P M Pryciak

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction
    P M Pryciak
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell Biol 16:2614-26. 1996
  2. ncbi Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients
    R Dorer
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    J Cell Biol 131:845-61. 1995
  3. ncbi Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway
    P M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester Foundation Campus, Shrewsbury, Massachusetts 01545, USA
    Genes Dev 12:2684-97. 1998
  4. ncbi The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
    A C Butty
    Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, 1066 Epalinges VD, Switzerland
    Science 282:1511-6. 1998
  5. ncbi Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae
    J J Moskow
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 20:7559-71. 2000
  6. ncbi MAP kinases bite back
    P M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605, USA
    Dev Cell 1:449-51. 2001
  7. ncbi Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins
    K Harris
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 11:1815-24. 2001

Collaborators

  • Daniel J Lew
  • K Harris
  • R E Lamson
  • J J Moskow
  • A C Butty
  • M J Marton
  • C Boone
  • C J Roberts
  • B Nelson
  • T R Hughes
  • R Dorer
  • A S Gladfelter
  • L S Huang
  • M Peter
  • I Herskowitz
  • L H Hartwell

Detail Information

Publications7

  1. ncbi AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction
    P M Pryciak
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell Biol 16:2614-26. 1996
    ....
  2. ncbi Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients
    R Dorer
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    J Cell Biol 131:845-61. 1995
    ..These observations reveal a molecular relationship between the mating and budding polarity pathways...
  3. ncbi Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway
    P M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester Foundation Campus, Shrewsbury, Massachusetts 01545, USA
    Genes Dev 12:2684-97. 1998
    ..Moreover, our results suggest that this event promotes kinase cascade activation by delivering the Ste5-associated kinases to the cell surface kinase Ste20, whose function may depend on Cdc42 and Cdc24...
  4. ncbi The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
    A C Butty
    Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, 1066 Epalinges VD, Switzerland
    Science 282:1511-6. 1998
    ..Thus, Far1p functions as an adaptor that recruits polarity establishment proteins to the site of extracellular signaling marked by Gbetagamma to polarize assembly of the cytoskeleton in a morphogenetic gradient...
  5. ncbi Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae
    J J Moskow
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 20:7559-71. 2000
    ....
  6. ncbi MAP kinases bite back
    P M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605, USA
    Dev Cell 1:449-51. 2001
    ..Recent studies in a model system challenge our understanding of how signal transmission through a MAP kinase cascade proceeds and how signaling specificity may be achieved...
  7. ncbi Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins
    K Harris
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 11:1815-24. 2001
    ..Our results give insight into the mechanisms and physiological importance of pathway insulation and provide a foundation for the design of customized signaling proteins...