B M Psaty

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Using built environment characteristics to predict walking for exercise
    Gina S Lovasi
    Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Int J Health Geogr 7:10. 2008
  2. ncbi Comparing a single-stage geocoding method to a multi-stage geocoding method: how much and where do they disagree?
    Gina S Lovasi
    Columbia University, Institute of Social and Economic Research and Policy, New York, NY, USA
    Int J Health Geogr 6:12. 2007
  3. ncbi The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
  4. ncbi Potential revisions to hypertension guidelines
    Bruce M Psaty
    Cardiovascular Health Research Unit, Seattle, Washington, USA
    Am J Hypertens 21:134-5. 2008
  5. ncbi Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis
    Bruce M Psaty
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 289:2534-44. 2003
  6. ncbi The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The Cardiovascular Health Study
    Bruce M Psaty
    Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
    J Am Geriatr Soc 52:1639-47. 2004
  7. ncbi Contemplating ACTION--long-acting nifedipine in stable angina
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Lancet 364:817-8. 2004
  8. ncbi The potential costs of upcoding for heart failure in the United States
    B M Psaty
    Department of Medicine, University of Washington, Seattle, USA
    Am J Cardiol 84:108-9, A9. 1999
  9. ncbi Hormone replacement therapy, prothrombotic mutations, and the risk of incident nonfatal myocardial infarction in postmenopausal women
    B M Psaty
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    JAMA 285:906-13. 2001
  10. ncbi Congress responds to the IOM drug safety report--in full
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, and Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    JAMA 298:2185-7. 2007

Research Grants

  1. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce M Psaty; Fiscal Year: 2010
  2. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
  3. Hormone Replacement Therapy and Prothrombotic Variants
    Bruce Psaty; Fiscal Year: 2005
  4. ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTS
    Bruce Psaty; Fiscal Year: 2004
  5. Trends in and Outcomes of Medication Use in Older Adults
    Bruce Psaty; Fiscal Year: 2004
  6. WGA Study to Identify Genetic Variants Associated with CV Events in CHS
    Bruce Psaty; Fiscal Year: 2007
  7. CHS Events Follow-up Study
    Bruce M Psaty; Fiscal Year: 2010
  8. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce Psaty; Fiscal Year: 2009
  9. WGA Study to Identify Genetic Variants Associated with CV Events in CHS
    Bruce Psaty; Fiscal Year: 2009
  10. CHS Events Follow-up Study
    Bruce Psaty; Fiscal Year: 2007

Collaborators

Detail Information

Publications145 found, 100 shown here

  1. ncbi Using built environment characteristics to predict walking for exercise
    Gina S Lovasi
    Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Int J Health Geogr 7:10. 2008
    ..In order to limit confounding by prior health conditions, the sample was restricted to participants in good self-reported health and without a documented history of cardiovascular disease...
  2. ncbi Comparing a single-stage geocoding method to a multi-stage geocoding method: how much and where do they disagree?
    Gina S Lovasi
    Columbia University, Institute of Social and Economic Research and Policy, New York, NY, USA
    Int J Health Geogr 6:12. 2007
    ..Area-level characteristics were collected from census data, and modeled as predictors of the discordance between geocoded address coordinates...
  3. ncbi The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
    ....
  4. ncbi Potential revisions to hypertension guidelines
    Bruce M Psaty
    Cardiovascular Health Research Unit, Seattle, Washington, USA
    Am J Hypertens 21:134-5. 2008
  5. ncbi Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis
    Bruce M Psaty
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 289:2534-44. 2003
    ..Establishing relative benefit or harm from specific antihypertensive agents is limited by the complex array of studies that compare treatments. Network meta-analysis combines direct and indirect evidence to better define risk or benefit...
  6. ncbi The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The Cardiovascular Health Study
    Bruce M Psaty
    Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
    J Am Geriatr Soc 52:1639-47. 2004
    ..To assess the association between lipid levels and cardiovascular events in older adults...
