Research Topics
| PETER PRYCIAKSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Designing new cellular signaling pathwaysPeter M Pryciak
Department of Molecular Genetics and Microbiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
Chem Biol 16:249-54. 2009..These synthetic biology approaches promise to deepen our understanding of existing signaling pathways and spur the development of new cellular tools for research, industry, and medicine...
Systems biology. Customized signaling circuitsPeter M Pryciak
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 319:1489-90. 2008- Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20Matthew J Winters
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation St, Four Biotech, Rm 330, Worcester, MA 01605, USA
Mol Cell Biol 25:2177-90. 2005..The overall results also illustrate how the final signaling function of a protein can be governed by combinatorial addition of multiple, independent protein-protein interaction modules... - A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone responseMatthew J Winters
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell 20:21-32. 2005..Therefore, weak membrane affinity is advantageous, ensuring a normal level of signaling quiescence in the absence of stimulus and imposing a requirement for Gbetagamma binding... - Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelityRachel E Lamson
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Curr Biol 16:618-23. 2006..The regulation of rate-limiting steps that lie after a branchpoint from shared components helps ensure signaling specificity... - A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathwayShelly C Strickfaden
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 128:519-31. 2007..These findings define a mechanism and physiological benefit of restricting antiproliferative signaling to G1... - Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascadeSatoe Takahashi
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Curr Biol 18:1184-91. 2008..It has been hypothesized that scaffold proteins promote graded behavior... - Identification of novel membrane-binding domains in multiple yeast Cdc42 effectorsSatoe Takahashi
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Biol Cell 18:4945-56. 2007.... - Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20Rachel E Lamson
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell Biol 22:2939-51. 2002..In total, our observations indicate that Cdc42 converts Ste20 to an active form, while pathway stimuli regulate the ability of this active Ste20 to trigger signaling through a particular pathway... - Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G proteinShelly C Strickfaden
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Biol Cell 19:181-97. 2008..These findings raise the possibility that the Galphabetagamma heterotrimer can function in a partially dissociated state, tethered by the N-terminal interface...
Research Grants
- YEAST PHEROMONE SIGNAL TRANSDUCTIONPETER PRYCIAK; Fiscal Year: 2007..Overall, we expect these studies to contribute to a sophisticated understanding of signal transduction by revealing mechanisms that are built into signaling systems to allow dynamic and integrative responses within a cell. ..
- YEAST HETEROTRIMERIC G PROTEIN AND CELL POLARITYPETER PRYCIAK; Fiscal Year: 2006..abstract_text> ..
- YEAST HETEROTRIMERIC G PROTEIN AND CELL POLARITYPETER PRYCIAK; Fiscal Year: 2003..abstract_text> ..
- YEAST PHEROMONE SIGNAL TRANSDUCTIONPeter M Pryciak; Fiscal Year: 2010..abstract_text> ..