:609-18. 2000
    ..Thus, the role of PI3Ks in the regulation of differentiation is clearly a very complex process implicating integration between different receptor systems and cell type-specific responses...
  3. ncbi request reprint Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
    Andrzej Ptasznik
    Division of Hematology Oncology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 10:1187-9. 2004
    ..This increased dependence on Lyn signaling for BCR-ABL1(+) blast survival provides the basis for rational treatment of drug-resistant CML blast crisis, particularly when lymphoid in nature...
  4. pmc BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells
    Ying Yu Chen
    Divisions of Hematology and Oncology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 111:5182-6. 2008
    ..These data provide a novel, LFA-1-mediated mechanism whereby BCR-ABL1 inhibits SDF-1 action in malignant progenitors...
  5. pmc Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes
    Monika Kasprzycka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Pathol 168:1631-41. 2006
    ..Furthermore, our results indicate that Brk may play a key role in lymphomagenesis, hence identifying the kinase as a potential therapeutic target in lymphomas...
  6. pmc The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages
    Brian Tomkowicz
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 108:1145-50. 2006
    ....
  7. pmc Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells
    Yuji Nakata
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 107:4234-9. 2006
    ..This cross talk may allow chemokine receptors to modulate the arrest of rolling hematopoietic precursors on the surface of bone marrow stromal cells...
  8. ncbi request reprint Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lab Invest 85:1544-54. 2005
    ..The above results represent the 'proof-of-principle' experiments with regard to the ALK enzymatic activity as an attractive therapeutic target in T-cell lymphomas and other malignancies that express the kinase in an active form...
  9. pmc Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells
    Andrzej Ptasznik
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
    J Exp Med 196:667-78. 2002
    ..These results define a Src tyrosine kinases-dependent mechanism whereby BCR/ABL (and potentially other oncoproteins) dysregulates G protein-coupled receptor signaling and function of mammalian precursors...
  10. pmc Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages
    Ricky Cheung
    Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 180:6675-84. 2008
    ..This study identifies a novel signaling mechanism for HIV-1-induced IL-1beta production by primary human macrophages that may be involved in the neuropathogenesis of HIV-associated dementia...

Research Grants3

  1. Crosstalk between oncoprotein and chemokine signaling
    Andrzej Ptasznik; Fiscal Year: 2007
    ..The analogous Src kinases-targeted strategy may have application to solid tumors. ..