  7. ncbi Contemplating ACTION--long-acting nifedipine in stable angina
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Lancet 364:817-8. 2004
  8. ncbi The potential costs of upcoding for heart failure in the United States
    B M Psaty
    Department of Medicine, University of Washington, Seattle, USA
    Am J Cardiol 84:108-9, A9. 1999
    ..Miscoding of hospital discharge diagnoses for heart failure in older adults is common, and the direction favors high levels of reimbursement to hospitals. The potential costs to Medicare may be as high as $993 million per year...
  9. ncbi Hormone replacement therapy, prothrombotic mutations, and the risk of incident nonfatal myocardial infarction in postmenopausal women
    B M Psaty
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    JAMA 285:906-13. 2001
    ....
  10. ncbi Congress responds to the IOM drug safety report--in full
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, and Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    JAMA 298:2185-7. 2007
  11. ncbi Opportunities for enhancing the FDA guidance on pharmacovigilance
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington and Center for Health Studies, Group Health, Seattle, WA 98101, USA
    JAMA 300:952-4. 2008
  12. ncbi FDA responds to institute of medicine drug safety recommendations--in part
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Center for Health Studies, Group Health, Seattle, WA 98101, USA
    JAMA 297:1917-20. 2007
  13. ncbi Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts
    Bruce M Psaty
    Departments of Medicine, Epidemiology, and Health Services, University of Wash, Seattle, USA
    Circ Cardiovasc Genet 2:73-80. 2009
    ....
  14. ncbi Clinical trial design and selected drug safety issues for antibiotics used to treat community-acquired pneumonia
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 47:S176-9. 2008
    ..Complete and proper evaluation of both safety and efficacy in specific situations is essential to define the risk-benefit profiles of all drugs, including antibiotics...
  15. ncbi Association between levels of blood pressure and measures of subclinical disease multi-ethnic study of atherosclerosis
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
    Am J Hypertens 19:1110-7. 2006
    ..High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease...
  16. ncbi Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
    JAMA 292:2622-31. 2004
    ..As a result, the challenge of early detection has largely shifted to the US postmarketing systems...
  17. ncbi FDA guidance on off-label promotion and the state of the literature from sponsors
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    JAMA 299:1949-51. 2008
  18. ncbi Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension
    Bruce M Psaty
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    JAMA 287:1680-9. 2002
    ..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown...
  19. ncbi Reporting mortality findings in trials of rofecoxib for Alzheimer disease or cognitive impairment: a case study based on documents from rofecoxib litigation
    Bruce M Psaty
    Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington and Center for Health Studies, Group Health, Seattle, WA 98101, USA
    JAMA 299:1813-7. 2008
    ..The findings from this case study suggest that additional protections for human research participants, including new approaches for the conduct, oversight, and reporting of industry-sponsored trials, are necessary...
  20. ncbi Surrogate end points and FDA approval: a tale of 2 lipid-altering drugs
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA
    JAMA 299:1474-6. 2008
  21. ncbi A new era of cardiovascular disease epidemiology
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington and Center for Health Studies, Group Health, Seattle, USA
    JAMA 298:2060-2. 2007
  22. ncbi Postmenopausal estrogens and risk of myocardial infarction in diabetic women
    R C Kaplan
    Cardiovascular Health Research Unit, University of Washington, Seattle 98101, USA
    Diabetes Care 21:1117-21. 1998
    ....
  23. ncbi Body mass index and the risk of recurrent coronary events following acute myocardial infarction
    T D Rea
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA
    Am J Cardiol 88:467-72. 2001
    ..Thus, excess adiposity as measured by BMI was associated with an increased risk of recurrent coronary events following AMI, particularly among those who were obese...
  24. ncbi Genetic variants of platelet glycoprotein receptors and risk of stroke in young women
    A P Reiner
    Departments of Medicine, University of Washington, Seattle, WA 98195 9756, USA
    Stroke 31:1628-33. 2000
    ..Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined...
