Gloria Pryhuber

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice
    Sara Saperstein
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mediators Inflamm 2009:958658. 2009
  2. pmc Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice
    Gloria S Pryhuber
    Department of Pediatrics, Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 72:150-7. 2003
  3. pmc Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Pathol 166:1637-45. 2005
  4. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
  5. pmc IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells
    Sara Saperstein
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Interferon Cytokine Res 29:273-84. 2009
  6. pmc G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 119:1524-32. 2009
  7. ncbi request reprint Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons
    William M Maniscalco
    Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 282:L811-23. 2002
  8. ncbi request reprint Pathogenesis of bronchopulmonary dysplasia
    Patricia R Chess
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
    Semin Perinatol 30:171-8. 2006
  9. ncbi request reprint TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia
    Terry W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:2511-21. 2004
  10. pmc Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway
    Rayman Choo-Wing
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Respir Cell Mol Biol 48:749-57. 2013

Research Grants

Detail Information

Publications13

  1. pmc The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice
    Sara Saperstein
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mediators Inflamm 2009:958658. 2009
    ..These results suggest IL-1beta contributes, in part, to TNF-alpha-mediated, chemokine release, and neutrophil recruitment to the lung, potentially associated with altered soluble TNFR1 release into the BALF...
  2. pmc Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice
    Gloria S Pryhuber
    Department of Pediatrics, Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 72:150-7. 2003
    ..Silica dependent recruitment of neutrophils to the alveolar space and alveolar protein leak were, however, not altered by the absence of the TNF receptor...
  3. pmc Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Pathol 166:1637-45. 2005
    ..These studies suggest that TRAF1 provides negative feedback for TNF-alpha synthesis and limits TNFRI-mediated systemic effects of TNF-alpha originating in the lung...
  4. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
    ..This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells...
  5. pmc IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells
    Sara Saperstein
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Interferon Cytokine Res 29:273-84. 2009
    ..These data suggest IL-1beta modulates TNF-alpha-mediated inflammatory lung diseases by enhancing epithelial cell TNF receptor surface expression...
  6. pmc G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 119:1524-32. 2009
    ..However, there have been no in vivo studies of GIT1 function to date...
  7. ncbi request reprint Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons
    William M Maniscalco
    Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 282:L811-23. 2002
    ..These data suggest that CLD impairs lung microvascular development and that a possible mechanism is disruption of VEGF and Flt-1 expression...
  8. ncbi request reprint Pathogenesis of bronchopulmonary dysplasia
    Patricia R Chess
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
    Semin Perinatol 30:171-8. 2006
    ..The contribution of hyperoxia and hypoxia, mechanical forces, vascular maldevelopment, inflammation, fluid management, patent ductus arteriosus (PDA), nutrition, and genetics will be discussed...
  9. ncbi request reprint TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia
    Terry W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:2511-21. 2004
    ....
  10. pmc Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway
    Rayman Choo-Wing
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Respir Cell Mol Biol 48:749-57. 2013
    ..Cox2, via CHOP, may significantly contribute to the final common pathway of hyperoxia-induced and IFN-γ-mediated injury in developing lungs and human BPD...
  11. ncbi request reprint Effect of cumulative oxygen exposure on respiratory symptoms during infancy among VLBW infants without bronchopulmonary dysplasia
    Timothy P Stevens
    Division of Neonatology, Department of Pediatrics, University of Rochester, Rochester, New York, USA
    Pediatr Pulmonol 45:371-9. 2010
    ..A possible explanation for these inconsistent findings is that the cumulative dosage of neonatal supplemental oxygen to which infants are exposure is difficult to accurately quantify...
  12. pmc Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans
    Matt K Lee
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southren California, 2250 Alcazar Street, CSA 113, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 171:1384-94. 2005
    ..The p66(Shc) adapter protein antagonizes mitogen-activated protein, or MAP, kinase, mediates oxidative stress, and is developmentally regulated in fetal mouse lungs...
  13. ncbi request reprint Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways
    Susan D Reynolds
    Departments of Environmental and Occupational Health, and Pediatrics, University of Pittsburgh, Pennsylvania 15260, USA
    Am J Respir Crit Care Med 166:1498-509. 2002
    ..Altered expression of secretoglobins in airway disease may contribute to immunoregulatory perturbations commonly seen in chronic airway disease...

Research Grants9

  1. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2001
    ..The proposed studies will demonstrate the cellular function of TRAF1 in vitro and the role of TRAF1 expression in vivo in transgenic overexpression and ablation models stressed by hyperoxia. ..
  2. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2003
    ..The proposed studies will demonstrate the cellular function of TRAF1 in vitro and the role of TRAF1 expression in vivo in transgenic overexpression and ablation models stressed by hyperoxia. ..
  3. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2006
    ..Lung disease caused by inhaled dust is a significant world wide health problem. This proposal will identify new targets for therapy of these chronic and often deadly diseases with reduced side effects. ..
  4. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2007
    ..Lung disease caused by inhaled dust is a significant world wide health problem. This proposal will identify new targets for therapy of these chronic and often deadly diseases with reduced side effects. ..
  5. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2009
    ..Lung disease caused by inhaled dust is a significant world wide health problem. This proposal will identify new targets for therapy of these chronic and often deadly diseases with reduced side effects. ..
  6. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2009
    ..Lung disease caused by inhaled dust is a significant world wide health problem. This proposal will identify new targets for therapy of these chronic and often deadly diseases with reduced side effects. ..
  7. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2000
    ..The proposed studies will demonstrate the cellular function of TRAF1 in vitro and the role of TRAF1 expression in vivo in transgenic overexpression and ablation models stressed by hyperoxia. ..
  8. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2002
    ..The proposed studies will demonstrate the cellular function of TRAF1 in vitro and the role of TRAF1 expression in vivo in transgenic overexpression and ablation models stressed by hyperoxia. ..