P M Pryciak
Affiliation: University of Massachusetts Medical Center
- Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathwayP M Pryciak
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester Foundation Campus, Shrewsbury, Massachusetts 01545, USA
Genes Dev 12:2684-97. 1998..Moreover, our results suggest that this event promotes kinase cascade activation by delivering the Ste5-associated kinases to the cell surface kinase Ste20, whose function may depend on Cdc42 and Cdc24...
- MAP kinases bite backP M Pryciak
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605, USA
Dev Cell 1:449-51. 2001..Recent studies in a model system challenge our understanding of how signal transmission through a MAP kinase cascade proceeds and how signaling specificity may be achieved...
- Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteinsK Harris
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
Curr Biol 11:1815-24. 2001..Our results give insight into the mechanisms and physiological importance of pathway insulation and provide a foundation for the design of customized signaling proteins...
- AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transductionP M Pryciak
Department of Genetics, University of Washington, Seattle 98195 7360, USA
Mol Cell Biol 16:2614-26. 1996....
- The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast matingA C Butty
Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, 1066 Epalinges VD, Switzerland
Science 282:1511-6. 1998..Thus, Far1p functions as an adaptor that recruits polarity establishment proteins to the site of extracellular signaling marked by Gbetagamma to polarize assembly of the cytoskeleton in a morphogenetic gradient...
- Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiaeJ J Moskow
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 20:7559-71. 2000....