  25. ncbi Risk of recurrent coronary events in relation to use and recent initiation of postmenopausal hormone therapy
    S R Heckbert
    Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
    Arch Intern Med 161:1709-13. 2001
    ..We assessed the risk of recurrent myocardial infarction or coronary heart disease death associated with the use and recent initiation of hormone therapy in women who survived a first myocardial infarction...
  26. ncbi Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups
    D L Tirschwell
    Department of Neurology, University of Washington, Seattle, USA
    Neurology 63:1868-75. 2004
    ..To perform a health maintenance organization-based case-control study to evaluate the association of total and high density lipoprotein (HDL) cholesterol with the risk of stroke subtypes and in patient subgroups...
  27. ncbi ABO genotype and risk of thrombotic events and hemorrhagic stroke
    K L Wiggins
    Department of Medicine, University of Washington, Seattle, WA 98101, USA
    J Thromb Haemost 7:263-9. 2009
    ..The non-O alleles of the ABO genotype have been associated with an increased risk of thrombosis. Risk associated with the specific A(1), A(2) or B alleles is not well defined...
  28. ncbi Health outcomes associated with beta-blocker and diltiazem treatment of unstable angina
    N L Smith
    Department of Medicine, University of Washington, Seattle, USA
    J Am Coll Cardiol 32:1305-11. 1998
    ..We compared long-term health outcomes associated with beta-adrenergic blocking agents and diltiazem treatment for unstable angina...
  29. ncbi Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke
    N L Smith
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Thromb Haemost 6:45-53. 2008
    ..We hypothesized that common variation in 24 coagulation-fibrinolysis genes would contribute to risk of incident myocardial infarction (MI) or ischemic stroke (IS)...
  30. ncbi Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women
    A P Reiner
    Department of Medicine, Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 32:2580-6. 2001
    ....
  31. ncbi Risk of stroke in young women and two prothrombotic mutations: factor V Leiden and prothrombin gene variant (G20210A)
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 29:577-80. 1998
    ..Factor V Leiden and a prothrombin gene variant, G20210A, are mutations associated with a thrombotic risk. The aim of our study was to assess whether these mutations increase the risk of stroke in women under 45 years of age...
  32. ncbi Blood pressure control and risk of incident atrial fibrillation
    M C Thomas
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 21:1111-6. 2008
    ..We sought to determine whether the risk of incident AF among patients treated for hypertension differs by the degree of blood pressure control...
  33. ncbi Blood pressure level and incidence of myocardial infarction among patients treated for hypertension
    R C Kaplan
    Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Am J Public Health 89:1414-7. 1999
    ..This study examined the relationship between achieved blood pressure and risk of myocardial infarction among patients treated for hypertension...
  34. ncbi Hormone replacement therapy, inflammation, and hemostasis in elderly women
    M Cushman
    Departments of Medicine, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 19:893-9. 1999
    ..Associations with hemostasis markers indicated no association with evidence of procoagulation and a possible association with increased fibrinolytic activity...
  35. ncbi Association of hypothyroidism and obstructive sleep apnea
    V K Kapur
    University of Washington, Seattle and Group Health Cooperative of Puget Sound, Redmond, Washington, USA
    Am J Respir Crit Care Med 158:1379-83. 1998
    ..47 (95% CI 0.8-2.8). Limitations in study design may have limited our ability to detect a statistically significant association between OSA and hypothyroidism...
  36. ncbi Post-menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Br J Haematol 114:162-8. 2001
    ..This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT-induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required...
  37. ncbi Use of calcium channel blockers and risk of hospitalized gastrointestinal tract bleeding
    R C Kaplan
    Department of Epidemiology, University of Washington, Seattle, USA
    Arch Intern Med 160:1849-55. 2000
    ..We conducted a case-control study of the association between calcium channel blocker use and gastrointestinal (GI) tract bleeding in hypertensive members of a health maintenance organization...
  38. ncbi Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women
    A P Reiner
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Br J Haematol 112:632-6. 2001
    ..Additional studies involving larger numbers of subjects are needed to confirm this preliminary finding...
