PETER PRYCIAK

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Designing new cellular signaling pathways
    Peter M Pryciak
    Department of Molecular Genetics and Microbiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Chem Biol 16:249-54. 2009
  2. doi request reprint Systems biology. Customized signaling circuits
    Peter M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 319:1489-90. 2008
  3. pmc Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20
    Matthew J Winters
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation St, Four Biotech, Rm 330, Worcester, MA 01605, USA
    Mol Cell Biol 25:2177-90. 2005
  4. ncbi request reprint A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response
    Matthew J Winters
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 20:21-32. 2005
  5. ncbi request reprint Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity
    Rachel E Lamson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 16:618-23. 2006
  6. pmc A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway
    Shelly C Strickfaden
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 128:519-31. 2007
  7. pmc Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade
    Satoe Takahashi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 18:1184-91. 2008
  8. pmc Identification of novel membrane-binding domains in multiple yeast Cdc42 effectors
    Satoe Takahashi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 18:4945-56. 2007
  9. pmc Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20
    Rachel E Lamson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 22:2939-51. 2002
  10. pmc Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein
    Shelly C Strickfaden
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 19:181-97. 2008

Research Grants

  1. YEAST PHEROMONE SIGNAL TRANSDUCTION
    PETER PRYCIAK; Fiscal Year: 2007
  2. YEAST HETEROTRIMERIC G PROTEIN AND CELL POLARITY
    PETER PRYCIAK; Fiscal Year: 2006
  3. YEAST HETEROTRIMERIC G PROTEIN AND CELL POLARITY
    PETER PRYCIAK; Fiscal Year: 2003
  4. YEAST PHEROMONE SIGNAL TRANSDUCTION
    Peter M Pryciak; Fiscal Year: 2010

Collaborators

  • A M Neiman
  • Matthew J Winters
  • Rachel E Lamson
  • Satoe Takahashi
  • Shelly C Strickfaden
  • Mike Tyers
  • Giora Ben-Ari
  • Hideki Nakanishi

Detail Information

Publications10

  1. pmc Designing new cellular signaling pathways
    Peter M Pryciak
    Department of Molecular Genetics and Microbiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Chem Biol 16:249-54. 2009
    ..These synthetic biology approaches promise to deepen our understanding of existing signaling pathways and spur the development of new cellular tools for research, industry, and medicine...
  2. doi request reprint Systems biology. Customized signaling circuits
    Peter M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 319:1489-90. 2008
  3. pmc Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20
    Matthew J Winters
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation St, Four Biotech, Rm 330, Worcester, MA 01605, USA
    Mol Cell Biol 25:2177-90. 2005
    ..The overall results also illustrate how the final signaling function of a protein can be governed by combinatorial addition of multiple, independent protein-protein interaction modules...
  4. ncbi request reprint A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response
    Matthew J Winters
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 20:21-32. 2005
    ..Therefore, weak membrane affinity is advantageous, ensuring a normal level of signaling quiescence in the absence of stimulus and imposing a requirement for Gbetagamma binding...
  5. ncbi request reprint Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity
    Rachel E Lamson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 16:618-23. 2006
    ..The regulation of rate-limiting steps that lie after a branchpoint from shared components helps ensure signaling specificity...
  6. pmc A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway
    Shelly C Strickfaden
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 128:519-31. 2007
    ..These findings define a mechanism and physiological benefit of restricting antiproliferative signaling to G1...
  7. pmc Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade
    Satoe Takahashi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 18:1184-91. 2008
    ..It has been hypothesized that scaffold proteins promote graded behavior...
  8. pmc Identification of novel membrane-binding domains in multiple yeast Cdc42 effectors
    Satoe Takahashi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 18:4945-56. 2007
    ....
  9. pmc Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20
    Rachel E Lamson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 22:2939-51. 2002
    ..In total, our observations indicate that Cdc42 converts Ste20 to an active form, while pathway stimuli regulate the ability of this active Ste20 to trigger signaling through a particular pathway...
  10. pmc Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein
    Shelly C Strickfaden
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 19:181-97. 2008
    ..These findings raise the possibility that the Galphabetagamma heterotrimer can function in a partially dissociated state, tethered by the N-terminal interface...

Research Grants13

  1. YEAST PHEROMONE SIGNAL TRANSDUCTION
    PETER PRYCIAK; Fiscal Year: 2007
    ..Overall, we expect these studies to contribute to a sophisticated understanding of signal transduction by revealing mechanisms that are built into signaling systems to allow dynamic and integrative responses within a cell. ..
  2. YEAST HETEROTRIMERIC G PROTEIN AND CELL POLARITY
    PETER PRYCIAK; Fiscal Year: 2006
    ..abstract_text> ..
  3. YEAST HETEROTRIMERIC G PROTEIN AND CELL POLARITY
    PETER PRYCIAK; Fiscal Year: 2003
    ..abstract_text> ..
  4. YEAST PHEROMONE SIGNAL TRANSDUCTION
    Peter M Pryciak; Fiscal Year: 2010
    ..abstract_text> ..