  39. ncbi Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
    ..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation...
  40. ncbi Estrogen plus progestin and risk of venous thrombosis
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington 05446, USA
    JAMA 292:1573-80. 2004
    ..Postmenopausal hormone therapy increases the risk of venous thrombosis. It is not known whether other factors influencing thrombosis add to this risk...
  41. ncbi Baseline depressive symptoms are not associated with clinically important levels of incident hypertension during two years of follow-up: the multi-ethnic study of atherosclerosis
    Joseph A C Delaney
    Department of Biostatistics, University of Washington, Seattle, Wash 98115, USA
    Hypertension 55:408-14. 2010
    ..8 mm Hg; 95% CI: -0.6 to 2.3) blood pressures. Depressive symptoms may be associated with slight increases in blood pressure in this multiethnic cohort, but it is premature to conclude much without longer studies in other populations...
  42. ncbi Control of blood pressure and risk of stroke among pharmacologically treated hypertensive patients
    O H Klungel
    Department of Epidemiology, Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 31:420-4. 2000
    ..We estimated the proportion of strokes occurring among treated hypertensive patients that may be attributable to uncontrolled blood pressure...
  43. ncbi Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene
    S M Schwartz
    Department of Epidemiology, University of Washington, Seattle 98101, USA
    Circulation 96:412-7. 1997
    ....
  44. ncbi The differential association of conjugated equine estrogen and esterified estrogen with activated protein C resistance in postmenopausal women
    N L Smith
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    J Thromb Haemost 4:1701-6. 2006
    ....
  45. ncbi Influenza vaccination and the risk of primary cardiac arrest
    D S Siscovick
    Department of Medicine, University of Washington, Seattle, USA
    Am J Epidemiol 152:674-7. 2000
    ....
  46. ncbi Trends in the post-hospitalization medical treatment of unstable angina pectoris: 1990 to 1995
    N L Smith
    Department of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, USA
    Am J Cardiol 84:632-8. 1999
    ....
  47. ncbi Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study
    Nathan D Wong
    Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, California, USA
    Am J Hypertens 23:161-7. 2010
    ..Hypertension and dyslipidemia are highly prevalent in the elderly. We studied the combined impact of both conditions on cardiovascular disease (CVD) events...
  48. ncbi CRP gene variation and risk of community-acquired pneumonia
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Respirology 15:160-4. 2010
    ..Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain...
  49. ncbi Replacing short-acting nifedipine with alternative medications at a large health maintenance organization
    R C Kaplan
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle 98101, USA
    Am J Hypertens 11:471-7. 1998
    ..By presenting physicians and patients with recent evidence about the safety of short-acting nifedipine, a large health maintenance organization was able to motivate broad-scale changes to safer alternative drug therapies...
  50. ncbi A screening study of drug-drug interactions in cerivastatin users: an adverse effect of clopidogrel
    J S Floyd
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Clin Pharmacol Ther 91:896-904. 2012
    ..These epidemiological and in vitro findings suggest that clopidogrel may cause clinically important, dose-dependent drug-drug interactions with other medications metabolized by CYP2C8...
  51. ncbi Antidiabetic treatment trends in a cohort of elderly people with diabetes. The cardiovascular health study, 1989-1997
    N L Smith
    Department of Medicine, University of Washington, Seattle, USA
    Diabetes Care 22:736-42. 1999
    ..This study characterizes the pharmaceutical treatment of type 2 diabetes from 1989-1990 to 1996-1997 in an elderly cohort...
  52. ncbi Temporal trends in the use of anticoagulants among older adults with atrial fibrillation
    N L Smith
    Department of Medicine, University of Washington, Seattle, USA
    Arch Intern Med 159:1574-8. 1999
    ..Insufficient documentation exists on the extent to which the use of these therapies following trial publications has continued to increase in the elderly with atrial fibrillation...
  53. ncbi Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study
    N A Zakai
    Department of Medicine, Brown University and Boston University, Providence, RI, USA
    J Thromb Haemost 5:1128-35. 2007
    ..There are few studies of inflammation and hemostasis biomarkers and cardiovascular disease risk (CVD) in older adults...
  54. ncbi Cardiovascular disease mortality in familial forms of hypertriglyceridemia: A 20-year prospective study
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195 7236, USA
    Circulation 101:2777-82. 2000
    ..The purposes of this study were to estimate 20-year total and CVD mortality risk among relatives in these families and to evaluate plasma triglyceride as a predictor of death...
  55. ncbi Diastolic blood pressure and the risk of primary cardiac arrest among pharmacologically treated hypertensive patients
    D S Siscovick
    Department of Medicine, University of Washington, Seattle, USA
    J Gen Intern Med 11:350-6. 1996
    ..CONCLUSIONS: Our findings support available evidence that among hypertensive patients a treated diastolic blood pressure level below 85 mm Hg is associated with cardiac hazards...
  56. ncbi Low density lipoprotein particle size and risk of early-onset myocardial infarction in women
    A S Kamigaki
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195-7236, USA
    Am J Epidemiol 153:939-45. 2001
    ..05). Therefore, in age-adjusted analyses, smaller LDL particle size was associated with MI in young women, but the risk was attenuated after adjustments for metabolic factors related to both LDL particle size and MI...
  57. ncbi Logic regression for analysis of the association between genetic variation in the renin-angiotensin system and myocardial infarction or stroke
    Charles Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 165:334-43. 2007
    ....
  58. ncbi Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency
    Michael G Shlipak
    Department of Medicine, University of California, San Francisco, and the Veterans Affairs Medical Center, San Francisco 94121, USA
    Circulation 107:87-92. 2003
    ..Little is known about the association of renal insufficiency with inflammatory and procoagulant markers, which are potential mediators for the cardiovascular risk of kidney disease...
  59. ncbi Thrombosis in the young: effect of atherosclerotic risk factors on the risk of myocardial infarction associated with prothrombotic factors
    D S Siscovick
    Department of Medicine, University of Washington, Seattle 98101, USA
    Thromb Haemost 78:7-12. 1997
    ....
  60. ncbi HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women
    C J M Doggen
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    J Thromb Haemost 2:700-1. 2004
  61. ncbi Risk factors for hospitalized upper or lower gastrointestinal tract bleeding in treated hypertensives
    Robert C Kaplan
    Cardiovascular Health Research Unit, University of Washington, USA
    Prev Med 34:455-62. 2002
    ..We examined risk factors for hospitalized gastrointestinal bleeding among health maintenance organization (HMO) members with hypertension...
  62. ncbi Validation of the health ABC heart failure model for incident heart failure risk prediction: the Cardiovascular Health Study
    Andreas Kalogeropoulos
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circ Heart Fail 3:495-502. 2010
    ..The recently developed and internally validated Health ABC HF model uses 9 routinely available clinical variables to determine incident heart failure risk. In this study, we sought to externally validate the Health ABC HF model...
  63. ncbi C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Circulation 112:25-31. 2005
    ..High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available...
  64. ncbi The association of antihypertensive medication with serum creatinine changes in older adults
    N L Smith
    Department of Epidemiology, University of Washington, Seattle, USA
    Am J Hypertens 10:1368-77. 1997
    ....
  65. ncbi Hypertension and outcomes research. From clinical trials to clinical epidemiology
    B M Psaty
    Department of Medicine, University of Washington, Seattle, USA
    Am J Hypertens 9:178-83. 1996
    ..Consistency of findings across various study designs, outcomes, and populations is critical to the practice of evidence-based medicine and the effort to maximize the health benefits of antihypertensive therapies...
  66. ncbi Diabetes in older adults: comparison of 1997 American Diabetes Association classification of diabetes mellitus with 1985 WHO classification
    P W Wahl
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, USA
    Lancet 352:1012-5. 1998
    ....
  67. ncbi Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality: the cardiovascular health study
    B M Psaty
    Cardiovascular Health Study, Coordinating Center, Plaza 600 Building, Seattle, WA 98101, USA
    Arch Intern Med 161:1183-92. 2001
    ....
  68. ncbi The Kozak sequence polymorphism of platelet glycoprotein Ibalpha and risk of nonfatal myocardial infarction and nonfatal stroke in young women
    M B Frank
    Division of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA
    Blood 97:875-9. 2001
    ..Paradoxically, the C allele may even be associated with a reduced risk of MI in this population. This finding requires further study...
  69. ncbi Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
    D S Siscovick
    Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA
    Am J Clin Nutr 71:208S-12S. 2000
    ..These findings also may help to explain the apparent inconsistencies in earlier studies of long-chain n-3 PUFA intake and ischemic heart disease...
  70. ncbi Common VKORC1 variants are not associated with arterial or venous thrombosis
    L A Hindorff
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Thromb Haemost 5:2025-7. 2007
  71. ncbi Risk of new-onset atrial fibrillation in relation to body mass index
    Sascha Dublin
    Veterans Affairs Puget Sound Health Care System, Seattle, WA 98101, USA
    Arch Intern Med 166:2322-8. 2006
    ..It is also unknown to what extent cardiovascular risk factors may mediate this association...
  72. ncbi Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study
    Inbal Boger-Megiddo
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA 98101, USA
    BMJ 340:c103. 2010
    ..Design Population based case-control study. Setting Group Health Cooperative, Seattle, WA, USA...
  73. ncbi Mortality in pharmacologically treated older adults with diabetes: the Cardiovascular Health Study, 1989-2001
    Richard A Kronmal
    Collaborative Heath Studies Coordinating Center and Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Med 3:e400. 2006
    ..Women treated with insulin therapy have an especially high mortality risk. Given the high absolute CVD mortality in older people, those with DM warrant aggressive CVD risk factor reduction...
  74. ncbi Lipoprotein-associated phospholipase A(2) and risk of congestive heart failure in older adults: the Cardiovascular Health Study
    Takeki Suzuki
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Circ Heart Fail 2:429-36. 2009
    ..One previous study showed an association of Lp-PLA(2) activity with CHF risk, but there were only 94 CHF cases and Lp-PLA(2) antigen, which is available clinically in the United States, was not measured...
  75. ncbi NSAID trials and the choice of comparators--questions of public health importance
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
    N Engl J Med 356:328-30. 2007
  76. ncbi The association of smoking with venous thrombosis in women. A population-based, case-control study
    M Blondon
    Marc Blondon, University of Washington, Cardiovascular Health Research Unit, Metropolitan Park East Tower, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA, Tel 1 206 287 2777, Fax 1 206 287 2662, E mail
    Thromb Haemost 109:891-6. 2013
    ..Our results do not support a direct biological effect of smoking on the risk of VT that is clinically relevant...
  77. ncbi Temporal patterns in the medical treatment of congestive heart failure with angiotensin-converting enzyme inhibitors in older adults, 1989 through 1995
    N L Smith
    Department of Medicine, University of Washington, Seattle, USA
    Arch Intern Med 158:1074-80. 1998
    ..The extent to which clinical practice has adopted ACE inhibitor therapy is unknown...
  78. ncbi Lack of association between first myocardial infarction and past use of erythromycin, tetracycline, or doxycycline
    L A Jackson
    University of Washington, Seattle, USA
    Emerg Infect Dis 5:281-4. 1999
    ..These results suggest little or no association between the use of these antibiotics and the risk for first myocardial infarction in the primary prevention setting...
  79. ncbi Serum lipid levels and the risk of venous thrombosis
    Carine J M Doggen
    Department of Epidemiology, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 24:1970-5. 2004
    ..Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results...
  80. ncbi Motivating factors for physician ordering of factor V Leiden genetic tests
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, USA
    Arch Intern Med 169:68-74. 2009
    ..The factor V Leiden (FVL) genetic test is used by many physicians despite its uncertain clinical utility...
  81. ncbi Medications and cardiovascular health in older adults: room for improvement in prevention and treatment
    Caroline S Rhoads
    Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Am J Geriatr Cardiol 13:161-7. 2004
  82. ncbi Human liver expression of CYP2C8: gender, age, and genotype effects
    Suresh Babu Naraharisetti
    Departments of Medicinal Chemistry, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 38:889-93. 2010
    ..CYP2C8 mRNA or protein expression levels were not significantly affected by CYP2C8*3 or *4 genotype, gender, or age, and variation observed clinically in CYP2C8 activity warrants further investigation...
  83. ncbi Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  84. ncbi Short-term and long-term risk of incident ischemic stroke after transient ischemic attack
    Evan L Thacker
    Department of Epidemiology, University of Washington, Seattle, Wash, USA
    Stroke 41:239-43. 2010
    ..We sought to estimate short-term and long-term relative risks of ischemic stroke associated with clinically diagnosed TIA...
  85. ncbi Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke
    Lucia A Hindorff
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
    Pharmacogenet Genomics 18:677-82. 2008
    ....
  86. ncbi Risk of myocardial ischaemia and beta-adrenoceptor agonists
    D H Au
    Department of Veterans Affairs, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Ann Med 33:287-90. 2001
    ..Furthermore, careful consideration should be given to distinguish symptoms caused by cardiovascular versus respiratory aetiologies...
  87. ncbi Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
    Arch Intern Med 162:1395-400. 2002
    ....
  88. ncbi Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients
    Kristin D Marciante
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    Am J Epidemiol 166:19-27. 2007
    ..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke...
  89. ncbi Use of alendronate and risk of incident atrial fibrillation in women
    Susan R Heckbert
    Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Ste 1360, Seattle, WA 98101 1448, USA
    Arch Intern Med 168:826-31. 2008
    ..This adverse effect was unexpected and had not been recognized previously...
  90. ncbi Discovering novel risk factors for venous thrombosis: a candidate-gene approach
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, USA
    Thromb Res 123:S25-9. 2009
    ..As an example, we present a candidate-gene approach to identify novel associations between variation in 24 clotting genes and the risk of incident venous thrombosis...
  91. ncbi Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke
    Joshua C Bis
    Department of Medicine, University of Washington, Seattle, WA 981041, USA
    Atherosclerosis 198:166-73. 2008
    ....
  92. ncbi Hormone replacement therapy and associated risk of stroke in postmenopausal women
    Rozenn N Lemaitre
    Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle 98101, USA
    Arch Intern Med 162:1954-60. 2002
    ..There is little information about the risk of stroke in relation to time since initiation of hormone therapy and in relation to estrogen dose...
  93. ncbi Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events
    Lisa A Jackson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101 1448, USA
    Am J Epidemiol 156:634-40. 2002
    ..06, 95% CI: 0.63, 1.78) or inactivity (May through October) (HR = 1.34, 95% CI: 0.76, 2.36). These results suggest that the benefit of influenza vaccine for older adults does not extend to protection against recurrent coronary events...
  94. ncbi Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 204:e58-63. 2009
    ..A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC)...
  95. ncbi Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 15:1050-6. 2002
    ..We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults...
  96. ncbi Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons
    Alexander P Reiner
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 90:66-8. 2002
  97. ncbi Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke
    Kristin D Marciante
    Cardiovascular Health Research Unit, Seattle, Washington 98101, USA
    Pharmacogenet Genomics 18:535-43. 2008
    ..We conducted a population-based, case-control study at Group Health to determine whether common genetic variation in the CYP2J2, CYP2C8, and CYP2C9 genes was associated with the risk of myocardial infarction and ischemic stroke...
  98. ncbi Generalizability of the results of randomized trials
    Noel S Weiss
    Department of Epidemiology, University of Washington, F263 Health Sciences Center, Campus Box 357236, Seattle, WA 98195, USA
    Arch Intern Med 168:133-5. 2008
  99. ncbi Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists
    Chris L Bryson
    VA Puget Sound Health Services Research and Development, VAMC, Seattle, Washington 98108, USA
    J Am Geriatr Soc 52:1648-54. 2004
    ....
  100. ncbi Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension
    Gina D Schellenbaum
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 53:1996-2000. 2005
    ..To determine whether angiotensin-converting enzyme (ACE) inhibitor use may be associated with weight maintenance and sustained muscle strength (measured by grip strength) in older adults...
  101. ncbi beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Hypertens 21:290-6. 2008
    ..The benefits of beta-blocker therapy may depend on underlying genetic susceptibility...

Research Grants49

  1. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce M Psaty; Fiscal Year: 2010
    ....
  2. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
    ..The primary defense is replication: we would therefore welcome collaboration from others in the Pharmacogenetics Network in validation efforts. ..
  3. Hormone Replacement Therapy and Prothrombotic Variants
    Bruce Psaty; Fiscal Year: 2005
    ..Power for primary and secondary aims is excellent. Information from this project may help physicians counsel women about HRT to maximize either effectiveness, or safety, or both. ..
  4. ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTS
    Bruce Psaty; Fiscal Year: 2004
    ..58 (the difference between an odds ratio of 0.46 and 0.79 in subjects with and without the variant, respectively). Power for other primary aims is excellent; power for secondary aims is good to excellent. ..
  5. Trends in and Outcomes of Medication Use in Older Adults
    Bruce Psaty; Fiscal Year: 2004
    ..abstract_text> ..
  6. WGA Study to Identify Genetic Variants Associated with CV Events in CHS
    Bruce Psaty; Fiscal Year: 2007
    ..The proposed three-part study is efficient, has excellent power to detect small to modest-sized hazard ratios, provides a large sample of WG scans for aim 2, and includes an external replication. (End of Abstract) ..
  7. CHS Events Follow-up Study
    Bruce M Psaty; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Additional knowledge about the determinants of cardiovascular health and disease in older adults will help physicians and their patients make diagnostic, prognostic, and therapeutic decisions. PROJECT/ ..
  8. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce Psaty; Fiscal Year: 2009
    ....
  9. WGA Study to Identify Genetic Variants Associated with CV Events in CHS
    Bruce Psaty; Fiscal Year: 2009
    ..The proposed three-part study is efficient, has excellent power to detect small to modest-sized hazard ratios, provides a large sample of WG scans for aim 2, and includes an external replication. (End of Abstract) ..
  10. CHS Events Follow-up Study
    Bruce Psaty; Fiscal Year: 2007
    ..Additional events follow-up will not only provide the opportunity to address the aims of this study, but also enhance the power of current and future CHS papers and ancillary studies by CHS and non-CHS colleagues. ..
  11. Pharmacoepidemiology and Pharmacogenetics of a Statin AE
    Bruce Psaty; Fiscal Year: 2007
    ..coli and evaluated for their functional significance. The study of cerivastatin-associated rhabdomyolysis may advance our understanding of the pharmacoepidemiology and the pharmacogenetics of CYP2C8, UGT1A1 and UGT1A3. ..
  12. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce Psaty; Fiscal Year: 2007
    ....
  13. EPIDEMIOLOGY OF ANTI-HYPERTENSIVE DRUGS IN THE ELDERLY
    Bruce Psaty; Fiscal Year: 1993
    ..This project will enable us to pursue vigorously a set of related analyses of the effects of anti-hypertensive medicines on a variety of outcomes in the elderly...
  14. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    ....
  15. ANTIHYPERTENSIVE MEDICATIONS, MI AND STROKE
    Bruce Psaty; Fiscal Year: 1999
    ..For individual calcium-channel blocking agents, the study will have 74-94% power to detect RRs in the range of 1.4-1.5 for MI and 72-91% power to detect RRs in the range of 1.3-1.4 for the combined endpoint of MI plus stroke. ..
  16. CALCIUM-CHANNEL BLOCKERS AND PRIMARY PREVENTION OF CHD
    Bruce Psaty; Fiscal Year: 1993
    ....